dut

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	48	Calcium 1Combined sources	1
Metal bindingⁱ	48	Calcium 2Combined sources	1
Metal bindingⁱ	48	Magnesium 1Combined sources	1
Metal bindingⁱ	48	Magnesium 2Combined sources	1
Metal bindingⁱ	51	Calcium 1Combined sources	1
Metal bindingⁱ	51	Calcium 2Combined sources	1
Metal bindingⁱ	51	Magnesium 1Combined sources	1
Metal bindingⁱ	51	Magnesium 2Combined sources	1
Metal bindingⁱ	76	Calcium 2Combined sources	1
Metal bindingⁱ	76	Magnesium 2Combined sources	1
Metal bindingⁱ	79	Calcium 2Combined sources	1
Metal bindingⁱ	79	Magnesium 2Combined sources	1

GO - Molecular functionⁱ

dUTP diphosphatase activity Source: UniProtKB-EC
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HydrolaseImported
Ligand	CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

SABIO-RKⁱ	O15826.

SABIO-RKⁱ

O15826.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative deoxyuridine triphosphataseImported Submitted name: dUTPaseImported (EC:3.6.1.23Imported)
Gene namesⁱ	Name:dutImported Synonyms:DUTImported ORF Names:LMJF_06_0560Imported
Organismⁱ	Leishmania majorImported
Taxonomic identifierⁱ	5664 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › Leishmania › Leishmania major species complex
Proteomesⁱ	UP000000542 Componentⁱ: Chromosome 6

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4418.

ChEMBLⁱ

CHEMBL4418.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	5664.LmjF.06.0560.

STRINGⁱ

5664.LmjF.06.0560.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CJE	X-ray	2.34	A	1-268	[»]
	2YAY	X-ray	1.86	A	1-268	[»]
	2YAZ	X-ray	2.40	A/B/D/E	1-268	[»]
	2YB0	X-ray	2.28	A/B/D/E	1-268	[»]
SMRⁱ	O15826.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410K2HU. Eukaryota. ENOG4112CGJ. LUCA.
HOGENOMⁱ	HOG000255273.
KEGG Orthology (KO) More...KOⁱ	K01520.
OMAⁱ	FRQDHGY.

Family and domain databases

InterProⁱ	View protein in InterPro IPR014871. dUTPase/dCTP_pyrophosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08761. dUTPase_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O15826-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRARSANIP GAILHSLAEL QDGLNAMIDP SWRAVRSLDN WALAITMEST 
        60         70         80         90        100
ELLDSYPWKW WKNLNATPDL ANVRIELVDI FHFSLSGAMQ MRSTPDDEIP 
       110        120        130        140        150
AASLKPLKEV MTTFLPAKEC TSDPYGFVFF PLTDTQNAIA SFRNIIQLAN 
       160        170        180        190        200
AYRFDVIIEC IIYAAEDLGF NLVAYYIAKH TLNCIRQLSG YKDGSYVKVN 
       210        220        230        240        250
NGVEDNSLLH NCIKDVSLDE VLDADKYVQA WNSIMANVYE AFQIKESDRK 
       260 
DAERWFALAK ENRLAIKA

Length:268

Mass (Da):30,354

Last modified:January 1, 1998 - v1

Checksum:ⁱB1F230CD5752F5F1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L76742 mRNA. Translation: AAC02795.1. FR796402 Genomic DNA. Translation: CAJ02101.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001680826.1. XM_001680774.1.

Genome annotation databases

EnsemblProtistsⁱ	LmjF.06.0560:mRNA; LmjF.06.0560:pep; LmjF.06.0560.
GeneDBⁱ	LmjF.06.0560:pep.
GeneIDⁱ	5649078.
KEGGⁱ	lma:LMJF_06_0560.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O15826	UPI0002003D4E A4HSU8 E9B8R8 E9AKT5	Leishmania major Leishmania infantum Leishmania donovani (strain BPK282A1) Leishmania mexicana (strain MHOM/GT/2001/U1103)	268	UniRef90_O15826	Cluster: Putative deoxyuridine triphosphatase	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O15826	UPI0002003D4E A4HSU8 E9B8R8 E9AKT5 A4H4M2 A0A088RKC7 A0A1E1IP56 W6KUU1 S9WGN8 S9V7M2 +6	Leishmania major Leishmania infantum Leishmania donovani (strain BPK282A1) Leishmania mexicana (strain MHOM/GT/2001/U1103) Leishmania braziliensis Leishmania panamensis Leishmania guyanensis Phytomonas sp. isolate EM1 Angomonas deanei Phytomonas sp. isolate Hart1 And more	268	UniRef50_O15826	Cluster: Putative deoxyuridine triphosphatase	17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L76742 mRNA. Translation: AAC02795.1. FR796402 Genomic DNA. Translation: CAJ02101.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001680826.1. XM_001680774.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CJE	X-ray	2.34	A	1-268	[»]
	2YAY	X-ray	1.86	A	1-268	[»]
	2YAZ	X-ray	2.40	A/B/D/E	1-268	[»]
	2YB0	X-ray	2.28	A/B/D/E	1-268	[»]
SMRⁱ	O15826.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	5664.LmjF.06.0560.

STRINGⁱ

5664.LmjF.06.0560.

Chemistry databases

ChEMBLⁱ	CHEMBL4418.

ChEMBLⁱ

CHEMBL4418.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	LmjF.06.0560:mRNA; LmjF.06.0560:pep; LmjF.06.0560.
GeneDBⁱ	LmjF.06.0560:pep.
GeneIDⁱ	5649078.
KEGGⁱ	lma:LMJF_06_0560.

Phylogenomic databases

eggNOGⁱ	ENOG410K2HU. Eukaryota. ENOG4112CGJ. LUCA.
HOGENOMⁱ	HOG000255273.
KEGG Orthology (KO) More...KOⁱ	K01520.
OMAⁱ	FRQDHGY.

Enzyme and pathway databases

SABIO-RKⁱ	O15826.

SABIO-RKⁱ

O15826.

Family and domain databases

InterProⁱ	View protein in InterPro IPR014871. dUTPase/dCTP_pyrophosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08761. dUTPase_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O15826_LEIMA
Accessionⁱ	O15826Primary (citable) accession number: O15826 Secondary accession number(s): Q4QJ22
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 1, 1998
	Last sequence update:	January 1, 1998
	Last modified:	March 28, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB - O15826 (O15826_LEIMA)

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Putative deoxyuridine triphosphatase

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Functionⁱ

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Chemistry databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15826 (O15826_LEIMA)

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Putative deoxyuridine triphosphatase

dut

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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Enzyme and pathway databases

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Chemistry databases

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Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ