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O15539 (RGS5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 5

Short name=RGS5
Gene names
Name:RGS5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha By similarity.

Subcellular location

Isoform 1: Cytoplasm. Membrane Ref.4.

Isoform 2: Cytoplasm Ref.4.

Sequence similarities

Contains 1 RGS domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15539-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15539-2)

Also known as: RGS5s;

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
Note: Acts as an endogenous negative regulator of isoform 1.
Isoform 3 (identifier: O15539-3)

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVGLW
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Regulator of G-protein signaling 5
PRO_0000204188

Regions

Domain64 – 180117RGS

Natural variations

Alternative sequence1 – 108108Missing in isoform 2.
VSP_043094
Alternative sequence1281E → EVGLW in isoform 3.
VSP_045086

Secondary structure

...................... 181
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 2E08CB0179DE7687

FASTA18120,946
        10         20         30         40         50         60 
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ 

        70         80         90        100        110        120 
WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF 

       130        140        150        160        170        180 
IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI 


K 

« Hide

Isoform 2 (RGS5s) [UniParc].

Checksum: 3B9DE08FBE577E5D
Show »

FASTA738,664
Isoform 3 [UniParc].

Checksum: 3B1840D1AB0D8DC0
Show »

FASTA18521,402

References

« Hide 'large scale' references
[1]Chatterjee T.K., Fisher R.A.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene."
Seki N., Sugano S., Suzuki Y., Nakagawara A., Ohira M., Muramatsu M.-A., Saito T., Hori T.
J. Hum. Genet. 43:202-205(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Neuroblastoma.
[3]"Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling."
Cismowski M.J., Takesono A., Ma C., Lizano J.S., Xie X., Fuernkranz H., Lanier S.M., Duzic E.
Nat. Biotechnol. 17:878-883(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[4]"Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues."
Liang Y., Li C., Gozamn V.W., Woodwrad D.F.
FEBS J. 272:791-799(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
Tissue: Eye.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cervix.
[7]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain and Melanoma.
[10]"Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5)."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 44-180.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030108 mRNA. Translation: AAB84001.1.
AB008109 mRNA. Translation: BAA22889.1.
AF159570 mRNA. Translation: AAD40957.1.
AJ891044 mRNA. Translation: CAI76926.1.
AF493929 mRNA. Translation: AAM12643.1.
BX537427 mRNA. Translation: CAD97669.1.
AL451063, AL499616, AL583850 Genomic DNA. Translation: CAH71851.1.
AL583850, AL451063, AL499616 Genomic DNA. Translation: CAH73764.1.
AL499616, AL451063, AL583850 Genomic DNA. Translation: CAI15095.1.
CH471067 Genomic DNA. Translation: EAW90731.1.
BC030059 mRNA. Translation: AAH30059.1.
BU172751 mRNA. No translation available.
CCDSCCDS1244.1. [O15539-1]
CCDS55652.1. [O15539-2]
CCDS58041.1. [O15539-3]
RefSeqNP_001182232.1. NM_001195303.2. [O15539-2]
NP_001241677.1. NM_001254748.1. [O15539-2]
NP_001241678.1. NM_001254749.1. [O15539-3]
NP_003608.1. NM_003617.3. [O15539-1]
UniGeneHs.24950.
Hs.677623.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRPNMR-A44-180[»]
ProteinModelPortalO15539.
SMRO15539. Positions 44-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114062. 6 interactions.
STRING9606.ENSP00000319308.

PTM databases

PhosphoSiteO15539.

Proteomic databases

PaxDbO15539.
PRIDEO15539.

Protocols and materials databases

DNASU8490.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313961; ENSP00000319308; ENSG00000143248. [O15539-1]
ENST00000527988; ENSP00000432313; ENSG00000143248. [O15539-2]
ENST00000530507; ENSP00000433001; ENSG00000143248. [O15539-3]
GeneID8490.
KEGGhsa:8490.
UCSCuc001gcn.3. human. [O15539-1]
uc009wvb.3. human. [O15539-2]

Organism-specific databases

CTD8490.
GeneCardsGC01M163080.
HGNCHGNC:10001. RGS5.
HPAHPA001821.
MIM603276. gene.
neXtProtNX_O15539.
PharmGKBPA34376.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285261.
HOGENOMHOG000233512.
HOVERGENHBG013233.
KOK16449.
OMAWRDSLEK.
OrthoDBEOG7VHSZ5.
PhylomeDBO15539.
TreeFamTF315837.

Gene expression databases

ArrayExpressO15539.
BgeeO15539.
CleanExHS_RGS5.
GenevestigatorO15539.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO15539.
GeneWikiRGS5.
GenomeRNAi8490.
NextBio31763.
PROO15539.
SOURCESearch...

Entry information

Entry nameRGS5_HUMAN
AccessionPrimary (citable) accession number: O15539
Secondary accession number(s): E9PMP5, Q53XA9, Q599J0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM