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Protein

Aryl hydrocarbon receptor nuclear translocator homolog

Gene

tgo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.4 Publications

GO - Molecular functioni

  • DNA binding transcription factor activity Source: FlyBase
  • myosin binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase

GO - Biological processi

  • brain development Source: FlyBase
  • cellular response to hypoxia Source: FlyBase
  • cellular response to insulin stimulus Source: FlyBase
  • central nervous system development Source: FlyBase
  • glial cell migration Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • limb development Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of R7 cell differentiation Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: FlyBase

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-DME-211945 Phase I - Functionalization of compounds
R-DME-211976 Endogenous sterols
R-DME-211981 Xenobiotics
R-DME-8937144 Aryl hydrocarbon receptor signalling
SignaLinkiO15945

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator homolog
Short name:
dARNT
Alternative name(s):
Hypoxia-inducible factor 1-beta
Protein tango
Gene namesi
Name:tgo
Synonyms:ARNT, HIF-1-beta
ORF Names:CG11987
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0264075 tgo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271171 – 642Aryl hydrocarbon receptor nuclear translocator homologAdd BLAST642

Proteomic databases

PaxDbiO15945
PRIDEiO15945

Expressioni

Tissue specificityi

At stage 11, expression is detected in tracheal pits. At later stages, strong expression is also detected in the CNS.2 Publications

Developmental stagei

Expressed both maternally and zygotically in pupae at a low level.2 Publications

Gene expression databases

BgeeiFBgn0264075
ExpressionAtlasiO15945 baseline and differential
GenevisibleiO15945 DM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with ahr, trh or sim.3 Publications

GO - Molecular functioni

  • myosin binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi66252, 11 interactors
IntActiO15945, 3 interactors
STRINGi7227.FBpp0081483

Structurei

3D structure databases

ProteinModelPortaliO15945
SMRiO15945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 66bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini85 – 156PAS 1PROSITE-ProRule annotationAdd BLAST72
Domaini271 – 341PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini346 – 389PACAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi404 – 563Gln-richAdd BLAST160
Compositional biasi566 – 604His/Pro-richAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5T Eukaryota
ENOG410XVHF LUCA
GeneTreeiENSGT00760000118788
InParanoidiO15945
KOiK09097
OMAiQHVYVQA
OrthoDBiEOG091G03AI
PhylomeDBiO15945

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 3 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequencei

Sequence statusi: Complete.

O15945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEANIQDKE RFASRENHCE IERRRRNKMT AYITELSDMV PTCSALARKP
60 70 80 90 100
DKLTILRMAV AHMKALRGTG NTSSDGTYKP SFLTDQELKH LILEAADGFL
110 120 130 140 150
FVVSCDSGRV IYVSDSVTPV LNYTQSDWYG TSLYEHIHPD DREKIREQLS
160 170 180 190 200
TQESQNAGRI LDLKSGTVKK EGHQSSMRLS MGARRGFICR MRVGNVNPES
210 220 230 240 250
MVSGHLNRLK QRNSLGPSRD GTNYAVVHCT GYIKNWPPTD MFPNMHMERD
260 270 280 290 300
VDDMSSHCCL VAIGRLQVTS TAANDMSGSN NQSEFITRHA MDGKFTFVDQ
310 320 330 340 350
RVLNILGYTP TELLGKICYD FFHPEDQSHM KESFDQVLKQ KGQMFSLLYR
360 370 380 390 400
ARAKNSEYVW LRTQAYAFLN PYTDEVEYIV CTNSSGKTMH GAPLDAAAAH
410 420 430 440 450
TPEQVQQQQQ QEQHVYVQAA PGVDYARREL TPVGSATNDG MYQTHMLAMQ
460 470 480 490 500
APTPQQQQQQ QQRPGSAQTT PVGYTYDTTH SPYSAGGPSP LAKIPKSGTS
510 520 530 540 550
PTPVAPNSWA ALRPQQQQQQ QQPVTEGYQY QQTSPARSPS GPTYTQLSAG
560 570 580 590 600
NGNRQQAQPG AYQAGPPPPP NAPGMWDWQQ AGGHPHPPHP TAHPHHPHAH
610 620 630 640
PGGPAGAGQP QGQEFSDMLQ MLDHTPTTFE DLNINMFSTP FE
Length:642
Mass (Da):71,475
Last modified:March 21, 2012 - v3
Checksum:i0D2EB5D7651C98CC
GO

Sequence cautioni

The sequence AAA28838 differs from that shown. Reason: Frameshift at position 607.Curated
The sequence AAB69695 differs from that shown. Reason: Frameshift at position 614.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110V → M in BAA22868 (PubMed:9374395).Curated1
Sequence conflicti410Q → QQQ in AAB69695 (PubMed:9284047).Curated1
Sequence conflicti410Q → QQQ in AAB88882 (PubMed:9409674).Curated1
Sequence conflicti410Q → QQQ in AAD38396 (PubMed:10581393).Curated1
Sequence conflicti465G → R in BAA22868 (PubMed:9374395).Curated1
Sequence conflicti488P → T in AAB69695 (PubMed:9284047).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002556 mRNA Translation: BAA22868.1
AF016053 mRNA Translation: AAB69695.1 Frameshift.
AF020426 mRNA Translation: AAB88882.1
AF154417 mRNA Translation: AAD38396.1
AE014297 Genomic DNA Translation: AAF54329.1
AY069581 mRNA Translation: AAL39726.1
M14550 Genomic DNA Translation: AAA28838.1 Frameshift.
RefSeqiNP_001262397.1, NM_001275468.1
NP_731308.1, NM_169254.2
UniGeneiDm.3376

Genome annotation databases

EnsemblMetazoaiFBtr0082005; FBpp0081483; FBgn0264075
FBtr0336755; FBpp0307731; FBgn0264075
GeneIDi41084
KEGGidme:Dmel_CG11987

Similar proteinsi

Entry informationi

Entry nameiARNT_DROME
AccessioniPrimary (citable) accession number: O15945
Secondary accession number(s): O16167
, O44082, Q24461, Q9VHI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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