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Protein

Calmodulin

Gene

cmd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi94 – 105123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi130 – 141124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: WormBase
  • cell migration Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of meiotic spindle orientation Source: WormBase
  • regulation of apoptotic process Source: WormBase
  • regulation of cell cycle Source: WormBase
  • regulation of protein localization Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-111933. Calmodulin induced events.
R-CEL-111957. Cam-PDE 1 activation.
R-CEL-114608. Platelet degranulation.
R-CEL-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-CEL-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-CEL-203615. eNOS activation.
R-CEL-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-CEL-2672351. Stimuli-sensing channels.
R-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-425561. Sodium/Calcium exchangers.
R-CEL-442729. CREB phosphorylation through the activation of CaMKII.
R-CEL-451308. Activation of Ca-permeable Kainate Receptor.
R-CEL-5218920. VEGFR2 mediated vascular permeability.
R-CEL-5578775. Ion homeostasis.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-CEL-5626467. RHO GTPases activate IQGAPs.
R-CEL-70221. Glycogen breakdown (glycogenolysis).
R-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:cmd-1
ORF Names:T21H3.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT21H3.3a; CE13902; WBGene00000552; cmd-1.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: WormBase
  • centrosome Source: WormBase
  • mitotic spindle Source: WormBase
  • nuclear membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 149148CalmodulinPRO_0000198250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei116 – 1161N6,N6,N6-trimethyllysineBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiO16305.
PaxDbiO16305.
PRIDEiO16305.

PTM databases

iPTMnetiO16305.

Expressioni

Gene expression databases

BgeeiWBGene00000552.
ExpressionAtlasiO16305. baseline.

Interactioni

Subunit structurei

Interacts (in the presence of Ca2+) with pde-1, madf-3, rpl-7A, tax-6, efk-1, npp-1, obr-4, sos-1, akt-1, unc-13, tag-196, ugt-48, nmy-2, F27D4.4, ddx-23, efa-6 and R11H6.4.1 Publication

Protein-protein interaction databases

BioGridi43683. 1 interaction.
DIPiDIP-25019N.
IntActiO16305. 1 interaction.
MINTiMINT-1114185.
STRINGi6239.T21H3.3.1.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2012Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 3910Combined sources
Helixi46 – 549Combined sources
Beta strandi61 – 655Combined sources
Helixi66 – 9328Combined sources
Beta strandi98 – 1014Combined sources
Helixi103 – 1119Combined sources
Turni112 – 1143Combined sources
Helixi119 – 12911Combined sources
Beta strandi134 – 1385Combined sources
Helixi139 – 1457Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OOJX-ray2.11A1-149[»]
ProteinModelPortaliO16305.
SMRiO16305. Positions 6-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO16305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiO16305.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG091G0V73.
PhylomeDBiO16305.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVTMMTTK
Length:149
Mass (Da):16,825
Last modified:January 23, 2007 - v3
Checksum:i6B40B8917FC7027B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132193 mRNA. Translation: CAA10601.1.
FO081216 Genomic DNA. Translation: CCD69969.1.
PIRiT31737.
RefSeqiNP_503386.1. NM_070985.5.
UniGeneiCel.17969.

Genome annotation databases

EnsemblMetazoaiT21H3.3a; T21H3.3a; WBGene00000552.
GeneIDi178614.
KEGGicel:CELE_T21H3.3.
UCSCiT21H3.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132193 mRNA. Translation: CAA10601.1.
FO081216 Genomic DNA. Translation: CCD69969.1.
PIRiT31737.
RefSeqiNP_503386.1. NM_070985.5.
UniGeneiCel.17969.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OOJX-ray2.11A1-149[»]
ProteinModelPortaliO16305.
SMRiO16305. Positions 6-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43683. 1 interaction.
DIPiDIP-25019N.
IntActiO16305. 1 interaction.
MINTiMINT-1114185.
STRINGi6239.T21H3.3.1.

PTM databases

iPTMnetiO16305.

Proteomic databases

EPDiO16305.
PaxDbiO16305.
PRIDEiO16305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT21H3.3a; T21H3.3a; WBGene00000552.
GeneIDi178614.
KEGGicel:CELE_T21H3.3.
UCSCiT21H3.3.1. c. elegans.

Organism-specific databases

CTDi178614.
WormBaseiT21H3.3a; CE13902; WBGene00000552; cmd-1.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiO16305.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG091G0V73.
PhylomeDBiO16305.

Enzyme and pathway databases

ReactomeiR-CEL-111933. Calmodulin induced events.
R-CEL-111957. Cam-PDE 1 activation.
R-CEL-114608. Platelet degranulation.
R-CEL-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-CEL-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-CEL-203615. eNOS activation.
R-CEL-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-CEL-2672351. Stimuli-sensing channels.
R-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-425561. Sodium/Calcium exchangers.
R-CEL-442729. CREB phosphorylation through the activation of CaMKII.
R-CEL-451308. Activation of Ca-permeable Kainate Receptor.
R-CEL-5218920. VEGFR2 mediated vascular permeability.
R-CEL-5578775. Ion homeostasis.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-CEL-5626467. RHO GTPases activate IQGAPs.
R-CEL-70221. Glycogen breakdown (glycogenolysis).
R-CEL-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiO16305.
PROiO16305.

Gene expression databases

BgeeiWBGene00000552.
ExpressionAtlasiO16305. baseline.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM_CAEEL
AccessioniPrimary (citable) accession number: O16305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.