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O15991 (KLOM_EISFO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lombricine kinase

Short name=LK
EC=2.7.3.5
OrganismEisenia foetida (Common brandling worm) (Common dung-worm)
Taxonomic identifier6396 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeEisenia

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + lombricine = ADP + N-phospholombricine.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the ATP:guanido phosphotransferase family.

Contains 1 phosphagen kinase C-terminal domain.

Contains 1 phosphagen kinase N-terminal domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

lombricine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Lombricine kinase
PRO_0000211985

Regions

Domain1 – 8686Phosphagen kinase N-terminal
Domain113 – 355243Phosphagen kinase C-terminal
Nucleotide binding116 – 1205ATP By similarity
Nucleotide binding308 – 3136ATP By similarity

Sites

Binding site1791ATP By similarity
Binding site2241ATP By similarity
Binding site2801ATP By similarity
Binding site3231ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O15991 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 8F8409D72F92ACB9

FASTA37141,781
        10         20         30         40         50         60 
MPKFTARQNF PDYKSNGHKC MVGRHLTEDM YERLYELRTP NGVSIDKCIQ PSVDNTGRII 

        70         80         90        100        110        120 
GLVAGDPESY EVFKELFDAV INEKHGGFGP TDKHPPPDLN ANALVGGQFD PKYVKSARIR 

       130        140        150        160        170        180 
TGRSVKGFCL PPSISRAERR EVERIIVDAL AGLEGDLAGV YYPLKKMTPE QEKQLIADHF 

       190        200        210        220        230        240 
LFQKPTGHLM VNSGAVRDWP DARGIWHNKD KTFLIWINEE DQVRIIAMQH GGDVKAVFER 

       250        260        270        280        290        300 
FSRGLTQIEG LMKKHGHEFA WSERLGYICT CPSNLGTGLR ASVHLQLHKL SKHPKFEEII 

       310        320        330        340        350        360 
LAFHLQKRGT GGEHTEAVDD VYDISNRARL KKSEREFVQL LIDGVGKLIE YEKLLEAGKS 

       370 
IDDVLPASLK G 

« Hide

References

[1]"Evolution of phosphagen kinase. VI. Isolation, characterization and cDNA-derived amino acid sequence of lombricine kinase from the earthworm Eisenia foetida, and identification of a possible candidate for the guanidine substrate recognition site."
Suzuki T., Kawasaki Y., Furukohri T., Ellington W.R.
Biochim. Biophys. Acta 1343:152-159(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB008013 mRNA. Translation: BAA22872.1.

3D structure databases

ProteinModelPortalO15991.
SMRO15991. Positions 2-368.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-18469.

Family and domain databases

Gene3D1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMSSF48034. SSF48034. 1 hit.
PROSITEPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKLOM_EISFO
AccessionPrimary (citable) accession number: O15991
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families