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O16099

- MAL2_DROVI

UniProt

O16099 - MAL2_DROVI

Protein

Maltase 2

Gene

Mal-B2

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei241 – 2411NucleophileBy similarity
    Active sitei310 – 3101Proton donorBy similarity
    Sitei377 – 3771Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Maltase 2 (EC:3.2.1.20)
    Gene namesi
    Name:Mal-B2
    Synonyms:Mav2
    ORF Names:GJ22506
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0022838. Dvir\Mal-B2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 594564Maltase 2PRO_0000001450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0236923.

    Structurei

    3D structure databases

    ProteinModelPortaliO16099.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0366.
    InParanoidiO16099.
    OMAiWDDSPYA.
    OrthoDBiEOG7B31NK.
    PhylomeDBiO16099.

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O16099-1 [UniParc]FASTAAdd to Basket

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    MAAAHQLTRT TQLLLLCSLL WTQAPRPVMS SLLSAQTEDF IDWWQHAVFY    50
    QIYPRSFKDS NGDGIGDLQG VISKLPYLAE TGITATWLSP IFQSPMVDFG 100
    YDVSDYKSIQ TEYGTMADFE QLVNTATSLG IKIILDFVPN HTSDKHEWFI 150
    KSAARDPLYD NFYVWADGKL DNQGVRQPPN NWQSVFYGSA WQWHEQRGQY 200
    YLHQFAKEQP DLNFRNPAVV RAMDDVLLFW LNKGVAGFRI DALNHLFEDE 250
    TLPDEPLSGK TTDPLSYDYT KHIYTKDLPE VLSMVQHWRQ LLDDYTAKHS 300
    EGATRIMMTE AYADLQVLMD YYEDAGGVRG SQLPFNFHFI TDVSGDSDAR 350
    DFVYNIEKWL IYMPRGHTAN WVMGNHDKPR VATRFGPASV DAMNMLLLTL 400
    PGVAVTYNGE ELGMQDYDEI SWEDTVDPPA RIAGKLDYKK VSRDPERTPF 450
    QWSNATNAGF STAAKTWLPV NPNYLVLNLE AQKQAVKSHY KVYKSLIELR 500
    KLPVLRRGRF SIEPLSRTVF AFKRTLKDYD TLVTIINVSA KEQLVNLTDF 550
    INRPQKLVVE VAGVDSVYAP GQTISSSALT LSAHEGLICK LLDA 594
    Length:594
    Mass (Da):67,586
    Last modified:July 27, 2011 - v2
    Checksum:i0AB84967886D3785
    GO

    Sequence cautioni

    The sequence AAB82328.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631D → N in AAB82328. (PubMed:9335139)Curated
    Sequence conflicti554 – 5552PQ → L in AAB82328. (PubMed:9335139)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940649 Genomic DNA. Translation: EDW64447.1.
    AF006573 Genomic DNA. Translation: AAB82328.1. Sequence problems.
    RefSeqiXP_002052292.1. XM_002052256.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0238431; FBpp0236923; FBgn0022838.
    GeneIDi6627886.
    KEGGidvi:Dvir_GJ22506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940649 Genomic DNA. Translation: EDW64447.1 .
    AF006573 Genomic DNA. Translation: AAB82328.1 . Sequence problems.
    RefSeqi XP_002052292.1. XM_002052256.1.

    3D structure databases

    ProteinModelPortali O16099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0236923.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0238431 ; FBpp0236923 ; FBgn0022838 .
    GeneIDi 6627886.
    KEGGi dvi:Dvir_GJ22506.

    Organism-specific databases

    FlyBasei FBgn0022838. Dvir\Mal-B2.

    Phylogenomic databases

    eggNOGi COG0366.
    InParanoidi O16099.
    OMAi WDDSPYA.
    OrthoDBi EOG7B31NK.
    PhylomeDBi O16099.

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87.
    2. "The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
      Vieira C.P., Vieira J., Hartl D.L.
      Mol. Biol. Evol. 14:985-993(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-562.
      Strain: 9.

    Entry informationi

    Entry nameiMAL2_DROVI
    AccessioniPrimary (citable) accession number: O16099
    Secondary accession number(s): B4LQJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3