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O16091 (ADHR_DROPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase-related 31 kDa protein
Gene names
Name:Adhr
Synonyms:Adh-dup
OrganismDrosophila persimilis (Fruit fly)
Taxonomic identifier7234 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular_functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Alcohol dehydrogenase-related 31 kDa protein
PRO_0000054510

Regions

Nucleotide binding11 – 3424NAD or NADP By similarity

Sites

Active site1521Proton acceptor By similarity
Binding site1391Substrate By similarity

Natural variations

Natural variant2001A → E in strain: Persimi42 and Persimi50.
Natural variant2041T → S in strain: Persimi42 and Persimi50.
Natural variant2221Q → K in strain: Persimi40 and Persimi42.

Sequences

Sequence LengthMass (Da)Tools
O16091 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 72195B6F261C2FBE

FASTA27830,851
        10         20         30         40         50         60 
MYDLTGKHVC YVADCGGIAL ETSKVLMTKN IAKLAILQSV ENPPAIAQLQ SIKHSTQIFF 

        70         80         90        100        110        120 
WTFDVTMARE EMKKYFDEVM VQMDYIDVLI NGATLCDERN IDATINTNLT GMMNTVATVL 

       130        140        150        160        170        180 
PYMDRKMGGS GGLIVNVTSV IGLDPSPVFC AYSASKFGVI GFTRSLADPL YYTQNGVAVM 

       190        200        210        220        230        240 
AVCCGPTKVF VDRELTAFLA YGQTFADRLR RAPCQSTAVC GQNIVNAIER SENGQIWIAD 

       250        260        270 
KGGLESVALH WYWHMADQFV NYMQSTDDED QEFFLGQR 

« Hide

References

[1]"Gene flow and natural selection in the origin of Drosophila pseudoobscura and close relatives."
Wang R.L., Wakeley J., Hey J.
Genetics 147:1091-1106(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Persimi40, Persimi42, Persimi44, Persimi49 and Persimi50.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF006564 Genomic DNA. Translation: AAB80703.1.
AF006565 Genomic DNA. Translation: AAB80705.1.
AF006566 Genomic DNA. Translation: AAB80707.1.
AF006567 Genomic DNA. Translation: AAB80709.1.
AF006568 Genomic DNA. Translation: AAB80711.1.

3D structure databases

ProteinModelPortalO16091.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0012636. Dper\Adhr.

Phylogenomic databases

OrthoDBEOG7966HT.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002427. ADH-rel.
IPR002424. ADH_insect.
IPR002198. DH_sc/Rdtase_SDR.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR01170. ADHRELATED.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADHR_DROPE
AccessionPrimary (citable) accession number: O16091
Secondary accession number(s): O16092 expand/collapse secondary AC list , O16094, O16096, P26621
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 13, 2013
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase