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O15943

- CADN_DROME

UniProt

O15943 - CADN_DROME

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Protein

Neural-cadherin

Gene
CadN, CG7100
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.

GO - Molecular functioni

  1. beta-catenin binding Source: FlyBase
  2. cadherin binding Source: FlyBase
  3. calcium ion binding Source: FlyBase
  4. cell adhesion molecule binding Source: FlyBase
  5. protein binding Source: UniProtKB
  6. protein homodimerization activity Source: FlyBase
  7. receptor activity Source: FlyBase

GO - Biological processi

  1. axonal fasciculation Source: FlyBase
  2. axon extension Source: FlyBase
  3. axon extension involved in axon guidance Source: FlyBase
  4. axon guidance Source: FlyBase
  5. axon target recognition Source: FlyBase
  6. calcium-dependent cell-cell adhesion Source: FlyBase
  7. cell-cell adhesion mediated by cadherin Source: FlyBase
  8. homophilic cell adhesion Source: FlyBase
  9. negative regulation of dendrite morphogenesis Source: FlyBase
  10. ommatidial rotation Source: FlyBase
  11. R7 cell development Source: FlyBase
  12. R8 cell development Source: FlyBase
  13. regulation of axon extension involved in axon guidance Source: FlyBase
  14. regulation of dendrite morphogenesis Source: FlyBase
  15. retinal ganglion cell axon guidance Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural-cadherin
Alternative name(s):
Cadherin-N
Short name:
dN-cadherin
Gene namesi
Name:CadN
ORF Names:CG7100
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015609. CadN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 2916Extracellular Reviewed prediction
Transmembranei2917 – 293721Helical; Reviewed predictionAdd
BLAST
Topological domaini2938 – 3097160Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: FlyBase
  2. cell-cell junction Source: FlyBase
  3. dendrite Source: FlyBase
  4. integral component of membrane Source: FlyBase
  5. integral component of plasma membrane Source: FlyBase
  6. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3097Neural-cadherinPRO_0000003882
Signal peptidei1 – 3636 Reviewed predictionAdd
BLAST
Propeptidei37 – ?PRO_0000003881

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi930 – 9301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1266 – 12661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2346 ↔ 2357 Reviewed prediction
Disulfide bondi2351 ↔ 2366 Reviewed prediction
Disulfide bondi2368 ↔ 2377 Reviewed prediction
Disulfide bondi2559 ↔ 2585 By similarity
Disulfide bondi2592 ↔ 2607 Reviewed prediction
Disulfide bondi2601 ↔ 2616 Reviewed prediction
Disulfide bondi2618 ↔ 2627 Reviewed prediction
Disulfide bondi2787 ↔ 2822 By similarity
Disulfide bondi2869 ↔ 2880 Reviewed prediction
Disulfide bondi2874 ↔ 2891 Reviewed prediction
Disulfide bondi2893 ↔ 2902 Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15943.
PRIDEiO15943.

Expressioni

Tissue specificityi

In the embryo, the protein first appears in the mesoderm at stage 9 and is present in the myoblasts and muscle fibers by stage 12 and stage 14, respectively. At stage 12 the protein is also located in the axons of the entire CNS, but not in the glial cells. In third instar larvae protein is expressed in the CNS neuropile, photoreceptor axons and precursors of adult muscles.

Gene expression databases

BgeeiO15943.

Interactioni

Protein-protein interaction databases

BioGridi61066. 5 interactions.
IntActiO15943. 1 interaction.
MINTiMINT-1327969.

Structurei

Secondary structure

1
3097
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi440 – 45011
Helixi451 – 4533
Beta strandi459 – 4624
Beta strandi466 – 4694
Beta strandi471 – 4766
Beta strandi479 – 4835
Beta strandi487 – 4937
Helixi497 – 4993
Beta strandi505 – 5139
Beta strandi519 – 5213
Beta strandi525 – 53410
Beta strandi546 – 5549
Beta strandi563 – 5664
Beta strandi578 – 58912
Beta strandi591 – 5933
Turni595 – 5973
Beta strandi599 – 6024
Beta strandi604 – 6063
Beta strandi613 – 62311
Beta strandi632 – 6343
Beta strandi638 – 6458
Beta strandi650 – 66112
Beta strandi669 – 6724
Beta strandi683 – 69210
Turni694 – 6963
Beta strandi697 – 6993
Turni701 – 7033
Beta strandi705 – 7084
Beta strandi721 – 73515
Beta strandi737 – 74711
Beta strandi755 – 76713
Beta strandi775 – 7784
Helixi787 – 7904
Beta strandi792 – 7976
Beta strandi801 – 8033
Beta strandi808 – 8114
Beta strandi815 – 8184
Beta strandi823 – 83210
Beta strandi839 – 84911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UBFX-ray2.50A439-753[»]
3UBGX-ray2.50A/B439-753[»]
3UBHX-ray2.70A434-851[»]
ProteinModelPortaliO15943.
SMRiO15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 305125Cadherin 1Add
BLAST
Domaini430 – 543114Cadherin 2Add
BLAST
Domaini554 – 65198Cadherin 3Add
BLAST
Domaini660 – 75697Cadherin 4Add
BLAST
Domaini766 – 85893Cadherin 5Add
BLAST
Domaini867 – 968102Cadherin 6Add
BLAST
Domaini978 – 1078101Cadherin 7Add
BLAST
Domaini1087 – 118397Cadherin 8Add
BLAST
Domaini1193 – 1299107Cadherin 9Add
BLAST
Domaini1307 – 1414108Cadherin 10Add
BLAST
Domaini1423 – 151492Cadherin 11Add
BLAST
Domaini1523 – 1630108Cadherin 12Add
BLAST
Domaini1639 – 1742104Cadherin 13Add
BLAST
Domaini1749 – 1861113Cadherin 14Add
BLAST
Domaini1870 – 196697Cadherin 15Add
BLAST
Domaini1974 – 2085112Cadherin 16Add
BLAST
Domaini2346 – 237732EGF-like 1Add
BLAST
Domaini2379 – 2585207Laminin G-like 1Add
BLAST
Domaini2592 – 262736EGF-like 2Add
BLAST
Domaini2631 – 2822192Laminin G-like 2Add
BLAST
Domaini2869 – 290234EGF-like 3Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 16 cadherin domains.
Contains 3 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298859.
GeneTreeiENSGT00750000117611.
InParanoidiO15943.
OrthoDBiEOG718KB7.
PhylomeDBiO15943.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 12 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 16 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform D (identifier: O15943-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA     50
ARMLAGSPGD VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS 100
HSGAAAYHML DTDYSKYFTV LEDGVVMTTA DISPLVNRPV QLVVVEQTPN 150
ATNTHNLQLF VMHRNDMLRF SGSLLDASGE VRENQPAGTR VRGVPLMQAF 200
SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ ISAKSLVING 250
DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 300
NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA 350
YRLKSPSNVV IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA 400
KVLLEFLAAE PVSFIMQHLE HDDINNHSHH REKRRVTRAV RPTKRIEFTE 450
ADGDTEGKSV FQLEKETDKE TFKIRDDNPW VTVETNGAVR VKKKWDYEEL 500
GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP PYFINRPLPM 550
QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 600
RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ 650
FYMPSYEAEI PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG 700
PTSGIVKLAK ELDFEDLRQP HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN 750
DNAPKFELPD YQAHNVDEDI PLGTSILRVK AMDSDSGSNA EIEYLVSDDH 800
FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG VATVRVYTKN 850
KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 900
SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS 950
TAVVVVFITD VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV 1000
NGQVKYSIVQ QPNQKGTKFT VDEETGEVST NKVFDREGDD GKFVSVTVKA 1050
TDQGDPSLEG VCSFTVEITD VNDNPPLFDR QKYVENVKQD ASIGTNILRV 1100
SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL KKPLDRETYK 1150
LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1200
GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD 1250
IKVNHPLDYE SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT 1300
EREQETVLEG EPIGTKVTQV NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF 1350
EINLQSGEIF TKTVFDREKK GAYALEVEAR DGAPSARPNS NGPNSVTKFI 1400
RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD HDESSRIRYE 1450
ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1500
IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN 1550
IVYFLTGQGI DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV 1600
FAQDEGGEGL VGYADVQVNL KDINDNAPIF PQGVYFGNVT ENGTAGMVVM 1650
TMTAVDYDDP NEGSNARLVY SIEKNVIEEE TGSPIFEIEP DTGVIKTAVC 1700
CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP QFTKDEWFTE 1750
VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1800
GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK 1850
LRDINDNKPH FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI 1900
DRSSDRQRQF AINQNGSVTI QRSLDREVVP RHQVKILAID DGSPPKTATA 1950
TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP RKVVEILATD DDDRSKSNGP 2000
PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS FDREQQKEYM 2050
IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2100
PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY 2150
HLRFKVYDRK HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR 2200
VWNYRTQSMS RSKMDRFRDK LADLLNTERE NVDIFSVQLK RKHPPLTDVR 2250
FSAHGSPYYK PVRLNGIVLM HREEIEKDVG INITMVGIDE CLYENQMCEG 2300
SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF TKPESCRTTP 2350
CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2400
SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID 2450
FGSGTLELRV KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED 2500
GTPPEFDDMS CQARGQIPPF NEYLNVNAPL QVGGLYREQF DQSLYFWHYM 2550
PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN SVAGCPQTEE VCAQTETTAR 2600
CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS YVKYALSFEP 2650
DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2700
RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV 2750
GHQWLLVDKQ EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL 2800
PPAMNGTQWG QATMARNLEK GCPSNKPCSN VICPDPFECV DLWNVYECTC 2850
GEGRIMSPDS KGCMDRNECL DMPCMNGATC INLEPRLRYR CICPDGFWGE 2900
NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR RREAHIKYPG 2950
PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM 3000
YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG 3050
SLSSLASGTD DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL 3097
Length:3,097
Mass (Da):347,204
Last modified:June 1, 2000 - v2
Checksum:i082242F28D9B5CC3
GO
Isoform A (identifier: O15943-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,741
Checksum:i37E1B66D6CA30974
GO
Isoform B (identifier: O15943-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM

Show »
Length:3,096
Mass (Da):346,863
Checksum:i5A7B35628893589D
GO
Isoform C (identifier: O15943-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,500
Checksum:iCB4EBB76A3574D75
GO
Isoform E (identifier: O15943-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV

Show »
Length:3,097
Mass (Da):347,082
Checksum:i867FD871827F6C92
GO
Isoform F (identifier: O15943-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,962
Checksum:i98BA24979B02FA5A
GO
Isoform G (identifier: O15943-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1206: ETYKLEAMAQ...MPVGGKVVSI → DRYRLRVSAS...VTVGTVVTSV
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,096
Mass (Da):346,840
Checksum:iF520A7987F32ABB3
GO
Isoform H (identifier: O15943-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1486-1536: RLAASDNLKE...DDRNLPKRVL → KLVASDSLNE...GMTNTPFTIM
     2851-2930: GEGRIMSPDS...ILVCLLIILI → PAGYKSSGST...LALCLGTLIL

Show »
Length:3,095
Mass (Da):346,622
Checksum:iE1CDB4929306A434
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1425 – 14251E → K in allele CADN-M12; muscle defects.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1147 – 120660ETYKL…KVVSI → DRYRLRVSASDKGTPASAAD VDVELDVVDRNNKPPIWDKS IYGPIHIRENVTVGTVVTSV in isoform A, isoform C, isoform E and isoform G. VSP_000667Add
BLAST
Alternative sequencei1486 – 153651RLAAS…PKRVL → KLVASDSLNENQTTIVINVR DVNDLPPQFPQTSYERTLDE GMTNTPFTIM in isoform A, isoform B, isoform C and isoform H. VSP_000668Add
BLAST
Alternative sequencei2851 – 293080GEGRI…LIILI → PAGYKSSGSTCVNDNECLLF PCRNGGRCRDHHPPKKYECH CPMGFTGMHCELELLASGVL TPSRDFIVALALCLGTLIL in isoform C, isoform F, isoform G and isoform H. VSP_000669Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1342 – 13421P → A in BAA22151. 1 Publication
Sequence conflicti2786 – 27861S → T in BAA22151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002397 mRNA. Translation: BAA22151.1.
AE014134 Genomic DNA. Translation: AAF53635.1.
AE014134 Genomic DNA. Translation: AAN10992.1.
AE014134 Genomic DNA. Translation: AAN10993.1.
AE014134 Genomic DNA. Translation: AAN10994.1.
AE014134 Genomic DNA. Translation: AAN10995.1.
AE014134 Genomic DNA. Translation: AAN10996.1.
AE014134 Genomic DNA. Translation: AAN10997.1.
AE014134 Genomic DNA. Translation: AAN10998.1.
PIRiT00021.
RefSeqiNP_724068.1. NM_165224.2. [O15943-8]
NP_724069.1. NM_165225.2. [O15943-3]
NP_724070.1. NM_165226.2. [O15943-6]
NP_724071.1. NM_165227.3. [O15943-1]
NP_724072.1. NM_165228.2. [O15943-4]
NP_724073.1. NM_165229.2. [O15943-2]
NP_724074.1. NM_165230.2. [O15943-7]
NP_724075.1. NM_165231.3. [O15943-5]
UniGeneiDm.5768.

Genome annotation databases

EnsemblMetazoaiFBtr0081015; FBpp0080568; FBgn0015609. [O15943-1]
GeneIDi35070.
KEGGidme:Dmel_CG7100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002397 mRNA. Translation: BAA22151.1 .
AE014134 Genomic DNA. Translation: AAF53635.1 .
AE014134 Genomic DNA. Translation: AAN10992.1 .
AE014134 Genomic DNA. Translation: AAN10993.1 .
AE014134 Genomic DNA. Translation: AAN10994.1 .
AE014134 Genomic DNA. Translation: AAN10995.1 .
AE014134 Genomic DNA. Translation: AAN10996.1 .
AE014134 Genomic DNA. Translation: AAN10997.1 .
AE014134 Genomic DNA. Translation: AAN10998.1 .
PIRi T00021.
RefSeqi NP_724068.1. NM_165224.2. [O15943-8 ]
NP_724069.1. NM_165225.2. [O15943-3 ]
NP_724070.1. NM_165226.2. [O15943-6 ]
NP_724071.1. NM_165227.3. [O15943-1 ]
NP_724072.1. NM_165228.2. [O15943-4 ]
NP_724073.1. NM_165229.2. [O15943-2 ]
NP_724074.1. NM_165230.2. [O15943-7 ]
NP_724075.1. NM_165231.3. [O15943-5 ]
UniGenei Dm.5768.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UBF X-ray 2.50 A 439-753 [» ]
3UBG X-ray 2.50 A/B 439-753 [» ]
3UBH X-ray 2.70 A 434-851 [» ]
ProteinModelPortali O15943.
SMRi O15943. Positions 438-2111, 2330-2770, 2822-2905, 2991-3084.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61066. 5 interactions.
IntActi O15943. 1 interaction.
MINTi MINT-1327969.

Proteomic databases

PaxDbi O15943.
PRIDEi O15943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081015 ; FBpp0080568 ; FBgn0015609 . [O15943-1 ]
GeneIDi 35070.
KEGGi dme:Dmel_CG7100.

Organism-specific databases

CTDi 35070.
FlyBasei FBgn0015609. CadN.

Phylogenomic databases

eggNOGi NOG298859.
GeneTreei ENSGT00750000117611.
InParanoidi O15943.
OrthoDBi EOG718KB7.
PhylomeDBi O15943.

Miscellaneous databases

GenomeRNAii 35070.
NextBioi 791671.

Gene expression databases

Bgeei O15943.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 17 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00028. Cadherin. 12 hits.
PF01049. Cadherin_C. 1 hit.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 16 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 18 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00232. CADHERIN_1. 9 hits.
PS50268. CADHERIN_2. 16 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS."
    Iwai Y., Usui T., Hirano S., Steward R., Takeichi M., Uemura T.
    Neuron 19:77-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D).
    Tissue: Embryo and Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. "Roles of Armadillo, a Drosophila catenin, during central nervous system development."
    Loureiro J., Peifer M.
    Curr. Biol. 8:622-632(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARM.

Entry informationi

Entry nameiCADN_DROME
AccessioniPrimary (citable) accession number: O15943
Secondary accession number(s): Q9VJB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2000
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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