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O15551

- CLD3_HUMAN

UniProt

O15551 - CLD3_HUMAN

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Protein
Claudin-3
Gene
CLDN3, C7orf1, CPETR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. calcium-independent cell-cell adhesion Source: Ensembl
  2. response to hypoxia Source: UniProtKB
  3. signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-3
Alternative name(s):
Clostridium perfringens enterotoxin receptor 2
Short name:
CPE-R 2
Short name:
CPE-receptor 2
Rat ventral prostate.1 protein homolog
Short name:
hRVP1
Gene namesi
Name:CLDN3
Synonyms:C7orf1, CPETR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2045. CLDN3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 8051Extracellular Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 11514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 15923Extracellular Reviewed prediction
Add
BLAST
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 22040Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. integral component of plasma membrane Source: ProtInc
  4. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

PharmGKBiPA26571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Claudin-3
PRO_0000144738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15551.
PaxDbiO15551.
PRIDEiO15551.

PTM databases

PhosphoSiteiO15551.

Expressioni

Gene expression databases

ArrayExpressiO15551.
BgeeiO15551.
CleanExiHS_CLDN3.
GenevestigatoriO15551.

Organism-specific databases

HPAi