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Protein

Chromodomain-helicase-DNA-binding protein 3

Gene

Chd3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Possible transcription activator.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 8248PHD-typePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi292 – 2998ATPPROSITE-ProRule annotationCurated

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent helicase activity Source: InterPro
  • DNA binding Source: FlyBase
  • helicase activity Source: FlyBase
  • nucleosome binding Source: FlyBase
  • nucleosome-dependent ATPase activity Source: FlyBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • chromatin assembly or disassembly Source: UniProtKB
  • nucleosome mobilization Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 3 (EC:3.6.4.12)
Alternative name(s):
ATP-dependent helicase Chd3
Gene namesi
Name:Chd3
ORF Names:CG9594
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0023395. Chd3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
  • transcriptionally active chromatin Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Chromodomain-helicase-DNA-binding protein 3PRO_0000080235Add
BLAST

Proteomic databases

PaxDbiO16102.

Expressioni

Gene expression databases

BgeeiFBgn0023395.
ExpressionAtlasiO16102. differential.
GenevisibleiO16102. DM.

Interactioni

GO - Molecular functioni

  • nucleosome binding Source: FlyBase

Protein-protein interaction databases

BioGridi65382. 2 interactions.
DIPiDIP-21327N.
IntActiO16102. 1 interaction.
MINTiMINT-1651376.
STRINGi7227.FBpp0074766.

Structurei

3D structure databases

ProteinModelPortaliO16102.
SMRiO16102. Positions 36-79, 82-775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 15673Chromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini179 – 24062Chromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 458180Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini590 – 739150Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi409 – 4124DEAH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 8248PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
InParanoidiO16102.
OMAiPQYAMME.
OrthoDBiEOG091G00G4.
PhylomeDBiO16102.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKRGADPD WKTPGKASKD KRPKTNAKKQ KFRDEEYCKV CSDGGDLLCC
60 70 80 90 100
DSCPSVYHRT CLSPPLKSIP KGDWICPRCI PLPGKAEKIL SWRWALDRSV
110 120 130 140 150
ELRTSKGEKR REYFIKWHGM SYWHCEWIPE GQMLLHHASM VASFQRRSDM
160 170 180 190 200
EEPSLEELDD QDGNLHERFY RYGIKPEWLL VQRVINHSEE PNGGTMYLVK
210 220 230 240 250
WRELSYNDSS WERESDSIPG LNQAIALYKK LRSSNKGRQR DRPAPTIDLN
260 270 280 290 300
KKYEDQPVFL KEAGLKLHPF QIEGVSWLRY SWGQGIPTIL ADEMGLGKTI
310 320 330 340 350
QTVVFLYSLF KEGHCRGPFL ISVPLSTLTN WERELELWAP ELYCVTYVGG
360 370 380 390 400
KTARAVIRKH EISFEEVTTK TMRENQTQYK FNVMLTSYEF ISVDAAFLGC
410 420 430 440 450
IDWAALVVDE AHRLRSNQSK FFRILSKYRI GYKLLLTGTP LQNNLEELFH
460 470 480 490 500
LLNFLSSGKF NDLQTFQAEF TDVSKEEQVK RLHEILEPHM LRRLKADVLK
510 520 530 540 550
SMPPKSEFIV RVELSSMQKK FYKHILTKNF KALNQKGGGR VCSLLNIMMD
560 570 580 590 600
LRKCCNHPYL FPSAAEEATI SPSGLYEMSS LTKASGKLDL LSKMLKQLKA
610 620 630 640 650
DNHRVLLFSQ MTKMLNVLEH FLEGEGYQYD RIDGSIKGDL RQKAIDRFND
660 670 680 690 700
PVSEHFVFLL STRAGGLGIN LATADTVIIF DSDWNPHNDV QAFSRAHRMG
710 720 730 740 750
QKKKVMIYRF VTHNSVEERI MQVAKHKMML THLVVRPGMG GMTTNFSKDE
760 770 780 790 800
LEDILRFGTE DLFKDGKSEA IHYDDKAVAD LLDRTNRGIE EKESWANEYL
810 820 830 840 850
SSFKVASYAT KEDHEEHDDY NNDAENTDPF YWENLMGKSQ PKLPKKQKKQ
860 870 880 890
SQQSQVDVES IMGKGKRIRK EIDYSNQYPS PNRATPSSIV LM
Length:892
Mass (Da):103,022
Last modified:October 1, 2002 - v3
Checksum:iE11DF7F65A1F6D6D
GO

Sequence cautioni

The sequence AAB87384 differs from that shown.Cloning artifacts.Curated
The sequence AAL49125 differs from that shown. Reason: Frameshift at position 720. Curated
The sequence AAL49125 differs from that shown. Reason: Erroneous termination at position 628. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti617 – 6171V → I in AAB87384 (PubMed:9326634).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49162.2.
AY071503 mRNA. Translation: AAL49125.1. Frameshift.
AF007780 mRNA. Translation: AAB87384.1. Sequence problems.
RefSeqiNP_649111.1. NM_140854.3.
UniGeneiDm.20115.

Genome annotation databases

EnsemblMetazoaiFBtr0074998; FBpp0074766; FBgn0023395.
GeneIDi40111.
KEGGidme:Dmel_CG9594.
UCSCiCG9594-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49162.2.
AY071503 mRNA. Translation: AAL49125.1. Frameshift.
AF007780 mRNA. Translation: AAB87384.1. Sequence problems.
RefSeqiNP_649111.1. NM_140854.3.
UniGeneiDm.20115.

3D structure databases

ProteinModelPortaliO16102.
SMRiO16102. Positions 36-79, 82-775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65382. 2 interactions.
DIPiDIP-21327N.
IntActiO16102. 1 interaction.
MINTiMINT-1651376.
STRINGi7227.FBpp0074766.

Proteomic databases

PaxDbiO16102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074998; FBpp0074766; FBgn0023395.
GeneIDi40111.
KEGGidme:Dmel_CG9594.
UCSCiCG9594-RA. d. melanogaster.

Organism-specific databases

CTDi1107.
FlyBaseiFBgn0023395. Chd3.

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
InParanoidiO16102.
OMAiPQYAMME.
OrthoDBiEOG091G00G4.
PhylomeDBiO16102.

Miscellaneous databases

GenomeRNAii40111.
PROiO16102.

Gene expression databases

BgeeiFBgn0023395.
ExpressionAtlasiO16102. differential.
GenevisibleiO16102. DM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR009463. DUF1087.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF06465. DUF1087. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00628. PHD. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 2 hits.
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHD3_DROME
AccessioniPrimary (citable) accession number: O16102
Secondary accession number(s): Q8SYJ8, Q9VVZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.