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Protein

DNA helicase

Gene

mcm-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • DNA replication initiation Source: InterPro
  • MCM complex assembly Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotationImported, Hydrolase

Keywords - Biological processi

DNA replicationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-69052. Switching of origins to a post-replicative state.
R-CEL-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:mcm-7Imported
ORF Names:CELE_F32D1.10Imported, F32D1.10Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF32D1.10; CE09874; WBGene00003159; mcm-7.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

  • MCM complex Source: WormBase
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiO16297.
PaxDbiO16297.
PeptideAtlasiO16297.

Expressioni

Gene expression databases

BgeeiWBGene00003159.

Interactioni

Protein-protein interaction databases

IntActiO16297. 1 interactor.
STRINGi6239.F32D1.10.1.

Structurei

3D structure databases

ProteinModelPortaliO16297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini341 – 546MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0482. Eukaryota.
COG1241. LUCA.
GeneTreeiENSGT00860000134967.
HOGENOMiHOG000224125.
InParanoidiO16297.
KOiK02210.
OMAiQEFYQDD.
OrthoDBiEOG091G02LB.
PhylomeDBiO16297.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR031327. MCM.
IPR008050. MCM7.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF26. PTHR11630:SF26. 2 hits.
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01663. MCMPROTEIN7.
SMARTiSM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTTYNTDW AAEKTKIRSF FDEYYVDNED GSGKAFPYRD QVFEIARRDK
60 70 80 90 100
QAIVVNVDHI KESDIPDALE LSEAITSNTK RYEVLFKDTI SDMIQDYLGD
110 120 130 140 150
KQAPVIDALD AYMFQRLHMD RNEGAANEEV SLQDKRKKYP PQLLQRFEVY
160 170 180 190 200
FTTDDAAHET CVRNIKATEI GHLVSMKGVV IRATEVKPCV EVMTYTCDTC
210 220 230 240 250
AAEVYQPVKG MQFTPPVNCP NKECVEAKAN GRLHMQLRGS KFVKFQELKI
260 270 280 290 300
QELSEQVPVG SIPRTMTVHV YGEMTRKCNT GNVVHVSGVF LPIMQSGFRP
310 320 330 340 350
TGGLVADTYL EAHYINNLDD NPTFNGVQSA ELEVLRRKGD NYETLAASIA
360 370 380 390 400
PEIFGHVDVK KCLLMALVGG NDNSSNGMKI RGCINVLMMG DPGVAKSQLL
410 420 430 440 450
GYVNRLAPRS QYTTGRGSSG VGLTAAVMKD PVTGEMSLEG GALVLADGGI
460 470 480 490 500
CCIDEFDKMM DHDRTAIHEV MEQQTISIAK AGIMTTLNAR TAIIAAANPA
510 520 530 540 550
YGRYNPNRSI EQNVDLPAAL LSRFDLILLM QDKADRENDK ILAEHITYVH
560 570 580 590 600
QHGCHPNREK KDLISLETLR EYISLCKTYT PTVDPALRER IVEAYVEMRR
610 620 630 640 650
DARYSSDPTF VSPRMILGIV RMATARAKLR LSTIVDESDV EEALRLMQFA
660 670 680 690 700
KDSLRPEQNK IEKRMAPVDA AFAVLRELYH ADNAPIAISN AIQRCARKGI
710 720 730
SEVALKKCLD QYTANGLLVM DRQNIVFAMN
Length:730
Mass (Da):81,617
Last modified:January 1, 1998 - v1
Checksum:iB286033F128809F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD68490.1.
PIRiT03920.
RefSeqiNP_504199.1. NM_071798.5.
UniGeneiCel.17496.

Genome annotation databases

EnsemblMetazoaiF32D1.10; F32D1.10; WBGene00003159.
GeneIDi178831.
KEGGicel:CELE_F32D1.10.
UCSCiF32D1.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD68490.1.
PIRiT03920.
RefSeqiNP_504199.1. NM_071798.5.
UniGeneiCel.17496.

3D structure databases

ProteinModelPortaliO16297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO16297. 1 interactor.
STRINGi6239.F32D1.10.1.

Proteomic databases

EPDiO16297.
PaxDbiO16297.
PeptideAtlasiO16297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32D1.10; F32D1.10; WBGene00003159.
GeneIDi178831.
KEGGicel:CELE_F32D1.10.
UCSCiF32D1.10.1. c. elegans.

Organism-specific databases

CTDi178831.
WormBaseiF32D1.10; CE09874; WBGene00003159; mcm-7.

Phylogenomic databases

eggNOGiKOG0482. Eukaryota.
COG1241. LUCA.
GeneTreeiENSGT00860000134967.
HOGENOMiHOG000224125.
InParanoidiO16297.
KOiK02210.
OMAiQEFYQDD.
OrthoDBiEOG091G02LB.
PhylomeDBiO16297.

Enzyme and pathway databases

ReactomeiR-CEL-69052. Switching of origins to a post-replicative state.
R-CEL-69300. Removal of licensing factors from origins.

Gene expression databases

BgeeiWBGene00003159.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR031327. MCM.
IPR008050. MCM7.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11630:SF26. PTHR11630:SF26. 2 hits.
PfamiPF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
[Graphical view]
PRINTSiPR01657. MCMFAMILY.
PR01663. MCMPROTEIN7.
SMARTiSM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO16297_CAEEL
AccessioniPrimary (citable) accession number: O16297
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.