O16127 (TPM_ECHGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin A Short name=EgTrpA
Organism	Echinococcus granulosus
Taxonomic identifier	6210 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Cestoda › Eucestoda › Cyclophyllidea › Taeniidae › Echinococcus

Protein attributes

Sequence length	278 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 278	›278	Tropomyosin A		PRO_0000205652
Regions
	Coiled coil	‹1 – 270	›270	By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	O16127 [UniParc]. Last modified April 8, 2008. Version 3. Checksum: 5227AEEB1B358885	FASTA	278	32,269
	10 20 30 40 50 60 IMMAMKLEKE NALEKAINLE NQLKEKAKDF EKKEEEMNDW LSKVKNIQTE VDTVQESLQE 70 80 90 100 110 120 AISKLEETEK RATNAEAEVA AMTRRIRLLE EDFEQSSGRL TETSTKLDDA SKAAEESERN 130 140 150 160 170 180 RKTLETRSIS DDERMAQLEE QVKEAKYIAE DAERKYDEAA RRLAVTEVDL ERAESRLETS 190 200 210 220 230 240 ESKIVELEEE LRIVGNNMKS LEVSEQESLQ REESYEETIR DLTERLKTAE QRAAEAERQV 250 260 270 SKLQNEVDRL EDELLSEKER YRAISGELDT TFAELTSF

References

[1]	Esteves A., Senorale M., Fernandez C., Bruzzone H., Ehrlich R. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF011923 mRNA. Translation: AAB65799.4.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_ECHGR

Accession

Primary (citable) accession number: O16127

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	April 8, 2008
Last modified:	November 30, 2010
This is version 34 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)