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O15943

- CADN_DROME

UniProt

O15943 - CADN_DROME

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Protein

Neural-cadherin

Gene

CadN

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.

GO - Molecular functioni

  1. beta-catenin binding Source: FlyBase
  2. cadherin binding Source: FlyBase
  3. calcium ion binding Source: FlyBase
  4. cell adhesion molecule binding Source: FlyBase
  5. protein homodimerization activity Source: FlyBase
  6. receptor activity Source: FlyBase

GO - Biological processi

  1. axonal fasciculation Source: FlyBase
  2. axon extension Source: FlyBase
  3. axon extension involved in axon guidance Source: FlyBase
  4. axon guidance Source: FlyBase
  5. axon target recognition Source: FlyBase
  6. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  7. cell-cell adhesion mediated by cadherin Source: FlyBase
  8. homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  9. negative regulation of dendrite morphogenesis Source: FlyBase
  10. ommatidial rotation Source: FlyBase
  11. R7 cell development Source: FlyBase
  12. R8 cell development Source: FlyBase
  13. regulation of axon extension involved in axon guidance Source: FlyBase
  14. regulation of dendrite morphogenesis Source: FlyBase
  15. retinal ganglion cell axon guidance Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural-cadherin
Alternative name(s):
Cadherin-N
Short name:
dN-cadherin
Gene namesi
Name:CadN
ORF Names:CG7100
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015609. CadN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 2916ExtracellularSequence Analysis
Transmembranei2917 – 293721HelicalSequence AnalysisAdd
BLAST
Topological domaini2938 – 3097160CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: FlyBase
  2. cell-cell junction Source: FlyBase
  3. dendrite Source: FlyBase
  4. integral component of membrane Source: FlyBase
  5. integral component of plasma membrane Source: FlyBase
  6. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3097Neural-cadherinPRO_0000003882
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Propeptidei37 – ?PRO_0000003881

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi930 – 9301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1266 – 12661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2346 ↔ 2357Sequence Analysis
Disulfide bondi2351 ↔ 2366Sequence Analysis
Disulfide bondi2368 ↔ 2377Sequence Analysis
Disulfide bondi2559 ↔ 2585By similarity
Disulfide bondi2592 ↔ 2607Sequence Analysis
Disulfide bondi2601 ↔ 2616Sequence Analysis
Disulfide bondi2618 ↔ 2627Sequence Analysis
Disulfide bondi2787 ↔ 2822By similarity
Disulfide bondi2869 ↔ 2880Sequence Analysis
Disulfide bondi2874 ↔ 2891Sequence Analysis
Disulfide bondi2893 ↔ 2902Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15943.
PRIDEiO15943.

Expressioni

Tissue specificityi

In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.

Gene expression databases

BgeeiO15943.
ExpressionAtlasiO15943. differential.

Interactioni

Protein-protein interaction databases

BioGridi61066. 5 interactions.
IntActiO15943. 1 interaction.
MINTiMINT-1327969.

Structurei

Secondary structure

1
3097
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi440 – 45011Combined sources
Helixi451 – 4533Combined sources
Beta strandi459 – 4624Combined sources
Beta strandi466 – 4694Combined sources
Beta strandi471 – 4766Combined sources
Beta strandi479 – 4835Combined sources
Beta strandi487 – 4937Combined sources
Helixi497 – 4993Combined sources
Beta strandi505 – 5139Combined sources
Beta strandi519 – 5213Combined sources
Beta strandi525 – 53410Combined sources
Beta strandi546 – 5549Combined sources
Beta strandi563 – 5664Combined sources
Beta strandi578 – 58912Combined sources
Beta strandi591 – 5933Combined sources
Turni595 – 5973Combined sources
Beta strandi599 – 6024Combined sources
Beta strandi604 – 6063Combined sources
Beta strandi613 – 62311Combined sources
Beta strandi632 – 6343Combined sources
Beta strandi638 – 6458Combined sources
Beta strandi650 – 66112Combined sources
Beta strandi669 – 6724Combined sources
Beta strandi683 – 69210Combined sources
Turni694 – 6963Combined sources
Beta strandi697 – 6993Combined sources
Turni701 – 7033Combined sources
Beta strandi705 – 7084Combined sources
Beta strandi721 – 73515Combined sources
Beta strandi737 – 74711Combined sources
Beta strandi755 – 76713Combined sources
Beta strandi775 – 7784Combined sources
Helixi787 – 7904Combined sources
Beta strandi792 – 7976Combined sources
Beta strandi801 – 8033Combined sources
Beta strandi808 – 8114Combined sources
Beta strandi815 – 8184Combined sources
Beta strandi823 – 83210Combined sources
Beta strandi839 – 84911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UBFX-ray2.50A439-753[»]
3UBGX-ray2.50A/B439-753[»]
3UBHX-ray2.70A434-851[»]
ProteinModelPortaliO15943.
SMRiO15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 305125Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 543114Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini554 – 65198Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini660 – 75697Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini766 – 85893Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini867 – 968102Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini978 – 1078101Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini1087 – 118397Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1193 – 1299107Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1307 – 1414108Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1423 – 151492Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1523 – 1630108Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1639 – 1742104Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1749 – 1861113Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1870 – 196697Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1974 – 2085112Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini2346 – 237732EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini2379 – 2585207Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini2592 – 262736EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini2631 – 2822192Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini2869 – 290234EGF-like 3PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 16 cadherin domains.PROSITE-ProRule annotation
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298859.
GeneTreeiENSGT00760000118805.
InParanoidiO15943.
OrthoDBiEOG718KB7.
PhylomeDBiO15943.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 12 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 16 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform D (identifier: O15943-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA
60 70 80 90 100
ARMLAGSPGD VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS
110 120 130 140 150
HSGAAAYHML DTDYSKYFTV LEDGVVMTTA DISPLVNRPV QLVVVEQTPN
160 170 180 190 200
ATNTHNLQLF VMHRNDMLRF SGSLLDASGE VRENQPAGTR VRGVPLMQAF
210 220 230 240 250
SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ ISAKSLVING
260 270 280 290 300
DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND
310 320 330 340 350
NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA
360 370 380 390 400
YRLKSPSNVV IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA
410 420 430 440 450
KVLLEFLAAE PVSFIMQHLE HDDINNHSHH REKRRVTRAV RPTKRIEFTE
460 470 480 490 500
ADGDTEGKSV FQLEKETDKE TFKIRDDNPW VTVETNGAVR VKKKWDYEEL
510 520 530 540 550
GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP PYFINRPLPM
560 570 580 590 600
QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV
610 620 630 640 650
RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ
660 670 680 690 700
FYMPSYEAEI PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG
710 720 730 740 750
PTSGIVKLAK ELDFEDLRQP HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN
760 770 780 790 800
DNAPKFELPD YQAHNVDEDI PLGTSILRVK AMDSDSGSNA EIEYLVSDDH
810 820 830 840 850
FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG VATVRVYTKN
860 870 880 890 900
KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS
910 920 930 940 950
SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS
960 970 980 990 1000
TAVVVVFITD VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV
1010 1020 1030 1040 1050
NGQVKYSIVQ QPNQKGTKFT VDEETGEVST NKVFDREGDD GKFVSVTVKA
1060 1070 1080 1090 1100
TDQGDPSLEG VCSFTVEITD VNDNPPLFDR QKYVENVKQD ASIGTNILRV
1110 1120 1130 1140 1150
SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL KKPLDRETYK
1160 1170 1180 1190 1200
LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG
1210 1220 1230 1240 1250
GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD
1260 1270 1280 1290 1300
IKVNHPLDYE SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT
1310 1320 1330 1340 1350
EREQETVLEG EPIGTKVTQV NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF
1360 1370 1380 1390 1400
EINLQSGEIF TKTVFDREKK GAYALEVEAR DGAPSARPNS NGPNSVTKFI
1410 1420 1430 1440 1450
RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD HDESSRIRYE
1460 1470 1480 1490 1500
ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV
1510 1520 1530 1540 1550
IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN
1560 1570 1580 1590 1600
IVYFLTGQGI DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV
1610 1620 1630 1640 1650
FAQDEGGEGL VGYADVQVNL KDINDNAPIF PQGVYFGNVT ENGTAGMVVM
1660 1670 1680 1690 1700
TMTAVDYDDP NEGSNARLVY SIEKNVIEEE TGSPIFEIEP DTGVIKTAVC
1710 1720 1730 1740 1750
CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP QFTKDEWFTE
1760 1770 1780 1790 1800
VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND
1810 1820 1830 1840 1850
GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK
1860 1870 1880 1890 1900
LRDINDNKPH FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI
1910 1920 1930 1940 1950
DRSSDRQRQF AINQNGSVTI QRSLDREVVP RHQVKILAID DGSPPKTATA
1960 1970 1980 1990 2000
TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP RKVVEILATD DDDRSKSNGP
2010 2020 2030 2040 2050
PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS FDREQQKEYM
2060 2070 2080 2090 2100
IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT
2110 2120 2130 2140 2150
PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY
2160 2170 2180 2190 2200
HLRFKVYDRK HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR
2210 2220 2230 2240 2250
VWNYRTQSMS RSKMDRFRDK LADLLNTERE NVDIFSVQLK RKHPPLTDVR
2260 2270 2280 2290 2300
FSAHGSPYYK PVRLNGIVLM HREEIEKDVG INITMVGIDE CLYENQMCEG
2310 2320 2330 2340 2350
SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF TKPESCRTTP
2360 2370 2380 2390 2400
CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE
2410 2420 2430 2440 2450
SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID
2460 2470 2480 2490 2500
FGSGTLELRV KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED
2510 2520 2530 2540 2550
GTPPEFDDMS CQARGQIPPF NEYLNVNAPL QVGGLYREQF DQSLYFWHYM
2560 2570 2580 2590 2600
PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN SVAGCPQTEE VCAQTETTAR
2610 2620 2630 2640 2650
CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS YVKYALSFEP
2660 2670 2680 2690 2700
DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL
2710 2720 2730 2740 2750
RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV
2760 2770 2780 2790 2800
GHQWLLVDKQ EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL
2810 2820 2830 2840 2850
PPAMNGTQWG QATMARNLEK GCPSNKPCSN VICPDPFECV DLWNVYECTC
2860 2870 2880 2890 2900
GEGRIMSPDS KGCMDRNECL DMPCMNGATC INLEPRLRYR CICPDGFWGE
2910 2920 2930 2940 2950
NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR RREAHIKYPG
2960 2970 2980 2990 3000
PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM
3010 3020 3030 3040 3050
YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG
3060 3070 3080 3090
SLSSLASGTD DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL
Length:3,097
Mass (Da):347,204
Last modified:June 1, 2000 - v2
Checksum:i082242F28D9B5CC3
GO
Isoform A (identifier: O15943-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,741
Checksum:i37E1B66D6CA30974
GO
Isoform B (identifier: O15943-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,863
Checksum:i5A7B35628893589D
GO
Isoform C (identifier: O15943-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,500
Checksum:iCB4EBB76A3574D75
GO
Isoform E (identifier: O15943-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV

Show »
Length:3,097
Mass (Da):347,082
Checksum:i867FD871827F6C92
GO
Isoform F (identifier: O15943-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,962
Checksum:i98BA24979B02FA5A
GO
Isoform G (identifier: O15943-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,840
Checksum:iF520A7987F32ABB3
GO
Isoform H (identifier: O15943-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,622
Checksum:iE1CDB4929306A434
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1342 – 13421P → A in BAA22151. (PubMed:9247265)Curated
Sequence conflicti2786 – 27861S → T in BAA22151. (PubMed:9247265)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1425 – 14251E → K in allele CADN-M12; muscle defects.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1147 – 120660ETYKL…KVVSI → DRYRLRVSASDKGTPASAAD VDVELDVVDRNNKPPIWDKS IYGPIHIRENVTVGTVVTSV in isoform A, isoform C, isoform E and isoform G. CuratedVSP_000667Add
BLAST
Alternative sequencei1486 – 153651RLAAS…PKRVL → KLVASDSLNENQTTIVINVR DVNDLPPQFPQTSYERTLDE GMTNTPFTIM in isoform A, isoform B, isoform C and isoform H. CuratedVSP_000668Add
BLAST
Alternative sequencei2851 – 293080GEGRI…LIILI → PAGYKSSGSTCVNDNECLLF PCRNGGRCRDHHPPKKYECH CPMGFTGMHCELELLASGVL TPSRDFIVALALCLGTLIL in isoform C, isoform F, isoform G and isoform H. CuratedVSP_000669Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002397 mRNA. Translation: BAA22151.1.
AE014134 Genomic DNA. Translation: AAF53635.1.
AE014134 Genomic DNA. Translation: AAN10992.1.
AE014134 Genomic DNA. Translation: AAN10993.1.
AE014134 Genomic DNA. Translation: AAN10994.1.
AE014134 Genomic DNA. Translation: AAN10995.1.
AE014134 Genomic DNA. Translation: AAN10996.1.
AE014134 Genomic DNA. Translation: AAN10997.1.
AE014134 Genomic DNA. Translation: AAN10998.1.
PIRiT00021.
RefSeqiNP_724068.1. NM_165224.2. [O15943-8]
NP_724069.1. NM_165225.2. [O15943-3]
NP_724070.1. NM_165226.2. [O15943-6]
NP_724071.1. NM_165227.3. [O15943-1]
NP_724072.1. NM_165228.2. [O15943-4]
NP_724073.1. NM_165229.2. [O15943-2]
NP_724074.1. NM_165230.2. [O15943-7]
NP_724075.1. NM_165231.3. [O15943-5]
UniGeneiDm.5768.

Genome annotation databases

EnsemblMetazoaiFBtr0081015; FBpp0080568; FBgn0015609. [O15943-1]
GeneIDi35070.
KEGGidme:Dmel_CG7100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002397 mRNA. Translation: BAA22151.1 .
AE014134 Genomic DNA. Translation: AAF53635.1 .
AE014134 Genomic DNA. Translation: AAN10992.1 .
AE014134 Genomic DNA. Translation: AAN10993.1 .
AE014134 Genomic DNA. Translation: AAN10994.1 .
AE014134 Genomic DNA. Translation: AAN10995.1 .
AE014134 Genomic DNA. Translation: AAN10996.1 .
AE014134 Genomic DNA. Translation: AAN10997.1 .
AE014134 Genomic DNA. Translation: AAN10998.1 .
PIRi T00021.
RefSeqi NP_724068.1. NM_165224.2. [O15943-8 ]
NP_724069.1. NM_165225.2. [O15943-3 ]
NP_724070.1. NM_165226.2. [O15943-6 ]
NP_724071.1. NM_165227.3. [O15943-1 ]
NP_724072.1. NM_165228.2. [O15943-4 ]
NP_724073.1. NM_165229.2. [O15943-2 ]
NP_724074.1. NM_165230.2. [O15943-7 ]
NP_724075.1. NM_165231.3. [O15943-5 ]
UniGenei Dm.5768.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UBF X-ray 2.50 A 439-753 [» ]
3UBG X-ray 2.50 A/B 439-753 [» ]
3UBH X-ray 2.70 A 434-851 [» ]
ProteinModelPortali O15943.
SMRi O15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61066. 5 interactions.
IntActi O15943. 1 interaction.
MINTi MINT-1327969.

Proteomic databases

PaxDbi O15943.
PRIDEi O15943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081015 ; FBpp0080568 ; FBgn0015609 . [O15943-1 ]
GeneIDi 35070.
KEGGi dme:Dmel_CG7100.

Organism-specific databases

CTDi 35070.
FlyBasei FBgn0015609. CadN.

Phylogenomic databases

eggNOGi NOG298859.
GeneTreei ENSGT00760000118805.
InParanoidi O15943.
OrthoDBi EOG718KB7.
PhylomeDBi O15943.

Miscellaneous databases

GenomeRNAii 35070.
NextBioi 791671.

Gene expression databases

Bgeei O15943.
ExpressionAtlasi O15943. differential.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00028. Cadherin. 12 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 16 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS."
    Iwai Y., Usui T., Hirano S., Steward R., Takeichi M., Uemura T.
    Neuron 19:77-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D).
    Tissue: Embryo and Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. "Roles of Armadillo, a Drosophila catenin, during central nervous system development."
    Loureiro J., Peifer M.
    Curr. Biol. 8:622-632(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARM.

Entry informationi

Entry nameiCADN_DROME
AccessioniPrimary (citable) accession number: O15943
Secondary accession number(s): Q9VJB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2000
Last modified: November 26, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3