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Protein

Lombricine kinase

Gene
N/A
Organism
Eisenia fetida (Red wiggler worm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + lombricine = ADP + N-phospholombricine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei179 – 1791ATPPROSITE-ProRule annotation
Binding sitei224 – 2241ATPPROSITE-ProRule annotation
Binding sitei280 – 2801ATPPROSITE-ProRule annotation
Binding sitei323 – 3231ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi116 – 1205ATPPROSITE-ProRule annotation
Nucleotide bindingi308 – 3136ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18469.

Names & Taxonomyi

Protein namesi
Recommended name:
Lombricine kinase (EC:2.7.3.5)
Short name:
LK
OrganismiEisenia fetida (Red wiggler worm)
Taxonomic identifieri6396 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeEisenia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Lombricine kinasePRO_0000211985Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO15991.
SMRiO15991. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8686Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini113 – 355243Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFTARQNF PDYKSNGHKC MVGRHLTEDM YERLYELRTP NGVSIDKCIQ
60 70 80 90 100
PSVDNTGRII GLVAGDPESY EVFKELFDAV INEKHGGFGP TDKHPPPDLN
110 120 130 140 150
ANALVGGQFD PKYVKSARIR TGRSVKGFCL PPSISRAERR EVERIIVDAL
160 170 180 190 200
AGLEGDLAGV YYPLKKMTPE QEKQLIADHF LFQKPTGHLM VNSGAVRDWP
210 220 230 240 250
DARGIWHNKD KTFLIWINEE DQVRIIAMQH GGDVKAVFER FSRGLTQIEG
260 270 280 290 300
LMKKHGHEFA WSERLGYICT CPSNLGTGLR ASVHLQLHKL SKHPKFEEII
310 320 330 340 350
LAFHLQKRGT GGEHTEAVDD VYDISNRARL KKSEREFVQL LIDGVGKLIE
360 370
YEKLLEAGKS IDDVLPASLK G
Length:371
Mass (Da):41,781
Last modified:January 1, 1998 - v1
Checksum:i8F8409D72F92ACB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008013 mRNA. Translation: BAA22872.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008013 mRNA. Translation: BAA22872.1.

3D structure databases

ProteinModelPortaliO15991.
SMRiO15991. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18469.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of phosphagen kinase. VI. Isolation, characterization and cDNA-derived amino acid sequence of lombricine kinase from the earthworm Eisenia foetida, and identification of a possible candidate for the guanidine substrate recognition site."
    Suzuki T., Kawasaki Y., Furukohri T., Ellington W.R.
    Biochim. Biophys. Acta 1343:152-159(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiKLOM_EISFE
AccessioniPrimary (citable) accession number: O15991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.