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O16098

- MAL1_DROVI

UniProt

O16098 - MAL1_DROVI

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Protein

Maltase 1

Gene
Mal-B1, Mav1, GJ22501
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei280 – 2801Nucleophile By similarity
Active sitei348 – 3481Proton donor By similarity
Sitei415 – 4151Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase 1 (EC:3.2.1.20)
Gene namesi
Name:Mal-B1
Synonyms:Mav1
ORF Names:GJ22501
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0022839. Dvir\Mal-B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 632Maltase 1PRO_0000001449
Signal peptidei1 – ? Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi575 – 5751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi578 – 5781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0236918.

Structurei

3D structure databases

ProteinModelPortaliO16098.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiO16098.
KOiK01187.
OMAiERDQYYF.
OrthoDBiEOG7B31NK.
PhylomeDBiO16098.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16098-1 [UniParc]FASTAAdd to Basket

« Hide

MEEGERWREG HVYQRSSETR KPTNYDRPDS PVTHYVSDTH IVGTLMDELE    50
VETGLITTIL IATFNEMRRS HKPNELDDNI NWWRHEVFYQ IYPRSFKDSD 100
GDGIGDLKGI TSKLQYFVDT GITAIWLSPI YKSPMVDFGY DISDYRDIQP 150
EYGTLEDFDA LIAKANQLGI KVILDFVPNH SSDEHEWFKK SAAREPGYED 200
FYVWEDGIPG DNETRLPPNN WVSVFSGSAW QWHEERQQFY LRQFTKGQPD 250
LNYRNPAVVQ AMDEVLLYWL QKGVAGFRID AVIYIYEDEQ LRDEPLSGST 300
SDPNSVDYLE HIYTRNLPEC YGLIQHWRQL LDNYTADNPG PVRIMMTEGY 350
ADLSLLMNYY EDEDGVQGAH FPFNFDFITE LNANSAAPDF VYFIQRWLTY 400
MPPGHSANWV MGNHDNPRVA SRYGVGTVDA MNMLMMTLPG IGITYYGEEL 450
GMVDYRDISW NDTVDQPACD AGLDNYKWVS RDPERTPMQW SDEKNAGFST 500
GDSTWLPVHP NYQELNLLTQ QEATYSHYKV YQSLIKLRQS RVLRDGSFTA 550
QALNRNVFAI KRELRGQPTL LTVINVSNRT QQVDVSNFID LPNRLTLLVV 600
GVCSQHRVSE RLKPAEVKLS PHEGLVIQLK AR 632
Length:632
Mass (Da):72,991
Last modified:July 27, 2011 - v2
Checksum:i5182C968F730CE0E
GO

Sequence cautioni

The sequence AAB82327.1 differs from that shown. Reason: Several sequencing errors.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940649 Genomic DNA. Translation: EDW64448.1.
AF006573 Genomic DNA. Translation: AAB82327.1. Sequence problems.
RefSeqiXP_002052293.1. XM_002052257.1.

Genome annotation databases

EnsemblMetazoaiFBtr0238426; FBpp0236918; FBgn0022839.
GeneIDi6627887.
KEGGidvi:Dvir_GJ22501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940649 Genomic DNA. Translation: EDW64448.1 .
AF006573 Genomic DNA. Translation: AAB82327.1 . Sequence problems.
RefSeqi XP_002052293.1. XM_002052257.1.

3D structure databases

ProteinModelPortali O16098.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0236918.

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0238426 ; FBpp0236918 ; FBgn0022839 .
GeneIDi 6627887.
KEGGi dvi:Dvir_GJ22501.

Organism-specific databases

FlyBasei FBgn0022839. Dvir\Mal-B1.

Phylogenomic databases

eggNOGi COG0366.
InParanoidi O16098.
KOi K01187.
OMAi ERDQYYF.
OrthoDBi EOG7B31NK.
PhylomeDBi O16098.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.
  2. "The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
    Vieira C.P., Vieira J., Hartl D.L.
    Mol. Biol. Evol. 14:985-993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-632.
    Strain: 9.

Entry informationi

Entry nameiMAL1_DROVI
AccessioniPrimary (citable) accession number: O16098
Secondary accession number(s): B4LQJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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