dut

Functionⁱ

Sites

Feature key	Position(s)	Length	Description
Metal bindingⁱ	48 – 48	1	Calcium 1Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	48 – 48	1	Calcium 2Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	48 – 48	1	MagnesiumCombined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2CJE PDB:2YAZ
Metal bindingⁱ	51 – 51	1	Calcium 1Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	51 – 51	1	Calcium 2Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	51 – 51	1	MagnesiumCombined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2CJE
Metal bindingⁱ	76 – 76	1	Calcium 2Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	76 – 76	1	MagnesiumCombined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2CJE PDB:2YAZ
Metal bindingⁱ	79 – 79	1	Calcium 2Combined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2YAY
Metal bindingⁱ	79 – 79	1	MagnesiumCombined sources Automatic assertion inferred from combination of experimental and computational evidenceⁱ PDB:2CJE PDB:2YAZ

GO - Molecular functionⁱ

dUTP diphosphatase activity Source: UniProtKB-EC
metal ion binding Source: UniProtKB-KW

Complete GO annotation...

Keywords - Molecular functionⁱ

HydrolaseImported

Keywords - Ligandⁱ

CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

SABIO-RK	O15826.

SABIO-RK

O15826.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DUTPaseImported Automatic assertion inferred from database entriesⁱ EMBL:AAC02795.1 (EC:3.6.1.23Imported Automatic assertion inferred from database entriesⁱ EMBL:AAC02795.1 EMBL:CAJ02101.1 ) Submitted name: Putative deoxyuridine triphosphataseImported Automatic assertion inferred from database entriesⁱ EMBL:CAJ02101.1
Gene namesⁱ	Name:dutImported Automatic assertion inferred from database entriesⁱ EMBL:AAC02795.1 Synonyms:DUTImported Automatic assertion inferred from database entriesⁱ EMBL:CAJ02101.1 ORF Names:LMJF_06_0560Imported Automatic assertion inferred from database entriesⁱ EMBL:CAJ02101.1
Organismⁱ	Leishmania majorImported Automatic assertion inferred from database entriesⁱ EMBL:AAC02795.1
Taxonomic identifierⁱ	5664 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › Leishmania › Leishmania major species complex
Proteomesⁱ	UP000000542 Componentⁱ: Chromosome 6

Pathology & Biotechⁱ

Chemistry

ChEMBLⁱ	CHEMBL4418.

ChEMBLⁱ

CHEMBL4418.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	5664.LmjF.06.0560.

STRINGⁱ

5664.LmjF.06.0560.

Structureⁱ

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CJE	X-ray	2.34	A	1-268	[»]
2YAY	X-ray	1.86	A	1-268	[»]
2YAZ	X-ray	2.40	A/B/D/E	1-268	[»]
2YB0	X-ray	2.28	A/B/D/E	1-268	[»]

SMRⁱ

O15826. Positions 8-265.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410K2HU. Eukaryota. ENOG4112CGJ. LUCA.
HOGENOMⁱ	HOG000255273.
KOⁱ	K01520.
OMAⁱ	FRQDHGY.

Family and domain databases

InterProⁱ	IPR014871. dUTPase/dCTP_pyrophosphatase. [Graphical view]
Pfamⁱ	PF08761. dUTPase_2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

O15826-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRARSANIP GAILHSLAEL QDGLNAMIDP SWRAVRSLDN WALAITMEST 
        60         70         80         90        100
ELLDSYPWKW WKNLNATPDL ANVRIELVDI FHFSLSGAMQ MRSTPDDEIP 
       110        120        130        140        150
AASLKPLKEV MTTFLPAKEC TSDPYGFVFF PLTDTQNAIA SFRNIIQLAN 
       160        170        180        190        200
AYRFDVIIEC IIYAAEDLGF NLVAYYIAKH TLNCIRQLSG YKDGSYVKVN 
       210        220        230        240        250
NGVEDNSLLH NCIKDVSLDE VLDADKYVQA WNSIMANVYE AFQIKESDRK 
       260 
DAERWFALAK ENRLAIKA

Length:268

Mass (Da):30,354

Last modified:January 1, 1998 - v1

Checksum:ⁱB1F230CD5752F5F1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L76742 mRNA. Translation: AAC02795.1. FR796402 Genomic DNA. Translation: CAJ02101.1.
RefSeqⁱ	XP_001680826.1. XM_001680774.1.

Genome annotation databases

EnsemblProtistsⁱ	LmjF.06.0560:mRNA; LmjF.06.0560:pep; LmjF.06.0560.
GeneIDⁱ	5649078.
KEGGⁱ	lma:LMJF_06_0560.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L76742 mRNA. Translation: AAC02795.1. FR796402 Genomic DNA. Translation: CAJ02101.1.
RefSeqⁱ	XP_001680826.1. XM_001680774.1.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CJE	X-ray	2.34	A	1-268	[»]
2YAY	X-ray	1.86	A	1-268	[»]
2YAZ	X-ray	2.40	A/B/D/E	1-268	[»]
2YB0	X-ray	2.28	A/B/D/E	1-268	[»]

SMRⁱ

O15826. Positions 8-265.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protein-protein interaction databases

STRINGⁱ	5664.LmjF.06.0560.

STRINGⁱ

5664.LmjF.06.0560.

Chemistry

ChEMBLⁱ	CHEMBL4418.

ChEMBLⁱ

CHEMBL4418.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblProtistsⁱ	LmjF.06.0560:mRNA; LmjF.06.0560:pep; LmjF.06.0560.
GeneIDⁱ	5649078.
KEGGⁱ	lma:LMJF_06_0560.

Phylogenomic databases

eggNOGⁱ	ENOG410K2HU. Eukaryota. ENOG4112CGJ. LUCA.
HOGENOMⁱ	HOG000255273.
KOⁱ	K01520.
OMAⁱ	FRQDHGY.

Enzyme and pathway databases

SABIO-RK	O15826.

SABIO-RK

O15826.

Family and domain databases

InterProⁱ	IPR014871. dUTPase/dCTP_pyrophosphatase. [Graphical view]
Pfamⁱ	PF08761. dUTPase_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

O15826_LEIMA

Accessionⁱ

Primary (citable) accession number: O15826
Secondary accession number(s): Q4QJ22

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - O15826 (O15826_LEIMA)

UniProt

O15826 - O15826_LEIMA

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DUTPase

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Functionⁱ

Sites

GO - Molecular functionⁱ

Keywords - Molecular functionⁱ

Keywords - Ligandⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Chemistry

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15826 (O15826_LEIMA)

UniProt

O15826 - O15826_LEIMA

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DUTPase

dut

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ