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O16091

- ADHR_DROPE

UniProt

O16091 - ADHR_DROPE

Protein

Alcohol dehydrogenase-related 31 kDa protein

Gene

Adhr

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei139 – 1391SubstrateBy similarity
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 3424NAD or NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase-related 31 kDa protein
    Gene namesi
    Name:Adhr
    Synonyms:Adh-dup
    OrganismiDrosophila persimilis (Fruit fly)
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0012636. Dper\Adhr.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Alcohol dehydrogenase-related 31 kDa proteinPRO_0000054510Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO16091.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7966HT.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002427. ADH-rel.
    IPR002424. ADH_insect.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR01170. ADHRELATED.
    PR01167. INSADHFAMILY.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O16091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ    50
    SIKHSTQIFF WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN 100
    IDATINTNLT GMMNTVATVL PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC 150
    AYSASKFGVI GFTRSLADPL YYTQNGVAVM AVCCGPTKVF VDRELTAFLA 200
    YGQTFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD KGGLESVALH 250
    WYWHMADQFV NYMQSTDDED QEFFLGQR 278
    Length:278
    Mass (Da):30,851
    Last modified:May 30, 2000 - v3
    Checksum:i72195B6F261C2FBE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti200 – 2001A → E in strain: Persimi42 and Persimi50.
    Natural varianti204 – 2041T → S in strain: Persimi42 and Persimi50.
    Natural varianti222 – 2221Q → K in strain: Persimi40 and Persimi42.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006564 Genomic DNA. Translation: AAB80703.1.
    AF006565 Genomic DNA. Translation: AAB80705.1.
    AF006566 Genomic DNA. Translation: AAB80707.1.
    AF006567 Genomic DNA. Translation: AAB80709.1.
    AF006568 Genomic DNA. Translation: AAB80711.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006564 Genomic DNA. Translation: AAB80703.1 .
    AF006565 Genomic DNA. Translation: AAB80705.1 .
    AF006566 Genomic DNA. Translation: AAB80707.1 .
    AF006567 Genomic DNA. Translation: AAB80709.1 .
    AF006568 Genomic DNA. Translation: AAB80711.1 .

    3D structure databases

    ProteinModelPortali O16091.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0012636. Dper\Adhr.

    Phylogenomic databases

    OrthoDBi EOG7966HT.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002427. ADH-rel.
    IPR002424. ADH_insect.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR01170. ADHRELATED.
    PR01167. INSADHFAMILY.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene flow and natural selection in the origin of Drosophila pseudoobscura and close relatives."
      Wang R.L., Wakeley J., Hey J.
      Genetics 147:1091-1106(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Persimi40, Persimi42, Persimi44, Persimi49 and Persimi50.

    Entry informationi

    Entry nameiADHR_DROPE
    AccessioniPrimary (citable) accession number: O16091
    Secondary accession number(s): O16092
    , O16094, O16096, P26621
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3