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O15910 (RIR2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene names
Name:RNR2
Synonyms:NRDB
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Ribonucleoside-diphosphate reductase small chain
PRO_0000190460

Sites

Active site1231 By similarity
Metal binding851Iron 1 By similarity
Metal binding1161Iron 1 By similarity
Metal binding1161Iron 2 By similarity
Metal binding1191Iron 1 By similarity
Metal binding1781Iron 2 By similarity
Metal binding2121Iron 2 By similarity
Metal binding2151Iron 2 By similarity

Experimental info

Sequence conflict8 – 103CSR → RSA in CAA71741. Ref.2
Sequence conflict431E → K in CAA71741. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O15910 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: BD39919280C65CAE

FASTA33739,009
        10         20         30         40         50         60 
MPPKSHKCSR KEGEVEEPLL TENPDRYVIF PIKYPDIWQK YKEAESSIWT VEEIDLGNDM 

        70         80         90        100        110        120 
TDWEKLDDGE RHFIKHVLAF FAASDGIVLE NLAERFMCEV QVPEVRCFYG FQIAMENIHS 

       130        140        150        160        170        180 
ETYSVLIDTY VVDPDEKQRL LHAIRTIPCI EKKAKWAIEW IGSQTSFPTR LVAFAAVEGI 

       190        200        210        220        230        240 
FFSGSFCAIF WLKKRGLMPG LTFSNELISR DEGLHTDFAC LLYEKYIVNK LPRDRVLEII 

       250        260        270        280        290        300 
CNAVSIEREF ICDALPVRLI GMNSQLMTQY IEFVADRLLV SLGYDRHYNS KNPFDFMDMI 

       310        320        330 
SLQGKTNFFE KKVGEYQKAG VMSSERSSKV FSLDADF 

« Hide

References

[1]"Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei."
Hofer A., Schmidt P.P., Graslund A., Thelander L.
Proc. Natl. Acad. Sci. U.S.A. 94:6959-6964(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 427.
[2]"Cloning, sequencing and expression of ribonucleotide reductase R2 from Trypanosoma brucei."
Dormeyer M., Schoneck R., Dittmar G.A.G., Krauth-Siegel R.L.
FEBS Lett. 414:449-453(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80911 mRNA. Translation: AAB70705.1.
Y10768 Genomic DNA. Translation: CAA71741.1.

3D structure databases

ProteinModelPortalO15910.
SMRO15910. Positions 16-298.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0208.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_TRYBB
AccessionPrimary (citable) accession number: O15910
Secondary accession number(s): O15880
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways