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Protein
Submitted name:

Notch homolog

Gene
N/A
Organism
Lytechinus variegatus (Green sea urchin) (Variegated urchin)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Notch homologImported
OrganismiLytechinus variegatus (Green sea urchin) (Variegated urchin)Imported
Taxonomic identifieri7654 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeLytechinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500415699936 – 2531Sequence analysisAdd BLAST2496

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO16004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 73EGF-likeInterPro annotationAdd BLAST39
Domaini74 – 117EGF-likeInterPro annotationAdd BLAST44
Domaini120 – 159EGF-likeInterPro annotationAdd BLAST40
Domaini160 – 196EGF-likeInterPro annotationAdd BLAST37
Domaini198 – 238EGF-likeInterPro annotationAdd BLAST41
Domaini240 – 277EGF-likeInterPro annotationAdd BLAST38
Domaini279 – 315EGF-likeInterPro annotationAdd BLAST37
Domaini317 – 355EGF-likeInterPro annotationAdd BLAST39
Domaini357 – 393EGF-likeInterPro annotationAdd BLAST37
Domaini394 – 432EGF-likeInterPro annotationAdd BLAST39
Domaini434 – 473EGF-likeInterPro annotationAdd BLAST40
Domaini475 – 511EGF-likeInterPro annotationAdd BLAST37
Domaini513 – 549EGF-likeInterPro annotationAdd BLAST37
Domaini551 – 587EGF-likeInterPro annotationAdd BLAST37
Domaini589 – 625EGF-likeInterPro annotationAdd BLAST37
Domaini627 – 663EGF-likeInterPro annotationAdd BLAST37
Domaini665 – 701EGF-likeInterPro annotationAdd BLAST37
Domaini703 – 739EGF-likeInterPro annotationAdd BLAST37
Domaini741 – 777EGF-likeInterPro annotationAdd BLAST37
Domaini779 – 815EGF-likeInterPro annotationAdd BLAST37
Domaini817 – 855EGF-likeInterPro annotationAdd BLAST39
Domaini857 – 893EGF-likeInterPro annotationAdd BLAST37
Domaini895 – 931EGF-likeInterPro annotationAdd BLAST37
Domaini933 – 969EGF-likeInterPro annotationAdd BLAST37
Domaini971 – 1007EGF-likeInterPro annotationAdd BLAST37
Domaini1009 – 1045EGF-likeInterPro annotationAdd BLAST37
Domaini1047 – 1085EGF-likeInterPro annotationAdd BLAST39
Domaini1097 – 1133EGF-likeInterPro annotationAdd BLAST37
Domaini1135 – 1171EGF-likeInterPro annotationAdd BLAST37
Domaini1173 – 1209EGF-likeInterPro annotationAdd BLAST37
Domaini1211 – 1247EGF-likeInterPro annotationAdd BLAST37
Domaini1249 – 1287EGF-likeInterPro annotationAdd BLAST39
Domaini1289 – 1325EGF-likeInterPro annotationAdd BLAST37
Domaini1327 – 1366EGF-likeInterPro annotationAdd BLAST40
Domaini1368 – 1404EGF-likeInterPro annotationAdd BLAST37
Domaini1436 – 1479LNR (Lin/Notch)InterPro annotationAdd BLAST44
Domaini1480 – 1520LNR (Lin/Notch)InterPro annotationAdd BLAST41
Domaini1521 – 1556LNR (Lin/Notch)InterPro annotationAdd BLAST36
Domaini1849 – 2080ANK_REP_REGIONInterPro annotationAdd BLAST232

Sequence similaritiesi

Contains 5 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 26 hits.
PF07645. EGF_CA. 4 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
SMARTiSM00248. ANK. 6 hits.
SM01334. DUF3454. 1 hit.
SM00181. EGF. 35 hits.
SM00179. EGF_CA. 30 hits.
SM00004. NL. 3 hits.
SM01338. NOD. 1 hit.
SM01339. NODP. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 21 hits.
PS00022. EGF_1. 33 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 20 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O16004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTTHSGIS IFCLPKVGLF LVVVISTLTS YGASGTSTCS PNPCNGGTCI
60 70 80 90 100
PPDTQDGEVT CSCERTHVGD RCQFENPCYH AEICQNDGEC EVRFNSDGSN
110 120 130 140 150
PYFHCNCPLG YELSLCEGEV DNVCKLEEPC QNGGTCRLTT SLWDYECFCT
160 170 180 190 200
PANTGENCTD DNHCVSNPCL NGAVCTSSSD GYSCECAQGF QGDTCNNDIN
210 220 230 240 250
ECTRPNGPTV CYNGGTCFNQ YGGFQCECPL GFTGDQCELV YEPCSPDPCR
260 270 280 290 300
NGGQCASTGP YTFTCTCQNG FTGETCELNL NDCTQHQCLN GGTCIDGVND
310 320 330 340 350
YTCSCLKEFT GTYCEMDFDE CDTAVDPCFN GGTCSNTYGN FSCICVRGWE
360 370 380 390 400
GQTCEINKDD CTPNPCQFEG ECEDRVASFK CTCPPGRTGL LCHLEDACMS
410 420 430 440 450
NPCHHTAQCS TSVVDGSFIC DCATGYQGFN CSEDIDECSL SMDSICQSGG
460 470 480 490 500
TCQNFDGGWS CLCSSGFTGS RCETDIDECD DDPCYNGGTC LNKRGGYACI
510 520 530 540 550
CLTGFTGTLC ETDINECSSN PCLNGASCFD ITGRFECACL AGYTGTTCQV
560 570 580 590 600
NIDDCQSSPC ENGGTCIDGV NQFTCLCETG YEGHRCEMDS DECASRPCMN
610 620 630 640 650
GGVCEDLIGF YQCNCPVGTS GDNCEYNHYD CSSNPCVNDG TCVDGINEYT
660 670 680 690 700
CMCHEGYRGL NCEEDIDDCE SRPCHNGGTC VDEVNGYHCL CPIGYHDPFC
710 720 730 740 750
MSNINECSSN PCVNGGSCHD GVNEYSCECM AGYTGTRCTD DFDECSSNPC
760 770 780 790 800
QHGGTCDNRH AFYNCTCQAG YTGLNCEVNI DDCVDEPCLN GGICIDEVNS
810 820 830 840 850
FQCVCPQTFV GLLCETERSP CEDNQCQNGA TCVYSEDYAG YSCRCTSGFQ
860 870 880 890 900
GNFCDDDRNE CLFSPCRNGG SCTNLEGSFE CSCLPGYDGP ICEINIDECA
910 920 930 940 950
SGPCTNGGIC TDLIDDYFCS CQRGFTGKNC QNDTDECLSS PCRNGATCHE
960 970 980 990 1000
YVDSYTCSCL VGFSGMHCEI NDQDCTTSSC LYGGTCIDGV NSYTCECVTG
1010 1020 1030 1040 1050
YTGSNCQIEI NECDSDPCEN GATCQDRFGS YSCHCDVGFT GLNCEHVVQW
1060 1070 1080 1090 1100
CSPQNNPCYN GATCVAMGHL YECHCASNWI GKLCDVPKVS CDIAASDKNV
1110 1120 1130 1140 1150
TRSELCLNGG TCIDATSSHS CLCQDGYTGS YCEVNIDECA SAPCHNGGTC
1160 1170 1180 1190 1200
TDGVYSYTCS CLPGFEGPRC QQNINECASS PCHNGGQCHD MVNGYTCSCP
1210 1220 1230 1240 1250
AGTQGTDCSI NLDDCYEGAC YHGGVCIDQV GTYTCDCPLG FVGQHCEGDV
1260 1270 1280 1290 1300
NECLSNPCDP VGSQDCVQLI NNYQCVCKPG YTGQDCEQEI PNCQNDPCQN
1310 1320 1330 1340 1350
NGLCLPSDEG YYCDCLRGFT GVHCETKLTP CGTHPCQNEG TCMEYGDDFD
1360 1370 1380 1390 1400
DYTCMCPSGV SGDNCEIDYN ECASSPCING GTCLDEYGQY RCDCPATWNG
1410 1420 1430 1440 1450
RNCHLFDPTF AGGIGMDPEI PTEPPVTIPI TVATTTEPPR CSQECLRKKG
1460 1470 1480 1490 1500
DYFCDEECNT HLCEWDGKDC SLNLDPWENC TAANVPCWNR FGDGSCDREC
1510 1520 1530 1540 1550
NNHGCLFDGF DCVDQKPEEC GEDAFCLERY GNGFCDEECN NIGCLYDGLD
1560 1570 1580 1590 1600
CEENPEFAHG VLIVDVMIPY AEMLTLNRSQ MFLQDMSVVL NTVVLFAPTA
1610 1620 1630 1640 1650
DNQNKIEPWE NDPRAVRAPV RRDVLAVSRE GKLTVKKRQA ELTPDDGTKC
1660 1670 1680 1690 1700
FLLLDNYKCH QDRPGNCFET AADAAAYLAA LVTSQLLPTS LPITGVGSET
1710 1720 1730 1740 1750
TPAQTVSPSV LIAVAIIGAF VIAAACVIAR KRFRTNGTWF PSNFVRTSST
1760 1770 1780 1790 1800
KSENPKVPRE CPIGNESPPS TICSSIDAGE DAMNALECRA PKRQRISRLS
1810 1820 1830 1840 1850
PVDYGQGHTT LDTDTPWMTM TSNGPLHPSM ALTPPRDQEP PFITNKGPDG
1860 1870 1880 1890 1900
LTPLMLAVMR SKASITDQEE ETHAHFIEDL ITRGGDINHR TETRGETALH
1910 1920 1930 1940 1950
LAARYNLPVA ARKLLEYSVN TNAEDNMGET PLHAAVRADA IEVFRLLIQN
1960 1970 1980 1990 2000
RSTQIDAKTK AGYTPMIIAV RLMVENMVEE LELAGADTAA TDNDGRSALM
2010 2020 2030 2040 2050
WAAALNHLPA LEFLLKKGSN KDLQDNQEQT PLFLAAKEGH VGAVKMLLDH
2060 2070 2080 2090 2100
GANREITDHL DMSPREIANR MSLQDVVRLL DTYSMMSPAL TPNSHVTSPM
2110 2120 2130 2140 2150
DMHNGELGYS NGAKPKKKRG TNKNGDVRER GKEKRKGKKR PSSDESLPPL
2160 2170 2180 2190 2200
VPSPPESVES PQGYNRTPPP GGIYSLPVTT QNVMMPQDHY QLKEVARHGQ
2210 2220 2230 2240 2250
GPHVVDMHPN TIMNGRLYVP GNNPSPAKGS MGGENMDIPG ASDLVSQTIW
2260 2270 2280 2290 2300
SPDHALLQNQ RSMHDPNVMV PGTTSQAMAM IRQAPSTQSM QQTLSPEARD
2310 2320 2330 2340 2350
SSPKPCTMVP SPTISNQYIM ASSPNLPSTT SQATHYARAN NPLYAGSPHR
2360 2370 2380 2390 2400
GKVPQQIHSM YQSQNRMNPR ACISELPNGH PNSPENCMQE YMIREPELLN
2410 2420 2430 2440 2450
PAKQSMYVVN GKVPNGQHRD ILSEKTSFSN PHNNNGSTVD PSCTYTMVAH
2460 2470 2480 2490 2500
MPDHSFPTPS PESPSKWSNP SPTSASDWSG SEAISSPPVP PNQQQVSGQE
2510 2520 2530
LMNGHTGRLL TGHDMPLGIS LQGSCTEVAY I
Length:2,531
Mass (Da):273,985
Last modified:January 1, 1998 - v1
Checksum:i5BF42BEC627CA303
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000634 mRNA. Translation: AAB82088.1.
PIRiT31070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000634 mRNA. Translation: AAB82088.1.
PIRiT31070.

3D structure databases

ProteinModelPortaliO16004.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 26 hits.
PF07645. EGF_CA. 4 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
SMARTiSM00248. ANK. 6 hits.
SM01334. DUF3454. 1 hit.
SM00181. EGF. 35 hits.
SM00179. EGF_CA. 30 hits.
SM00004. NL. 3 hits.
SM01338. NOD. 1 hit.
SM01339. NODP. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 21 hits.
PS00022. EGF_1. 33 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 20 hits.
PS50258. LNR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO16004_LYTVA
AccessioniPrimary (citable) accession number: O16004
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.