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Protein

Probable 26S proteasome regulatory subunit 4

Gene

rpt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1 (PubMed:22621901).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 236ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit 4
Gene namesi
Name:rpt-2
ORF Names:F29G9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF29G9.5; CE09799; WBGene00004502; rpt-2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown at the L1 larval stage, causes 20 percent increase in mei-1 protein levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846811 – 443Probable 26S proteasome regulatory subunit 4Add BLAST443

Proteomic databases

EPDiO16368.
PaxDbiO16368.
PeptideAtlasiO16368.
PRIDEiO16368.

Expressioni

Gene expression databases

BgeeiWBGene00004502.

Interactioni

GO - Molecular functioni

  • TBP-class protein binding Source: GO_Central
  • ubiquitin protein ligase binding Source: WormBase

Protein-protein interaction databases

BioGridi44036. 2 interactors.
IntActiO16368. 3 interactors.
MINTiMINT-210699.
STRINGi6239.F29G9.5.1.

Structurei

3D structure databases

ProteinModelPortaliO16368.
SMRiO16368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0726. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074818.
HOGENOMiHOG000225143.
InParanoidiO16368.
KOiK03062.
OMAiNATFIRV.
OrthoDBiEOG091G07NC.
PhylomeDBiO16368.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

O16368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQQSGFGG RGNDRGAGDG EKKEKKKYEA PIPSRIGKKK KGSKGPDAAS
60 70 80 90 100
KLPAVTPHAR CRLKLLKSER IKDYLLMEQE FIQNQERLKP QEERQEEERA
110 120 130 140 150
KVDELRGTPM AVGSLEEIID DQHAIVSTNV GSEHYVNIMS FVDKEQLEPG
160 170 180 190 200
CSVLLNHKNH AVIGVLSDDT DPMVSVMKLE KAPQETYADV GGLDQQIQEI
210 220 230 240 250
KEAVELPLTH PEYYEEMGIR PPKGVILYGC PGTGKTLLAK AVANQTSATF
260 270 280 290 300
LRIVGSELIQ KYLGDGPKMV RELFRVAEEN APSIVFIDEI DAVGTKRYDS
310 320 330 340 350
NSGGEREIQR TMLELLNQLD GFDSRGDVKV LMATNRIESL DPALIRPGRI
360 370 380 390 400
DRKIEFPLPD EKTKRRIFQI HTSRMTLGKE VNLEEFITAK DELSGADIKA
410 420 430 440
MCTEAGLLAL RERRMRVTME DFQKSKENVL YRKKEGAPEE LYL
Length:443
Mass (Da):49,723
Last modified:January 1, 1998 - v1
Checksum:i6908E4AB5C15C642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080494 Genomic DNA. Translation: CCD64135.1.
PIRiT31800.
RefSeqiNP_504558.1. NM_072157.6.
UniGeneiCel.2745.

Genome annotation databases

EnsemblMetazoaiF29G9.5; F29G9.5; WBGene00004502.
GeneIDi178988.
KEGGicel:CELE_F29G9.5.
UCSCiF29G9.5. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRS4_CAEEL
AccessioniPrimary (citable) accession number: O16368
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 5, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families