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Protein

Polycomb protein esc

Gene

esc

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb protein esc
Alternative name(s):
Protein extra sex combs
Gene namesi
Name:esc
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Polycomb protein escPRO_0000050974Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the Esc/E(z) complex, composed of Esc, E(z), Su(z)12, Rpd3, Caf1 and probably Pho. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO16023.
SMRiO16023. Positions 63-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati72 – 11544WD 1Add
BLAST
Repeati124 – 16643WD 2Add
BLAST
Repeati169 – 20941WD 3Add
BLAST
Repeati215 – 25440WD 4Add
BLAST
Repeati285 – 32238WD 5Add
BLAST
Repeati341 – 38040WD 6Add
BLAST
Repeati389 – 42739WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ESC family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVKADKQS PKENTKAENS DNESIDDTAS VATSTTSRSK SPGSRGRRQS
60 70 80 90 100
RGHSKSKAKR PAYKYDCHLK EDHGQAIFGV SFNHLLGKDQ SMVFATAGSN
110 120 130 140 150
RCNIYECPRK GGLKLIMCYA DPDPDEVFYT CSWSYDLKTS APLLATAGYR
160 170 180 190 200
GVIRVIDIHR NESVGNYVGH GQAINELKFH PRQANLLLSG SKDHAIRLWN
210 220 230 240 250
IQTHVCIAIF GGVEGHRDEV LSIDFDLRGE RIMSSGMDHS LKLWRIDTPE
260 270 280 290 300
FKDKIEMSRT FNPNKSQLPF PTIMQHFPEF STRDIHRNYV DCVQWFGDFV
310 320 330 340 350
LSKSCENSIV CWKPGQLHQT LSQLKPNDPS CTIISEFNYD ECEIWFVRFG
360 370 380 390 400
FNPWHKIVAL GNQYGKVYVW ELDPSDPRHT HSSTLNNIRC TSIVRQTAFS
410 420
RDATVLVWVC DDGTVWRWNR RNAEVHTP
Length:428
Mass (Da):48,796
Last modified:January 1, 1998 - v1
Checksum:i5A1D09D63D1A86C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003605 Genomic DNA. Translation: AAC05333.1.

Genome annotation databases

VectorBaseiMDOA004331-RA; MDOA004331-PA; MDOA004331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003605 Genomic DNA. Translation: AAC05333.1.

3D structure databases

ProteinModelPortaliO16023.
SMRiO16023. Positions 63-420.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

VectorBaseiMDOA004331-RA; MDOA004331-PA; MDOA004331.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESC_MUSDO
AccessioniPrimary (citable) accession number: O16023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.