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Protein

GMP reductase

Gene

F32D1.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi182Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi184Potassium; via carbonyl oxygenUniRule annotation1
Active sitei187Thioimidate intermediateUniRule annotation1
Metal bindingi187Potassium; via carbonyl oxygenUniRule annotation1
Active sitei189Proton donor/acceptorUniRule annotation1
Metal bindingi190PotassiumUniRule annotation1
Binding sitei270NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi130 – 132NADPUniRule annotation3
Nucleotide bindingi181 – 182NADPUniRule annotation2
Nucleotide bindingi286 – 287NADPUniRule annotation2
Nucleotide bindingi315 – 318NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandMetal-binding, NADP, Potassium

Enzyme and pathway databases

ReactomeiR-CEL-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPRUniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
ORF Names:F32D1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF32D1.5a ; CE09869 ; WBGene00017984

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937291 – 358GMP reductaseAdd BLAST358

Proteomic databases

EPDiO16294
PaxDbiO16294
PeptideAtlasiO16294
PRIDEiO16294

Expressioni

Gene expression databases

BgeeiWBGene00017984
ExpressionAtlasiO16294 baseline and differential

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

BioGridi43886, 1 interactor
STRINGi6239.F32D1.5.1

Structurei

3D structure databases

ProteinModelPortaliO16294
SMRiO16294
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 222GMP bindingUniRule annotation3
Regioni243 – 244GMP bindingUniRule annotation2
Regioni269 – 271GMP bindingUniRule annotation3
Regioni287 – 291GMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00530000062923
HOGENOMiHOG000165756
InParanoidiO16294
KOiK00364
OMAiAKVLCKF
OrthoDBiEOG091G09KQ
PhylomeDBiO16294

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

Sequencei

Sequence statusi: Complete.

O16294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIENEPKL DFKDVLLRPK RSTLKSRADV ELDREYVFRN SKATYTGVPV
60 70 80 90 100
VASNMDTVGT FEMAAALNNH KIFTTIHKHY SVDEWKAFAA SASPDTFNNL
110 120 130 140 150
AISSGISDND WTKLNTVITE LPQLKYICLD VANGYSESFV EFIRRVREAY
160 170 180 190 200
PKHTIMAGNV VTGEMVEELI LSGADIVKVG IGPGSVCTTR KKAGVGYPQL
210 220 230 240 250
SAVLECADAA HGLNGHVMSD GGCSNPGDVA KAFGAGADFV MIGGLFAGHD
260 270 280 290 300
QSGGDLIEHN GKKFKLFYGM SSDTAMKKHH GSVAEYRASE GKTVTIPYRG
310 320 330 340 350
DVNGTVQDIL GGIRSACTYT GAKHLKELAK RATFIRVTQQ TNDMYVPFEV

PTVPAPSK
Length:358
Mass (Da):38,806
Last modified:January 1, 1998 - v1
Checksum:iA4AEE84F2CB72360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081012 Genomic DNA Translation: CCD68485.1
PIRiT03917
RefSeqiNP_504202.1, NM_071801.6
UniGeneiCel.6523

Genome annotation databases

EnsemblMetazoaiF32D1.5a.1; F32D1.5a.1; WBGene00017984
F32D1.5a.2; F32D1.5a.2; WBGene00017984
GeneIDi178834
KEGGicel:CELE_F32D1.5
UCSCiF32D1.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGMPR_CAEEL
AccessioniPrimary (citable) accession number: O16294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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