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O16098

- MAL1_DROVI

UniProt

O16098 - MAL1_DROVI

Protein

Maltase 1

Gene

Mal-B1

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei280 – 2801NucleophileBy similarity
    Active sitei348 – 3481Proton donorBy similarity
    Sitei415 – 4151Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Maltase 1 (EC:3.2.1.20)
    Gene namesi
    Name:Mal-B1
    Synonyms:Mav1
    ORF Names:GJ22501
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0022839. Dvir\Mal-B1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 632Maltase 1PRO_0000001449
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0236918.

    Structurei

    3D structure databases

    ProteinModelPortaliO16098.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0366.
    InParanoidiO16098.
    KOiK01187.
    OMAiERDQYYF.
    OrthoDBiEOG7B31NK.
    PhylomeDBiO16098.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O16098-1 [UniParc]FASTAAdd to Basket

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    MEEGERWREG HVYQRSSETR KPTNYDRPDS PVTHYVSDTH IVGTLMDELE    50
    VETGLITTIL IATFNEMRRS HKPNELDDNI NWWRHEVFYQ IYPRSFKDSD 100
    GDGIGDLKGI TSKLQYFVDT GITAIWLSPI YKSPMVDFGY DISDYRDIQP 150
    EYGTLEDFDA LIAKANQLGI KVILDFVPNH SSDEHEWFKK SAAREPGYED 200
    FYVWEDGIPG DNETRLPPNN WVSVFSGSAW QWHEERQQFY LRQFTKGQPD 250
    LNYRNPAVVQ AMDEVLLYWL QKGVAGFRID AVIYIYEDEQ LRDEPLSGST 300
    SDPNSVDYLE HIYTRNLPEC YGLIQHWRQL LDNYTADNPG PVRIMMTEGY 350
    ADLSLLMNYY EDEDGVQGAH FPFNFDFITE LNANSAAPDF VYFIQRWLTY 400
    MPPGHSANWV MGNHDNPRVA SRYGVGTVDA MNMLMMTLPG IGITYYGEEL 450
    GMVDYRDISW NDTVDQPACD AGLDNYKWVS RDPERTPMQW SDEKNAGFST 500
    GDSTWLPVHP NYQELNLLTQ QEATYSHYKV YQSLIKLRQS RVLRDGSFTA 550
    QALNRNVFAI KRELRGQPTL LTVINVSNRT QQVDVSNFID LPNRLTLLVV 600
    GVCSQHRVSE RLKPAEVKLS PHEGLVIQLK AR 632
    Length:632
    Mass (Da):72,991
    Last modified:July 27, 2011 - v2
    Checksum:i5182C968F730CE0E
    GO

    Sequence cautioni

    The sequence AAB82327.1 differs from that shown. Reason: Several sequencing errors.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940649 Genomic DNA. Translation: EDW64448.1.
    AF006573 Genomic DNA. Translation: AAB82327.1. Sequence problems.
    RefSeqiXP_002052293.1. XM_002052257.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0238426; FBpp0236918; FBgn0022839.
    GeneIDi6627887.
    KEGGidvi:Dvir_GJ22501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940649 Genomic DNA. Translation: EDW64448.1 .
    AF006573 Genomic DNA. Translation: AAB82327.1 . Sequence problems.
    RefSeqi XP_002052293.1. XM_002052257.1.

    3D structure databases

    ProteinModelPortali O16098.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0236918.

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0238426 ; FBpp0236918 ; FBgn0022839 .
    GeneIDi 6627887.
    KEGGi dvi:Dvir_GJ22501.

    Organism-specific databases

    FlyBasei FBgn0022839. Dvir\Mal-B1.

    Phylogenomic databases

    eggNOGi COG0366.
    InParanoidi O16098.
    KOi K01187.
    OMAi ERDQYYF.
    OrthoDBi EOG7B31NK.
    PhylomeDBi O16098.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87.
    2. "The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
      Vieira C.P., Vieira J., Hartl D.L.
      Mol. Biol. Evol. 14:985-993(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-632.
      Strain: 9.

    Entry informationi

    Entry nameiMAL1_DROVI
    AccessioniPrimary (citable) accession number: O16098
    Secondary accession number(s): B4LQJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3