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O16115

- GST2_CAEEL

UniProt

O16115 - GST2_CAEEL

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Protein

Glutathione S-transferase 2

Gene

gst-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 2 (EC:2.5.1.18)
Alternative name(s):
CeGST2
GST class-sigma
Gene namesi
Name:gst-2
ORF Names:K08F4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08F4.6; CE25051; WBGene00001750; gst-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Glutathione S-transferase 2PRO_0000185925Add
BLAST

Proteomic databases

PRIDEiO16115.

Interactioni

Protein-protein interaction databases

STRINGi6239.K08F4.6.

Structurei

3D structure databases

ProteinModelPortaliO16115.
SMRiO16115. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 188108GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG318621.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiO16115.
KOiK00799.
OMAiNAWENAW.
OrthoDBiEOG78WKT1.
PhylomeDBiO16115.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16115-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHYKLMCFD VRGLGEVIRQ LFYLGDVSFE DFRVSREEFK SLKSNLPSGQ
60 70 80 90 100
LPVLEIDGVM ISQSASIGRF LARQYGYSGK TPTEEMQVDS IIDLFKDFML
110 120 130 140 150
TFRQFFFAVI HGYPEYEKER MKRDIVKPAI KNYFIALNKI LLRSKSGFLV
160 170 180
GDDLTWADLQ IADNLSTLIN IRLFAEKEPH LNVFIRKL
Length:188
Mass (Da):21,848
Last modified:January 1, 1998 - v1
Checksum:i06B095CC022C7CED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010240 mRNA. Translation: AAB65418.1.
Z68879 Genomic DNA. Translation: CAA93087.2.
PIRiT23484.
T37463.
RefSeqiNP_501847.1. NM_069446.3.
UniGeneiCel.7725.

Genome annotation databases

EnsemblMetazoaiK08F4.6; K08F4.6; WBGene00001750.
GeneIDi177884.
KEGGicel:CELE_K08F4.6.
UCSCiK08F4.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010240 mRNA. Translation: AAB65418.1 .
Z68879 Genomic DNA. Translation: CAA93087.2 .
PIRi T23484.
T37463.
RefSeqi NP_501847.1. NM_069446.3.
UniGenei Cel.7725.

3D structure databases

ProteinModelPortali O16115.
SMRi O16115. Positions 1-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K08F4.6.

Proteomic databases

PRIDEi O16115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08F4.6 ; K08F4.6 ; WBGene00001750 .
GeneIDi 177884.
KEGGi cel:CELE_K08F4.6.
UCSCi K08F4.6. c. elegans.

Organism-specific databases

CTDi 177884.
WormBasei K08F4.6 ; CE25051 ; WBGene00001750 ; gst-2.

Phylogenomic databases

eggNOGi NOG318621.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi O16115.
KOi K00799.
OMAi NAWENAW.
OrthoDBi EOG78WKT1.
PhylomeDBi O16115.

Miscellaneous databases

NextBioi 898792.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Paraquat mediates differential gene expression in C. elegans."
    Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST2_CAEEL
AccessioniPrimary (citable) accession number: O16115
Secondary accession number(s): Q21356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3