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Protein

Calmodulin

Gene

cmd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1053PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 1414PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: WormBase
  • cell migration Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of meiotic spindle orientation Source: WormBase
  • regulation of apoptotic process Source: WormBase
  • regulation of cell cycle Source: WormBase
  • regulation of protein localization Source: WormBase

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-111933 Calmodulin induced events
R-CEL-111957 Cam-PDE 1 activation
R-CEL-114608 Platelet degranulation
R-CEL-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-CEL-163615 PKA activation
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-203615 eNOS activation
R-CEL-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-CEL-2672351 Stimuli-sensing channels
R-CEL-2871809 FCERI mediated Ca+2 mobilization
R-CEL-4086398 Ca2+ pathway
R-CEL-418359 Reduction of cytosolic Ca++ levels
R-CEL-425561 Sodium/Calcium exchangers
R-CEL-5218920 VEGFR2 mediated vascular permeability
R-CEL-5578775 Ion homeostasis
R-CEL-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-CEL-5626467 RHO GTPases activate IQGAPs
R-CEL-6798695 Neutrophil degranulation
R-CEL-70221 Glycogen breakdown (glycogenolysis)
R-CEL-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:cmd-1
ORF Names:T21H3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT21H3.3a ; CE13902 ; WBGene00000552 ; cmd-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001982502 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiO16305
PaxDbiO16305
PeptideAtlasiO16305
PRIDEiO16305

PTM databases

iPTMnetiO16305

Expressioni

Gene expression databases

BgeeiWBGene00000552
ExpressionAtlasiO16305 baseline

Interactioni

Subunit structurei

Interacts (in the presence of Ca2+) with pde-1, madf-3, rpl-7A, tax-6, efk-1, npp-1, obr-4, sos-1, akt-1, unc-13, tag-196, ugt-48, nmy-2, F27D4.4, ddx-23, efa-6 and R11H6.4.1 Publication

Protein-protein interaction databases

BioGridi43683, 1 interactor
DIPiDIP-25019N
IntActiO16305, 1 interactor
STRINGi6239.T21H3.3.1

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 20Combined sources12
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 54Combined sources9
Beta strandi61 – 65Combined sources5
Helixi66 – 93Combined sources28
Beta strandi98 – 101Combined sources4
Helixi103 – 111Combined sources9
Turni112 – 114Combined sources3
Helixi119 – 129Combined sources11
Beta strandi134 – 138Combined sources5
Helixi139 – 145Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OOJX-ray2.11A1-149[»]
5H7DX-ray2.57E/F/G/H/K/L/O/P1-75[»]
ProteinModelPortaliO16305
SMRiO16305
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO16305

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
InParanoidiO16305
KOiK02183
OMAiESELTDM
OrthoDBiEOG091G0V73
PhylomeDBiO16305

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVTMMTTK
Length:149
Mass (Da):16,825
Last modified:January 23, 2007 - v3
Checksum:i6B40B8917FC7027B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132193 mRNA Translation: CAA10601.1
FO081216 Genomic DNA Translation: CCD69969.1
PIRiT31737
RefSeqiNP_503386.1, NM_070985.5
UniGeneiCel.17969

Genome annotation databases

EnsemblMetazoaiT21H3.3a; T21H3.3a; WBGene00000552
GeneIDi178614
KEGGicel:CELE_T21H3.3
UCSCiT21H3.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCALM_CAEEL
AccessioniPrimary (citable) accession number: O16305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health