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Protein

Trypanin

Gene
N/A
Organism
Trypanosoma brucei rhodesiense
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytoskeletal linker that plays a central role in the flagellum cell motility. Required for directional cell motility. Plays a role as part of a dynein regulatory system that regulates flagellar beat in response to signals from the central pair apparatus and radial spokes in procyclic cells. Plays also an essential role in the bloodstream form of the trypanosomes as its silencing is lethal for the circulating form.3 Publications

GO - Biological processi

  • cilium-dependent cell motility Source: GeneDB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trypanin
Alternative name(s):
T lymphocyte-triggering factor
Short name:
TLTF
OrganismiTrypanosoma brucei rhodesiense
Taxonomic identifieri31286 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

  • cilium Source: GeneDB
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: CACAO
  • microtubule Source: UniProtKB-KW
  • motile cilium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203791 – 453TrypaninAdd BLAST453

Structurei

3D structure databases

ProteinModelPortaliO15697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 156Sequence analysisAdd BLAST97
Coiled coili185 – 377Sequence analysisAdd BLAST193

Sequence similaritiesi

Belongs to the GAS8 family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRTAAERG GRRKSVKAPP PVDPLVELTT LESVHDALAK AERLRNYFQV
60 70 80 90 100
ERDKVNDFWT ITKGEVETYR NRLFNAEASI EELERSHQVE MKVYKQRVRH
110 120 130 140 150
LIYERKKKAQ ACQDESDRLL REAEDRHLQR MNEIQAKLQQ QDQQLRAAAA
160 170 180 190 200
DHEMNVYEKR DSHSYMVTVT KTQSHEKELA RLQVSCEAKL KVLRDELELR
210 220 230 240 250
RRAEIHEIEE RKNEHINALI KQHEEKFHEM KTYYNQITTN NLEIIHSLKE
260 270 280 290 300
EIAQMKQNDE HNETLMYDID RENQNLVAPL EEAQREVAEL QQKRKQNEQN
310 320 330 340 350
KRGLEVTRVK LRSLREEIRR QREEHQALEE RYACVHRERE ELKGKFESAL
360 370 380 390 400
RQAVMVVEER NEVLQQKLIE SHALVEERDV QLEGVLRAMN LEPKTLELIA
410 420 430 440 450
TEVDEWLQRK NQLIKDLHFE LKKGEKLYSA TLLEMERRCQ TANIASLPRS

NFE
Length:453
Mass (Da):53,954
Last modified:January 1, 1998 - v1
Checksum:i842A5E2AAA384215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012853 mRNA. Translation: AAB81499.1.

Genome annotation databases

GeneDBiTb927.10.6350:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012853 mRNA. Translation: AAB81499.1.

3D structure databases

ProteinModelPortaliO15697.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.10.6350:pep.

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS8_TRYBR
AccessioniPrimary (citable) accession number: O15697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Procyclic parasite mutants lacking trypanin exhibit a motility defect indicative of abnormal dynein regulation, but have an actively beating flagellum and are able to spin and tumble in place. However, bloodstream form mutants lacking trypanin exhibit a severe growth defect and are not viable. They revealed a failure of cytokinesis.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.