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O16116

- GST3_CAEEL

UniProt

O16116 - GST3_CAEEL

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Protein
Glutathione S-transferase 3
Gene
gst-3, K08F4.11
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei43 – 431Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
CeGST3
GST class-sigma
Gene namesi
Name:gst-3
ORF Names:K08F4.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08F4.11; CE25050; WBGene00001751; gst-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Glutathione S-transferase 3
PRO_0000185926Add
BLAST

Proteomic databases

PaxDbiO16116.
PRIDEiO16116.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F4.11.

Structurei

3D structure databases

ProteinModelPortaliO16116.
SMRiO16116. Positions 1-203.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminal
Add
BLAST
Domaini81 – 207127GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione binding By similarity
Regioni63 – 642Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.By similarity

Phylogenomic databases

eggNOGiNOG318621.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16116.
KOiK00799.
OMAiIARSEWP.
OrthoDBiEOG78WKT1.
PhylomeDBiO16116.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16116-1 [UniParc]FASTAAdd to Basket

« Hide

MVHYKLTYFN ARGLAEISRQ LFHMAGVEFE DERINEEKFS QLKPTFPSGQ    50
VPILCIDGAQ FSQSTAIARY LARKFGFVGQ TAEEELQADE VVDTFKDFIE 100
SFRKFVIAVL SGESEEILKN IREEVIKPAV KTYTAYLKAI LEKSSSGYLV 150
GNELTWADLV IADNLTTLIN AELLDIENDK LLKEFREKII ETPKLKEWLA 200
KRPETRF 207
Length:207
Mass (Da):23,735
Last modified:January 1, 1998 - v1
Checksum:i72545319FCFCEDBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010241 mRNA. Translation: AAB65419.1.
Z68879 Genomic DNA. Translation: CAA93088.2.
PIRiT23485.
T37464.
RefSeqiNP_501846.1. NM_069445.5.
UniGeneiCel.35663.

Genome annotation databases

EnsemblMetazoaiK08F4.11; K08F4.11; WBGene00001751.
GeneIDi177883.
KEGGicel:CELE_K08F4.11.
UCSCiK08F4.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010241 mRNA. Translation: AAB65419.1 .
Z68879 Genomic DNA. Translation: CAA93088.2 .
PIRi T23485.
T37464.
RefSeqi NP_501846.1. NM_069445.5.
UniGenei Cel.35663.

3D structure databases

ProteinModelPortali O16116.
SMRi O16116. Positions 1-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K08F4.11.

Proteomic databases

PaxDbi O16116.
PRIDEi O16116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08F4.11 ; K08F4.11 ; WBGene00001751 .
GeneIDi 177883.
KEGGi cel:CELE_K08F4.11.
UCSCi K08F4.11. c. elegans.

Organism-specific databases

CTDi 177883.
WormBasei K08F4.11 ; CE25050 ; WBGene00001751 ; gst-3.

Phylogenomic databases

eggNOGi NOG318621.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi O16116.
KOi K00799.
OMAi IARSEWP.
OrthoDBi EOG78WKT1.
PhylomeDBi O16116.

Miscellaneous databases

NextBioi 898788.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Paraquat mediates differential gene expression in C. elegans."
    Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST3_CAEEL
AccessioniPrimary (citable) accession number: O16116
Secondary accession number(s): Q21357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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