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O15943

- CADN_DROME

UniProt

O15943 - CADN_DROME

Protein

Neural-cadherin

Gene

CadN

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (01 Jun 2000)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.

    GO - Molecular functioni

    1. beta-catenin binding Source: FlyBase
    2. cadherin binding Source: FlyBase
    3. calcium ion binding Source: FlyBase
    4. cell adhesion molecule binding Source: FlyBase
    5. protein binding Source: UniProtKB
    6. protein homodimerization activity Source: FlyBase
    7. receptor activity Source: FlyBase

    GO - Biological processi

    1. axonal fasciculation Source: FlyBase
    2. axon extension Source: FlyBase
    3. axon extension involved in axon guidance Source: FlyBase
    4. axon guidance Source: FlyBase
    5. axon target recognition Source: FlyBase
    6. calcium-dependent cell-cell adhesion Source: FlyBase
    7. cell-cell adhesion mediated by cadherin Source: FlyBase
    8. homophilic cell adhesion Source: FlyBase
    9. negative regulation of dendrite morphogenesis Source: FlyBase
    10. ommatidial rotation Source: FlyBase
    11. R7 cell development Source: FlyBase
    12. R8 cell development Source: FlyBase
    13. regulation of axon extension involved in axon guidance Source: FlyBase
    14. regulation of dendrite morphogenesis Source: FlyBase
    15. retinal ganglion cell axon guidance Source: FlyBase

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neural-cadherin
    Alternative name(s):
    Cadherin-N
    Short name:
    dN-cadherin
    Gene namesi
    Name:CadN
    ORF Names:CG7100
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0015609. CadN.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: FlyBase
    2. cell-cell junction Source: FlyBase
    3. dendrite Source: FlyBase
    4. integral component of membrane Source: FlyBase
    5. integral component of plasma membrane Source: FlyBase
    6. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 3097Neural-cadherinPRO_0000003882
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Propeptidei37 – ?PRO_0000003881

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1266 – 12661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2346 ↔ 2357Sequence Analysis
    Disulfide bondi2351 ↔ 2366Sequence Analysis
    Disulfide bondi2368 ↔ 2377Sequence Analysis
    Disulfide bondi2559 ↔ 2585By similarity
    Disulfide bondi2592 ↔ 2607Sequence Analysis
    Disulfide bondi2601 ↔ 2616Sequence Analysis
    Disulfide bondi2618 ↔ 2627Sequence Analysis
    Disulfide bondi2787 ↔ 2822By similarity
    Disulfide bondi2869 ↔ 2880Sequence Analysis
    Disulfide bondi2874 ↔ 2891Sequence Analysis
    Disulfide bondi2893 ↔ 2902Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO15943.
    PRIDEiO15943.

    Expressioni

    Tissue specificityi

    In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.

    Gene expression databases

    BgeeiO15943.

    Interactioni

    Protein-protein interaction databases

    BioGridi61066. 5 interactions.
    IntActiO15943. 1 interaction.
    MINTiMINT-1327969.

    Structurei

    Secondary structure

    1
    3097
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi440 – 45011
    Helixi451 – 4533
    Beta strandi459 – 4624
    Beta strandi466 – 4694
    Beta strandi471 – 4766
    Beta strandi479 – 4835
    Beta strandi487 – 4937
    Helixi497 – 4993
    Beta strandi505 – 5139
    Beta strandi519 – 5213
    Beta strandi525 – 53410
    Beta strandi546 – 5549
    Beta strandi563 – 5664
    Beta strandi578 – 58912
    Beta strandi591 – 5933
    Turni595 – 5973
    Beta strandi599 – 6024
    Beta strandi604 – 6063
    Beta strandi613 – 62311
    Beta strandi632 – 6343
    Beta strandi638 – 6458
    Beta strandi650 – 66112
    Beta strandi669 – 6724
    Beta strandi683 – 69210
    Turni694 – 6963
    Beta strandi697 – 6993
    Turni701 – 7033
    Beta strandi705 – 7084
    Beta strandi721 – 73515
    Beta strandi737 – 74711
    Beta strandi755 – 76713
    Beta strandi775 – 7784
    Helixi787 – 7904
    Beta strandi792 – 7976
    Beta strandi801 – 8033
    Beta strandi808 – 8114
    Beta strandi815 – 8184
    Beta strandi823 – 83210
    Beta strandi839 – 84911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UBFX-ray2.50A439-753[»]
    3UBGX-ray2.50A/B439-753[»]
    3UBHX-ray2.70A434-851[»]
    ProteinModelPortaliO15943.
    SMRiO15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini? – 2916ExtracellularSequence Analysis
    Topological domaini2938 – 3097160CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2917 – 293721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 305125Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 543114Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini554 – 65198Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini660 – 75697Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini766 – 85893Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini867 – 968102Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini978 – 1078101Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1087 – 118397Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1193 – 1299107Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1307 – 1414108Cadherin 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1423 – 151492Cadherin 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1523 – 1630108Cadherin 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1639 – 1742104Cadherin 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1749 – 1861113Cadherin 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1870 – 196697Cadherin 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1974 – 2085112Cadherin 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini2346 – 237732EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2379 – 2585207Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2592 – 262736EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2631 – 2822192Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2869 – 290234EGF-like 3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 16 cadherin domains.PROSITE-ProRule annotation
    Contains 3 EGF-like domains.PROSITE-ProRule annotation
    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG298859.
    GeneTreeiENSGT00750000117611.
    InParanoidiO15943.
    OrthoDBiEOG718KB7.
    PhylomeDBiO15943.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    2.60.40.60. 17 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00028. Cadherin. 12 hits.
    PF01049. Cadherin_C. 1 hit.
    PF00008. EGF. 2 hits.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 16 hits.
    SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 18 hits.
    SSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00232. CADHERIN_1. 9 hits.
    PS50268. CADHERIN_2. 16 hits.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform D (identifier: O15943-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA     50
    ARMLAGSPGD VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS 100
    HSGAAAYHML DTDYSKYFTV LEDGVVMTTA DISPLVNRPV QLVVVEQTPN 150
    ATNTHNLQLF VMHRNDMLRF SGSLLDASGE VRENQPAGTR VRGVPLMQAF 200
    SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ ISAKSLVING 250
    DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 300
    NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA 350
    YRLKSPSNVV IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA 400
    KVLLEFLAAE PVSFIMQHLE HDDINNHSHH REKRRVTRAV RPTKRIEFTE 450
    ADGDTEGKSV FQLEKETDKE TFKIRDDNPW VTVETNGAVR VKKKWDYEEL 500
    GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP PYFINRPLPM 550
    QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 600
    RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ 650
    FYMPSYEAEI PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG 700
    PTSGIVKLAK ELDFEDLRQP HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN 750
    DNAPKFELPD YQAHNVDEDI PLGTSILRVK AMDSDSGSNA EIEYLVSDDH 800
    FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG VATVRVYTKN 850
    KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 900
    SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS 950
    TAVVVVFITD VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV 1000
    NGQVKYSIVQ QPNQKGTKFT VDEETGEVST NKVFDREGDD GKFVSVTVKA 1050
    TDQGDPSLEG VCSFTVEITD VNDNPPLFDR QKYVENVKQD ASIGTNILRV 1100
    SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL KKPLDRETYK 1150
    LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1200
    GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD 1250
    IKVNHPLDYE SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT 1300
    EREQETVLEG EPIGTKVTQV NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF 1350
    EINLQSGEIF TKTVFDREKK GAYALEVEAR DGAPSARPNS NGPNSVTKFI 1400
    RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD HDESSRIRYE 1450
    ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1500
    IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN 1550
    IVYFLTGQGI DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV 1600
    FAQDEGGEGL VGYADVQVNL KDINDNAPIF PQGVYFGNVT ENGTAGMVVM 1650
    TMTAVDYDDP NEGSNARLVY SIEKNVIEEE TGSPIFEIEP DTGVIKTAVC 1700
    CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP QFTKDEWFTE 1750
    VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1800
    GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK 1850
    LRDINDNKPH FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI 1900
    DRSSDRQRQF AINQNGSVTI QRSLDREVVP RHQVKILAID DGSPPKTATA 1950
    TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP RKVVEILATD DDDRSKSNGP 2000
    PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS FDREQQKEYM 2050
    IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2100
    PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY 2150
    HLRFKVYDRK HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR 2200
    VWNYRTQSMS RSKMDRFRDK LADLLNTERE NVDIFSVQLK RKHPPLTDVR 2250
    FSAHGSPYYK PVRLNGIVLM HREEIEKDVG INITMVGIDE CLYENQMCEG 2300
    SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF TKPESCRTTP 2350
    CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2400
    SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID 2450
    FGSGTLELRV KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED 2500
    GTPPEFDDMS CQARGQIPPF NEYLNVNAPL QVGGLYREQF DQSLYFWHYM 2550
    PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN SVAGCPQTEE VCAQTETTAR 2600
    CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS YVKYALSFEP 2650
    DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2700
    RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV 2750
    GHQWLLVDKQ EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL 2800
    PPAMNGTQWG QATMARNLEK GCPSNKPCSN VICPDPFECV DLWNVYECTC 2850
    GEGRIMSPDS KGCMDRNECL DMPCMNGATC INLEPRLRYR CICPDGFWGE 2900
    NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR RREAHIKYPG 2950
    PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM 3000
    YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG 3050
    SLSSLASGTD DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL 3097
    Length:3,097
    Mass (Da):347,204
    Last modified:June 1, 2000 - v2
    Checksum:i082242F28D9B5CC3
    GO
    Isoform A (identifier: O15943-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
         1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

    Show »
    Length:3,096
    Mass (Da):346,741
    Checksum:i37E1B66D6CA30974
    GO
    Isoform B (identifier: O15943-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

    Show »
    Length:3,096
    Mass (Da):346,863
    Checksum:i5A7B35628893589D
    GO
    Isoform C (identifier: O15943-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
         1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
         2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

    Show »
    Length:3,095
    Mass (Da):346,500
    Checksum:iCB4EBB76A3574D75
    GO
    Isoform E (identifier: O15943-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV

    Show »
    Length:3,097
    Mass (Da):347,082
    Checksum:i867FD871827F6C92
    GO
    Isoform F (identifier: O15943-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

    Show »
    Length:3,096
    Mass (Da):346,962
    Checksum:i98BA24979B02FA5A
    GO
    Isoform G (identifier: O15943-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
         2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

    Show »
    Length:3,096
    Mass (Da):346,840
    Checksum:iF520A7987F32ABB3
    GO
    Isoform H (identifier: O15943-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
         2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

    Show »
    Length:3,095
    Mass (Da):346,622
    Checksum:iE1CDB4929306A434
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1342 – 13421P → A in BAA22151. (PubMed:9247265)Curated
    Sequence conflicti2786 – 27861S → T in BAA22151. (PubMed:9247265)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1425 – 14251E → K in allele CADN-M12; muscle defects.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1147 – 120660ETYKL…KVVSI → DRYRLRVSASDKGTPASAAD VDVELDVVDRNNKPPIWDKS IYGPIHIRENVTVGTVVTSV in isoform A, isoform C, isoform E and isoform G. CuratedVSP_000667Add
    BLAST
    Alternative sequencei1486 – 153651RLAAS…PKRVL → KLVASDSLNENQTTIVINVR DVNDLPPQFPQTSYERTLDE GMTNTPFTIM in isoform A, isoform B, isoform C and isoform H. CuratedVSP_000668Add
    BLAST
    Alternative sequencei2851 – 293080GEGRI…LIILI → PAGYKSSGSTCVNDNECLLF PCRNGGRCRDHHPPKKYECH CPMGFTGMHCELELLASGVL TPSRDFIVALALCLGTLIL in isoform C, isoform F, isoform G and isoform H. CuratedVSP_000669Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002397 mRNA. Translation: BAA22151.1.
    AE014134 Genomic DNA. Translation: AAF53635.1.
    AE014134 Genomic DNA. Translation: AAN10992.1.
    AE014134 Genomic DNA. Translation: AAN10993.1.
    AE014134 Genomic DNA. Translation: AAN10994.1.
    AE014134 Genomic DNA. Translation: AAN10995.1.
    AE014134 Genomic DNA. Translation: AAN10996.1.
    AE014134 Genomic DNA. Translation: AAN10997.1.
    AE014134 Genomic DNA. Translation: AAN10998.1.
    PIRiT00021.
    RefSeqiNP_724068.1. NM_165224.2. [O15943-8]
    NP_724069.1. NM_165225.2. [O15943-3]
    NP_724070.1. NM_165226.2. [O15943-6]
    NP_724071.1. NM_165227.3. [O15943-1]
    NP_724072.1. NM_165228.2. [O15943-4]
    NP_724073.1. NM_165229.2. [O15943-2]
    NP_724074.1. NM_165230.2. [O15943-7]
    NP_724075.1. NM_165231.3. [O15943-5]
    UniGeneiDm.5768.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081015; FBpp0080568; FBgn0015609. [O15943-1]
    GeneIDi35070.
    KEGGidme:Dmel_CG7100.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002397 mRNA. Translation: BAA22151.1 .
    AE014134 Genomic DNA. Translation: AAF53635.1 .
    AE014134 Genomic DNA. Translation: AAN10992.1 .
    AE014134 Genomic DNA. Translation: AAN10993.1 .
    AE014134 Genomic DNA. Translation: AAN10994.1 .
    AE014134 Genomic DNA. Translation: AAN10995.1 .
    AE014134 Genomic DNA. Translation: AAN10996.1 .
    AE014134 Genomic DNA. Translation: AAN10997.1 .
    AE014134 Genomic DNA. Translation: AAN10998.1 .
    PIRi T00021.
    RefSeqi NP_724068.1. NM_165224.2. [O15943-8 ]
    NP_724069.1. NM_165225.2. [O15943-3 ]
    NP_724070.1. NM_165226.2. [O15943-6 ]
    NP_724071.1. NM_165227.3. [O15943-1 ]
    NP_724072.1. NM_165228.2. [O15943-4 ]
    NP_724073.1. NM_165229.2. [O15943-2 ]
    NP_724074.1. NM_165230.2. [O15943-7 ]
    NP_724075.1. NM_165231.3. [O15943-5 ]
    UniGenei Dm.5768.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UBF X-ray 2.50 A 439-753 [» ]
    3UBG X-ray 2.50 A/B 439-753 [» ]
    3UBH X-ray 2.70 A 434-851 [» ]
    ProteinModelPortali O15943.
    SMRi O15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61066. 5 interactions.
    IntActi O15943. 1 interaction.
    MINTi MINT-1327969.

    Proteomic databases

    PaxDbi O15943.
    PRIDEi O15943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081015 ; FBpp0080568 ; FBgn0015609 . [O15943-1 ]
    GeneIDi 35070.
    KEGGi dme:Dmel_CG7100.

    Organism-specific databases

    CTDi 35070.
    FlyBasei FBgn0015609. CadN.

    Phylogenomic databases

    eggNOGi NOG298859.
    GeneTreei ENSGT00750000117611.
    InParanoidi O15943.
    OrthoDBi EOG718KB7.
    PhylomeDBi O15943.

    Miscellaneous databases

    GenomeRNAii 35070.
    NextBioi 791671.

    Gene expression databases

    Bgeei O15943.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    2.60.40.60. 17 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00028. Cadherin. 12 hits.
    PF01049. Cadherin_C. 1 hit.
    PF00008. EGF. 2 hits.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 16 hits.
    SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 1 hit.
    SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 18 hits.
    SSF49899. SSF49899. 2 hits.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00232. CADHERIN_1. 9 hits.
    PS50268. CADHERIN_2. 16 hits.
    PS00022. EGF_1. 3 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS."
      Iwai Y., Usui T., Hirano S., Steward R., Takeichi M., Uemura T.
      Neuron 19:77-89(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D).
      Tissue: Embryo and Head.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. "Roles of Armadillo, a Drosophila catenin, during central nervous system development."
      Loureiro J., Peifer M.
      Curr. Biol. 8:622-632(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARM.

    Entry informationi

    Entry nameiCADN_DROME
    AccessioniPrimary (citable) accession number: O15943
    Secondary accession number(s): Q9VJB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: June 1, 2000
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3