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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-1Imported
ORF Names:CELE_T05B4.1Imported, T05B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT05B4.1; CE51658; WBGene00020236; lgc-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei255 – 280HelicalSequence analysisAdd BLAST26
Transmembranei287 – 305HelicalSequence analysisAdd BLAST19
Transmembranei317 – 343HelicalSequence analysisAdd BLAST27
Transmembranei364 – 390HelicalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500792175519 – 391Sequence analysisAdd BLAST373

Proteomic databases

PaxDbiO16426.

Expressioni

Gene expression databases

BgeeiWBGene00020236.

Interactioni

Protein-protein interaction databases

STRINGi6239.T05B4.1.

Structurei

3D structure databases

ProteinModelPortaliO16426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 206Neur_chan_LBDInterPro annotationAdd BLAST170
Domaini262 – 364Neur_chan_membInterPro annotationAdd BLAST103

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000019212.
InParanoidiO16426.
OMAiQNICAES.
OrthoDBiEOG091G0D55.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLYFTLCL LVIPNFLAQD MTKAEMATYN KFLADQKRLW DDLFKDYDPT
60 70 80 90 100
LSAIYTLHKS QWINQTATIH PPITELKLTM AMLKLVDVVE VEEKVTFLFD
110 120 130 140 150
YLAEWTDQRL KWNPLEYGGI SHIYVPQRMI WLPEVTIADA HEVKFFESDD
160 170 180 190 200
APRTAWINYN GTTGFYTSTV SSVICQLDVY KFPLDRHECG VSVLFHTYFA
210 220 230 240 250
DEYVIKSDME PLPKPLSQLG NGEWKVTYIG VAEEIGNGNF SAVQRFVARI
260 270 280 290 300
ERNPGFYVTL VMVPAFFINF LSIIALCLNI ENVGEKITVG LTNIMAMTFI
310 320 330 340 350
LVILAQDLPK TKRIPLLAIY VIVGLVIVMA SIGVVLTLPL IRNHLKKRQK
360 370 380 390
GKEEKPVETR FSKWFGWLTV EYVVMFVFQL ANLINFIILF I
Length:391
Mass (Da):44,982
Last modified:July 6, 2016 - v4
Checksum:i33ED120C38298753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70839.2.
RefSeqiNP_504154.4. NM_071753.5.

Genome annotation databases

EnsemblMetazoaiT05B4.1; T05B4.1; WBGene00020236.
GeneIDi188099.
KEGGicel:CELE_T05B4.1.
UCSCiT05B4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD70839.2.
RefSeqiNP_504154.4. NM_071753.5.

3D structure databases

ProteinModelPortaliO16426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T05B4.1.

Proteomic databases

PaxDbiO16426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05B4.1; T05B4.1; WBGene00020236.
GeneIDi188099.
KEGGicel:CELE_T05B4.1.
UCSCiT05B4.1. c. elegans.

Organism-specific databases

CTDi188099.
WormBaseiT05B4.1; CE51658; WBGene00020236; lgc-1.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000019212.
InParanoidiO16426.
OMAiQNICAES.
OrthoDBiEOG091G0D55.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Gene expression databases

BgeeiWBGene00020236.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO16426_CAEEL
AccessioniPrimary (citable) accession number: O16426
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: July 6, 2016
Last modified: November 30, 2016
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.