Reviewed, UniProtKB/Swiss-Prot O15547 (P2RX6_HUMAN)

Names and origin

Protein names

Recommended name:
    P2X purinoceptor 6
      Short name=P2X6
Alternative name(s):
    ATP receptor
    Purinergic receptor
    P2XM
    Purinergic receptor P2X-like 1

Gene names

Name:	P2RX6
Synonyms:	P2RXL1, P2X6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for ATP that acts as a ligand gated ion channel By similarity.
Subunit structure	Homo- or heteropolymers By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed predominantly in skeletal muscle.
Sequence similarities	Belongs to the P2X receptor family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	Ionic channel Receptor
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW muscle contraction Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cell junction Inferred from direct assay. Source: UniProtKB cytoplasm Inferred from direct assay. Source: UniProtKB integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB ATP-gated cation channel activity Non-traceable author statement. Source: UniProtKB protein heterodimerization activity Non-traceable author statement. Source: UniProtKB purinergic nucleotide receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	P2X purinoceptor 6		PRO_0000161557
Regions
	Topological domain	1 – 29	29	Cytoplasmic Potential
	Transmembrane	30 – 50	21	1 Potential
	Topological domain	51 – 323	273	Extracellular Potential
	Transmembrane	324 – 344	21	2 Potential
	Topological domain	345 – 431	87	Cytoplasmic Potential
Amino acid modifications
	Modified residue	54	1	Phosphotyrosine Ref.5
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
	Glycosylation	185	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	28	1	V → G: dbSNP rs2006846.		VAR_057664
	Natural variant	232	1	R → H: dbSNP rs2277838.		VAR_020338
Experimental info
	Sequence conflict	383	1	L → F in AAF13303. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O15547-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0DE1920178225F3B	FASTA	431	47,913
	10 20 30 40 50 60 MGSPGATTGW GLLDYKTEKY VMTRNWRVGA LQRLLQFGIV VYVVGWALLA KKGYQERDLE 70 80 90 100 110 120 PQFSIITKLK GVSVTQIKEL GNRLWDVADF VKPPQGENVF FLVTNFLVTP AQVQGRCPEH 130 140 150 160 170 180 PSVPLANCWV DEDCPEGEGG THSHGVKTGQ CVVFNGTHRT CEIWSWCPVE SGVVPSRPLL 190 200 210 220 230 240 AQAQNFTLFI KNTVTFSKFN FSKSNALETW DPTYFKHCRY EPQFSPYCPV FRIGDLVAKA 250 260 270 280 290 300 GGTFEDLALL GGSVGIRVHW DCDLDTGDSG CWPHYSFQLQ EKSYNFRTAT HWWEQPGVEA 310 320 330 340 350 360 RTLLKLYGIR FDILVTGQAG KFGLIPTAVT LGTGAAWLGV VTFFCDLLLL YVDREAHFYW 370 380 390 400 410 420 RTKYEEAKAP KATANSVWRE LALASQARLA ECLRRSSAPA PTATAAGSQT QTPGWPCPSS 430 DTHLPTHSGS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of P2XM, a novel human P2X receptor gene regulated by p53." Urano T., Nishimori H., Han H., Furuhata T., Kimura Y., Nakamura Y., Tokino T. Cancer Res. 57:3281-3287(1997) [PubMed: 9242461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Cloning and tissue distribution of a human cDNA encoding P2X6 purinoceptor." Cheng X., Jin H., Huang C.-C. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Identification of the phosphotyrosine proteome from thrombin activated platelets." Maguire P.B., Wynne K.J., Harney D.F., O'Donoghue N.M., Stephens G., Fitzgerald D.J. Proteomics 2:642-648(2002) [PubMed: 12112843] [Abstract] Cited for: PHOSPHORYLATION AT TYR-54.
+	Additional computationally mapped references.

Web resources

Wikipedia

P2X receptor entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB002059 Genomic DNA. Translation: BAA22047.1. AB002058 mRNA. Translation: BAA22046.1. AF065385 mRNA. Translation: AAF13303.1. CR456535 mRNA. Translation: CAG30421.1. Different initiation. BC033488 mRNA. Translation: AAH33488.1.
IPI	IPI00395827.
RefSeq	NP_005437.2.
UniGene	Hs.113275
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000099957. Homo sapiens. [Contig view]
GeneID	9127.
KEGG	hsa:9127.
Organism-specific databases
GeneCards	GC22P019699.
H-InvDB	HIX0041112. HIX0060088.
HGNC	HGNC:8538. P2RX6.
MIM	608077. gene.
PharmGKB	PA32867.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O15547.
HOVERGEN	O15547.
Gene expression databases
ArrayExpress	O15547.
Bgee	O15547.
CleanEx	HS_P2RX6.
GermOnline	ENSG00000099957. Homo sapiens.
Family and domain databases
InterPro	IPR003049. P2X6_purnocptor. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. ATP_P2X_rcpt. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01313. P2X6RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	34213.
SOURCE	Search...

Entry information

Entry name

P2RX6_HUMAN

Accession

Primary (citable) accession number: O15547
Secondary accession number(s): Q58F04, Q6IC33, Q9UL50

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)