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Protein

Protein tipD

Gene

tipD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Not known; disruption of the gene for tipD results in morphological defects.

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: dictyBase
  • culmination involved in sorocarp development Source: dictyBase
  • macroautophagy Source: dictyBase
  • phagocytosis Source: dictyBase
  • phagosome maturation Source: dictyBase
  • pinocytosis Source: dictyBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: dictyBase
  • sorocarp development Source: dictyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DDI-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tipD
Gene namesi
Name:tipD
ORF Names:DDB_G0275323
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275323. tipD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Protein tipDPRO_0000051275Add
BLAST

Proteomic databases

PaxDbiO15736.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215341.

Structurei

3D structure databases

ProteinModelPortaliO15736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati322 – 36140WD 1Add
BLAST
Repeati364 – 40340WD 2Add
BLAST
Repeati406 – 44439WD 3Add
BLAST
Repeati447 – 48640WD 4Add
BLAST
Repeati490 – 53041WD 5Add
BLAST
Repeati535 – 57642WD 6Add
BLAST
Repeati582 – 61130WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 134Poly-Met
Compositional biasi14 – 196Poly-Gly
Compositional biasi113 – 1208Poly-Ser

Sequence similaritiesi

Belongs to the WD repeat tipD family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0288. Eukaryota.
ENOG410XQYA. LUCA.
InParanoidiO15736.
KOiK17890.
OMAiYVFDAHD.
PhylomeDBiO15736.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF08614. ATG16. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSQNNSYM MMMGGGGIGN INNNQFYSPI ISTSAQSFNS IVEWKRDIIR
60 70 80 90 100
QLNDRNQNQT NNYSEFMRIY TDLLKRERTL NDRTLLYEKE IVSLRNEKKT
110 120 130 140 150
QQQPPSGSSK MDSSSSSSSS NRVSGMGSTI EEMEQKLFKL QEDLTNSYKR
160 170 180 190 200
NADNASSILL LNDKNKDLQN ELMSKEIEIE RIRSTIQQDL DSIKRLEMVV
210 220 230 240 250
IEKENVSQII RDELSSLQTE FLHNESKVVK LEQENSSLVE RWLRKKNEEA
260 270 280 290 300
SKMNEANDFY QKMVEQRDST PAKAAVQLSE SISNLVVKLP DANDVPIPIV
310 320 330 340 350
LERGVFSSEA MLPSKAKKRW TGHNSEIYCM AFNSIGNLLA TGGGDKCVKV
360 370 380 390 400
WDVISGQQKS TLLGASQSIV SVSFSPNDES ILGTSNDNSA RLWNTELGRS
410 420 430 440 450
RHTLTGHIGK VYTGKFINSN RVVTGSHDRT IKLWDLQKGY CTRTIFCFSS
460 470 480 490 500
CNDLVILGGS GTHLASGHVD HSVRFWDSNA GEPTQVLSSI HEGQITSITN
510 520 530 540 550
SPTNTNQILT NSRDHTLKII DIRTFDTIRT FKDPEYRNGL NWTKASWSPD
560 570 580 590 600
GRYIASGSID GSICIWDATN GKTVKVLTKV HNNGSSVCCC SWSPLANIFI
610
SADKDKNIIQ WE
Length:612
Mass (Da):68,747
Last modified:January 1, 1998 - v1
Checksum:i4DB6D03EDEC0B6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019236 Genomic DNA. Translation: AAB70659.1.
AAFI02000013 Genomic DNA. Translation: EAL69727.1.
PIRiT08602.
RefSeqiXP_643673.1. XM_638581.1.

Genome annotation databases

EnsemblProtistsiDDB0215341; DDB0215341; DDB_G0275323.
GeneIDi8619939.
KEGGiddi:DDB_G0275323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019236 Genomic DNA. Translation: AAB70659.1.
AAFI02000013 Genomic DNA. Translation: EAL69727.1.
PIRiT08602.
RefSeqiXP_643673.1. XM_638581.1.

3D structure databases

ProteinModelPortaliO15736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215341.

Proteomic databases

PaxDbiO15736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0215341; DDB0215341; DDB_G0275323.
GeneIDi8619939.
KEGGiddi:DDB_G0275323.

Organism-specific databases

dictyBaseiDDB_G0275323. tipD.

Phylogenomic databases

eggNOGiKOG0288. Eukaryota.
ENOG410XQYA. LUCA.
InParanoidiO15736.
KOiK17890.
OMAiYVFDAHD.
PhylomeDBiO15736.

Enzyme and pathway databases

ReactomeiR-DDI-1632852. Macroautophagy.

Miscellaneous databases

PROiO15736.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF08614. ATG16. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIPD_DICDI
AccessioniPrimary (citable) accession number: O15736
Secondary accession number(s): Q553S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.