Reviewed, UniProtKB/Swiss-Prot O16116 (GST3_CAEEL)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase 3
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma
    CeGST3

Gene names

Name:	gst-3
ORF Names:	K08F4.11

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Glutathione S-transferase 3		PRO_0000185926
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 207	127	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	O16116-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 72545319FCFCEDBA	FASTA	207	23,735
	10 20 30 40 50 60 MVHYKLTYFN ARGLAEISRQ LFHMAGVEFE DERINEEKFS QLKPTFPSGQ VPILCIDGAQ 70 80 90 100 110 120 FSQSTAIARY LARKFGFVGQ TAEEELQADE VVDTFKDFIE SFRKFVIAVL SGESEEILKN 130 140 150 160 170 180 IREEVIKPAV KTYTAYLKAI LEKSSSGYLV GNELTWADLV IADNLTTLIN AELLDIENDK 190 200 LLKEFREKII ETPKLKEWLA KRPETRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Paraquat mediates differential gene expression in C. elegans." Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF010241 mRNA. Translation: AAB65419.1. Z68879 Genomic DNA. Translation: CAA93088.2.
PIR	T23485. T37464.
RefSeq	NP_501846.1.
UniGene	Cel.19689 Cel.35663
3D structure databases
HSSP	HSSP built from PDB template 1GUK based on UniProtKB P24472.
ModBase	Search...
Genome annotation databases
Ensembl	K08F4.11. Caenorhabditis elegans. [Contig view]
GeneID	177883.
KEGG	cel:K08F4.11.
Organism-specific databases
WormBase	WBGene00001751. gst-3.
WormPep	K08F4.11. CE25050. [WorfDB]
Phylogenomic databases
OMA	O16116. DTFKDFI.
Enzyme and pathway databases
BRENDA	2.5.1.18. 672.
Gene expression databases
ArrayExpress	O16116.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	898788.

Entry information

Entry name

GST3_CAEEL

Accession

Primary (citable) accession number: O16116
Secondary accession number(s): Q21357

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project