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Protein

Protein Wnt-5

Gene

WNT5

Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5
Gene namesi
Name:WNT5
OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)
Taxonomic identifieri7729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 363336Protein Wnt-5PRO_0000041439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 99By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 145By similarity
Disulfide bondi147 ↔ 165By similarity
Disulfide bondi221 ↔ 235By similarity
Disulfide bondi223 ↔ 230By similarity
Lipidationi227 – 2271O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi308 ↔ 323By similarity
Disulfide bondi338 ↔ 353By similarity
Disulfide bondi340 ↔ 350By similarity
Disulfide bondi345 ↔ 346By similarity

Post-translational modificationi

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGMTRIQSA EPVWILFVLT LYSSVLMQVK PQLWSVGIER KKLFGETNTS
60 70 80 90 100
VHCDEIRGLS RNQRSLCRTY NDHMYYVESG SKQGVEECQW QFRGQRWNCS
110 120 130 140 150
LASNASPDKI IAVGSKETAF TYAITSGGVV QSIARACKSG NLMACGCSKR
160 170 180 190 200
ERPTGLGKDW NWGGCGDDID YAYGFAHEFI DAQERDNSSP NDRRVKSHKA
210 220 230 240 250
MNIHNNEAGR LSVVRASHTT CKCHGVSGSC SIKTCWLQTP QFRTIGDKLR
260 270 280 290 300
QRYDDALEMR VTHRGQMKTR FSSDRNPSNI DLVYIDSSPD YCKVNHKLGI
310 320 330 340 350
LGTSGRECQL DSLAMDGCGL MCCGRGYTTK MVEVVKSCNC KFQWCCFVKC
360
QQCKEKVLKH ICN
Length:363
Mass (Da):40,828
Last modified:January 1, 1998 - v1
Checksum:i79A820F8796527B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006608 Genomic DNA. Translation: BAA21878.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006608 Genomic DNA. Translation: BAA21878.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG001595.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sasakura Y., Ogasawara M., Makabe K.W.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiWNT5_HALRO
AccessioniPrimary (citable) accession number: O15978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.