O16091 (ADHR_DROPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase-related 31 kDa protein

Gene names

Name:	Adhr
Synonyms:	Adh-dup

Organism

Drosophila persimilis (Fruit fly)

Taxonomic identifier

7234 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular_function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Alcohol dehydrogenase-related 31 kDa protein		PRO_0000054510
Regions
	Nucleotide binding	11 – 34	24	NAD or NADP By similarity
Sites
	Active site	152	1	Proton acceptor By similarity
	Binding site	139	1	Substrate By similarity
Natural variations
	Natural variant	200	1	A → E in strain: Persimi42 and Persimi50.
	Natural variant	204	1	T → S in strain: Persimi42 and Persimi50.
	Natural variant	222	1	Q → K in strain: Persimi40 and Persimi42.

Sequences

	Sequence		Length	Mass (Da)
	O16091 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 72195B6F261C2FBE	FASTA	278	30,851
	10 20 30 40 50 60 MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF 70 80 90 100 110 120 WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL 130 140 150 160 170 180 PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM 190 200 210 220 230 240 AVCCGPTKVF VDRELTAFLA YGQTFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD 250 260 270 KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR

References

[1]	"Gene flow and natural selection in the origin of Drosophila pseudoobscura and close relatives." Wang R.L., Wakeley J., Hey J. Genetics 147:1091-1106(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Persimi40, Persimi42, Persimi44, Persimi49 and Persimi50.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF006564 Genomic DNA. Translation: AAB80703.1. AF006565 Genomic DNA. Translation: AAB80705.1. AF006566 Genomic DNA. Translation: AAB80707.1. AF006567 Genomic DNA. Translation: AAB80709.1. AF006568 Genomic DNA. Translation: AAB80711.1.
3D structure databases
ProteinModelPortal	O16091.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0012636. Dper\Adhr.
Phylogenomic databases
OrthoDB	EOG44F4RW.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002427. ADH-rel. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01170. ADHRELATED. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHR_DROPE

Accession

Primary (citable) accession number: O16091
Secondary accession number(s): O16092 , O16094, O16096, P26621

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project