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O16099

- MAL2_DROVI

UniProt

O16099 - MAL2_DROVI

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Protein
Maltase 2
Gene
Mal-B2, Mav2, GJ22506
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei241 – 2411Nucleophile By similarity
Active sitei310 – 3101Proton donor By similarity
Sitei377 – 3771Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase 2 (EC:3.2.1.20)
Gene namesi
Name:Mal-B2
Synonyms:Mav2
ORF Names:GJ22506
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0022838. Dvir\Mal-B2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 594564Maltase 2
PRO_0000001450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi537 – 5371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0236923.

Structurei

3D structure databases

ProteinModelPortaliO16099.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiO16099.
OMAiWDDSPYA.
OrthoDBiEOG7B31NK.
PhylomeDBiO16099.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16099-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAHQLTRT TQLLLLCSLL WTQAPRPVMS SLLSAQTEDF IDWWQHAVFY    50
QIYPRSFKDS NGDGIGDLQG VISKLPYLAE TGITATWLSP IFQSPMVDFG 100
YDVSDYKSIQ TEYGTMADFE QLVNTATSLG IKIILDFVPN HTSDKHEWFI 150
KSAARDPLYD NFYVWADGKL DNQGVRQPPN NWQSVFYGSA WQWHEQRGQY 200
YLHQFAKEQP DLNFRNPAVV RAMDDVLLFW LNKGVAGFRI DALNHLFEDE 250
TLPDEPLSGK TTDPLSYDYT KHIYTKDLPE VLSMVQHWRQ LLDDYTAKHS 300
EGATRIMMTE AYADLQVLMD YYEDAGGVRG SQLPFNFHFI TDVSGDSDAR 350
DFVYNIEKWL IYMPRGHTAN WVMGNHDKPR VATRFGPASV DAMNMLLLTL 400
PGVAVTYNGE ELGMQDYDEI SWEDTVDPPA RIAGKLDYKK VSRDPERTPF 450
QWSNATNAGF STAAKTWLPV NPNYLVLNLE AQKQAVKSHY KVYKSLIELR 500
KLPVLRRGRF SIEPLSRTVF AFKRTLKDYD TLVTIINVSA KEQLVNLTDF 550
INRPQKLVVE VAGVDSVYAP GQTISSSALT LSAHEGLICK LLDA 594
Length:594
Mass (Da):67,586
Last modified:July 27, 2011 - v2
Checksum:i0AB84967886D3785
GO

Sequence cautioni

The sequence AAB82328.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631D → N in AAB82328. 1 Publication
Sequence conflicti554 – 5552PQ → L in AAB82328. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940649 Genomic DNA. Translation: EDW64447.1.
AF006573 Genomic DNA. Translation: AAB82328.1. Sequence problems.
RefSeqiXP_002052292.1. XM_002052256.1.

Genome annotation databases

EnsemblMetazoaiFBtr0238431; FBpp0236923; FBgn0022838.
GeneIDi6627886.
KEGGidvi:Dvir_GJ22506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940649 Genomic DNA. Translation: EDW64447.1 .
AF006573 Genomic DNA. Translation: AAB82328.1 . Sequence problems.
RefSeqi XP_002052292.1. XM_002052256.1.

3D structure databases

ProteinModelPortali O16099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0236923.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0238431 ; FBpp0236923 ; FBgn0022838 .
GeneIDi 6627886.
KEGGi dvi:Dvir_GJ22506.

Organism-specific databases

FlyBasei FBgn0022838. Dvir\Mal-B2.

Phylogenomic databases

eggNOGi COG0366.
InParanoidi O16099.
OMAi WDDSPYA.
OrthoDBi EOG7B31NK.
PhylomeDBi O16099.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.
  2. "The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
    Vieira C.P., Vieira J., Hartl D.L.
    Mol. Biol. Evol. 14:985-993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-562.
    Strain: 9.

Entry informationi

Entry nameiMAL2_DROVI
AccessioniPrimary (citable) accession number: O16099
Secondary accession number(s): B4LQJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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