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O15552

- FFAR2_HUMAN

UniProt

O15552 - FFAR2_HUMAN

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Protein

Free fatty acid receptor 2

Gene
FFAR2, GPR43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_21268. Free fatty acid receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Free fatty acid receptor 2
Alternative name(s):
G-protein coupled receptor 43
Gene namesi
Name:FFAR2
Synonyms:GPR43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4501. FFAR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Extracellular Reviewed predictionAdd
BLAST
Transmembranei13 – 3321Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini34 – 418Cytoplasmic
Transmembranei42 – 6221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini63 – 8422Extracellular Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini106 – 12621Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini148 – 17326Extracellular Reviewed predictionAdd
BLAST
Transmembranei174 – 19421Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini195 – 21925Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei220 – 24021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini241 – 25515Extracellular Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini277 – 33054Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Free fatty acid receptor 2PRO_0000069571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15552.
PRIDEiO15552.

PTM databases

PhosphoSiteiO15552.

Expressioni

Tissue specificityi

Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen.2 Publications

Gene expression databases

ArrayExpressiO15552.
BgeeiO15552.
CleanExiHS_FFAR2.
GenevestigatoriO15552.

Organism-specific databases

HPAiHPA023985.

Interactioni

Protein-protein interaction databases

BioGridi109125. 2 interactions.
IntActiO15552. 3 interactions.
STRINGi9606.ENSP00000246549.

Structurei

3D structure databases

ProteinModelPortaliO15552.
SMRiO15552. Positions 5-288.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47521.
HOGENOMiHOG000026778.
HOVERGENiHBG051811.
InParanoidiO15552.
KOiK04328.
OMAiTGFGFYS.
OrthoDBiEOG7SFHXH.
PhylomeDBiO15552.
TreeFamiTF350010.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15552-1 [UniParc]FASTAAdd to Basket

« Hide

MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS    50
LTLADLLLLL LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL 100
AGISIERYLG VAFPVQYKLS RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL 150
NTTEQVRSGN EITCYENFTD NQLDVVLPVR LELCLVLFFI PMAVTIFCYW 200
RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV SHLVGYHQRK 250
SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG 300
RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE 330
Length:330
Mass (Da):37,144
Last modified:January 1, 1998 - v1
Checksum:iF4A8AC6AFBDF1E90
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti211 – 2111L → H.
Corresponds to variant rs409093 [ dbSNP | Ensembl ].
VAR_011861

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271T → M in AAH96201. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024690 Genomic DNA. Translation: AAB86713.1.
AC002511 Genomic DNA. Translation: AAB67886.1.
EU432114 Genomic DNA. Translation: ABY87913.1.
BC095535 mRNA. Translation: AAH95535.1.
BC096198 mRNA. Translation: AAH96198.1.
BC096199 mRNA. Translation: AAH96199.1.
BC096200 mRNA. Translation: AAH96200.1.
BC096201 mRNA. Translation: AAH96201.1.
CCDSiCCDS12461.1.
PIRiJC5717.
RefSeqiNP_005297.1. NM_005306.2.
UniGeneiHs.248056.

Genome annotation databases

EnsembliENST00000246549; ENSP00000246549; ENSG00000126262.
ENST00000599180; ENSP00000473159; ENSG00000126262.
GeneIDi2867.
KEGGihsa:2867.
UCSCiuc002nzg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024690 Genomic DNA. Translation: AAB86713.1 .
AC002511 Genomic DNA. Translation: AAB67886.1 .
EU432114 Genomic DNA. Translation: ABY87913.1 .
BC095535 mRNA. Translation: AAH95535.1 .
BC096198 mRNA. Translation: AAH96198.1 .
BC096199 mRNA. Translation: AAH96199.1 .
BC096200 mRNA. Translation: AAH96200.1 .
BC096201 mRNA. Translation: AAH96201.1 .
CCDSi CCDS12461.1.
PIRi JC5717.
RefSeqi NP_005297.1. NM_005306.2.
UniGenei Hs.248056.

3D structure databases

ProteinModelPortali O15552.
SMRi O15552. Positions 5-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109125. 2 interactions.
IntActi O15552. 3 interactions.
STRINGi 9606.ENSP00000246549.

Chemistry

BindingDBi O15552.
ChEMBLi CHEMBL5493.
GuidetoPHARMACOLOGYi 226.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O15552.

Proteomic databases

PaxDbi O15552.
PRIDEi O15552.

Protocols and materials databases

DNASUi 2867.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246549 ; ENSP00000246549 ; ENSG00000126262 .
ENST00000599180 ; ENSP00000473159 ; ENSG00000126262 .
GeneIDi 2867.
KEGGi hsa:2867.
UCSCi uc002nzg.2. human.

Organism-specific databases

CTDi 2867.
GeneCardsi GC19P035940.
H-InvDB HIX0027605.
HGNCi HGNC:4501. FFAR2.
HPAi HPA023985.
MIMi 603823. gene.
neXtProti NX_O15552.
PharmGKBi PA28890.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47521.
HOGENOMi HOG000026778.
HOVERGENi HBG051811.
InParanoidi O15552.
KOi K04328.
OMAi TGFGFYS.
OrthoDBi EOG7SFHXH.
PhylomeDBi O15552.
TreeFami TF350010.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_21268. Free fatty acid receptors.

Miscellaneous databases

GenomeRNAii 2867.
NextBioi 11305.
PROi O15552.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15552.
Bgeei O15552.
CleanExi HS_FFAR2.
Genevestigatori O15552.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
    Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
    Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids."
    Nilsson N.E., Kotarsky K., Owman C., Olde B.
    Biochem. Biophys. Res. Commun. 303:1047-1052(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFFAR2_HUMAN
AccessioniPrimary (citable) accession number: O15552
Secondary accession number(s): B0M0J9
, Q4VAZ3, Q4VAZ5, Q4VBL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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