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O15552 (FFAR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Free fatty acid receptor 2
Alternative name(s):
G-protein coupled receptor 43
Gene names
Name:FFAR2
Synonyms:GPR43
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. Ref.5 Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen. Ref.5 Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Free fatty acid receptor 2
PRO_0000069571

Regions

Topological domain1 – 1212Extracellular Potential
Transmembrane13 – 3321Helical; Name=1; Potential
Topological domain34 – 418Cytoplasmic
Transmembrane42 – 6221Helical; Name=2; Potential
Topological domain63 – 8422Extracellular Potential
Transmembrane85 – 10521Helical; Name=3; Potential
Topological domain106 – 12621Cytoplasmic Potential
Transmembrane127 – 14721Helical; Name=4; Potential
Topological domain148 – 17326Extracellular Potential
Transmembrane174 – 19421Helical; Name=5; Potential
Topological domain195 – 21925Cytoplasmic Potential
Transmembrane220 – 24021Helical; Name=6; Potential
Topological domain241 – 25515Extracellular Potential
Transmembrane256 – 27621Helical; Name=7; Potential
Topological domain277 – 33054Cytoplasmic Potential

Amino acid modifications

Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential

Natural variations

Natural variant2111L → H.
Corresponds to variant rs409093 [ dbSNP | Ensembl ].
VAR_011861

Experimental info

Sequence conflict2271T → M in AAH96201. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O15552 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: F4A8AC6AFBDF1E90

FASTA33037,144
        10         20         30         40         50         60 
MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS LTLADLLLLL 

        70         80         90        100        110        120 
LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL AGISIERYLG VAFPVQYKLS 

       130        140        150        160        170        180 
RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL NTTEQVRSGN EITCYENFTD NQLDVVLPVR 

       190        200        210        220        230        240 
LELCLVLFFI PMAVTIFCYW RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV 

       250        260        270        280        290        300 
SHLVGYHQRK SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG 

       310        320        330 
RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE 

« Hide

References

« Hide 'large scale' references
[1]"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids."
Nilsson N.E., Kotarsky K., Owman C., Olde B.
Biochem. Biophys. Res. Commun. 303:1047-1052(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids."
Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J., Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C., Marshall F.H., Szekeres P.G., Wilson S. expand/collapse author list , Ignar D.M., Foord S.M., Wise A., Dowell S.J.
J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024690 Genomic DNA. Translation: AAB86713.1.
AC002511 Genomic DNA. Translation: AAB67886.1.
EU432114 Genomic DNA. Translation: ABY87913.1.
BC095535 mRNA. Translation: AAH95535.1.
BC096198 mRNA. Translation: AAH96198.1.
BC096199 mRNA. Translation: AAH96199.1.
BC096200 mRNA. Translation: AAH96200.1.
BC096201 mRNA. Translation: AAH96201.1.
CCDSCCDS12461.1.
PIRJC5717.
RefSeqNP_005297.1. NM_005306.2.
UniGeneHs.248056.

3D structure databases

ProteinModelPortalO15552.
SMRO15552. Positions 5-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109125. 2 interactions.
IntActO15552. 3 interactions.
STRING9606.ENSP00000246549.

Chemistry

BindingDBO15552.
ChEMBLCHEMBL5493.
GuidetoPHARMACOLOGY226.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO15552.

Proteomic databases

PaxDbO15552.
PRIDEO15552.

Protocols and materials databases

DNASU2867.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246549; ENSP00000246549; ENSG00000126262.
ENST00000599180; ENSP00000473159; ENSG00000126262.
GeneID2867.
KEGGhsa:2867.
UCSCuc002nzg.2. human.

Organism-specific databases

CTD2867.
GeneCardsGC19P035940.
H-InvDBHIX0027605.
HGNCHGNC:4501. FFAR2.
HPAHPA023985.
MIM603823. gene.
neXtProtNX_O15552.
PharmGKBPA28890.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47521.
HOGENOMHOG000026778.
HOVERGENHBG051811.
InParanoidO15552.
KOK04328.
OMATGFGFYS.
OrthoDBEOG7SFHXH.
PhylomeDBO15552.
TreeFamTF350010.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO15552.
BgeeO15552.
CleanExHS_FFAR2.
GenevestigatorO15552.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2867.
NextBio11305.
PROO15552.
SOURCESearch...

Entry information

Entry nameFFAR2_HUMAN
AccessionPrimary (citable) accession number: O15552
Secondary accession number(s): B0M0J9 expand/collapse secondary AC list , Q4VAZ3, Q4VAZ5, Q4VBL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries