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Protein

DNA helicase

Gene

mcm-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • DNA replication initiation Source: InterPro
  • MCM complex assembly Source: WormBase

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseSAAS annotationImported, Hydrolase
Biological processDNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-69052. Switching of origins to a post-replicative state.
R-CEL-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:mcm-7Imported
ORF Names:CELE_F32D1.10Imported, F32D1.10Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF32D1.10; CE09874; WBGene00003159; mcm-7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiO16297.
PaxDbiO16297.
PeptideAtlasiO16297.

Expressioni

Gene expression databases

BgeeiWBGene00003159.

Interactioni

Protein-protein interaction databases

IntActiO16297. 1 interactor.
STRINGi6239.F32D1.10.1.

Structurei

3D structure databases

ProteinModelPortaliO16297.
SMRiO16297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini341 – 546MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0482. Eukaryota.
COG1241. LUCA.
GeneTreeiENSGT00900000141136.
HOGENOMiHOG000224125.
InParanoidiO16297.
KOiK02210.
OMAiVKIQEMA.
OrthoDBiEOG091G02LB.
PhylomeDBiO16297.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR031327. MCM.
IPR008050. MCM7.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11630:SF26. PTHR11630:SF26. 1 hit.
PfamiView protein in Pfam
PF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
PRINTSiPR01657. MCMFAMILY.
PR01663. MCMPROTEIN7.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O16297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTTYNTDW AAEKTKIRSF FDEYYVDNED GSGKAFPYRD QVFEIARRDK
60 70 80 90 100
QAIVVNVDHI KESDIPDALE LSEAITSNTK RYEVLFKDTI SDMIQDYLGD
110 120 130 140 150
KQAPVIDALD AYMFQRLHMD RNEGAANEEV SLQDKRKKYP PQLLQRFEVY
160 170 180 190 200
FTTDDAAHET CVRNIKATEI GHLVSMKGVV IRATEVKPCV EVMTYTCDTC
210 220 230 240 250
AAEVYQPVKG MQFTPPVNCP NKECVEAKAN GRLHMQLRGS KFVKFQELKI
260 270 280 290 300
QELSEQVPVG SIPRTMTVHV YGEMTRKCNT GNVVHVSGVF LPIMQSGFRP
310 320 330 340 350
TGGLVADTYL EAHYINNLDD NPTFNGVQSA ELEVLRRKGD NYETLAASIA
360 370 380 390 400
PEIFGHVDVK KCLLMALVGG NDNSSNGMKI RGCINVLMMG DPGVAKSQLL
410 420 430 440 450
GYVNRLAPRS QYTTGRGSSG VGLTAAVMKD PVTGEMSLEG GALVLADGGI
460 470 480 490 500
CCIDEFDKMM DHDRTAIHEV MEQQTISIAK AGIMTTLNAR TAIIAAANPA
510 520 530 540 550
YGRYNPNRSI EQNVDLPAAL LSRFDLILLM QDKADRENDK ILAEHITYVH
560 570 580 590 600
QHGCHPNREK KDLISLETLR EYISLCKTYT PTVDPALRER IVEAYVEMRR
610 620 630 640 650
DARYSSDPTF VSPRMILGIV RMATARAKLR LSTIVDESDV EEALRLMQFA
660 670 680 690 700
KDSLRPEQNK IEKRMAPVDA AFAVLRELYH ADNAPIAISN AIQRCARKGI
710 720 730
SEVALKKCLD QYTANGLLVM DRQNIVFAMN
Length:730
Mass (Da):81,617
Last modified:January 1, 1998 - v1
Checksum:iB286033F128809F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD68490.1.
PIRiT03920.
RefSeqiNP_504199.1. NM_071798.5.
UniGeneiCel.17496.

Genome annotation databases

EnsemblMetazoaiF32D1.10; F32D1.10; WBGene00003159.
GeneIDi178831.
KEGGicel:CELE_F32D1.10.
UCSCiF32D1.10.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiO16297_CAEEL
AccessioniPrimary (citable) accession number: O16297
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported