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Protein

Neural-cadherin

Gene

CadN

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.

GO - Molecular functioni

  • beta-catenin binding Source: FlyBase
  • cadherin binding Source: FlyBase
  • calcium ion binding Source: FlyBase
  • cell adhesion molecule binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • receptor activity Source: FlyBase

GO - Biological processi

  • axonal fasciculation Source: FlyBase
  • axon extension Source: FlyBase
  • axon extension involved in axon guidance Source: FlyBase
  • axon guidance Source: FlyBase
  • axon target recognition Source: FlyBase
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • cell-cell adhesion mediated by cadherin Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • negative regulation of dendrite morphogenesis Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • R7 cell development Source: FlyBase
  • R8 cell development Source: FlyBase
  • regulation of axon extension involved in axon guidance Source: FlyBase
  • regulation of dendrite morphogenesis Source: FlyBase
  • retinal ganglion cell axon guidance Source: FlyBase
  • sensory perception of pain Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural-cadherin
Alternative name(s):
Cadherin-N
Short name:
dN-cadherin
Gene namesi
Name:CadN
ORF Names:CG7100
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015609. CadN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 2916ExtracellularSequence analysis
Transmembranei2917 – 2937HelicalSequence analysisAdd BLAST21
Topological domaini2938 – 3097CytoplasmicSequence analysisAdd BLAST160

GO - Cellular componenti

  • axon Source: FlyBase
  • cell-cell junction Source: FlyBase
  • dendrite Source: FlyBase
  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000003882? – 3097Neural-cadherin
Signal peptidei1 – 36Sequence analysisAdd BLAST36
PropeptideiPRO_000000388137 – ?

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi930N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1266N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2346 ↔ 2357Sequence analysis
Disulfide bondi2351 ↔ 2366Sequence analysis
Disulfide bondi2368 ↔ 2377Sequence analysis
Disulfide bondi2559 ↔ 2585By similarity
Disulfide bondi2592 ↔ 2607Sequence analysis
Disulfide bondi2601 ↔ 2616Sequence analysis
Disulfide bondi2618 ↔ 2627Sequence analysis
Disulfide bondi2787 ↔ 2822By similarity
Disulfide bondi2869 ↔ 2880Sequence analysis
Disulfide bondi2874 ↔ 2891Sequence analysis
Disulfide bondi2893 ↔ 2902Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15943.
PRIDEiO15943.

Expressioni

Tissue specificityi

In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.

Gene expression databases

BgeeiFBgn0015609.
ExpressionAtlasiO15943. baseline.
GenevisibleiO15943. DM.

Interactioni

GO - Molecular functioni

  • beta-catenin binding Source: FlyBase
  • cadherin binding Source: FlyBase
  • cell adhesion molecule binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi61066. 6 interactors.
IntActiO15943. 8 interactors.
MINTiMINT-1327969.
STRINGi7227.FBpp0099721.

Structurei

Secondary structure

13097
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi440 – 450Combined sources11
Helixi451 – 453Combined sources3
Beta strandi459 – 462Combined sources4
Beta strandi466 – 469Combined sources4
Beta strandi471 – 476Combined sources6
Beta strandi479 – 483Combined sources5
Beta strandi487 – 493Combined sources7
Helixi497 – 499Combined sources3
Beta strandi505 – 513Combined sources9
Beta strandi519 – 521Combined sources3
Beta strandi525 – 534Combined sources10
Beta strandi546 – 554Combined sources9
Beta strandi563 – 566Combined sources4
Beta strandi578 – 589Combined sources12
Beta strandi591 – 593Combined sources3
Turni595 – 597Combined sources3
Beta strandi599 – 602Combined sources4
Beta strandi604 – 606Combined sources3
Beta strandi613 – 623Combined sources11
Beta strandi632 – 634Combined sources3
Beta strandi638 – 645Combined sources8
Beta strandi650 – 661Combined sources12
Beta strandi669 – 672Combined sources4
Beta strandi683 – 692Combined sources10
Turni694 – 696Combined sources3
Beta strandi697 – 699Combined sources3
Turni701 – 703Combined sources3
Beta strandi705 – 708Combined sources4
Beta strandi721 – 735Combined sources15
Beta strandi737 – 747Combined sources11
Beta strandi755 – 767Combined sources13
Beta strandi775 – 778Combined sources4
Helixi787 – 790Combined sources4
Beta strandi792 – 797Combined sources6
Beta strandi801 – 803Combined sources3
Beta strandi808 – 811Combined sources4
Beta strandi815 – 818Combined sources4
Beta strandi823 – 832Combined sources10
Beta strandi839 – 849Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UBFX-ray2.50A439-753[»]
3UBGX-ray2.50A/B439-753[»]
3UBHX-ray2.70A434-851[»]
ProteinModelPortaliO15943.
SMRiO15943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 305Cadherin 1PROSITE-ProRule annotationAdd BLAST125
Domaini430 – 543Cadherin 2PROSITE-ProRule annotationAdd BLAST114
Domaini554 – 651Cadherin 3PROSITE-ProRule annotationAdd BLAST98
Domaini660 – 756Cadherin 4PROSITE-ProRule annotationAdd BLAST97
Domaini766 – 858Cadherin 5PROSITE-ProRule annotationAdd BLAST93
Domaini867 – 968Cadherin 6PROSITE-ProRule annotationAdd BLAST102
Domaini978 – 1078Cadherin 7PROSITE-ProRule annotationAdd BLAST101
Domaini1087 – 1183Cadherin 8PROSITE-ProRule annotationAdd BLAST97
Domaini1193 – 1299Cadherin 9PROSITE-ProRule annotationAdd BLAST107
Domaini1307 – 1414Cadherin 10PROSITE-ProRule annotationAdd BLAST108
Domaini1423 – 1514Cadherin 11PROSITE-ProRule annotationAdd BLAST92
Domaini1523 – 1630Cadherin 12PROSITE-ProRule annotationAdd BLAST108
Domaini1639 – 1742Cadherin 13PROSITE-ProRule annotationAdd BLAST104
Domaini1749 – 1861Cadherin 14PROSITE-ProRule annotationAdd BLAST113
Domaini1870 – 1966Cadherin 15PROSITE-ProRule annotationAdd BLAST97
Domaini1974 – 2085Cadherin 16PROSITE-ProRule annotationAdd BLAST112
Domaini2346 – 2377EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini2379 – 2585Laminin G-like 1PROSITE-ProRule annotationAdd BLAST207
Domaini2592 – 2627EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini2631 – 2822Laminin G-like 2PROSITE-ProRule annotationAdd BLAST192
Domaini2869 – 2902EGF-like 3PROSITE-ProRule annotationAdd BLAST34

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 16 cadherin domains.PROSITE-ProRule annotation
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiO15943.
OrthoDBiEOG091G00V9.
PhylomeDBiO15943.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 13 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 16 hits.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform D (identifier: O15943-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA
60 70 80 90 100
ARMLAGSPGD VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS
110 120 130 140 150
HSGAAAYHML DTDYSKYFTV LEDGVVMTTA DISPLVNRPV QLVVVEQTPN
160 170 180 190 200
ATNTHNLQLF VMHRNDMLRF SGSLLDASGE VRENQPAGTR VRGVPLMQAF
210 220 230 240 250
SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ ISAKSLVING
260 270 280 290 300
DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND
310 320 330 340 350
NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA
360 370 380 390 400
YRLKSPSNVV IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA
410 420 430 440 450
KVLLEFLAAE PVSFIMQHLE HDDINNHSHH REKRRVTRAV RPTKRIEFTE
460 470 480 490 500
ADGDTEGKSV FQLEKETDKE TFKIRDDNPW VTVETNGAVR VKKKWDYEEL
510 520 530 540 550
GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP PYFINRPLPM
560 570 580 590 600
QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV
610 620 630 640 650
RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ
660 670 680 690 700
FYMPSYEAEI PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG
710 720 730 740 750
PTSGIVKLAK ELDFEDLRQP HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN
760 770 780 790 800
DNAPKFELPD YQAHNVDEDI PLGTSILRVK AMDSDSGSNA EIEYLVSDDH
810 820 830 840 850
FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG VATVRVYTKN
860 870 880 890 900
KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS
910 920 930 940 950
SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS
960 970 980 990 1000
TAVVVVFITD VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV
1010 1020 1030 1040 1050
NGQVKYSIVQ QPNQKGTKFT VDEETGEVST NKVFDREGDD GKFVSVTVKA
1060 1070 1080 1090 1100
TDQGDPSLEG VCSFTVEITD VNDNPPLFDR QKYVENVKQD ASIGTNILRV
1110 1120 1130 1140 1150
SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL KKPLDRETYK
1160 1170 1180 1190 1200
LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG
1210 1220 1230 1240 1250
GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD
1260 1270 1280 1290 1300
IKVNHPLDYE SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT
1310 1320 1330 1340 1350
EREQETVLEG EPIGTKVTQV NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF
1360 1370 1380 1390 1400
EINLQSGEIF TKTVFDREKK GAYALEVEAR DGAPSARPNS NGPNSVTKFI
1410 1420 1430 1440 1450
RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD HDESSRIRYE
1460 1470 1480 1490 1500
ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV
1510 1520 1530 1540 1550
IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN
1560 1570 1580 1590 1600
IVYFLTGQGI DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV
1610 1620 1630 1640 1650
FAQDEGGEGL VGYADVQVNL KDINDNAPIF PQGVYFGNVT ENGTAGMVVM
1660 1670 1680 1690 1700
TMTAVDYDDP NEGSNARLVY SIEKNVIEEE TGSPIFEIEP DTGVIKTAVC
1710 1720 1730 1740 1750
CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP QFTKDEWFTE
1760 1770 1780 1790 1800
VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND
1810 1820 1830 1840 1850
GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK
1860 1870 1880 1890 1900
LRDINDNKPH FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI
1910 1920 1930 1940 1950
DRSSDRQRQF AINQNGSVTI QRSLDREVVP RHQVKILAID DGSPPKTATA
1960 1970 1980 1990 2000
TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP RKVVEILATD DDDRSKSNGP
2010 2020 2030 2040 2050
PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS FDREQQKEYM
2060 2070 2080 2090 2100
IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT
2110 2120 2130 2140 2150
PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY
2160 2170 2180 2190 2200
HLRFKVYDRK HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR
2210 2220 2230 2240 2250
VWNYRTQSMS RSKMDRFRDK LADLLNTERE NVDIFSVQLK RKHPPLTDVR
2260 2270 2280 2290 2300
FSAHGSPYYK PVRLNGIVLM HREEIEKDVG INITMVGIDE CLYENQMCEG
2310 2320 2330 2340 2350
SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF TKPESCRTTP
2360 2370 2380 2390 2400
CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE
2410 2420 2430 2440 2450
SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID
2460 2470 2480 2490 2500
FGSGTLELRV KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED
2510 2520 2530 2540 2550
GTPPEFDDMS CQARGQIPPF NEYLNVNAPL QVGGLYREQF DQSLYFWHYM
2560 2570 2580 2590 2600
PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN SVAGCPQTEE VCAQTETTAR
2610 2620 2630 2640 2650
CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS YVKYALSFEP
2660 2670 2680 2690 2700
DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL
2710 2720 2730 2740 2750
RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV
2760 2770 2780 2790 2800
GHQWLLVDKQ EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL
2810 2820 2830 2840 2850
PPAMNGTQWG QATMARNLEK GCPSNKPCSN VICPDPFECV DLWNVYECTC
2860 2870 2880 2890 2900
GEGRIMSPDS KGCMDRNECL DMPCMNGATC INLEPRLRYR CICPDGFWGE
2910 2920 2930 2940 2950
NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR RREAHIKYPG
2960 2970 2980 2990 3000
PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM
3010 3020 3030 3040 3050
YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG
3060 3070 3080 3090
SLSSLASGTD DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL
Length:3,097
Mass (Da):347,204
Last modified:June 1, 2000 - v2
Checksum:i082242F28D9B5CC3
GO
Isoform A (identifier: O15943-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,741
Checksum:i37E1B66D6CA30974
GO
Isoform B (identifier: O15943-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,863
Checksum:i5A7B35628893589D
GO
Isoform C (identifier: O15943-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,500
Checksum:iCB4EBB76A3574D75
GO
Isoform E (identifier: O15943-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV

Show »
Length:3,097
Mass (Da):347,082
Checksum:i867FD871827F6C92
GO
Isoform F (identifier: O15943-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,962
Checksum:i98BA24979B02FA5A
GO
Isoform G (identifier: O15943-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,840
Checksum:iF520A7987F32ABB3
GO
Isoform H (identifier: O15943-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,622
Checksum:iE1CDB4929306A434
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1342P → A in BAA22151 (PubMed:9247265).Curated1
Sequence conflicti2786S → T in BAA22151 (PubMed:9247265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1425E → K in allele CADN-M12; muscle defects. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0006671147 – 1206ETYKL…KVVSI → DRYRLRVSASDKGTPASAAD VDVELDVVDRNNKPPIWDKS IYGPIHIRENVTVGTVVTSV in isoform A, isoform C, isoform E and isoform G. CuratedAdd BLAST60
Alternative sequenceiVSP_0006681486 – 1536RLAAS…PKRVL → KLVASDSLNENQTTIVINVR DVNDLPPQFPQTSYERTLDE GMTNTPFTIM in isoform A, isoform B, isoform C and isoform H. CuratedAdd BLAST51
Alternative sequenceiVSP_0006692851 – 2930GEGRI…LIILI → PAGYKSSGSTCVNDNECLLF PCRNGGRCRDHHPPKKYECH CPMGFTGMHCELELLASGVL TPSRDFIVALALCLGTLIL in isoform C, isoform F, isoform G and isoform H. CuratedAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002397 mRNA. Translation: BAA22151.1.
AE014134 Genomic DNA. Translation: AAF53635.1.
AE014134 Genomic DNA. Translation: AAN10992.1.
AE014134 Genomic DNA. Translation: AAN10993.1.
AE014134 Genomic DNA. Translation: AAN10994.1.
AE014134 Genomic DNA. Translation: AAN10995.1.
AE014134 Genomic DNA. Translation: AAN10996.1.
AE014134 Genomic DNA. Translation: AAN10997.1.
AE014134 Genomic DNA. Translation: AAN10998.1.
PIRiT00021.
RefSeqiNP_724068.1. NM_165224.2. [O15943-8]
NP_724069.1. NM_165225.2. [O15943-3]
NP_724070.1. NM_165226.2. [O15943-6]
NP_724071.1. NM_165227.3. [O15943-1]
NP_724072.1. NM_165228.2. [O15943-4]
NP_724073.1. NM_165229.2. [O15943-2]
NP_724074.1. NM_165230.2. [O15943-7]
NP_724075.1. NM_165231.3. [O15943-5]
UniGeneiDm.5768.

Genome annotation databases

EnsemblMetazoaiFBtr0081015; FBpp0080568; FBgn0015609. [O15943-1]
GeneIDi35070.
KEGGidme:Dmel_CG7100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002397 mRNA. Translation: BAA22151.1.
AE014134 Genomic DNA. Translation: AAF53635.1.
AE014134 Genomic DNA. Translation: AAN10992.1.
AE014134 Genomic DNA. Translation: AAN10993.1.
AE014134 Genomic DNA. Translation: AAN10994.1.
AE014134 Genomic DNA. Translation: AAN10995.1.
AE014134 Genomic DNA. Translation: AAN10996.1.
AE014134 Genomic DNA. Translation: AAN10997.1.
AE014134 Genomic DNA. Translation: AAN10998.1.
PIRiT00021.
RefSeqiNP_724068.1. NM_165224.2. [O15943-8]
NP_724069.1. NM_165225.2. [O15943-3]
NP_724070.1. NM_165226.2. [O15943-6]
NP_724071.1. NM_165227.3. [O15943-1]
NP_724072.1. NM_165228.2. [O15943-4]
NP_724073.1. NM_165229.2. [O15943-2]
NP_724074.1. NM_165230.2. [O15943-7]
NP_724075.1. NM_165231.3. [O15943-5]
UniGeneiDm.5768.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UBFX-ray2.50A439-753[»]
3UBGX-ray2.50A/B439-753[»]
3UBHX-ray2.70A434-851[»]
ProteinModelPortaliO15943.
SMRiO15943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61066. 6 interactors.
IntActiO15943. 8 interactors.
MINTiMINT-1327969.
STRINGi7227.FBpp0099721.

Proteomic databases

PaxDbiO15943.
PRIDEiO15943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081015; FBpp0080568; FBgn0015609. [O15943-1]
GeneIDi35070.
KEGGidme:Dmel_CG7100.

Organism-specific databases

CTDi35070.
FlyBaseiFBgn0015609. CadN.

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiO15943.
OrthoDBiEOG091G00V9.
PhylomeDBiO15943.

Miscellaneous databases

GenomeRNAii35070.
PROiO15943.

Gene expression databases

BgeeiFBgn0015609.
ExpressionAtlasiO15943. baseline.
GenevisibleiO15943. DM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 13 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 16 hits.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADN_DROME
AccessioniPrimary (citable) accession number: O15943
Secondary accession number(s): Q9VJB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2000
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.