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O16099 (MAL2_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Maltase 2

EC=3.2.1.20
Gene names
Name:Mal-B2
Synonyms:Mav2
ORF Names:GJ22506
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Sequence caution

The sequence AAB82328.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncation binding

Inferred from electronic annotation. Source: InterPro

maltose alpha-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 594564Maltase 2
PRO_0000001450

Sites

Active site2411Nucleophile By similarity
Active site3101Proton donor By similarity
Site3771Transition state stabilizer By similarity

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation4541N-linked (GlcNAc...) Potential
Glycosylation5371N-linked (GlcNAc...) Potential
Glycosylation5461N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2631D → N in AAB82328. Ref.2
Sequence conflict554 – 5552PQ → L in AAB82328. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O16099 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 0AB84967886D3785

FASTA59467,586
        10         20         30         40         50         60 
MAAAHQLTRT TQLLLLCSLL WTQAPRPVMS SLLSAQTEDF IDWWQHAVFY QIYPRSFKDS 

        70         80         90        100        110        120 
NGDGIGDLQG VISKLPYLAE TGITATWLSP IFQSPMVDFG YDVSDYKSIQ TEYGTMADFE 

       130        140        150        160        170        180 
QLVNTATSLG IKIILDFVPN HTSDKHEWFI KSAARDPLYD NFYVWADGKL DNQGVRQPPN 

       190        200        210        220        230        240 
NWQSVFYGSA WQWHEQRGQY YLHQFAKEQP DLNFRNPAVV RAMDDVLLFW LNKGVAGFRI 

       250        260        270        280        290        300 
DALNHLFEDE TLPDEPLSGK TTDPLSYDYT KHIYTKDLPE VLSMVQHWRQ LLDDYTAKHS 

       310        320        330        340        350        360 
EGATRIMMTE AYADLQVLMD YYEDAGGVRG SQLPFNFHFI TDVSGDSDAR DFVYNIEKWL 

       370        380        390        400        410        420 
IYMPRGHTAN WVMGNHDKPR VATRFGPASV DAMNMLLLTL PGVAVTYNGE ELGMQDYDEI 

       430        440        450        460        470        480 
SWEDTVDPPA RIAGKLDYKK VSRDPERTPF QWSNATNAGF STAAKTWLPV NPNYLVLNLE 

       490        500        510        520        530        540 
AQKQAVKSHY KVYKSLIELR KLPVLRRGRF SIEPLSRTVF AFKRTLKDYD TLVTIINVSA 

       550        560        570        580        590 
KEQLVNLTDF INRPQKLVVE VAGVDSVYAP GQTISSSALT LSAHEGLICK LLDA 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.
[2]"The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
Vieira C.P., Vieira J., Hartl D.L.
Mol. Biol. Evol. 14:985-993(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-562.
Strain: 9.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940649 Genomic DNA. Translation: EDW64447.1.
AF006573 Genomic DNA. Translation: AAB82328.1. Sequence problems.
RefSeqXP_002052292.1. XM_002052256.1.

3D structure databases

ProteinModelPortalO16099.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0236923.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0238431; FBpp0236923; FBgn0022838.
GeneID6627886.
KEGGdvi:Dvir_GJ22506.

Organism-specific databases

FlyBaseFBgn0022838. Dvir\Mal-B2.

Phylogenomic databases

eggNOGCOG0366.
InParanoidO16099.
KOK01187.
OMAYVQSFND.
OrthoDBEOG7B31NK.

Family and domain databases

Gene3D3.20.20.80. 2 hits.
InterProIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMAL2_DROVI
AccessionPrimary (citable) accession number: O16099
Secondary accession number(s): B4LQJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase