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O15551 (CLD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name=CPE-R 2
Short name=CPE-receptor 2
Rat ventral prostate.1 protein homolog
Short name=hRVP1
Gene names
Name:CLDN3
Synonyms:C7orf1, CPETR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subunit structure

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Involvement in disease

CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Sequence similarities

Belongs to the claudin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Claudin-3
PRO_0000144738

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Potential
Topological domain30 – 8051Extracellular Potential
Transmembrane81 – 10121Helical; Potential
Topological domain102 – 11514Cytoplasmic Potential
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 15923Extracellular Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 22040Cytoplasmic Potential
Region219 – 2202Interactions with TJP1, TJP2 and TJP3 By similarity

Amino acid modifications

Modified residue1981Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
O15551 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1C826EFFF1563C56

FASTA22023,319
        10         20         30         40         50         60 
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 

        70         80         90        100        110        120 
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 

       130        140        150        160        170        180 
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 

       190        200        210        220 
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a human gene homologous to rat ventral prostate.1 protein."
Peacock R.E., Keen T.J., Inglehearn C.F.
Genomics 46:443-449(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo."
Katahira J., Sugiyama H., Inoue N., Horiguchi Y., Matsuda M., Sugimoto N.
J. Biol. Chem. 272:26652-26658(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007189 Genomic DNA. Translation: AAC78277.1.
AB000714 mRNA. Translation: BAA22986.1.
BC016056 mRNA. Translation: AAH16056.1.
RefSeqNP_001297.1. NM_001306.3.
UniGeneHs.647023.

3D structure databases

ProteinModelPortalO15551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107757. 6 interactions.
MINTMINT-5003820.
STRING9606.ENSP00000378577.

PTM databases

PhosphoSiteO15551.

Proteomic databases

PaxDbO15551.
PRIDEO15551.

Protocols and materials databases

DNASU1365.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395145; ENSP00000378577; ENSG00000165215.
ENST00000572891; ENSP00000458165; ENSG00000262073.
GeneID1365.
KEGGhsa:1365.
UCSCuc003tzg.4. human.

Organism-specific databases

CTD1365.
GeneCardsGC07M073183.
HGNCHGNC:2045. CLDN3.
HPACAB002702.
HPA007322.
HPA014361.
MIM602910. gene.
neXtProtNX_O15551.
PharmGKBPA26571.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281814.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidO15551.
KOK06087.
OMAVPDAQKR.
OrthoDBEOG79KPGQ.
PhylomeDBO15551.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressO15551.
BgeeO15551.
CleanExHS_CLDN3.
GenevestigatorO15551.

Family and domain databases

InterProIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLDN3.
GenomeRNAi1365.
NextBio5531.
PROO15551.
SOURCESearch...

Entry information

Entry nameCLD3_HUMAN
AccessionPrimary (citable) accession number: O15551
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM