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Protein

Putative histone H1.6

Gene

hil-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone H1.6
Alternative name(s):
Histone H1-like protein 6
Gene namesi
Name:hil-6
ORF Names:F59A7.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF59A7.4; CE11442; WBGene00001857; hil-6.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 190189Putative histone H1.6PRO_0000195986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCurated

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO16277.
PaxDbiO16277.
PRIDEiO16277.

Expressioni

Gene expression databases

BgeeiWBGene00001857.

Interactioni

Protein-protein interaction databases

BioGridi51320. 1 interaction.
STRINGi6239.F59A7.4.

Structurei

3D structure databases

ProteinModelPortaliO16277.
SMRiO16277. Positions 34-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11077H15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00730000111466.
HOGENOMiHOG000251627.
InParanoidiO16277.
KOiK11275.
OrthoDBiEOG091G0XGD.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVAVAETP AVKTPTKAPK ANATKVPKVK TAAAHPPFIN MVTAAISSLK
60 70 80 90 100
ERKGSSKIAI LKYITANYKL GDQVKKINSN LRSALKKGVA SKALVQTVGT
110 120 130 140 150
GATGRFRVAE KTAATAKKPT VKKAATGEKV KKTVVKKTVA KKTGDKVKKA
160 170 180 190
KSPKKIAKPA AKKATKSPSK KVAPKKAAAK PAKKTAALKA
Length:190
Mass (Da):19,747
Last modified:January 23, 2007 - v3
Checksum:i91A58F0A00C54525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081510 Genomic DNA. Translation: CCD72097.1.
PIRiA88961.
RefSeqiNP_503554.1. NM_071153.1.
UniGeneiCel.3300.

Genome annotation databases

EnsemblMetazoaiF59A7.4; F59A7.4; WBGene00001857.
GeneIDi186584.
KEGGicel:CELE_F59A7.4.
UCSCiF59A7.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081510 Genomic DNA. Translation: CCD72097.1.
PIRiA88961.
RefSeqiNP_503554.1. NM_071153.1.
UniGeneiCel.3300.

3D structure databases

ProteinModelPortaliO16277.
SMRiO16277. Positions 34-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi51320. 1 interaction.
STRINGi6239.F59A7.4.

Proteomic databases

EPDiO16277.
PaxDbiO16277.
PRIDEiO16277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59A7.4; F59A7.4; WBGene00001857.
GeneIDi186584.
KEGGicel:CELE_F59A7.4.
UCSCiF59A7.4. c. elegans.

Organism-specific databases

CTDi186584.
WormBaseiF59A7.4; CE11442; WBGene00001857; hil-6.

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00730000111466.
HOGENOMiHOG000251627.
InParanoidiO16277.
KOiK11275.
OrthoDBiEOG091G0XGD.

Miscellaneous databases

PROiO16277.

Gene expression databases

BgeeiWBGene00001857.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH16_CAEEL
AccessioniPrimary (citable) accession number: O16277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

PubMed:11245572 has not been able to detect expression of this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.