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O15978

- WNT5_HALRO

UniProt

O15978 - WNT5_HALRO

Protein

Protein Wnt-5

Gene

WNT5

Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5
    Gene namesi
    Name:WNT5
    OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)
    Taxonomic identifieri7729 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 363336Protein Wnt-5PRO_0000041439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi88 ↔ 99By similarity
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 145By similarity
    Disulfide bondi147 ↔ 165By similarity
    Disulfide bondi221 ↔ 235By similarity
    Disulfide bondi223 ↔ 230By similarity
    Lipidationi227 – 2271O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi308 ↔ 323By similarity
    Disulfide bondi338 ↔ 353By similarity
    Disulfide bondi340 ↔ 350By similarity
    Disulfide bondi345 ↔ 346By similarity

    Post-translational modificationi

    Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG001595.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15978-1 [UniParc]FASTAAdd to Basket

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    MVGMTRIQSA EPVWILFVLT LYSSVLMQVK PQLWSVGIER KKLFGETNTS    50
    VHCDEIRGLS RNQRSLCRTY NDHMYYVESG SKQGVEECQW QFRGQRWNCS 100
    LASNASPDKI IAVGSKETAF TYAITSGGVV QSIARACKSG NLMACGCSKR 150
    ERPTGLGKDW NWGGCGDDID YAYGFAHEFI DAQERDNSSP NDRRVKSHKA 200
    MNIHNNEAGR LSVVRASHTT CKCHGVSGSC SIKTCWLQTP QFRTIGDKLR 250
    QRYDDALEMR VTHRGQMKTR FSSDRNPSNI DLVYIDSSPD YCKVNHKLGI 300
    LGTSGRECQL DSLAMDGCGL MCCGRGYTTK MVEVVKSCNC KFQWCCFVKC 350
    QQCKEKVLKH ICN 363
    Length:363
    Mass (Da):40,828
    Last modified:January 1, 1998 - v1
    Checksum:i79A820F8796527B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006608 Genomic DNA. Translation: BAA21878.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006608 Genomic DNA. Translation: BAA21878.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001595.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sasakura Y., Ogasawara M., Makabe K.W.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiWNT5_HALRO
    AccessioniPrimary (citable) accession number: O15978
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3