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O16116

- GST3_CAEEL

UniProt

O16116 - GST3_CAEEL

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Protein

Glutathione S-transferase 3

Gene

gst-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
CeGST3
GST class-sigma
Gene namesi
Name:gst-3
ORF Names:K08F4.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08F4.11; CE25050; WBGene00001751; gst-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Glutathione S-transferase 3PRO_0000185926Add
BLAST

Proteomic databases

PaxDbiO16116.
PRIDEiO16116.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F4.11.

Structurei

3D structure databases

ProteinModelPortaliO16116.
SMRiO16116. Positions 1-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 207127GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG318621.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16116.
KOiK00799.
OMAiIARSEWP.
OrthoDBiEOG78WKT1.
PhylomeDBiO16116.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHYKLTYFN ARGLAEISRQ LFHMAGVEFE DERINEEKFS QLKPTFPSGQ
60 70 80 90 100
VPILCIDGAQ FSQSTAIARY LARKFGFVGQ TAEEELQADE VVDTFKDFIE
110 120 130 140 150
SFRKFVIAVL SGESEEILKN IREEVIKPAV KTYTAYLKAI LEKSSSGYLV
160 170 180 190 200
GNELTWADLV IADNLTTLIN AELLDIENDK LLKEFREKII ETPKLKEWLA

KRPETRF
Length:207
Mass (Da):23,735
Last modified:January 1, 1998 - v1
Checksum:i72545319FCFCEDBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010241 mRNA. Translation: AAB65419.1.
Z68879 Genomic DNA. Translation: CAA93088.2.
PIRiT23485.
T37464.
RefSeqiNP_501846.1. NM_069445.5.
UniGeneiCel.35663.

Genome annotation databases

EnsemblMetazoaiK08F4.11; K08F4.11; WBGene00001751.
GeneIDi177883.
KEGGicel:CELE_K08F4.11.
UCSCiK08F4.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010241 mRNA. Translation: AAB65419.1 .
Z68879 Genomic DNA. Translation: CAA93088.2 .
PIRi T23485.
T37464.
RefSeqi NP_501846.1. NM_069445.5.
UniGenei Cel.35663.

3D structure databases

ProteinModelPortali O16116.
SMRi O16116. Positions 1-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K08F4.11.

Proteomic databases

PaxDbi O16116.
PRIDEi O16116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08F4.11 ; K08F4.11 ; WBGene00001751 .
GeneIDi 177883.
KEGGi cel:CELE_K08F4.11.
UCSCi K08F4.11. c. elegans.

Organism-specific databases

CTDi 177883.
WormBasei K08F4.11 ; CE25050 ; WBGene00001751 ; gst-3.

Phylogenomic databases

eggNOGi NOG318621.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi O16116.
KOi K00799.
OMAi IARSEWP.
OrthoDBi EOG78WKT1.
PhylomeDBi O16116.

Miscellaneous databases

NextBioi 898788.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Paraquat mediates differential gene expression in C. elegans."
    Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST3_CAEEL
AccessioniPrimary (citable) accession number: O16116
Secondary accession number(s): Q21357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3