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Protein

Glutathione S-transferase 2

Gene

gst-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 2 (EC:2.5.1.18)
Alternative name(s):
CeGST2
GST class-sigma
Gene namesi
Name:gst-2
ORF Names:K08F4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08F4.6; CE25051; WBGene00001750; gst-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Glutathione S-transferase 2PRO_0000185925Add
BLAST

Proteomic databases

PRIDEiO16115.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F4.6.

Structurei

3D structure databases

ProteinModelPortaliO16115.
SMRiO16115. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 188108GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG318621.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16115.
KOiK00799.
OMAiNAWENAW.
OrthoDBiEOG78WKT1.
PhylomeDBiO16115.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKLMCFD VRGLGEVIRQ LFYLGDVSFE DFRVSREEFK SLKSNLPSGQ
60 70 80 90 100
LPVLEIDGVM ISQSASIGRF LARQYGYSGK TPTEEMQVDS IIDLFKDFML
110 120 130 140 150
TFRQFFFAVI HGYPEYEKER MKRDIVKPAI KNYFIALNKI LLRSKSGFLV
160 170 180
GDDLTWADLQ IADNLSTLIN IRLFAEKEPH LNVFIRKL
Length:188
Mass (Da):21,848
Last modified:January 1, 1998 - v1
Checksum:i06B095CC022C7CED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010240 mRNA. Translation: AAB65418.1.
Z68879 Genomic DNA. Translation: CAA93087.2.
PIRiT23484.
T37463.
RefSeqiNP_501847.1. NM_069446.3.
UniGeneiCel.7725.

Genome annotation databases

EnsemblMetazoaiK08F4.6; K08F4.6; WBGene00001750.
GeneIDi177884.
KEGGicel:CELE_K08F4.6.
UCSCiK08F4.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010240 mRNA. Translation: AAB65418.1.
Z68879 Genomic DNA. Translation: CAA93087.2.
PIRiT23484.
T37463.
RefSeqiNP_501847.1. NM_069446.3.
UniGeneiCel.7725.

3D structure databases

ProteinModelPortaliO16115.
SMRiO16115. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K08F4.6.

Proteomic databases

PRIDEiO16115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08F4.6; K08F4.6; WBGene00001750.
GeneIDi177884.
KEGGicel:CELE_K08F4.6.
UCSCiK08F4.6. c. elegans.

Organism-specific databases

CTDi177884.
WormBaseiK08F4.6; CE25051; WBGene00001750; gst-2.

Phylogenomic databases

eggNOGiNOG318621.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16115.
KOiK00799.
OMAiNAWENAW.
OrthoDBiEOG78WKT1.
PhylomeDBiO16115.

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Miscellaneous databases

NextBioi898792.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Paraquat mediates differential gene expression in C. elegans."
    Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST2_CAEEL
AccessioniPrimary (citable) accession number: O16115
Secondary accession number(s): Q21356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.