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Protein

Plasma membrane ATPase

Gene

TCH3

Organism
Trypanosoma cruzi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPaseUniRule annotation (EC:3.6.3.6UniRule annotation)
Gene namesi
Name:TCH3Imported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei261 – 28222HelicalUniRule annotationAdd
BLAST
Transmembranei294 – 31724HelicalUniRule annotationAdd
BLAST
Transmembranei658 – 68023HelicalUniRule annotationAdd
BLAST
Transmembranei692 – 71726HelicalUniRule annotationAdd
BLAST
Transmembranei729 – 75729HelicalUniRule annotationAdd
BLAST
Transmembranei809 – 83830HelicalUniRule annotationAdd
BLAST
Transmembranei858 – 87417HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO15637.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_804256.1.

Structurei

3D structure databases

ProteinModelPortaliO15637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11072Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQKNDKSVL NNSNNGNFNE QHPPQKPQKR QSVLSKAISE HKEDGVDEVP
60 70 80 90 100
MLPPSKGLTT AEAEELLAKY GRNELPEKKT PSWLIFVRNL WGPMPFALWV
110 120 130 140 150
AIIIEFALEN WPDGAILLAI QLANATIGWY ETIKAGDAVA ALKNSLKPVA
160 170 180 190 200
TVHRDGAWKQ LDAALLVPGD LVKLASGSAV PADCSINEGV IDVDEAALTG
210 220 230 240 250
ESLPVTMGTD HMPKMGSNVV RGEVDGTVQY TGQNTFFGKT AVLLQSVESD
260 270 280 290 300
LGNIHVILSR VMVVLTSFSF TLCLICFIYL MVKFKESFRR SLQFSVVVLV
310 320 330 340 350
VSIPIALEIV VTTTLAVGSK KLSRHKIIVT KLTAIEMMSG VNMLCSDKTG
360 370 380 390 400
TLTLNKMEIQ DQCFTFEKGH DLRSVLVLAA LAAKWREPPR DALDTMVLGA
410 420 430 440 450
ADLDECDNYT QTEFVPFDPT TKRTAATLVD KRTNEKFSVT KGAPHVIIQL
460 470 480 490 500
VYNQDEINDQ VVEIIDSLAA RGVRCLSVAK TDSQGRWHLC GILTFLDPPR
510 520 530 540 550
PDTKETIRRS KQYGVDVKMI TGDHVLIAKE MCRMLNLDPN ILTADKLPKV
560 570 580 590 600
DVNDLPDDLG EKYGEMMLGV GGFAQVFPEH KFMIVEALRQ YGFTCAMTGD
610 620 630 640 650
GVNDAPALKR ADVGIAVQGA TDAARAAADM VLTGPGLSVV VEAMLVSRQV
660 670 680 690 700
FQCMLSFLTY RISATLQLVC FFFIACFSLT PRNYGSADAD FQFFHLPVLM
710 720 730 740 750
FMLITLLNDG CLMTIGYDRV VPSKLPQRWN LPVVFTIAII LAAVACGSSL
760 770 780 790 800
MLLWIALEGW SDETYPNSWF KALGLAQLKQ GKVVTLLYLK ISISDFLTLF
810 820 830 840 850
SSRTGGRWFF TMAPGLVLLI GAIISLFVSS MVASFWHTSR PDGLLTEGLA
860 870 880 890 900
WGDTNSERLL PLWVWIYCIV WWLIQDAVKV GTHKLMEWMD LFGCVSRAYG
910 920
GKVVEQYEDE TPNSGNKNES KEPTV
Length:925
Mass (Da):102,027
Last modified:January 1, 1998 - v1
Checksum:i59DA911364E9CD31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000161 Genomic DNA. Translation: AAB70152.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000161 Genomic DNA. Translation: AAB70152.1.

3D structure databases

ProteinModelPortaliO15637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_804256.1.

Proteomic databases

PaxDbiO15637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO15637_TRYCR
AccessioniPrimary (citable) accession number: O15637
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.