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O15551

- CLD3_HUMAN

UniProt

O15551 - CLD3_HUMAN

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Protein
Claudin-3
Gene
CLDN3, C7orf1, CPETR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: Ensembl
  2. response to hypoxia Source: UniProtKB
  3. signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Rat ventral prostate.1 protein homolog
Short name:
hRVP1
Gene namesi
Name:CLDN3
Synonyms:C7orf1, CPETR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2045. CLDN3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 8051Extracellular Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 11514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 15923Extracellular Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 22040Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. integral component of plasma membrane Source: ProtInc
  4. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

PharmGKBiPA26571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Claudin-3
PRO_0000144738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15551.
PaxDbiO15551.
PRIDEiO15551.

PTM databases

PhosphoSiteiO15551.

Expressioni

Gene expression databases

ArrayExpressiO15551.
BgeeiO15551.
CleanExiHS_CLDN3.
GenevestigatoriO15551.

Organism-specific databases

HPAiCAB002702.
HPA007322.
HPA014361.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.

Protein-protein interaction databases

BioGridi107757. 6 interactions.
MINTiMINT-5003820.
STRINGi9606.ENSP00000378577.

Structurei

3D structure databases

ProteinModelPortaliO15551.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2202Interactions with TJP1, TJP2 and TJP3 By similarity

Sequence similaritiesi

Belongs to the claudin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281814.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO15551.
KOiK06087.
OMAiVPDAQKR.
OrthoDBiEOG79KPGQ.
PhylomeDBiO15551.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15551-1 [UniParc]FASTAAdd to Basket

« Hide

MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW    50
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG 100
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV 150
VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA 200
PRSTGPGASL GTGYDRKDYV 220
Length:220
Mass (Da):23,319
Last modified:January 1, 1998 - v1
Checksum:i1C826EFFF1563C56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007189 Genomic DNA. Translation: AAC78277.1.
AB000714 mRNA. Translation: BAA22986.1.
BC016056 mRNA. Translation: AAH16056.1.
CCDSiCCDS5559.1.
RefSeqiNP_001297.1. NM_001306.3.
UniGeneiHs.647023.

Genome annotation databases

EnsembliENST00000395145; ENSP00000378577; ENSG00000165215.
ENST00000572891; ENSP00000458165; ENSG00000262073.
GeneIDi1365.
KEGGihsa:1365.
UCSCiuc003tzg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007189 Genomic DNA. Translation: AAC78277.1 .
AB000714 mRNA. Translation: BAA22986.1 .
BC016056 mRNA. Translation: AAH16056.1 .
CCDSi CCDS5559.1.
RefSeqi NP_001297.1. NM_001306.3.
UniGenei Hs.647023.

3D structure databases

ProteinModelPortali O15551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107757. 6 interactions.
MINTi MINT-5003820.
STRINGi 9606.ENSP00000378577.

PTM databases

PhosphoSitei O15551.

Proteomic databases

MaxQBi O15551.
PaxDbi O15551.
PRIDEi O15551.

Protocols and materials databases

DNASUi 1365.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395145 ; ENSP00000378577 ; ENSG00000165215 .
ENST00000572891 ; ENSP00000458165 ; ENSG00000262073 .
GeneIDi 1365.
KEGGi hsa:1365.
UCSCi uc003tzg.4. human.

Organism-specific databases

CTDi 1365.
GeneCardsi GC07M073183.
HGNCi HGNC:2045. CLDN3.
HPAi CAB002702.
HPA007322.
HPA014361.
MIMi 602910. gene.
neXtProti NX_O15551.
PharmGKBi PA26571.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281814.
HOGENOMi HOG000220937.
HOVERGENi HBG000643.
InParanoidi O15551.
KOi K06087.
OMAi VPDAQKR.
OrthoDBi EOG79KPGQ.
PhylomeDBi O15551.
TreeFami TF331936.

Enzyme and pathway databases

Reactomei REACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikii CLDN3.
GenomeRNAii 1365.
NextBioi 5531.
PROi O15551.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15551.
Bgeei O15551.
CleanExi HS_CLDN3.
Genevestigatori O15551.

Family and domain databases

InterProi IPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PR01378. CLAUDIN3.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a human gene homologous to rat ventral prostate.1 protein."
    Peacock R.E., Keen T.J., Inglehearn C.F.
    Genomics 46:443-449(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo."
    Katahira J., Sugiyama H., Inoue N., Horiguchi Y., Matsuda M., Sugimoto N.
    J. Biol. Chem. 272:26652-26658(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiCLD3_HUMAN
AccessioniPrimary (citable) accession number: O15551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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