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O15551

- CLD3_HUMAN

UniProt

O15551 - CLD3_HUMAN

Protein

Claudin-3

Gene

CLDN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: Ensembl
    2. response to hypoxia Source: UniProtKB
    3. signal transduction Source: GOC

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-3
    Alternative name(s):
    Clostridium perfringens enterotoxin receptor 2
    Short name:
    CPE-R 2
    Short name:
    CPE-receptor 2
    Rat ventral prostate.1 protein homolog
    Short name:
    hRVP1
    Gene namesi
    Name:CLDN3
    Synonyms:C7orf1, CPETR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:2045. CLDN3.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: ProtInc
    3. integral component of plasma membrane Source: ProtInc
    4. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Involvement in diseasei

    CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

    Keywords - Diseasei

    Williams-Beuren syndrome

    Organism-specific databases

    PharmGKBiPA26571.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Claudin-3PRO_0000144738Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15551.
    PaxDbiO15551.
    PRIDEiO15551.

    PTM databases

    PhosphoSiteiO15551.

    Expressioni

    Gene expression databases

    ArrayExpressiO15551.
    BgeeiO15551.
    CleanExiHS_CLDN3.
    GenevestigatoriO15551.

    Organism-specific databases

    HPAiCAB002702.
    HPA007322.
    HPA014361.

    Interactioni

    Subunit structurei

    Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107757. 6 interactions.
    MINTiMINT-5003820.
    STRINGi9606.ENSP00000378577.

    Structurei

    3D structure databases

    ProteinModelPortaliO15551.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 8051ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 11514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 22040CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2202Interactions with TJP1, TJP2 and TJP3By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281814.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiO15551.
    KOiK06087.
    OMAiVPDAQKR.
    OrthoDBiEOG79KPGQ.
    PhylomeDBiO15551.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003549. Claudin3.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01378. CLAUDIN3.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15551-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW    50
    MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG 100
    AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPV 150
    VPEAQKREMG AGLYVGWAAA ALQLLGGALL CCSCPPREKK YTATKVVYSA 200
    PRSTGPGASL GTGYDRKDYV 220
    Length:220
    Mass (Da):23,319
    Last modified:January 1, 1998 - v1
    Checksum:i1C826EFFF1563C56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007189 Genomic DNA. Translation: AAC78277.1.
    AB000714 mRNA. Translation: BAA22986.1.
    BC016056 mRNA. Translation: AAH16056.1.
    CCDSiCCDS5559.1.
    RefSeqiNP_001297.1. NM_001306.3.
    UniGeneiHs.647023.

    Genome annotation databases

    EnsembliENST00000395145; ENSP00000378577; ENSG00000165215.
    GeneIDi1365.
    KEGGihsa:1365.
    UCSCiuc003tzg.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007189 Genomic DNA. Translation: AAC78277.1 .
    AB000714 mRNA. Translation: BAA22986.1 .
    BC016056 mRNA. Translation: AAH16056.1 .
    CCDSi CCDS5559.1.
    RefSeqi NP_001297.1. NM_001306.3.
    UniGenei Hs.647023.

    3D structure databases

    ProteinModelPortali O15551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107757. 6 interactions.
    MINTi MINT-5003820.
    STRINGi 9606.ENSP00000378577.

    PTM databases

    PhosphoSitei O15551.

    Proteomic databases

    MaxQBi O15551.
    PaxDbi O15551.
    PRIDEi O15551.

    Protocols and materials databases

    DNASUi 1365.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395145 ; ENSP00000378577 ; ENSG00000165215 .
    GeneIDi 1365.
    KEGGi hsa:1365.
    UCSCi uc003tzg.4. human.

    Organism-specific databases

    CTDi 1365.
    GeneCardsi GC07M073183.
    HGNCi HGNC:2045. CLDN3.
    HPAi CAB002702.
    HPA007322.
    HPA014361.
    MIMi 602910. gene.
    neXtProti NX_O15551.
    PharmGKBi PA26571.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281814.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi O15551.
    KOi K06087.
    OMAi VPDAQKR.
    OrthoDBi EOG79KPGQ.
    PhylomeDBi O15551.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN3.
    GenomeRNAii 1365.
    NextBioi 5531.
    PROi O15551.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15551.
    Bgeei O15551.
    CleanExi HS_CLDN3.
    Genevestigatori O15551.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003549. Claudin3.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01378. CLAUDIN3.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a human gene homologous to rat ventral prostate.1 protein."
      Peacock R.E., Keen T.J., Inglehearn C.F.
      Genomics 46:443-449(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo."
      Katahira J., Sugiyama H., Inoue N., Horiguchi Y., Matsuda M., Sugimoto N.
      J. Biol. Chem. 272:26652-26658(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiCLD3_HUMAN
    AccessioniPrimary (citable) accession number: O15551
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3