O15565 (O15565_TRIVA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Methionine gamma-lyase EMBL CAA04125.1
EC=4.4.1.11 EMBL CAA04125.1

Gene names

Name:	mgl2 EMBL CAA04125.1
ORF Names:	TVAG_147790 EMBL EAX91132.1

Organism

Trichomonas vaginalis EMBL CAA04125.1

Taxonomic identifier

5722 [NCBI]

Taxonomic lineage

Eukaryota › Parabasalia › Trichomonadida › Trichomonadidae › Trichomonas

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the trans-sulfuration enzymes family. RuleBase RU004079

Ontologies

Keywords
Molecular function	Lyase EMBL CAA04125.1
Technical term	3D-structure PDB 1PFF Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	methionine gamma-lyase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O15565 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 48A1AB942B3B400A	FASTA	398	43,112
	10 20 30 40 50 60 MSGHAIDPTH TDTLSIHANP QKDQFGAIVA PIYQTSTFLF DNCDQGGARF GGKEAGYMYT 70 80 90 100 110 120 RIGNPTNSAL EGKIAKLEHA EACAATASGM GAIAASVWTF LKAGDHLISD DCLYGCTHAL 130 140 150 160 170 180 FEHQLRKFGV EVDFIDMAVP GNIEKHLKPN TRIVYFETPA NPTLKVIDIE DAVKQARKQK 190 200 210 220 230 240 DILVIVDNTF ASPILTNPLD LGVDIVVHSA TKYINGHTDV VAGLVCSRAD IIAKVKSQGI 250 260 270 280 290 300 KDITGAIISP HDAWLITRGT LTLDMRVKRA AENAQKVAEF LHEHKAVKKV YYPGLPDHPG 310 320 330 340 350 360 HEIAKKQMKM FGSMIAFDVD GLEKAKKVLD NCHVVSLAVS LGGPESLIQH PASMTHAGVP 370 380 390 KEEREAAGLT DNLIRLSVGC ENVQDIIDDL KQALDLVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis." Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J. , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J. Science 315:207-212(2007) [PubMed: 17218520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC PRA-98 / G3.
[2]	"The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes." McKie A.E., Edlind T., Walker J., Mottram J.C., Coombs G.H. J. Biol. Chem. 273:5549-5556(1998) [PubMed: 9488680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ000487 Genomic DNA. Translation: CAA04125.1.
DS114056 Genomic DNA. Translation: EAX91132.1.

RefSeq

XP_001304062.1. XM_001304061.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PFF	X-ray	2.50	A/B	68-397	[»]

ProteinModelPortal

O15565.

SMR

O15565. Positions 13-398.

ModBase

Search...

Protein-protein interaction databases

STRING

O15565.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

4748825.

KEGG

tva:TVAG_147790.

Organism-specific databases

EuPathDB

EupathDB:TVAG_147790.

Family and domain databases

InterPro

IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006237. Met_gamma_lys.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.

KO

K01761.

PANTHER

PTHR11808. Cys_Met_Meta_PP. 1 hit.

Pfam

PF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]

PIRSF

PIRSF001434. CGS. 1 hit.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

TIGRFAMs

TIGR01328. Met_gam_lyase. 1 hit.

ProtoNet

Search...

Entry information

Entry name

O15565_TRIVA

Accession

Primary (citable) accession number: O15565
Secondary accession number(s): A2FVC9

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)