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Protein

Probable RNA 3'-terminal phosphate cyclase

Gene

rtca

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).By similarity

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137ATPBy similarity1
Active sitei354Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi328 – 332ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
Short name:
RNA cyclase
Short name:
RNA-3'-phosphate cyclase
Gene namesi
Name:rtca
Synonyms:R2037, rtc1
ORF Names:DDB_G0276159
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276159 rtc1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564131 – 433Probable RNA 3'-terminal phosphate cyclaseAdd BLAST433

Proteomic databases

PaxDbiO15746

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0185053

Structurei

3D structure databases

ProteinModelPortaliO15746
SMRiO15746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3980 Eukaryota
COG0430 LUCA
InParanoidiO15746
KOiK01974
OMAiANRPKPG
PhylomeDBiO15746

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
SUPFAMiSSF52913 SSF52913, 1 hit
SSF55205 SSF55205, 2 hits
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

O15746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKNKNYNKN QFKKSKTNND TTVAQQQQTI EEKPDFKIDG SILEGGGQIL
60 70 80 90 100
RNSVALASLF NKAISIEKIR YNRDQPGLKN QHKAGIDLMS RLFKAHLTGC
110 120 130 140 150
SVGSCKLYYQ PTQKTIQDDG VIEADTKTAG SICLMIQVSL PCLIFAPHST
160 170 180 190 200
KMVLGGGTNC DFAPAADYIQ NVFLPIATTM GFKCEMSIDK RGFYPKGGGA
210 220 230 240 250
VTLTTQPLTQ PLSPITIVNK GEVNRIVIKS YFTSPRISPL VAERMNNTAK
260 270 280 290 300
KLIKKDFKKV DVETELIDVS KFSFGDGTFI EIRAYTDQGC IFGATGNGAI
310 320 330 340 350
GVPAEKVAED AANSLLKDLQ DGGCMDEYLQ DQLIIFMALA KGKSQIKTGP
360 370 380 390 400
ISLHTQTSIH ITSLMTGAIF TITPLTNNTQ SGEETNLITC EGISYFPSDL
410 420 430
NNNNNNSNSN TTTTTTTTTI STTTIDNQNS EEK
Length:433
Mass (Da):47,111
Last modified:January 1, 1998 - v1
Checksum:iF3AEFBC044458CE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020279 Genomic DNA Translation: AAB70847.1
AAFI02000014 Genomic DNA Translation: EAL69379.1
RefSeqiXP_643263.1, XM_638171.1

Genome annotation databases

EnsemblProtistsiEAL69379; EAL69379; DDB_G0276159
GeneIDi8620306
KEGGiddi:DDB_G0276159

Similar proteinsi

Entry informationi

Entry nameiRTCA_DICDI
AccessioniPrimary (citable) accession number: O15746
Secondary accession number(s): Q552F0, Q75JH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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