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Protein

Claudin-3

Gene

CLDN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: Ensembl
  2. epithelial cell morphogenesis Source: UniProtKB
  3. response to hypoxia Source: UniProtKB
  4. signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Rat ventral prostate.1 protein homolog
Short name:
hRVP1
Gene namesi
Name:CLDN3
Synonyms:C7orf1, CPETR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:2045. CLDN3.

Subcellular locationi

Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence Analysis
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 8051ExtracellularSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Topological domaini102 – 11514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 15923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 22040CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: ProtInc
  3. integral component of plasma membrane Source: ProtInc
  4. lateral plasma membrane Source: Ensembl
  5. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

PharmGKBiPA26571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Claudin-3PRO_0000144738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981PhosphotyrosineBy similarity
Modified residuei209 – 2091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15551.
PaxDbiO15551.
PRIDEiO15551.

PTM databases

PhosphoSiteiO15551.

Expressioni

Gene expression databases

BgeeiO15551.
CleanExiHS_CLDN3.
ExpressionAtlasiO15551. baseline and differential.
GenevestigatoriO15551.

Organism-specific databases

HPAiCAB002702.
HPA007322.
HPA014361.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107757. 6 interactions.
DIPiDIP-61079N.
MINTiMINT-5003820.
STRINGi9606.ENSP00000378577.

Structurei

3D structure databases

ProteinModelPortaliO15551.
SMRiO15551. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2202Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281814.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO15551.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiO15551.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV
160 170 180 190 200
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA
210 220
PRSTGPGASL GTGYDRKDYV
Length:220
Mass (Da):23,319
Last modified:January 1, 1998 - v1
Checksum:i1C826EFFF1563C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007189 Genomic DNA. Translation: AAC78277.1.
AB000714 mRNA. Translation: BAA22986.1.
BC016056 mRNA. Translation: AAH16056.1.
CCDSiCCDS5559.1.
RefSeqiNP_001297.1. NM_001306.3.
UniGeneiHs.647023.

Genome annotation databases

EnsembliENST00000395145; ENSP00000378577; ENSG00000165215.
GeneIDi1365.
KEGGihsa:1365.
UCSCiuc003tzg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007189 Genomic DNA. Translation: AAC78277.1.
AB000714 mRNA. Translation: BAA22986.1.
BC016056 mRNA. Translation: AAH16056.1.
CCDSiCCDS5559.1.
RefSeqiNP_001297.1. NM_001306.3.
UniGeneiHs.647023.

3D structure databases

ProteinModelPortaliO15551.
SMRiO15551. Positions 1-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107757. 6 interactions.
DIPiDIP-61079N.
MINTiMINT-5003820.
STRINGi9606.ENSP00000378577.

PTM databases

PhosphoSiteiO15551.

Proteomic databases

MaxQBiO15551.
PaxDbiO15551.
PRIDEiO15551.

Protocols and materials databases

DNASUi1365.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395145; ENSP00000378577; ENSG00000165215.
GeneIDi1365.
KEGGihsa:1365.
UCSCiuc003tzg.4. human.

Organism-specific databases

CTDi1365.
GeneCardsiGC07M073183.
HGNCiHGNC:2045. CLDN3.
HPAiCAB002702.
HPA007322.
HPA014361.
MIMi602910. gene.
neXtProtiNX_O15551.
PharmGKBiPA26571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG281814.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO15551.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiO15551.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN3.
GenomeRNAii1365.
NextBioi5531.
PROiO15551.
SOURCEiSearch...

Gene expression databases

BgeeiO15551.
CleanExiHS_CLDN3.
ExpressionAtlasiO15551. baseline and differential.
GenevestigatoriO15551.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a human gene homologous to rat ventral prostate.1 protein."
    Peacock R.E., Keen T.J., Inglehearn C.F.
    Genomics 46:443-449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo."
    Katahira J., Sugiyama H., Inoue N., Horiguchi Y., Matsuda M., Sugimoto N.
    J. Biol. Chem. 272:26652-26658(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLD3_HUMAN
AccessioniPrimary (citable) accession number: O15551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.