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Protein

Glutathione S-transferase 3

Gene

gst-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
CeGST3
GST class-sigma
Gene namesi
Name:gst-3
ORF Names:K08F4.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08F4.11; CE25050; WBGene00001751; gst-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859261 – 207Glutathione S-transferase 3Add BLAST207

Proteomic databases

PaxDbiO16116.
PeptideAtlasiO16116.

Expressioni

Gene expression databases

BgeeiWBGene00001751.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F4.11.

Structurei

3D structure databases

ProteinModelPortaliO16116.
SMRiO16116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 207GST C-terminalAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16116.
KOiK00799.
OMAiFTETDEQ.
OrthoDBiEOG091G0MBB.
PhylomeDBiO16116.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKLTYFN ARGLAEISRQ LFHMAGVEFE DERINEEKFS QLKPTFPSGQ
60 70 80 90 100
VPILCIDGAQ FSQSTAIARY LARKFGFVGQ TAEEELQADE VVDTFKDFIE
110 120 130 140 150
SFRKFVIAVL SGESEEILKN IREEVIKPAV KTYTAYLKAI LEKSSSGYLV
160 170 180 190 200
GNELTWADLV IADNLTTLIN AELLDIENDK LLKEFREKII ETPKLKEWLA

KRPETRF
Length:207
Mass (Da):23,735
Last modified:January 1, 1998 - v1
Checksum:i72545319FCFCEDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010241 mRNA. Translation: AAB65419.1.
Z68879 Genomic DNA. Translation: CAA93088.2.
PIRiT23485.
T37464.
RefSeqiNP_501846.1. NM_069445.5.
UniGeneiCel.35663.

Genome annotation databases

EnsemblMetazoaiK08F4.11; K08F4.11; WBGene00001751.
GeneIDi177883.
KEGGicel:CELE_K08F4.11.
UCSCiK08F4.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010241 mRNA. Translation: AAB65419.1.
Z68879 Genomic DNA. Translation: CAA93088.2.
PIRiT23485.
T37464.
RefSeqiNP_501846.1. NM_069445.5.
UniGeneiCel.35663.

3D structure databases

ProteinModelPortaliO16116.
SMRiO16116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08F4.11.

Proteomic databases

PaxDbiO16116.
PeptideAtlasiO16116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08F4.11; K08F4.11; WBGene00001751.
GeneIDi177883.
KEGGicel:CELE_K08F4.11.
UCSCiK08F4.11. c. elegans.

Organism-specific databases

CTDi177883.
WormBaseiK08F4.11; CE25050; WBGene00001751; gst-3.

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16116.
KOiK00799.
OMAiFTETDEQ.
OrthoDBiEOG091G0MBB.
PhylomeDBiO16116.

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Miscellaneous databases

PROiO16116.

Gene expression databases

BgeeiWBGene00001751.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST3_CAEEL
AccessioniPrimary (citable) accession number: O16116
Secondary accession number(s): Q21357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.