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Protein

Maltase 1

Gene

Mal-B1

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei280 – 2801NucleophileBy similarity
Active sitei348 – 3481Proton donorBy similarity
Sitei415 – 4151Transition state stabilizerBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltase 1 (EC:3.2.1.20)
Gene namesi
Name:Mal-B1
Synonyms:Mav1
ORF Names:GJ22501
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0022839. Dvir\Mal-B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 632Maltase 1PRO_0000001449
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0236918.

Structurei

3D structure databases

ProteinModelPortaliO16098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiO16098.
KOiK01187.
OMAiMLATFTH.
OrthoDBiEOG7B31NK.
PhylomeDBiO16098.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O16098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGERWREG HVYQRSSETR KPTNYDRPDS PVTHYVSDTH IVGTLMDELE
60 70 80 90 100
VETGLITTIL IATFNEMRRS HKPNELDDNI NWWRHEVFYQ IYPRSFKDSD
110 120 130 140 150
GDGIGDLKGI TSKLQYFVDT GITAIWLSPI YKSPMVDFGY DISDYRDIQP
160 170 180 190 200
EYGTLEDFDA LIAKANQLGI KVILDFVPNH SSDEHEWFKK SAAREPGYED
210 220 230 240 250
FYVWEDGIPG DNETRLPPNN WVSVFSGSAW QWHEERQQFY LRQFTKGQPD
260 270 280 290 300
LNYRNPAVVQ AMDEVLLYWL QKGVAGFRID AVIYIYEDEQ LRDEPLSGST
310 320 330 340 350
SDPNSVDYLE HIYTRNLPEC YGLIQHWRQL LDNYTADNPG PVRIMMTEGY
360 370 380 390 400
ADLSLLMNYY EDEDGVQGAH FPFNFDFITE LNANSAAPDF VYFIQRWLTY
410 420 430 440 450
MPPGHSANWV MGNHDNPRVA SRYGVGTVDA MNMLMMTLPG IGITYYGEEL
460 470 480 490 500
GMVDYRDISW NDTVDQPACD AGLDNYKWVS RDPERTPMQW SDEKNAGFST
510 520 530 540 550
GDSTWLPVHP NYQELNLLTQ QEATYSHYKV YQSLIKLRQS RVLRDGSFTA
560 570 580 590 600
QALNRNVFAI KRELRGQPTL LTVINVSNRT QQVDVSNFID LPNRLTLLVV
610 620 630
GVCSQHRVSE RLKPAEVKLS PHEGLVIQLK AR
Length:632
Mass (Da):72,991
Last modified:July 26, 2011 - v2
Checksum:i5182C968F730CE0E
GO

Sequence cautioni

The sequence AAB82327.1 differs from that shown.Several sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940649 Genomic DNA. Translation: EDW64448.1.
AF006573 Genomic DNA. Translation: AAB82327.1. Sequence problems.
RefSeqiXP_002052293.1. XM_002052257.1.

Genome annotation databases

EnsemblMetazoaiFBtr0238426; FBpp0236918; FBgn0022839.
GeneIDi6627887.
KEGGidvi:Dvir_GJ22501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940649 Genomic DNA. Translation: EDW64448.1.
AF006573 Genomic DNA. Translation: AAB82327.1. Sequence problems.
RefSeqiXP_002052293.1. XM_002052257.1.

3D structure databases

ProteinModelPortaliO16098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0236918.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0238426; FBpp0236918; FBgn0022839.
GeneIDi6627887.
KEGGidvi:Dvir_GJ22501.

Organism-specific databases

FlyBaseiFBgn0022839. Dvir\Mal-B1.

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiO16098.
KOiK01187.
OMAiMLATFTH.
OrthoDBiEOG7B31NK.
PhylomeDBiO16098.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.
  2. "The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster."
    Vieira C.P., Vieira J., Hartl D.L.
    Mol. Biol. Evol. 14:985-993(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-632.
    Strain: 9.

Entry informationi

Entry nameiMAL1_DROVI
AccessioniPrimary (citable) accession number: O16098
Secondary accession number(s): B4LQJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: July 26, 2011
Last modified: January 6, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.