O15943 (CADN_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neural-cadherin

Alternative name(s):
Cadherin-N
Short name=dN-cadherin

Gene names

Name:	CadN
ORF Names:	CG7100

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	3097 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 16 cadherin domains. Contains 3 EGF-like domains. Contains 2 laminin G-like domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	R7 cell development Inferred from mutant phenotype PubMed 17320070PubMed 18400161PubMed 21835342. Source: FlyBase R8 cell development Inferred from mutant phenotype PubMed 17320070PubMed 18400161. Source: FlyBase axon extension involved in axon guidance Inferred from mutant phenotype PubMed 15735641. Source: FlyBase axon target recognition Inferred from mutant phenotype PubMed 11395005. Source: FlyBase axonal fasciculation Traceable author statement PubMed 10218152. Source: FlyBase calcium-dependent cell-cell adhesion Inferred from physical interaction Ref.1. Source: FlyBase cell-cell adhesion mediated by cadherin Inferred from direct assay PubMed 17320070. Source: FlyBase homophilic cell adhesion Inferred from direct assay PubMed 17320070Ref.1. Source: FlyBase negative regulation of dendrite morphogenesis Inferred from mutant phenotype PubMed 15066265. Source: FlyBase ommatidial rotation Inferred from mutant phenotype PubMed 16887833. Source: FlyBase regulation of axon extension involved in axon guidance Inferred from mutant phenotype PubMed 19766621. Source: FlyBase retinal ganglion cell axon guidance Inferred from mutant phenotype PubMed 16864799. Source: FlyBase
Cellular_component	cell-cell junction Inferred from direct assay Ref.1. Source: FlyBase integral to plasma membrane Inferred from sequence or structural similarity PubMed 10908592. Source: FlyBase
Molecular_function	beta-catenin binding Non-traceable author statement PubMed 11253370. Source: FlyBase calcium ion binding Inferred from direct assay PubMed 22171007. Source: FlyBase cell adhesion molecule binding Inferred from sequence or structural similarity PubMed 10908592. Source: FlyBase receptor activity Inferred from sequence or structural similarity PubMed 10908592. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform D (identifier: O15943-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: O15943-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Isoform B (identifier: O15943-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Isoform C (identifier: O15943-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Isoform E (identifier: O15943-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV

Isoform F (identifier: O15943-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Isoform G (identifier: O15943-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Isoform H (identifier: O15943-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 36

36

Potential

Propeptide

37 – ?

PRO_0000003881

Chain

? – 3097

Neural-cadherin

PRO_0000003882

Regions

Topological domain

? – 2916

Extracellular Potential

Transmembrane

2917 – 2937

21

Helical; Potential

Topological domain

2938 – 3097

160

Cytoplasmic Potential

Domain

181 – 305

125

Cadherin 1

Domain

430 – 543

114

Cadherin 2

Domain

554 – 651

98

Cadherin 3

Domain

660 – 756

97

Cadherin 4

Domain

766 – 858

93

Cadherin 5

Domain

867 – 968

102

Cadherin 6

Domain

978 – 1078

101

Cadherin 7

Domain

1087 – 1183

97

Cadherin 8

Domain

1193 – 1299

107

Cadherin 9

Domain

1307 – 1414

108

Cadherin 10

Domain

1423 – 1514

92

Cadherin 11

Domain

1523 – 1630

108

Cadherin 12

Domain

1639 – 1742

104

Cadherin 13

Domain

1749 – 1861

113

Cadherin 14

Domain

1870 – 1966

97

Cadherin 15

Domain

1974 – 2085

112

Cadherin 16

Domain

2346 – 2377

32

EGF-like 1

Domain

2379 – 2585

207

Laminin G-like 1

Domain

2592 – 2627

36

EGF-like 2

Domain

2631 – 2822

192

Laminin G-like 2

Domain

2869 – 2902

34

EGF-like 3

Amino acid modifications

Glycosylation

97

1

N-linked (GlcNAc...) Potential

Glycosylation

150

1

N-linked (GlcNAc...) Potential

Glycosylation

325

1

N-linked (GlcNAc...) Potential

Glycosylation

426

1

N-linked (GlcNAc...) Potential

Glycosylation

930

1

N-linked (GlcNAc...) Potential

Glycosylation

1266

1

N-linked (GlcNAc...) Potential

Disulfide bond

2346 ↔ 2357

Potential

Disulfide bond

2351 ↔ 2366

Potential

Disulfide bond

2368 ↔ 2377

Potential

Disulfide bond

2559 ↔ 2585

By similarity

Disulfide bond

2592 ↔ 2607

Potential

Disulfide bond

2601 ↔ 2616

Potential

Disulfide bond

2618 ↔ 2627

Potential

Disulfide bond

2787 ↔ 2822

By similarity

Disulfide bond

2869 ↔ 2880

Potential

Disulfide bond

2874 ↔ 2891

Potential

Disulfide bond

2893 ↔ 2902

Potential

Natural variations

Alternative sequence

1147 – 1206

60

ETYKL…KVVSI → DRYRLRVSASDKGTPASAAD VDVELDVVDRNNKPPIWDKS IYGPIHIRENVTVGTVVTSV in isoform A, isoform C, isoform E and isoform G.

VSP_000667

Alternative sequence

1486 – 1536

51

RLAAS…PKRVL → KLVASDSLNENQTTIVINVR DVNDLPPQFPQTSYERTLDE GMTNTPFTIM in isoform A, isoform B, isoform C and isoform H.

VSP_000668

Alternative sequence

2851 – 2930

80

GEGRI…LIILI → PAGYKSSGSTCVNDNECLLF PCRNGGRCRDHHPPKKYECH CPMGFTGMHCELELLASGVL TPSRDFIVALALCLGTLIL in isoform C, isoform F, isoform G and isoform H.

VSP_000669

Natural variant

1425

1

E → K in allele CADN-M12; muscle defects.

Experimental info

Sequence conflict

1342

1

P → A in BAA22151. Ref.1

Sequence conflict

2786

1

S → T in BAA22151. Ref.1

Secondary structure

1

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3097

Helix Strand Turn

Details...

Beta strand

440 – 450

11

Helix

451 – 453

3

Beta strand

459 – 462

4

Beta strand

466 – 469

4

Beta strand

471 – 476

6

Beta strand

479 – 483

5

Beta strand

487 – 493

7

Helix

497 – 499

3

Beta strand

505 – 513

9

Beta strand

519 – 521

3

Beta strand

525 – 534

10

Beta strand

546 – 554

9

Beta strand

563 – 566

4

Beta strand

578 – 589

12

Beta strand

591 – 593

3

Turn

595 – 597

3

Beta strand

599 – 602

4

Beta strand

604 – 606

3

Beta strand

613 – 623

11

Beta strand

632 – 634

3

Beta strand

638 – 645

8

Beta strand

650 – 661

12

Beta strand

669 – 672

4

Beta strand

683 – 692

10

Turn

694 – 696

3

Beta strand

697 – 699

3

Turn

701 – 703

3

Beta strand

705 – 708

4

Beta strand

721 – 735

15

Beta strand

737 – 747

11

Beta strand

755 – 767

13

Beta strand

775 – 778

4

Helix

787 – 790

4

Beta strand

792 – 797

6

Beta strand

801 – 803

3

Beta strand

808 – 811

4

Beta strand

815 – 818

4

Beta strand

823 – 832

10

Beta strand

839 – 849

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform D [UniParc]. Last modified June 1, 2000. Version 2. Checksum: 082242F28D9B5CC3	FASTA	3,097	347,204
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRETYK LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1210 1220 1230 1240 1250 1260 GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1510 1520 1530 1540 1550 1560 IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN IVYFLTGQGI 1570 1580 1590 1600 1610 1620 DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV FAQDEGGEGL VGYADVQVNL 1630 1640 1650 1660 1670 1680 KDINDNAPIF PQGVYFGNVT ENGTAGMVVM TMTAVDYDDP NEGSNARLVY SIEKNVIEEE 1690 1700 1710 1720 1730 1740 TGSPIFEIEP DTGVIKTAVC CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP 1750 1760 1770 1780 1790 1800 QFTKDEWFTE VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1810 1820 1830 1840 1850 1860 GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK LRDINDNKPH 1870 1880 1890 1900 1910 1920 FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI DRSSDRQRQF AINQNGSVTI 1930 1940 1950 1960 1970 1980 QRSLDREVVP RHQVKILAID DGSPPKTATA TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP 1990 2000 2010 2020 2030 2040 RKVVEILATD DDDRSKSNGP PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS 2050 2060 2070 2080 2090 2100 FDREQQKEYM IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2110 2120 2130 2140 2150 2160 PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY HLRFKVYDRK 2170 2180 2190 2200 2210 2220 HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR VWNYRTQSMS RSKMDRFRDK 2230 2240 2250 2260 2270 2280 LADLLNTERE NVDIFSVQLK RKHPPLTDVR FSAHGSPYYK PVRLNGIVLM HREEIEKDVG 2290 2300 2310 2320 2330 2340 INITMVGIDE CLYENQMCEG SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF 2350 2360 2370 2380 2390 2400 TKPESCRTTP CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2410 2420 2430 2440 2450 2460 SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID FGSGTLELRV 2470 2480 2490 2500 2510 2520 KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED GTPPEFDDMS CQARGQIPPF 2530 2540 2550 2560 2570 2580 NEYLNVNAPL QVGGLYREQF DQSLYFWHYM PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN 2590 2600 2610 2620 2630 2640 SVAGCPQTEE VCAQTETTAR CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS 2650 2660 2670 2680 2690 2700 YVKYALSFEP DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2710 2720 2730 2740 2750 2760 RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV GHQWLLVDKQ 2770 2780 2790 2800 2810 2820 EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL PPAMNGTQWG QATMARNLEK 2830 2840 2850 2860 2870 2880 GCPSNKPCSN VICPDPFECV DLWNVYECTC GEGRIMSPDS KGCMDRNECL DMPCMNGATC 2890 2900 2910 2920 2930 2940 INLEPRLRYR CICPDGFWGE NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR 2950 2960 2970 2980 2990 3000 RREAHIKYPG PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM 3010 3020 3030 3040 3050 3060 YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG SLSSLASGTD 3070 3080 3090 DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL
	Isoform A [UniParc]. Checksum: 37E1B66D6CA30974	FASTA	3,096	346,741
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRDRYR LRVSASDKGT PASAADVDVE LDVVDRNNKP PIWDKSIYGP IHIRENVTVG 1210 1220 1230 1240 1250 1260 TVVTSVKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELKLVAS DSLNENQTTI 1510 1520 1530 1540 1550 1560 VINVRDVNDL PPQFPQTSYE RTLDEGMTNT PFTIMQVTAT DGDKDRPQNI VYFLTGQGID 1570 1580 1590 1600 1610 1620 PDNPANSKFD INRTTGEIFV LKPLDRDQPN GRPQWRFTVF AQDEGGEGLV GYADVQVNLK 1630 1640 1650 1660 1670 1680 DINDNAPIFP QGVYFGNVTE NGTAGMVVMT MTAVDYDDPN EGSNARLVYS IEKNVIEEET 1690 1700 1710 1720 1730 1740 GSPIFEIEPD TGVIKTAVCC LDRERTPDYS IQVVAMDGGG LKGTGTASIR VKDINDMPPQ 1750 1760 1770 1780 1790 1800 FTKDEWFTEV DETDGTALPE MPILTVTVHD EDETNKFQYK VIDNSGYGAD KFTMVRNNDG 1810 1820 1830 1840 1850 1860 TGSLKIVQPL DYEDQLQSNG FRFRIQVNDK GEDNDNDKYH VAYSWVVVKL RDINDNKPHF 1870 1880 1890 1900 1910 1920 ERANVEVSVF EDTKVGTELE KFKATDPDQG GKSKVSYSID RSSDRQRQFA INQNGSVTIQ 1930 1940 1950 1960 1970 1980 RSLDREVVPR HQVKILAIDD GSPPKTATAT LTVIVQDIND NAPKFLKDYR PVLPEHVPPR 1990 2000 2010 2020 2030 2040 KVVEILATDD DDRSKSNGPP FQFRLDPSAD DIIRASFKVE QDQKGANGDG MAVISSLRSF 2050 2060 2070 2080 2090 2100 DREQQKEYMI PIVIKDHGSP AMTGTSTLTV IIGDVNDNKM QPGSKDIFVY NYQGQSPDTP 2110 2120 2130 2140 2150 2160 IGRVYVYDLD DWDLPDKKFY WEAMEHPRFK LDEDSGMVTM RAGTREGRYH LRFKVYDRKH 2170 2180 2190 2200 2210 2220 TQTDIPANVT VTVREIPHEA VVNSGSVRLS GISDEDFIRV WNYRTQSMSR SKMDRFRDKL 2230 2240 2250 2260 2270 2280 ADLLNTEREN VDIFSVQLKR KHPPLTDVRF SAHGSPYYKP VRLNGIVLMH REEIEKDVGI 2290 2300 2310 2320 2330 2340 NITMVGIDEC LYENQMCEGS CTNSLEISPL PYMVNANKTA LVGVRVDTIA DCTCGARNFT 2350 2360 2370 2380 2390 2400 KPESCRTTPC HNGGRCVDTR FGPHCSCPVG YTGPRCQQTT RSFRGNGWAW YPPLEMCDES 2410 2420 2430 2440 2450 2460 HLSLEFITRK PDGLIIYNGP IVPPERDETL ISDFIALELE RGYPRLLIDF GSGTLELRVK 2470 2480 2490 2500 2510 2520 TKKTLDDGEW HRIDLFWDTE SIRMVVDFCK SAEIAEMEDG TPPEFDDMSC QARGQIPPFN 2530 2540 2550 2560 2570 2580 EYLNVNAPLQ VGGLYREQFD QSLYFWHYMP TAKGFDGCIR NLVHNSKLYD LAHPGLSRNS 2590 2600 2610 2620 2630 2640 VAGCPQTEEV CAQTETTARC WEHGNCVGSL SEARCHCRPG WTGPACNIPT IPTTFKAQSY 2650 2660 2670 2680 2690 2700 VKYALSFEPD RFSTQVQLRF RTREEYGELF RVSDQHNREY GILEIKDGHL HFRYNLNSLR 2710 2720 2730 2740 2750 2760 TEEKDLWLNA IVVNDGQWHV VKVNRYGSAA TLELDGGEGR RYNETFEFVG HQWLLVDKQE 2770 2780 2790 2800 2810 2820 GVYAGGKAEY TGVRTFEVYA DYQKSCLDDI RLEGKHLPLP PAMNGTQWGQ ATMARNLEKG 2830 2840 2850 2860 2870 2880 CPSNKPCSNV ICPDPFECVD LWNVYECTCG EGRIMSPDSK GCMDRNECLD MPCMNGATCI 2890 2900 2910 2920 2930 2940 NLEPRLRYRC ICPDGFWGEN CELVQEGQTL KLSMGALAAI LVCLLIILIL VLVFVVYNRR 2950 2960 2970 2980 2990 3000 REAHIKYPGP DDDVRENIIN YDDEGGGEDD MTAFDITPLQ IPIGGPMPPE LAPMKMPIMY 3010 3020 3030 3040 3050 3060 PVMTLMPGQE PNVGMFIEEH KKRADGDPNA PPFDDLRNYA YEGGGSTAGS LSSLASGTDD 3070 3080 3090 EQQEYDYLGA WGPRFDKLAN MYGPEAPNPH NTELEL
	Isoform B [UniParc]. Checksum: 5A7B35628893589D	FASTA	3,096	346,863
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRETYK LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1210 1220 1230 1240 1250 1260 GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELKLVAS DSLNENQTTI 1510 1520 1530 1540 1550 1560 VINVRDVNDL PPQFPQTSYE RTLDEGMTNT PFTIMQVTAT DGDKDRPQNI VYFLTGQGID 1570 1580 1590 1600 1610 1620 PDNPANSKFD INRTTGEIFV LKPLDRDQPN GRPQWRFTVF AQDEGGEGLV GYADVQVNLK 1630 1640 1650 1660 1670 1680 DINDNAPIFP QGVYFGNVTE NGTAGMVVMT MTAVDYDDPN EGSNARLVYS IEKNVIEEET 1690 1700 1710 1720 1730 1740 GSPIFEIEPD TGVIKTAVCC LDRERTPDYS IQVVAMDGGG LKGTGTASIR VKDINDMPPQ 1750 1760 1770 1780 1790 1800 FTKDEWFTEV DETDGTALPE MPILTVTVHD EDETNKFQYK VIDNSGYGAD KFTMVRNNDG 1810 1820 1830 1840 1850 1860 TGSLKIVQPL DYEDQLQSNG FRFRIQVNDK GEDNDNDKYH VAYSWVVVKL RDINDNKPHF 1870 1880 1890 1900 1910 1920 ERANVEVSVF EDTKVGTELE KFKATDPDQG GKSKVSYSID RSSDRQRQFA INQNGSVTIQ 1930 1940 1950 1960 1970 1980 RSLDREVVPR HQVKILAIDD GSPPKTATAT LTVIVQDIND NAPKFLKDYR PVLPEHVPPR 1990 2000 2010 2020 2030 2040 KVVEILATDD DDRSKSNGPP FQFRLDPSAD DIIRASFKVE QDQKGANGDG MAVISSLRSF 2050 2060 2070 2080 2090 2100 DREQQKEYMI PIVIKDHGSP AMTGTSTLTV IIGDVNDNKM QPGSKDIFVY NYQGQSPDTP 2110 2120 2130 2140 2150 2160 IGRVYVYDLD DWDLPDKKFY WEAMEHPRFK LDEDSGMVTM RAGTREGRYH LRFKVYDRKH 2170 2180 2190 2200 2210 2220 TQTDIPANVT VTVREIPHEA VVNSGSVRLS GISDEDFIRV WNYRTQSMSR SKMDRFRDKL 2230 2240 2250 2260 2270 2280 ADLLNTEREN VDIFSVQLKR KHPPLTDVRF SAHGSPYYKP VRLNGIVLMH REEIEKDVGI 2290 2300 2310 2320 2330 2340 NITMVGIDEC LYENQMCEGS CTNSLEISPL PYMVNANKTA LVGVRVDTIA DCTCGARNFT 2350 2360 2370 2380 2390 2400 KPESCRTTPC HNGGRCVDTR FGPHCSCPVG YTGPRCQQTT RSFRGNGWAW YPPLEMCDES 2410 2420 2430 2440 2450 2460 HLSLEFITRK PDGLIIYNGP IVPPERDETL ISDFIALELE RGYPRLLIDF GSGTLELRVK 2470 2480 2490 2500 2510 2520 TKKTLDDGEW HRIDLFWDTE SIRMVVDFCK SAEIAEMEDG TPPEFDDMSC QARGQIPPFN 2530 2540 2550 2560 2570 2580 EYLNVNAPLQ VGGLYREQFD QSLYFWHYMP TAKGFDGCIR NLVHNSKLYD LAHPGLSRNS 2590 2600 2610 2620 2630 2640 VAGCPQTEEV CAQTETTARC WEHGNCVGSL SEARCHCRPG WTGPACNIPT IPTTFKAQSY 2650 2660 2670 2680 2690 2700 VKYALSFEPD RFSTQVQLRF RTREEYGELF RVSDQHNREY GILEIKDGHL HFRYNLNSLR 2710 2720 2730 2740 2750 2760 TEEKDLWLNA IVVNDGQWHV VKVNRYGSAA TLELDGGEGR RYNETFEFVG HQWLLVDKQE 2770 2780 2790 2800 2810 2820 GVYAGGKAEY TGVRTFEVYA DYQKSCLDDI RLEGKHLPLP PAMNGTQWGQ ATMARNLEKG 2830 2840 2850 2860 2870 2880 CPSNKPCSNV ICPDPFECVD LWNVYECTCG EGRIMSPDSK GCMDRNECLD MPCMNGATCI 2890 2900 2910 2920 2930 2940 NLEPRLRYRC ICPDGFWGEN CELVQEGQTL KLSMGALAAI LVCLLIILIL VLVFVVYNRR 2950 2960 2970 2980 2990 3000 REAHIKYPGP DDDVRENIIN YDDEGGGEDD MTAFDITPLQ IPIGGPMPPE LAPMKMPIMY 3010 3020 3030 3040 3050 3060 PVMTLMPGQE PNVGMFIEEH KKRADGDPNA PPFDDLRNYA YEGGGSTAGS LSSLASGTDD 3070 3080 3090 EQQEYDYLGA WGPRFDKLAN MYGPEAPNPH NTELEL
	Isoform C [UniParc]. Checksum: CB4EBB76A3574D75	FASTA	3,095	346,500
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRDRYR LRVSASDKGT PASAADVDVE LDVVDRNNKP PIWDKSIYGP IHIRENVTVG 1210 1220 1230 1240 1250 1260 TVVTSVKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELKLVAS DSLNENQTTI 1510 1520 1530 1540 1550 1560 VINVRDVNDL PPQFPQTSYE RTLDEGMTNT PFTIMQVTAT DGDKDRPQNI VYFLTGQGID 1570 1580 1590 1600 1610 1620 PDNPANSKFD INRTTGEIFV LKPLDRDQPN GRPQWRFTVF AQDEGGEGLV GYADVQVNLK 1630 1640 1650 1660 1670 1680 DINDNAPIFP QGVYFGNVTE NGTAGMVVMT MTAVDYDDPN EGSNARLVYS IEKNVIEEET 1690 1700 1710 1720 1730 1740 GSPIFEIEPD TGVIKTAVCC LDRERTPDYS IQVVAMDGGG LKGTGTASIR VKDINDMPPQ 1750 1760 1770 1780 1790 1800 FTKDEWFTEV DETDGTALPE MPILTVTVHD EDETNKFQYK VIDNSGYGAD KFTMVRNNDG 1810 1820 1830 1840 1850 1860 TGSLKIVQPL DYEDQLQSNG FRFRIQVNDK GEDNDNDKYH VAYSWVVVKL RDINDNKPHF 1870 1880 1890 1900 1910 1920 ERANVEVSVF EDTKVGTELE KFKATDPDQG GKSKVSYSID RSSDRQRQFA INQNGSVTIQ 1930 1940 1950 1960 1970 1980 RSLDREVVPR HQVKILAIDD GSPPKTATAT LTVIVQDIND NAPKFLKDYR PVLPEHVPPR 1990 2000 2010 2020 2030 2040 KVVEILATDD DDRSKSNGPP FQFRLDPSAD DIIRASFKVE QDQKGANGDG MAVISSLRSF 2050 2060 2070 2080 2090 2100 DREQQKEYMI PIVIKDHGSP AMTGTSTLTV IIGDVNDNKM QPGSKDIFVY NYQGQSPDTP 2110 2120 2130 2140 2150 2160 IGRVYVYDLD DWDLPDKKFY WEAMEHPRFK LDEDSGMVTM RAGTREGRYH LRFKVYDRKH 2170 2180 2190 2200 2210 2220 TQTDIPANVT VTVREIPHEA VVNSGSVRLS GISDEDFIRV WNYRTQSMSR SKMDRFRDKL 2230 2240 2250 2260 2270 2280 ADLLNTEREN VDIFSVQLKR KHPPLTDVRF SAHGSPYYKP VRLNGIVLMH REEIEKDVGI 2290 2300 2310 2320 2330 2340 NITMVGIDEC LYENQMCEGS CTNSLEISPL PYMVNANKTA LVGVRVDTIA DCTCGARNFT 2350 2360 2370 2380 2390 2400 KPESCRTTPC HNGGRCVDTR FGPHCSCPVG YTGPRCQQTT RSFRGNGWAW YPPLEMCDES 2410 2420 2430 2440 2450 2460 HLSLEFITRK PDGLIIYNGP IVPPERDETL ISDFIALELE RGYPRLLIDF GSGTLELRVK 2470 2480 2490 2500 2510 2520 TKKTLDDGEW HRIDLFWDTE SIRMVVDFCK SAEIAEMEDG TPPEFDDMSC QARGQIPPFN 2530 2540 2550 2560 2570 2580 EYLNVNAPLQ VGGLYREQFD QSLYFWHYMP TAKGFDGCIR NLVHNSKLYD LAHPGLSRNS 2590 2600 2610 2620 2630 2640 VAGCPQTEEV CAQTETTARC WEHGNCVGSL SEARCHCRPG WTGPACNIPT IPTTFKAQSY 2650 2660 2670 2680 2690 2700 VKYALSFEPD RFSTQVQLRF RTREEYGELF RVSDQHNREY GILEIKDGHL HFRYNLNSLR 2710 2720 2730 2740 2750 2760 TEEKDLWLNA IVVNDGQWHV VKVNRYGSAA TLELDGGEGR RYNETFEFVG HQWLLVDKQE 2770 2780 2790 2800 2810 2820 GVYAGGKAEY TGVRTFEVYA DYQKSCLDDI RLEGKHLPLP PAMNGTQWGQ ATMARNLEKG 2830 2840 2850 2860 2870 2880 CPSNKPCSNV ICPDPFECVD LWNVYECTCP AGYKSSGSTC VNDNECLLFP CRNGGRCRDH 2890 2900 2910 2920 2930 2940 HPPKKYECHC PMGFTGMHCE LELLASGVLT PSRDFIVALA LCLGTLILLV LVFVVYNRRR 2950 2960 2970 2980 2990 3000 EAHIKYPGPD DDVRENIINY DDEGGGEDDM TAFDITPLQI PIGGPMPPEL APMKMPIMYP 3010 3020 3030 3040 3050 3060 VMTLMPGQEP NVGMFIEEHK KRADGDPNAP PFDDLRNYAY EGGGSTAGSL SSLASGTDDE 3070 3080 3090 QQEYDYLGAW GPRFDKLANM YGPEAPNPHN TELEL
	Isoform E [UniParc]. Checksum: 867FD871827F6C92	FASTA	3,097	347,082
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRDRYR LRVSASDKGT PASAADVDVE LDVVDRNNKP PIWDKSIYGP IHIRENVTVG 1210 1220 1230 1240 1250 1260 TVVTSVKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1510 1520 1530 1540 1550 1560 IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN IVYFLTGQGI 1570 1580 1590 1600 1610 1620 DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV FAQDEGGEGL VGYADVQVNL 1630 1640 1650 1660 1670 1680 KDINDNAPIF PQGVYFGNVT ENGTAGMVVM TMTAVDYDDP NEGSNARLVY SIEKNVIEEE 1690 1700 1710 1720 1730 1740 TGSPIFEIEP DTGVIKTAVC CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP 1750 1760 1770 1780 1790 1800 QFTKDEWFTE VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1810 1820 1830 1840 1850 1860 GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK LRDINDNKPH 1870 1880 1890 1900 1910 1920 FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI DRSSDRQRQF AINQNGSVTI 1930 1940 1950 1960 1970 1980 QRSLDREVVP RHQVKILAID DGSPPKTATA TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP 1990 2000 2010 2020 2030 2040 RKVVEILATD DDDRSKSNGP PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS 2050 2060 2070 2080 2090 2100 FDREQQKEYM IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2110 2120 2130 2140 2150 2160 PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY HLRFKVYDRK 2170 2180 2190 2200 2210 2220 HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR VWNYRTQSMS RSKMDRFRDK 2230 2240 2250 2260 2270 2280 LADLLNTERE NVDIFSVQLK RKHPPLTDVR FSAHGSPYYK PVRLNGIVLM HREEIEKDVG 2290 2300 2310 2320 2330 2340 INITMVGIDE CLYENQMCEG SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF 2350 2360 2370 2380 2390 2400 TKPESCRTTP CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2410 2420 2430 2440 2450 2460 SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID FGSGTLELRV 2470 2480 2490 2500 2510 2520 KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED GTPPEFDDMS CQARGQIPPF 2530 2540 2550 2560 2570 2580 NEYLNVNAPL QVGGLYREQF DQSLYFWHYM PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN 2590 2600 2610 2620 2630 2640 SVAGCPQTEE VCAQTETTAR CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS 2650 2660 2670 2680 2690 2700 YVKYALSFEP DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2710 2720 2730 2740 2750 2760 RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV GHQWLLVDKQ 2770 2780 2790 2800 2810 2820 EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL PPAMNGTQWG QATMARNLEK 2830 2840 2850 2860 2870 2880 GCPSNKPCSN VICPDPFECV DLWNVYECTC GEGRIMSPDS KGCMDRNECL DMPCMNGATC 2890 2900 2910 2920 2930 2940 INLEPRLRYR CICPDGFWGE NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR 2950 2960 2970 2980 2990 3000 RREAHIKYPG PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM 3010 3020 3030 3040 3050 3060 YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG SLSSLASGTD 3070 3080 3090 DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL
	Isoform F [UniParc]. Checksum: 98BA24979B02FA5A	FASTA	3,096	346,962
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRETYK LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1210 1220 1230 1240 1250 1260 GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1510 1520 1530 1540 1550 1560 IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN IVYFLTGQGI 1570 1580 1590 1600 1610 1620 DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV FAQDEGGEGL VGYADVQVNL 1630 1640 1650 1660 1670 1680 KDINDNAPIF PQGVYFGNVT ENGTAGMVVM TMTAVDYDDP NEGSNARLVY SIEKNVIEEE 1690 1700 1710 1720 1730 1740 TGSPIFEIEP DTGVIKTAVC CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP 1750 1760 1770 1780 1790 1800 QFTKDEWFTE VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1810 1820 1830 1840 1850 1860 GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK LRDINDNKPH 1870 1880 1890 1900 1910 1920 FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI DRSSDRQRQF AINQNGSVTI 1930 1940 1950 1960 1970 1980 QRSLDREVVP RHQVKILAID DGSPPKTATA TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP 1990 2000 2010 2020 2030 2040 RKVVEILATD DDDRSKSNGP PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS 2050 2060 2070 2080 2090 2100 FDREQQKEYM IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2110 2120 2130 2140 2150 2160 PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY HLRFKVYDRK 2170 2180 2190 2200 2210 2220 HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR VWNYRTQSMS RSKMDRFRDK 2230 2240 2250 2260 2270 2280 LADLLNTERE NVDIFSVQLK RKHPPLTDVR FSAHGSPYYK PVRLNGIVLM HREEIEKDVG 2290 2300 2310 2320 2330 2340 INITMVGIDE CLYENQMCEG SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF 2350 2360 2370 2380 2390 2400 TKPESCRTTP CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2410 2420 2430 2440 2450 2460 SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID FGSGTLELRV 2470 2480 2490 2500 2510 2520 KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED GTPPEFDDMS CQARGQIPPF 2530 2540 2550 2560 2570 2580 NEYLNVNAPL QVGGLYREQF DQSLYFWHYM PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN 2590 2600 2610 2620 2630 2640 SVAGCPQTEE VCAQTETTAR CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS 2650 2660 2670 2680 2690 2700 YVKYALSFEP DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2710 2720 2730 2740 2750 2760 RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV GHQWLLVDKQ 2770 2780 2790 2800 2810 2820 EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL PPAMNGTQWG QATMARNLEK 2830 2840 2850 2860 2870 2880 GCPSNKPCSN VICPDPFECV DLWNVYECTC PAGYKSSGST CVNDNECLLF PCRNGGRCRD 2890 2900 2910 2920 2930 2940 HHPPKKYECH CPMGFTGMHC ELELLASGVL TPSRDFIVAL ALCLGTLILL VLVFVVYNRR 2950 2960 2970 2980 2990 3000 REAHIKYPGP DDDVRENIIN YDDEGGGEDD MTAFDITPLQ IPIGGPMPPE LAPMKMPIMY 3010 3020 3030 3040 3050 3060 PVMTLMPGQE PNVGMFIEEH KKRADGDPNA PPFDDLRNYA YEGGGSTAGS LSSLASGTDD 3070 3080 3090 EQQEYDYLGA WGPRFDKLAN MYGPEAPNPH NTELEL
	Isoform G [UniParc]. Checksum: F520A7987F32ABB3	FASTA	3,096	346,840
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRDRYR LRVSASDKGT PASAADVDVE LDVVDRNNKP PIWDKSIYGP IHIRENVTVG 1210 1220 1230 1240 1250 1260 TVVTSVKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1510 1520 1530 1540 1550 1560 IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN IVYFLTGQGI 1570 1580 1590 1600 1610 1620 DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV FAQDEGGEGL VGYADVQVNL 1630 1640 1650 1660 1670 1680 KDINDNAPIF PQGVYFGNVT ENGTAGMVVM TMTAVDYDDP NEGSNARLVY SIEKNVIEEE 1690 1700 1710 1720 1730 1740 TGSPIFEIEP DTGVIKTAVC CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP 1750 1760 1770 1780 1790 1800 QFTKDEWFTE VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1810 1820 1830 1840 1850 1860 GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK LRDINDNKPH 1870 1880 1890 1900 1910 1920 FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI DRSSDRQRQF AINQNGSVTI 1930 1940 1950 1960 1970 1980 QRSLDREVVP RHQVKILAID DGSPPKTATA TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP 1990 2000 2010 2020 2030 2040 RKVVEILATD DDDRSKSNGP PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS 2050 2060 2070 2080 2090 2100 FDREQQKEYM IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2110 2120 2130 2140 2150 2160 PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY HLRFKVYDRK 2170 2180 2190 2200 2210 2220 HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR VWNYRTQSMS RSKMDRFRDK 2230 2240 2250 2260 2270 2280 LADLLNTERE NVDIFSVQLK RKHPPLTDVR FSAHGSPYYK PVRLNGIVLM HREEIEKDVG 2290 2300 2310 2320 2330 2340 INITMVGIDE CLYENQMCEG SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF 2350 2360 2370 2380 2390 2400 TKPESCRTTP CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2410 2420 2430 2440 2450 2460 SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID FGSGTLELRV 2470 2480 2490 2500 2510 2520 KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED GTPPEFDDMS CQARGQIPPF 2530 2540 2550 2560 2570 2580 NEYLNVNAPL QVGGLYREQF DQSLYFWHYM PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN 2590 2600 2610 2620 2630 2640 SVAGCPQTEE VCAQTETTAR CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS 2650 2660 2670 2680 2690 2700 YVKYALSFEP DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2710 2720 2730 2740 2750 2760 RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV GHQWLLVDKQ 2770 2780 2790 2800 2810 2820 EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL PPAMNGTQWG QATMARNLEK 2830 2840 2850 2860 2870 2880 GCPSNKPCSN VICPDPFECV DLWNVYECTC PAGYKSSGST CVNDNECLLF PCRNGGRCRD 2890 2900 2910 2920 2930 2940 HHPPKKYECH CPMGFTGMHC ELELLASGVL TPSRDFIVAL ALCLGTLILL VLVFVVYNRR 2950 2960 2970 2980 2990 3000 REAHIKYPGP DDDVRENIIN YDDEGGGEDD MTAFDITPLQ IPIGGPMPPE LAPMKMPIMY 3010 3020 3030 3040 3050 3060 PVMTLMPGQE PNVGMFIEEH KKRADGDPNA PPFDDLRNYA YEGGGSTAGS LSSLASGTDD 3070 3080 3090 EQQEYDYLGA WGPRFDKLAN MYGPEAPNPH NTELEL
	Isoform H [UniParc]. Checksum: E1CDB4929306A434	FASTA	3,095	346,622
	10 20 30 40 50 60 MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 70 80 90 100 110 120 VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 130 140 150 160 170 180 LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 190 200 210 220 230 240 VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 250 260 270 280 290 300 ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 310 320 330 340 350 360 NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 370 380 390 400 410 420 IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 430 440 450 460 470 480 HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 490 500 510 520 530 540 VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 550 560 570 580 590 600 PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 610 620 630 640 650 660 RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 670 680 690 700 710 720 PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 730 740 750 760 770 780 HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 790 800 810 820 830 840 AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 850 860 870 880 890 900 VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 910 920 930 940 950 960 SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 970 980 990 1000 1010 1020 VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1030 1040 1050 1060 1070 1080 VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1090 1100 1110 1120 1130 1140 QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1150 1160 1170 1180 1190 1200 KKPLDRETYK LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1210 1220 1230 1240 1250 1260 GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1270 1280 1290 1300 1310 1320 SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1330 1340 1350 1360 1370 1380 NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1390 1400 1410 1420 1430 1440 DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1450 1460 1470 1480 1490 1500 HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELKLVAS DSLNENQTTI 1510 1520 1530 1540 1550 1560 VINVRDVNDL PPQFPQTSYE RTLDEGMTNT PFTIMQVTAT DGDKDRPQNI VYFLTGQGID 1570 1580 1590 1600 1610 1620 PDNPANSKFD INRTTGEIFV LKPLDRDQPN GRPQWRFTVF AQDEGGEGLV GYADVQVNLK 1630 1640 1650 1660 1670 1680 DINDNAPIFP QGVYFGNVTE NGTAGMVVMT MTAVDYDDPN EGSNARLVYS IEKNVIEEET 1690 1700 1710 1720 1730 1740 GSPIFEIEPD TGVIKTAVCC LDRERTPDYS IQVVAMDGGG LKGTGTASIR VKDINDMPPQ 1750 1760 1770 1780 1790 1800 FTKDEWFTEV DETDGTALPE MPILTVTVHD EDETNKFQYK VIDNSGYGAD KFTMVRNNDG 1810 1820 1830 1840 1850 1860 TGSLKIVQPL DYEDQLQSNG FRFRIQVNDK GEDNDNDKYH VAYSWVVVKL RDINDNKPHF 1870 1880 1890 1900 1910 1920 ERANVEVSVF EDTKVGTELE KFKATDPDQG GKSKVSYSID RSSDRQRQFA INQNGSVTIQ 1930 1940 1950 1960 1970 1980 RSLDREVVPR HQVKILAIDD GSPPKTATAT LTVIVQDIND NAPKFLKDYR PVLPEHVPPR 1990 2000 2010 2020 2030 2040 KVVEILATDD DDRSKSNGPP FQFRLDPSAD DIIRASFKVE QDQKGANGDG MAVISSLRSF 2050 2060 2070 2080 2090 2100 DREQQKEYMI PIVIKDHGSP AMTGTSTLTV IIGDVNDNKM QPGSKDIFVY NYQGQSPDTP 2110 2120 2130 2140 2150 2160 IGRVYVYDLD DWDLPDKKFY WEAMEHPRFK LDEDSGMVTM RAGTREGRYH LRFKVYDRKH 2170 2180 2190 2200 2210 2220 TQTDIPANVT VTVREIPHEA VVNSGSVRLS GISDEDFIRV WNYRTQSMSR SKMDRFRDKL 2230 2240 2250 2260 2270 2280 ADLLNTEREN VDIFSVQLKR KHPPLTDVRF SAHGSPYYKP VRLNGIVLMH REEIEKDVGI 2290 2300 2310 2320 2330 2340 NITMVGIDEC LYENQMCEGS CTNSLEISPL PYMVNANKTA LVGVRVDTIA DCTCGARNFT 2350 2360 2370 2380 2390 2400 KPESCRTTPC HNGGRCVDTR FGPHCSCPVG YTGPRCQQTT RSFRGNGWAW YPPLEMCDES 2410 2420 2430 2440 2450 2460 HLSLEFITRK PDGLIIYNGP IVPPERDETL ISDFIALELE RGYPRLLIDF GSGTLELRVK 2470 2480 2490 2500 2510 2520 TKKTLDDGEW HRIDLFWDTE SIRMVVDFCK SAEIAEMEDG TPPEFDDMSC QARGQIPPFN 2530 2540 2550 2560 2570 2580 EYLNVNAPLQ VGGLYREQFD QSLYFWHYMP TAKGFDGCIR NLVHNSKLYD LAHPGLSRNS 2590 2600 2610 2620 2630 2640 VAGCPQTEEV CAQTETTARC WEHGNCVGSL SEARCHCRPG WTGPACNIPT IPTTFKAQSY 2650 2660 2670 2680 2690 2700 VKYALSFEPD RFSTQVQLRF RTREEYGELF RVSDQHNREY GILEIKDGHL HFRYNLNSLR 2710 2720 2730 2740 2750 2760 TEEKDLWLNA IVVNDGQWHV VKVNRYGSAA TLELDGGEGR RYNETFEFVG HQWLLVDKQE 2770 2780 2790 2800 2810 2820 GVYAGGKAEY TGVRTFEVYA DYQKSCLDDI RLEGKHLPLP PAMNGTQWGQ ATMARNLEKG 2830 2840 2850 2860 2870 2880 CPSNKPCSNV ICPDPFECVD LWNVYECTCP AGYKSSGSTC VNDNECLLFP CRNGGRCRDH 2890 2900 2910 2920 2930 2940 HPPKKYECHC PMGFTGMHCE LELLASGVLT PSRDFIVALA LCLGTLILLV LVFVVYNRRR 2950 2960 2970 2980 2990 3000 EAHIKYPGPD DDVRENIINY DDEGGGEDDM TAFDITPLQI PIGGPMPPEL APMKMPIMYP 3010 3020 3030 3040 3050 3060 VMTLMPGQEP NVGMFIEEHK KRADGDPNAP PFDDLRNYAY EGGGSTAGSL SSLASGTDDE 3070 3080 3090 QQEYDYLGAW GPRFDKLANM YGPEAPNPHN TELEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS." Iwai Y., Usui T., Hirano S., Steward R., Takeichi M., Uemura T. Neuron 19:77-89(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D). Tissue: Embryo and Head.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"Roles of Armadillo, a Drosophila catenin, during central nervous system development." Loureiro J., Peifer M. Curr. Biol. 8:622-632(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ARM.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB002397 mRNA. Translation: BAA22151.1.
AE014134 Genomic DNA. Translation: AAF53635.1.
AE014134 Genomic DNA. Translation: AAN10992.1.
AE014134 Genomic DNA. Translation: AAN10993.1.
AE014134 Genomic DNA. Translation: AAN10994.1.
AE014134 Genomic DNA. Translation: AAN10995.1.
AE014134 Genomic DNA. Translation: AAN10996.1.
AE014134 Genomic DNA. Translation: AAN10997.1.
AE014134 Genomic DNA. Translation: AAN10998.1.

PIR

T00021.

RefSeq

NP_724068.1. NM_165224.2.
NP_724069.1. NM_165225.2.
NP_724070.1. NM_165226.2.
NP_724071.1. NM_165227.3.
NP_724072.1. NM_165228.2.
NP_724073.1. NM_165229.2.
NP_724074.1. NM_165230.2.
NP_724075.1. NM_165231.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3UBF	X-ray	2.50	A	439-753	[»]
3UBG	X-ray	2.50	A/B	439-753	[»]
3UBH	X-ray	2.70	A	434-851	[»]

ProteinModelPortal

O15943.

SMR

O15943. Positions 291-316, 438-2111, 2337-2770, 2822-2904, 2991-3084.

ModBase

Search...

Protein-protein interaction databases

IntAct

O15943. 1 interaction.

MINT

MINT-1327969.

Proteomic databases

PaxDb

O15943.

PRIDE

O15943.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0081015; FBpp0080568; FBgn0015609.

GeneID

35070.

KEGG

dme:Dmel_CG7100.

Organism-specific databases

CTD

35070.

FlyBase

FBgn0015609. CadN.

Phylogenomic databases

eggNOG

NOG298859.

GeneTree

ENSGT00700000104156.

InParanoid

O15943.

OrthoDB

EOG41ZCRN.

Gene expression databases

Bgee

O15943.

GermOnline

CG7100. Drosophila melanogaster.

Family and domain databases

Gene3D

2.60.120.200. 2 hits.
2.60.40.60. 17 hits.

InterPro

IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR001791. Laminin_G.
[Graphical view]

Pfam

PF00028. Cadherin. 12 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]

PRINTS

PR00205. CADHERIN.

SMART

SM00112. CA. 16 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]

SUPFAM

SSF49313. Cadherin. 18 hits.
SSF49899. ConA_like_lec_gl. 2 hits.

PROSITE

PS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

35070.

NextBio

791671.

Entry information

Entry name

CADN_DROME

Accession

Primary (citable) accession number: O15943
Secondary accession number(s): Q9VJB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	June 1, 2000
Last modified:	May 1, 2013
This is version 126 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project