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Protein

Arginine kinase

Gene
N/A
Organism
Anthopleura japonica (Sea anemone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei189ATPPROSITE-ProRule annotation1
Binding sitei229SubstrateBy similarity1
Binding sitei233ATPPROSITE-ProRule annotation1
Binding sitei275SubstrateBy similarity1
Binding sitei317SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 130ATPPROSITE-ProRule annotation5
Nucleotide bindingi284 – 288ATPPROSITE-ProRule annotation5
Nucleotide bindingi312 – 317ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.3.3. 370.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
OrganismiAnthopleura japonica (Sea anemone)
Taxonomic identifieri67755 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaActiniidaeAnthopleura

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120071 – 715Arginine kinaseAdd BLAST715

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 11Combined sources8
Turni12 – 14Combined sources3
Helixi18 – 21Combined sources4
Helixi30 – 34Combined sources5
Helixi37 – 43Combined sources7
Helixi54 – 63Combined sources10
Helixi76 – 81Combined sources6
Helixi83 – 93Combined sources11
Turni94 – 96Combined sources3
Turni99 – 101Combined sources3
Helixi109 – 111Combined sources3
Beta strandi122 – 133Combined sources12
Turni141 – 143Combined sources3
Helixi146 – 160Combined sources15
Helixi165 – 167Combined sources3
Beta strandi169 – 174Combined sources6
Helixi179 – 187Combined sources9
Helixi197 – 201Combined sources5
Turni202 – 211Combined sources10
Beta strandi213 – 217Combined sources5
Beta strandi222 – 241Combined sources20
Helixi243 – 261Combined sources19
Turni267 – 269Combined sources3
Helixi276 – 278Combined sources3
Beta strandi283 – 290Combined sources8
Helixi292 – 295Combined sources4
Helixi300 – 307Combined sources8
Beta strandi309 – 313Combined sources5
Beta strandi315 – 318Combined sources4
Beta strandi320 – 323Combined sources4
Beta strandi328 – 333Combined sources6
Beta strandi337 – 339Combined sources3
Helixi341 – 367Combined sources27
Helixi372 – 375Combined sources4
Helixi382 – 386Combined sources5
Helixi389 – 395Combined sources7
Helixi406 – 415Combined sources10
Helixi430 – 433Combined sources4
Helixi435 – 445Combined sources11
Turni446 – 448Combined sources3
Helixi451 – 453Combined sources3
Helixi461 – 463Combined sources3
Beta strandi474 – 485Combined sources12
Helixi493 – 495Combined sources3
Helixi498 – 513Combined sources16
Helixi517 – 519Combined sources3
Beta strandi521 – 526Combined sources6
Helixi531 – 539Combined sources9
Helixi549 – 554Combined sources6
Turni555 – 563Combined sources9
Beta strandi565 – 569Combined sources5
Beta strandi574 – 593Combined sources20
Helixi595 – 613Combined sources19
Turni619 – 621Combined sources3
Helixi628 – 630Combined sources3
Beta strandi635 – 642Combined sources8
Helixi644 – 648Combined sources5
Helixi652 – 658Combined sources7
Beta strandi661 – 665Combined sources5
Beta strandi679 – 685Combined sources7
Beta strandi689 – 691Combined sources3
Helixi693 – 711Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RF6X-ray1.95A/B1-715[»]
4RF7X-ray2.10A/B1-715[»]
4RF8X-ray2.17A/B1-715[»]
4RF9X-ray2.35A/B1-715[»]
ProteinModelPortaliO15992.
SMRiO15992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 366ApproximateAdd BLAST366
Domaini11 – 95Phosphagen kinase N-terminal 1PROSITE-ProRule annotationAdd BLAST85
Domaini123 – 362Phosphagen kinase C-terminal 1PROSITE-ProRule annotationAdd BLAST240
Domaini365 – 447Phosphagen kinase N-terminal 2PROSITE-ProRule annotationAdd BLAST83
Repeati367 – 715ApproximateAdd BLAST349
Domaini475 – 714Phosphagen kinase C-terminal 2PROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 72Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.135.10. 2 hits.
InterProiView protein in InterPro
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR036802. ATP-guanido_PTrfase_N_sf.
IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiView protein in Pfam
PF00217. ATP-gua_Ptrans. 2 hits.
PF02807. ATP-gua_PtransN. 2 hits.
SUPFAMiSSF48034. SSF48034. 2 hits.
SSF55931. SSF55931. 2 hits.
PROSITEiView protein in PROSITE
PS00112. PHOSPHAGEN_KINASE. 2 hits.
PS51510. PHOSPHAGEN_KINASE_C. 2 hits.
PS51509. PHOSPHAGEN_KINASE_N. 2 hits.

Sequencei

Sequence statusi: Complete.

O15992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPETAAKF KSKNAFPDPL NDPKCNPKSL VKKYLTPKVF ESLKNKKTKL
60 70 80 90 100
GITLWDCINS GVVNLDSGVG VYAGDEESYT LFGPLFDAII EDYHSPYKLA
110 120 130 140 150
TGHNSDMNPA HVKAPDLDPA NRYIRSTRIR VARSLKGYGL APGVTKAHRL
160 170 180 190 200
EIEKKVVGVL TSLTGDLAGK YYPLSGMDEK TRQQLVDDHF LFKKGDRFLE
210 220 230 240 250
AAGINKEWPE GRGIYHNNDK TFLVWLNEED HLRIISMEKG SDIGSVFSRL
260 270 280 290 300
CRAVNEIDKK LGFQHTKKHG YLTSCPSNLG TGMRASVHVK IPHAKEHPDF
310 320 330 340 350
ENILTKYHIQ ARGIHGEHSE STGEDAGVYD ISNRRRLGLS EVQCVQDMYD
360 370 380 390 400
GVKALMELEK EAIAKKRSVF PEVLKNPEVK SLLRKYLTPE LFDSLKDKKT
410 420 430 440 450
AKGISLYDCI NSGVENLDSS CGVYAGDEEC YTLFAPLFDK IVEDYHSPYK
460 470 480 490 500
LANKHTSDMN PEKVDAPNLD PEGTYIRSTR IRVARNVKGY ALTPGLTRNE
510 520 530 540 550
RLDIERKVVG VLSSLTGDLA GQYYPLTGMD EATRQKLVND HFLFKKGDRF
560 570 580 590 600
LEAAGVNKLW PEGRGIFHNN DKTFLVWINE EDQLRIISME KGSDIGSVFG
610 620 630 640 650
RLCRAVNEID KQLGFQHTDA HGYLSGCPTN LGTGMRASVH VKIPKASAHP
660 670 680 690 700
DFQKICDEFH IQARGIHGEH SVSTGEDAGV FDISNRRRLG LSEVQCVQDM
710
YNGVKKLLEI EKSTK
Length:715
Mass (Da):80,024
Last modified:January 1, 1998 - v1
Checksum:iC8E756E726CEDA48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008014 mRNA. Translation: BAA22888.1.

Similar proteinsi

Entry informationi

Entry nameiKARG_ANTJA
AccessioniPrimary (citable) accession number: O15992
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing