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O15991

- KLOM_EISFO

UniProt

O15991 - KLOM_EISFO

Protein

Lombricine kinase

Gene
N/A
Organism
Eisenia foetida (Common brandling worm) (Common dung-worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + lombricine = ADP + N-phospholombricine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei179 – 1791ATPPROSITE-ProRule annotation
    Binding sitei224 – 2241ATPPROSITE-ProRule annotation
    Binding sitei280 – 2801ATPPROSITE-ProRule annotation
    Binding sitei323 – 3231ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi116 – 1205ATPPROSITE-ProRule annotation
    Nucleotide bindingi308 – 3136ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. lombricine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18469.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lombricine kinase (EC:2.7.3.5)
    Short name:
    LK
    OrganismiEisenia foetida (Common brandling worm) (Common dung-worm)
    Taxonomic identifieri6396 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeEisenia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Lombricine kinasePRO_0000211985Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO15991.
    SMRiO15991. Positions 2-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8686Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 355243Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 phosphagen kinase N-terminal domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view]
    PfamiPF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48034. SSF48034. 1 hit.
    PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15991-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKFTARQNF PDYKSNGHKC MVGRHLTEDM YERLYELRTP NGVSIDKCIQ    50
    PSVDNTGRII GLVAGDPESY EVFKELFDAV INEKHGGFGP TDKHPPPDLN 100
    ANALVGGQFD PKYVKSARIR TGRSVKGFCL PPSISRAERR EVERIIVDAL 150
    AGLEGDLAGV YYPLKKMTPE QEKQLIADHF LFQKPTGHLM VNSGAVRDWP 200
    DARGIWHNKD KTFLIWINEE DQVRIIAMQH GGDVKAVFER FSRGLTQIEG 250
    LMKKHGHEFA WSERLGYICT CPSNLGTGLR ASVHLQLHKL SKHPKFEEII 300
    LAFHLQKRGT GGEHTEAVDD VYDISNRARL KKSEREFVQL LIDGVGKLIE 350
    YEKLLEAGKS IDDVLPASLK G 371
    Length:371
    Mass (Da):41,781
    Last modified:January 1, 1998 - v1
    Checksum:i8F8409D72F92ACB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008013 mRNA. Translation: BAA22872.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008013 mRNA. Translation: BAA22872.1 .

    3D structure databases

    ProteinModelPortali O15991.
    SMRi O15991. Positions 2-368.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-18469.

    Family and domain databases

    Gene3Di 1.10.135.10. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR022415. ATP-guanido_PTrfase_AS.
    IPR022414. ATP-guanido_PTrfase_cat.
    IPR022413. ATP-guanido_PTrfase_N.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    [Graphical view ]
    Pfami PF00217. ATP-gua_Ptrans. 1 hit.
    PF02807. ATP-gua_PtransN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48034. SSF48034. 1 hit.
    PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
    PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
    PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of phosphagen kinase. VI. Isolation, characterization and cDNA-derived amino acid sequence of lombricine kinase from the earthworm Eisenia foetida, and identification of a possible candidate for the guanidine substrate recognition site."
      Suzuki T., Kawasaki Y., Furukohri T., Ellington W.R.
      Biochim. Biophys. Acta 1343:152-159(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiKLOM_EISFO
    AccessioniPrimary (citable) accession number: O15991
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3