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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 2By similarity1
Metal bindingi119Iron 1PROSITE-ProRule annotation1
Active sitei123PROSITE-ProRule annotation1
Metal bindingi178Iron 2By similarity1
Metal bindingi212Iron 2By similarity1
Metal bindingi215Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene namesi
Name:RNR2
Synonyms:NRDB
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904601 – 337Ribonucleoside-diphosphate reductase small chainAdd BLAST337

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliO15910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKSHKCSR KEGEVEEPLL TENPDRYVIF PIKYPDIWQK YKEAESSIWT
60 70 80 90 100
VEEIDLGNDM TDWEKLDDGE RHFIKHVLAF FAASDGIVLE NLAERFMCEV
110 120 130 140 150
QVPEVRCFYG FQIAMENIHS ETYSVLIDTY VVDPDEKQRL LHAIRTIPCI
160 170 180 190 200
EKKAKWAIEW IGSQTSFPTR LVAFAAVEGI FFSGSFCAIF WLKKRGLMPG
210 220 230 240 250
LTFSNELISR DEGLHTDFAC LLYEKYIVNK LPRDRVLEII CNAVSIEREF
260 270 280 290 300
ICDALPVRLI GMNSQLMTQY IEFVADRLLV SLGYDRHYNS KNPFDFMDMI
310 320 330
SLQGKTNFFE KKVGEYQKAG VMSSERSSKV FSLDADF
Length:337
Mass (Da):39,009
Last modified:January 1, 1998 - v1
Checksum:iBD39919280C65CAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 10CSR → RSA in CAA71741 (PubMed:9315738).Curated3
Sequence conflicti43E → K in CAA71741 (PubMed:9315738).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80911 mRNA. Translation: AAB70705.1.
Y10768 Genomic DNA. Translation: CAA71741.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80911 mRNA. Translation: AAB70705.1.
Y10768 Genomic DNA. Translation: CAA71741.1.

3D structure databases

ProteinModelPortaliO15910.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_TRYBB
AccessioniPrimary (citable) accession number: O15910
Secondary accession number(s): O15880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.