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O16115

- GST2_CAEEL

UniProt

O16115 - GST2_CAEEL

Protein

Glutathione S-transferase 2

Gene

gst-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 2 (EC:2.5.1.18)
    Alternative name(s):
    CeGST2
    GST class-sigma
    Gene namesi
    Name:gst-2
    ORF Names:K08F4.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiK08F4.6; CE25051; WBGene00001750; gst-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Glutathione S-transferase 2PRO_0000185925Add
    BLAST

    Proteomic databases

    PRIDEiO16115.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K08F4.6.

    Structurei

    3D structure databases

    ProteinModelPortaliO16115.
    SMRiO16115. Positions 1-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7978GST N-terminalAdd
    BLAST
    Domaini81 – 188108GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Glutathione bindingBy similarity
    Regioni63 – 642Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Sigma family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG318621.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115733.
    InParanoidiO16115.
    KOiK00799.
    OMAiNAWENAW.
    OrthoDBiEOG78WKT1.
    PhylomeDBiO16115.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O16115-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHYKLMCFD VRGLGEVIRQ LFYLGDVSFE DFRVSREEFK SLKSNLPSGQ    50
    LPVLEIDGVM ISQSASIGRF LARQYGYSGK TPTEEMQVDS IIDLFKDFML 100
    TFRQFFFAVI HGYPEYEKER MKRDIVKPAI KNYFIALNKI LLRSKSGFLV 150
    GDDLTWADLQ IADNLSTLIN IRLFAEKEPH LNVFIRKL 188
    Length:188
    Mass (Da):21,848
    Last modified:January 1, 1998 - v1
    Checksum:i06B095CC022C7CED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010240 mRNA. Translation: AAB65418.1.
    Z68879 Genomic DNA. Translation: CAA93087.2.
    PIRiT23484.
    T37463.
    RefSeqiNP_501847.1. NM_069446.3.
    UniGeneiCel.7725.

    Genome annotation databases

    EnsemblMetazoaiK08F4.6; K08F4.6; WBGene00001750.
    GeneIDi177884.
    KEGGicel:CELE_K08F4.6.
    UCSCiK08F4.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010240 mRNA. Translation: AAB65418.1 .
    Z68879 Genomic DNA. Translation: CAA93087.2 .
    PIRi T23484.
    T37463.
    RefSeqi NP_501847.1. NM_069446.3.
    UniGenei Cel.7725.

    3D structure databases

    ProteinModelPortali O16115.
    SMRi O16115. Positions 1-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K08F4.6.

    Proteomic databases

    PRIDEi O16115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K08F4.6 ; K08F4.6 ; WBGene00001750 .
    GeneIDi 177884.
    KEGGi cel:CELE_K08F4.6.
    UCSCi K08F4.6. c. elegans.

    Organism-specific databases

    CTDi 177884.
    WormBasei K08F4.6 ; CE25051 ; WBGene00001750 ; gst-2.

    Phylogenomic databases

    eggNOGi NOG318621.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115733.
    InParanoidi O16115.
    KOi K00799.
    OMAi NAWENAW.
    OrthoDBi EOG78WKT1.
    PhylomeDBi O16115.

    Miscellaneous databases

    NextBioi 898792.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Paraquat mediates differential gene expression in C. elegans."
      Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGST2_CAEEL
    AccessioniPrimary (citable) accession number: O16115
    Secondary accession number(s): Q21356
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3