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O15978

- WNT5_HALRO

UniProt

O15978 - WNT5_HALRO

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Protein
Protein Wnt-5
Gene
WNT5
Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5
Gene namesi
Name:WNT5
OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)
Taxonomic identifieri7729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 363336Protein Wnt-5
PRO_0000041439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi88 ↔ 99 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi137 ↔ 145 By similarity
Disulfide bondi147 ↔ 165 By similarity
Disulfide bondi221 ↔ 235 By similarity
Disulfide bondi223 ↔ 230 By similarity
Lipidationi227 – 2271O-palmitoyl serine; by PORCN By similarity
Disulfide bondi308 ↔ 323 By similarity
Disulfide bondi338 ↔ 353 By similarity
Disulfide bondi340 ↔ 350 By similarity
Disulfide bondi345 ↔ 346 By similarity

Post-translational modificationi

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15978-1 [UniParc]FASTAAdd to Basket

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MVGMTRIQSA EPVWILFVLT LYSSVLMQVK PQLWSVGIER KKLFGETNTS    50
VHCDEIRGLS RNQRSLCRTY NDHMYYVESG SKQGVEECQW QFRGQRWNCS 100
LASNASPDKI IAVGSKETAF TYAITSGGVV QSIARACKSG NLMACGCSKR 150
ERPTGLGKDW NWGGCGDDID YAYGFAHEFI DAQERDNSSP NDRRVKSHKA 200
MNIHNNEAGR LSVVRASHTT CKCHGVSGSC SIKTCWLQTP QFRTIGDKLR 250
QRYDDALEMR VTHRGQMKTR FSSDRNPSNI DLVYIDSSPD YCKVNHKLGI 300
LGTSGRECQL DSLAMDGCGL MCCGRGYTTK MVEVVKSCNC KFQWCCFVKC 350
QQCKEKVLKH ICN 363
Length:363
Mass (Da):40,828
Last modified:January 1, 1998 - v1
Checksum:i79A820F8796527B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006608 Genomic DNA. Translation: BAA21878.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006608 Genomic DNA. Translation: BAA21878.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG001595.

Family and domain databases

InterProi IPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sasakura Y., Ogasawara M., Makabe K.W.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiWNT5_HALRO
AccessioniPrimary (citable) accession number: O15978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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