Reviewed, UniProtKB/Swiss-Prot O16115 (GST2_CAEEL)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase 2
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma
    CeGST2

Gene names

Name:	gst-2
ORF Names:	K08F4.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Glutathione S-transferase 2		PRO_0000185925
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 188	108	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	O16115-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 06B095CC022C7CED	FASTA	188	21,848
	10 20 30 40 50 60 MVHYKLMCFD VRGLGEVIRQ LFYLGDVSFE DFRVSREEFK SLKSNLPSGQ LPVLEIDGVM 70 80 90 100 110 120 ISQSASIGRF LARQYGYSGK TPTEEMQVDS IIDLFKDFML TFRQFFFAVI HGYPEYEKER 130 140 150 160 170 180 MKRDIVKPAI KNYFIALNKI LLRSKSGFLV GDDLTWADLQ IADNLSTLIN IRLFAEKEPH LNVFIRKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Paraquat mediates differential gene expression in C. elegans." Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF010240 mRNA. Translation: AAB65418.1. Z68879 Genomic DNA. Translation: CAA93087.2.
PIR	T23484. T37463.
RefSeq	NP_501847.1.
UniGene	Cel.7725
3D structure databases
HSSP	HSSP built from PDB template 1M0U based on UniProtKB P41043.
ModBase	Search...
Genome annotation databases
Ensembl	K08F4.6. Caenorhabditis elegans. [Contig view]
GeneID	177884.
KEGG	cel:K08F4.6.
NMPDR	fig|6239.3.peg.14801.
Organism-specific databases
WormBase	WBGene00001750. gst-2.
WormPep	K08F4.6. CE25051. [WorfDB]
Phylogenomic databases
OMA	O16115. HFEDIRI.
Enzyme and pathway databases
BRENDA	2.5.1.18. 672.
Gene expression databases
ArrayExpress	O16115.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	898792.

Entry information

Entry name

GST2_CAEEL

Accession

Primary (citable) accession number: O16115
Secondary accession number(s): Q21356

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project