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O15978 (WNT5_HALRO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-5
Gene names
Name:WNT5
OrganismHalocynthia roretzi (Sea squirt) (Cynthia roretzi)
Taxonomic identifier7729 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-88. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 363336Protein Wnt-5
PRO_0000041439

Amino acid modifications

Lipidation881S-palmitoyl cysteine By similarity
Lipidation2271O-palmitoyl serine; by PORCN By similarity
Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O15978 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 79A820F8796527B9

FASTA36340,828
        10         20         30         40         50         60 
MVGMTRIQSA EPVWILFVLT LYSSVLMQVK PQLWSVGIER KKLFGETNTS VHCDEIRGLS 

        70         80         90        100        110        120 
RNQRSLCRTY NDHMYYVESG SKQGVEECQW QFRGQRWNCS LASNASPDKI IAVGSKETAF 

       130        140        150        160        170        180 
TYAITSGGVV QSIARACKSG NLMACGCSKR ERPTGLGKDW NWGGCGDDID YAYGFAHEFI 

       190        200        210        220        230        240 
DAQERDNSSP NDRRVKSHKA MNIHNNEAGR LSVVRASHTT CKCHGVSGSC SIKTCWLQTP 

       250        260        270        280        290        300 
QFRTIGDKLR QRYDDALEMR VTHRGQMKTR FSSDRNPSNI DLVYIDSSPD YCKVNHKLGI 

       310        320        330        340        350        360 
LGTSGRECQL DSLAMDGCGL MCCGRGYTTK MVEVVKSCNC KFQWCCFVKC QQCKEKVLKH 


ICN 

« Hide

References

[1]Sasakura Y., Ogasawara M., Makabe K.W.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006608 Genomic DNA. Translation: BAA21878.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001595.

Family and domain databases

InterProIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT5_HALRO
AccessionPrimary (citable) accession number: O15978
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families