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Protein

Stress-induced-phosphoprotein 1

Gene

sti-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity.2 Publications

GO - Molecular functioni

  • ATPase inhibitor activity Source: WormBase
  • Hsp70 protein binding Source: WormBase
  • Hsp90 protein binding Source: WormBase

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • negative regulation of ATPase activity Source: WormBase
  • reproduction Source: WormBase
  • response to heat Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-induced-phosphoprotein 11 PublicationImported
Short name:
CeSTI11 Publication
Short name:
STI11 Publication
Alternative name(s):
Hsc70/Hsp90-organizing protein1 Publication
Short name:
CeHop1 Publication
Short name:
Hop1 Publication
Gene namesi
Name:sti-1Imported
ORF Names:R09E12.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiR09E12.3; CE12646; WBGene00019983; sti-1.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Detected in cytoplasm in early-stage embryos.1 Publication

GO - Cellular componenti

  • cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Reduced brood size and decreased fertility under heat stress. Decreased thermotolerance and shortening of life span by 68% and 77% at 20 degrees Celsius and 25 degrees Celsius respectively. Growth of gonads is hampered resulting in shortened arms of the gonads, abnormally shaped spermathecae, lower sperm number and endomitotic oocyte development.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Stress-induced-phosphoprotein 1PRO_0000422047Add
BLAST

Proteomic databases

EPDiO16259.
PaxDbiO16259.
PRIDEiO16259.

Expressioni

Tissue specificityi

Expressed ubiquitously in the whole body. Detected predominantly in the pharyngeal muscles, vulva epithelial cells, striated body-wall muscles, spermathecae and intestinal cell ring. Also observed in the tail regions of hermaphrodite and in the sensory rays and spicules of males.2 Publications

Developmental stagei

Expressed at all developmental stages.1 Publication

Inductioni

Up-regulated by heat stress (at protein level).1 Publication

Gene expression databases

BgeeiWBGene00019983.

Interactioni

Subunit structurei

Forms a complex with hsp-1/hsp70 and daf-21/hsp90. Interacts with daf-21/hsp90 (via the C-terminal MEEVD pentapeptide).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
daf-21Q186883EBI-6514174,EBI-313329
hsp-1P094463EBI-6514174,EBI-322448

GO - Molecular functioni

  • Hsp70 protein binding Source: WormBase
  • Hsp90 protein binding Source: WormBase

Protein-protein interaction databases

IntActiO16259. 22 interactions.
STRINGi6239.R09E12.3.

Structurei

Secondary structure

320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1717Combined sources
Helixi21 – 3414Combined sources
Helixi39 – 5113Combined sources
Helixi55 – 7117Combined sources
Helixi76 – 9217Combined sources
Helixi96 – 10914Combined sources
Helixi113 – 12311Combined sources
Helixi137 – 15216Combined sources
Helixi156 – 16914Combined sources
Helixi174 – 18613Combined sources
Helixi190 – 20314Combined sources
Helixi208 – 22013Combined sources
Helixi224 – 23714Combined sources
Helixi242 – 25110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCNX-ray1.85A/B1-124[»]
4GCOX-ray1.60A131-253[»]
ProteinModelPortaliO16259.
SMRiO16259. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3834TPR 1Sequence analysisAdd
BLAST
Repeati40 – 7233TPR 2Sequence analysisAdd
BLAST
Repeati80 – 11334TPR 3Sequence analysisAdd
BLAST
Repeati140 – 17334TPR 4Sequence analysisAdd
BLAST
Repeati175 – 20733TPR 5Sequence analysisAdd
BLAST
Repeati208 – 24134TPR 6Sequence analysisAdd
BLAST
Domaini269 – 30840STI1Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 STI1 domain.Sequence analysis
Contains 6 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000186562.
InParanoidiO16259.
KOiK09553.
OMAiLMEFQRA.
OrthoDBiEOG091G0E5W.
PhylomeDBiO16259.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAAIAEKD LGNAAYKQKD FEKAHVHYDK AIELDPSNIT FYNNKAAVYF
60 70 80 90 100
EEKKFAECVQ FCEKAVEVGR ETRADYKLIA KAMSRAGNAF QKQNDLSLAV
110 120 130 140 150
QWFHRSLSEF RDPELVKKVK ELEKQLKAAE RLAYINPELA QEEKNKGNEY
160 170 180 190 200
FKKGDYPTAM RHYNEAVKRD PENAILYSNR AACLTKLMEF QRALDDCDTC
210 220 230 240 250
IRLDSKFIKG YIRKAACLVA MREWSKAQRA YEDALQVDPS NEEAREGVRN
260 270 280 290 300
CLRSNDEDPE KAKERSLADP EVQEILRDPG MRMILEQMSN DPGAVREHLK
310 320
NPEIFQKLMK LRDAGVIQMR
Length:320
Mass (Da):36,962
Last modified:January 1, 1998 - v1
Checksum:i9D21907275A09780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080369 Genomic DNA. Translation: CCD63252.1.
PIRiT03899.
RefSeqiNP_503322.1. NM_070921.6.
UniGeneiCel.2824.

Genome annotation databases

EnsemblMetazoaiR09E12.3; R09E12.3; WBGene00019983.
GeneIDi178587.
KEGGicel:CELE_R09E12.3.
UCSCiR09E12.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080369 Genomic DNA. Translation: CCD63252.1.
PIRiT03899.
RefSeqiNP_503322.1. NM_070921.6.
UniGeneiCel.2824.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCNX-ray1.85A/B1-124[»]
4GCOX-ray1.60A131-253[»]
ProteinModelPortaliO16259.
SMRiO16259. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO16259. 22 interactions.
STRINGi6239.R09E12.3.

Proteomic databases

EPDiO16259.
PaxDbiO16259.
PRIDEiO16259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR09E12.3; R09E12.3; WBGene00019983.
GeneIDi178587.
KEGGicel:CELE_R09E12.3.
UCSCiR09E12.3. c. elegans.

Organism-specific databases

CTDi178587.
WormBaseiR09E12.3; CE12646; WBGene00019983; sti-1.

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000186562.
InParanoidiO16259.
KOiK09553.
OMAiLMEFQRA.
OrthoDBiEOG091G0E5W.
PhylomeDBiO16259.

Miscellaneous databases

PROiO16259.

Gene expression databases

BgeeiWBGene00019983.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTIP1_CAEEL
AccessioniPrimary (citable) accession number: O16259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.