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O16091

- ADHR_DROPE

UniProt

O16091 - ADHR_DROPE

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Protein

Alcohol dehydrogenase-related 31 kDa protein

Gene

Adhr

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391SubstrateBy similarity
Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 3424NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-related 31 kDa protein
Gene namesi
Name:Adhr
Synonyms:Adh-dup
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012636. Dper\Adhr.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Alcohol dehydrogenase-related 31 kDa proteinPRO_0000054510Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO16091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7966HT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002427. ADH-rel.
IPR002424. ADH_insect.
IPR002198. DH_sc/Rdtase_SDR.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR01170. ADHRELATED.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16091-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ
60 70 80 90 100
SIKHSTQIFF WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN
110 120 130 140 150
IDATINTNLT GMMNTVATVL PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC
160 170 180 190 200
AYSASKFGVI GFTRSLADPL YYTQNGVAVM AVCCGPTKVF VDRELTAFLA
210 220 230 240 250
YGQTFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD KGGLESVALH
260 270
WYWHMADQFV NYMQSTDDED QEFFLGQR
Length:278
Mass (Da):30,851
Last modified:May 30, 2000 - v3
Checksum:i72195B6F261C2FBE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001A → E in strain: Persimi42 and Persimi50.
Natural varianti204 – 2041T → S in strain: Persimi42 and Persimi50.
Natural varianti222 – 2221Q → K in strain: Persimi40 and Persimi42.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006564 Genomic DNA. Translation: AAB80703.1.
AF006565 Genomic DNA. Translation: AAB80705.1.
AF006566 Genomic DNA. Translation: AAB80707.1.
AF006567 Genomic DNA. Translation: AAB80709.1.
AF006568 Genomic DNA. Translation: AAB80711.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006564 Genomic DNA. Translation: AAB80703.1 .
AF006565 Genomic DNA. Translation: AAB80705.1 .
AF006566 Genomic DNA. Translation: AAB80707.1 .
AF006567 Genomic DNA. Translation: AAB80709.1 .
AF006568 Genomic DNA. Translation: AAB80711.1 .

3D structure databases

ProteinModelPortali O16091.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0012636. Dper\Adhr.

Phylogenomic databases

OrthoDBi EOG7966HT.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002427. ADH-rel.
IPR002424. ADH_insect.
IPR002198. DH_sc/Rdtase_SDR.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR01170. ADHRELATED.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene flow and natural selection in the origin of Drosophila pseudoobscura and close relatives."
    Wang R.L., Wakeley J., Hey J.
    Genetics 147:1091-1106(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Persimi40, Persimi42, Persimi44, Persimi49 and Persimi50.

Entry informationi

Entry nameiADHR_DROPE
AccessioniPrimary (citable) accession number: O16091
Secondary accession number(s): O16092
, O16094, O16096, P26621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 1, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3