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Protein

NADH-cytochrome b5 reductase

Gene

hpo-19

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.UniRule annotation

Cofactori

FADUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein, NADUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation
R-CEL-196836 Vitamin C (ascorbate) metabolism
R-CEL-211945 Phase I - Functionalization of compounds
R-CEL-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-cytochrome b5 reductaseUniRule annotation (EC:1.6.2.2UniRule annotation)
Gene namesi
Name:hpo-19Imported
ORF Names:CELE_T05H4.5Imported, T05H4.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT05H4.5 ; CE13277 ; WBGene00020268 ; hpo-19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 25HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO16521
PaxDbiO16521
PeptideAtlasiO16521

Expressioni

Gene expression databases

BgeeiWBGene00020268

Interactioni

Protein-protein interaction databases

STRINGi6239.T05H4.5.1

Structurei

3D structure databases

ProteinModelPortaliO16521
SMRiO16521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 160FAD-binding FR-typeInterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0534 Eukaryota
COG0543 LUCA
GeneTreeiENSGT00390000008881
HOGENOMiHOG000175005
InParanoidiO16521
KOiK00326
OMAiHNTAIYR
OrthoDBiEOG091G0EIS
PhylomeDBiO16521

Family and domain databases

InterProiView protein in InterPro
IPR017927 Fd_Rdtase_FAD-bd
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001834 NADH-Cyt_B5_reductase
IPR008333 OxRdtase_FAD-bd_dom
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00970 FAD_binding_6, 1 hit
PF00175 NAD_binding_1, 1 hit
PRINTSiPR00406 CYTB5RDTASE
PR00371 FPNCR
SUPFAMiSSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

O16521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVENNTLIIT GGVVVVSSIA IYIYLKATNT CPFSLCKKSK KRTLVDDSVK
60 70 80 90 100
YPLPLIEKFE ISHDTRKFRF GLPSKDHILG LPIGQHVYLT ANIDGKIIVR
110 120 130 140 150
PYTPVSSDED LGFVDLMVKV YFKNTNEKFP EGGKMSQHLE SLKIGDTINF
160 170 180 190 200
RGPQGNIVYK GHGLFSIKAD KKAEPKNRVF KHLSMIAGGT GITPMLQVIA
210 220 230 240 250
AILRDPTDTT QIRLLFANQT EDDILCRQEL DDLAKEHPTR FRVWYTVDRP
260 270 280 290 300
PVMWSYSSGF INDSMIKENL FPPGDDSAVL LCGPPPMINF ACIPNLEKLE

YDPANRLLF
Length:309
Mass (Da):34,750
Last modified:January 1, 1998 - v1
Checksum:i529B89AB21B4A2C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD72032.1
PIRiT31908
RefSeqiNP_504638.1, NM_072237.4
UniGeneiCel.2461

Genome annotation databases

EnsemblMetazoaiT05H4.5.1; T05H4.5.1; WBGene00020268
T05H4.5.2; T05H4.5.2; WBGene00020268
GeneIDi179029
KEGGicel:CELE_T05H4.5
UCSCiT05H4.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO16521_CAEEL
AccessioniPrimary (citable) accession number: O16521
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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