O16098 (MAL1_DROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltase 1
EC=3.2.1.20

Gene names

Name:	Mal-B1
Synonyms:	Mav1
ORF Names:	GJ22501

Organism

Drosophila virilis (Fruit fly) [Complete proteome]

Taxonomic identifier

7244 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family.
Sequence caution	The sequence AAB82327.1 differs from that shown. Reason: Several sequencing errors.

Ontologies

Keywords
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro maltose alpha-glucosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 632		Maltase 1		PRO_0000001449
Sites
	Active site	280	1	Nucleophile By similarity
	Active site	348	1	Proton donor By similarity
	Site	415	1	Transition state stabilizer By similarity
Amino acid modifications
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	333	1	N-linked (GlcNAc...) Potential
	Glycosylation	461	1	N-linked (GlcNAc...) Potential
	Glycosylation	575	1	N-linked (GlcNAc...) Potential
	Glycosylation	578	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O16098 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 5182C968F730CE0E	FASTA	632	72,991
	10 20 30 40 50 60 MEEGERWREG HVYQRSSETR KPTNYDRPDS PVTHYVSDTH IVGTLMDELE VETGLITTIL 70 80 90 100 110 120 IATFNEMRRS HKPNELDDNI NWWRHEVFYQ IYPRSFKDSD GDGIGDLKGI TSKLQYFVDT 130 140 150 160 170 180 GITAIWLSPI YKSPMVDFGY DISDYRDIQP EYGTLEDFDA LIAKANQLGI KVILDFVPNH 190 200 210 220 230 240 SSDEHEWFKK SAAREPGYED FYVWEDGIPG DNETRLPPNN WVSVFSGSAW QWHEERQQFY 250 260 270 280 290 300 LRQFTKGQPD LNYRNPAVVQ AMDEVLLYWL QKGVAGFRID AVIYIYEDEQ LRDEPLSGST 310 320 330 340 350 360 SDPNSVDYLE HIYTRNLPEC YGLIQHWRQL LDNYTADNPG PVRIMMTEGY ADLSLLMNYY 370 380 390 400 410 420 EDEDGVQGAH FPFNFDFITE LNANSAAPDF VYFIQRWLTY MPPGHSANWV MGNHDNPRVA 430 440 450 460 470 480 SRYGVGTVDA MNMLMMTLPG IGITYYGEEL GMVDYRDISW NDTVDQPACD AGLDNYKWVS 490 500 510 520 530 540 RDPERTPMQW SDEKNAGFST GDSTWLPVHP NYQELNLLTQ QEATYSHYKV YQSLIKLRQS 550 560 570 580 590 600 RVLRDGSFTA QALNRNVFAI KRELRGQPTL LTVINVSNRT QQVDVSNFID LPNRLTLLVV 610 620 630 GVCSQHRVSE RLKPAEVKLS PHEGLVIQLK AR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15010-1051.87.
[2]	"The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster." Vieira C.P., Vieira J., Hartl D.L. Mol. Biol. Evol. 14:985-993(1997) [PubMed: 9335139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-632. Strain: 9.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH940649 Genomic DNA. Translation: EDW64448.1. AF006573 Genomic DNA. Translation: AAB82327.1. Sequence problems.
RefSeq	XP_002052293.1. XM_002052257.1.
3D structure databases
ProteinModelPortal	O16098.
ModBase	Search...
Protein family/group databases
CAZy	GH13. Glycoside Hydrolase Family 13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0238426; FBpp0236918; FBgn0022839.
GeneID	6627887.
KEGG	dvi:Dvir_GJ22501.
Organism-specific databases
FlyBase	FBgn0022839. Dvir\Mal-B1.
Phylogenomic databases
GeneTree	EMGT00050000007451.
InParanoid	O16098.
OrthoDB	EOG4THT89.
Family and domain databases
InterPro	IPR015902. Alpha_amylase. IPR013780. Glyco_hydro_13_b. IPR006047. Glyco_hydro_13_cat_dom. IPR006589. Glyco_hydro_13_sub_cat_dom. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:2.60.40.1180. Glyco_hydro_13_b. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits.
KO	K01187.
PANTHER	PTHR10357. Alpha_amylase. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. [Graphical view]
SMART	SM00642. Aamy. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MAL1_DROVI

Accession

Primary (citable) accession number: O16098
Secondary accession number(s): B4LQJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 27, 2011
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project