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Protein

Clustered mitochondria protein homolog

Gene

clua

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation1 Publication

GO - Biological processi

  • intracellular distribution of mitochondria Source: dictyBase
  • mitochondrial fission Source: dictyBase
  • mitochondrial fusion Source: dictyBase
  • mitotic cytokinesis Source: dictyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
Gene namesi
Name:cluaUniRule annotation
ORF Names:DDB_G0292806
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0292806. cluA.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Causes mitochondria to cluster within cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Clustered mitochondria protein homologPRO_0000123555Add
BLAST

Proteomic databases

PaxDbiO15818.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215379.

Structurei

3D structure databases

ProteinModelPortaliO15818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati955 – 98834TPR 1Add
BLAST
Repeati997 – 103034TPR 2Add
BLAST
Repeati1039 – 107234TPR 3Add
BLAST
Repeati1081 – 111434TPR 4Add
BLAST
Repeati1123 – 115634TPR 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi178 – 1858Poly-Gln
Compositional biasi562 – 5654Poly-Glu
Compositional biasi1250 – 126314Poly-ThrAdd
BLAST

Sequence similaritiesi

Belongs to the CLU family.UniRule annotation
Contains 5 TPR repeats.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
InParanoidiO15818.
KOiK03255.
OMAiQFWESEL.
PhylomeDBiO15818.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR007967. DUF727.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
PF05303. DUF727. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

O15818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETIDNPTV EEYNEKETVV SGEQVEQVEQ VEQENEQVSQ SFQISIKTPA
60 70 80 90 100
EIGTINIQVQ PTDTLIDIQS FLYETSETCL YSSFEFRLYG KQIPEYSELS
110 120 130 140 150
SIEGLVEGAT LEMVPVDYNE RSAKLHVKRL RDIMNTGLTE FANMNNPSLF
160 170 180 190 200
TSFSFPEKSN ILTEEQQLEE QKQKFEQQQQ QQQQTEDKEE KETIATEQQQ
210 220 230 240 250
NKKNKHHNKK GNKKNNGDES LNNENNEEKL TPQQKERKQK MTEIKGIDKP
260 270 280 290 300
MLSSYYPESP IAPVQCVKSM IYSGWSPVPG YRKLFGDLFY LDITLLEGTT
310 320 330 340 350
ICVTASTQGF FINQSSNATF NPSVSPKATI NHSLHQLLTQ VSRLFRRGLN
360 370 380 390 400
QILTNIGRNH PFDMLPGVLP VHNWVASSKT NRYDINKGTD TFVSVQDVEL
410 420 430 440 450
RGNPRDWNEE IQAPKELPKS TVQERIIRDR AISKVNSEFV ECAIRGAQVI
460 470 480 490 500
VDKAILPINP AENQRSHMFL YNNIFFSYAL DTRDSFTDCG GDDAARTSAN
510 520 530 540 550
NDLKGIRLYN LADIDGLYTL GTAIVDYKGQ RIIAQSLIPG ILTTEKTSKI
560 570 580 590 600
YYGSMDTPTN EEEEQQQKEE NEENKNNNTK SIKADPEFHS RLLQAASLLH
610 620 630 640 650
LSESKVISED TNQEVSVCTS FESKGIIGID GRRYILDLIK ATPRDPNYTE
660 670 680 690 700
TKDQLSVLRP EAIATYSEYF KVTWLNQKRQ QKLKEKEERQ KKEGIDPPTA
710 720 730 740 750
TARDEDVQLT EEDLAQSPVV SFNPNLFSKV KLGGTPEEQQ KDIEDLKAIG
760 770 780 790 800
AFLKGILIPR LIEDLMLFNV APVDGQTLTQ VMHVRGINMR YLGYIAKNES
810 820 830 840 850
ANVPFIQDLL FNEMVSRAAK HCFNRLLRST NASDMAHSIS HFLNCFLGTE
860 870 880 890 900
TGSVSADEKS KKAKQIKSSA INELTQGKLW SEIAQLVSSK FDFEIPTHSV
910 920 930 940 950
PMESRLIVLR CICLKMGIQI LAKDYNFTTD APFSPEDIVD LFPIVKHVNP
960 970 980 990 1000
RSTDGLDLLE AGKTFFNQRK YELATELLGE ALAIYHQVHG PIHPDAGACF
1010 1020 1030 1040 1050
THLAMLAYQN EQYDLAIEYQ KNALVITEKT AGLDHHETVQ AYTTLAVFCQ
1060 1070 1080 1090 1100
RSGRYNESIG YMKHVLYLTD LLGGEYNPER ASIYTAIAAI LEDTERFDLA
1110 1120 1130 1140 1150
LEFLKQTLKH QEFLFTPDHL MCSTTYHKMA IVCARATNFD DSIIHQKKST
1160 1170 1180 1190 1200
DILEKELGEA HPRTKESLEF YTGLSQTANQ IKLFKQHQAL KAEQDELARL
1210 1220 1230 1240 1250
QKEKADQFKK SQPRVSAMPP SLENGSVSEL LNYINGKPKK SQSKKSKSTN
1260 1270 1280 1290 1300
TTTTTNTTTA TTSKSKITMA KTPNPTTKAT TSKSSATASS AATNKSTTKT
1310 1320
NPTSSSAADS SKPNKKSSKN
Length:1,320
Mass (Da):148,687
Last modified:December 4, 2007 - v2
Checksum:i3EF4E6D787621958
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221G → GEQV in AAC26527 (PubMed:9207087).Curated
Sequence conflicti97 – 982SE → Q in AAC26527 (PubMed:9207087).Curated
Sequence conflicti158 – 1614KSNI → NQY in AAC26527 (PubMed:9207087).Curated
Sequence conflicti1166 – 11661E → Q in AAC26527 (PubMed:9207087).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49332 mRNA. Translation: AAC26527.1.
AAFI02000197 Genomic DNA. Translation: EAL60952.1.
RefSeqiXP_629429.1. XM_629427.1.

Genome annotation databases

EnsemblProtistsiDDB0215379; DDB0215379; DDB_G0292806.
GeneIDi8628948.
KEGGiddi:DDB_G0292806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49332 mRNA. Translation: AAC26527.1.
AAFI02000197 Genomic DNA. Translation: EAL60952.1.
RefSeqiXP_629429.1. XM_629427.1.

3D structure databases

ProteinModelPortaliO15818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215379.

Proteomic databases

PaxDbiO15818.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0215379; DDB0215379; DDB_G0292806.
GeneIDi8628948.
KEGGiddi:DDB_G0292806.

Organism-specific databases

dictyBaseiDDB_G0292806. cluA.

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
InParanoidiO15818.
KOiK03255.
OMAiQFWESEL.
PhylomeDBiO15818.

Miscellaneous databases

PROiO15818.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR007967. DUF727.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
PF05303. DUF727. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cluA-mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria."
    Zhu Q., Hulen D., Liu T., Clarke M.
    Proc. Natl. Acad. Sci. U.S.A. 94:7308-7313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. Bienvenut W.V., Ura S., Insall R.H.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 532-546; 592-605 AND 634-640, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: AX2.

Entry informationi

Entry nameiCLU_DICDI
AccessioniPrimary (citable) accession number: O15818
Secondary accession number(s): Q54CI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 4, 2007
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.