Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15539

- RGS5_HUMAN

UniProt

O15539 - RGS5_HUMAN

Protein

Regulator of G-protein signaling 5

Gene

RGS5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    3. signal transduction Source: Ensembl
    4. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 5
    Short name:
    RGS5
    Gene namesi
    Name:RGS5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10001. RGS5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Regulator of G-protein signaling 5PRO_0000204188Add
    BLAST

    Proteomic databases

    PaxDbiO15539.
    PRIDEiO15539.

    PTM databases

    PhosphoSiteiO15539.

    Expressioni

    Gene expression databases

    ArrayExpressiO15539.
    BgeeiO15539.
    CleanExiHS_RGS5.
    GenevestigatoriO15539.

    Organism-specific databases

    HPAiHPA001821.

    Interactioni

    Protein-protein interaction databases

    BioGridi114062. 7 interactions.
    STRINGi9606.ENSP00000319308.

    Structurei

    Secondary structure

    1
    181
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi55 – 584
    Helixi60 – 634
    Helixi65 – 706
    Helixi72 – 8413
    Helixi88 – 10114
    Helixi108 – 11912
    Helixi133 – 1419
    Helixi149 – 1513
    Helixi152 – 16413
    Helixi166 – 1727
    Helixi174 – 1807

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CRPNMR-A44-180[»]
    ProteinModelPortaliO15539.
    SMRiO15539. Positions 44-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15539.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 180117RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285261.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    KOiK16449.
    OMAiWRDSLEK.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiO15539.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15539-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT    50
    QKTSLDEALQ WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY 100
    KKIKSPAKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSLSS 150
    FDMAQKRIHA LMEKDSLPRF VRSEFYQELI K 181
    Length:181
    Mass (Da):20,946
    Last modified:January 1, 1998 - v1
    Checksum:i2E08CB0179DE7687
    GO
    Isoform 2 (identifier: O15539-2) [UniParc]FASTAAdd to Basket

    Also known as: RGS5s

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.

    Note: Acts as an endogenous negative regulator of isoform 1.

    Show »
    Length:73
    Mass (Da):8,664
    Checksum:i3B9DE08FBE577E5D
    GO
    Isoform 3 (identifier: O15539-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         128-128: E → EVGLW

    Note: No experimental confirmation available.

    Show »
    Length:185
    Mass (Da):21,402
    Checksum:i3B1840D1AB0D8DC0
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 108108Missing in isoform 2. 1 PublicationVSP_043094Add
    BLAST
    Alternative sequencei128 – 1281E → EVGLW in isoform 3. 1 PublicationVSP_045086

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030108 mRNA. Translation: AAB84001.1.
    AB008109 mRNA. Translation: BAA22889.1.
    AF159570 mRNA. Translation: AAD40957.1.
    AJ891044 mRNA. Translation: CAI76926.1.
    AF493929 mRNA. Translation: AAM12643.1.
    BX537427 mRNA. Translation: CAD97669.1.
    AL451063, AL499616, AL583850 Genomic DNA. Translation: CAH71851.1.
    AL583850, AL451063, AL499616 Genomic DNA. Translation: CAH73764.1.
    AL499616, AL451063, AL583850 Genomic DNA. Translation: CAI15095.1.
    CH471067 Genomic DNA. Translation: EAW90731.1.
    BC030059 mRNA. Translation: AAH30059.1.
    BU172751 mRNA. No translation available.
    CCDSiCCDS1244.1. [O15539-1]
    CCDS55652.1. [O15539-2]
    CCDS58041.1. [O15539-3]
    RefSeqiNP_001182232.1. NM_001195303.2. [O15539-2]
    NP_001241677.1. NM_001254748.1. [O15539-2]
    NP_001241678.1. NM_001254749.1. [O15539-3]
    NP_003608.1. NM_003617.3. [O15539-1]
    UniGeneiHs.24950.
    Hs.677623.

    Genome annotation databases

    EnsembliENST00000313961; ENSP00000319308; ENSG00000143248. [O15539-1]
    ENST00000527988; ENSP00000432313; ENSG00000143248. [O15539-2]
    ENST00000530507; ENSP00000433001; ENSG00000143248. [O15539-3]
    GeneIDi8490.
    KEGGihsa:8490.
    UCSCiuc001gcn.3. human. [O15539-1]
    uc009wvb.3. human. [O15539-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030108 mRNA. Translation: AAB84001.1 .
    AB008109 mRNA. Translation: BAA22889.1 .
    AF159570 mRNA. Translation: AAD40957.1 .
    AJ891044 mRNA. Translation: CAI76926.1 .
    AF493929 mRNA. Translation: AAM12643.1 .
    BX537427 mRNA. Translation: CAD97669.1 .
    AL451063 , AL499616 , AL583850 Genomic DNA. Translation: CAH71851.1 .
    AL583850 , AL451063 , AL499616 Genomic DNA. Translation: CAH73764.1 .
    AL499616 , AL451063 , AL583850 Genomic DNA. Translation: CAI15095.1 .
    CH471067 Genomic DNA. Translation: EAW90731.1 .
    BC030059 mRNA. Translation: AAH30059.1 .
    BU172751 mRNA. No translation available.
    CCDSi CCDS1244.1. [O15539-1 ]
    CCDS55652.1. [O15539-2 ]
    CCDS58041.1. [O15539-3 ]
    RefSeqi NP_001182232.1. NM_001195303.2. [O15539-2 ]
    NP_001241677.1. NM_001254748.1. [O15539-2 ]
    NP_001241678.1. NM_001254749.1. [O15539-3 ]
    NP_003608.1. NM_003617.3. [O15539-1 ]
    UniGenei Hs.24950.
    Hs.677623.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CRP NMR - A 44-180 [» ]
    ProteinModelPortali O15539.
    SMRi O15539. Positions 44-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114062. 7 interactions.
    STRINGi 9606.ENSP00000319308.

    PTM databases

    PhosphoSitei O15539.

    Proteomic databases

    PaxDbi O15539.
    PRIDEi O15539.

    Protocols and materials databases

    DNASUi 8490.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313961 ; ENSP00000319308 ; ENSG00000143248 . [O15539-1 ]
    ENST00000527988 ; ENSP00000432313 ; ENSG00000143248 . [O15539-2 ]
    ENST00000530507 ; ENSP00000433001 ; ENSG00000143248 . [O15539-3 ]
    GeneIDi 8490.
    KEGGi hsa:8490.
    UCSCi uc001gcn.3. human. [O15539-1 ]
    uc009wvb.3. human. [O15539-2 ]

    Organism-specific databases

    CTDi 8490.
    GeneCardsi GC01M163080.
    HGNCi HGNC:10001. RGS5.
    HPAi HPA001821.
    MIMi 603276. gene.
    neXtProti NX_O15539.
    PharmGKBi PA34376.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285261.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    KOi K16449.
    OMAi WRDSLEK.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi O15539.
    TreeFami TF315837.

    Miscellaneous databases

    EvolutionaryTracei O15539.
    GeneWikii RGS5.
    GenomeRNAii 8490.
    NextBioi 31763.
    PROi O15539.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15539.
    Bgeei O15539.
    CleanExi HS_RGS5.
    Genevestigatori O15539.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chatterjee T.K., Fisher R.A.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene."
      Seki N., Sugano S., Suzuki Y., Nakagawara A., Ohira M., Muramatsu M.-A., Saito T., Hori T.
      J. Hum. Genet. 43:202-205(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Neuroblastoma.
    3. "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling."
      Cismowski M.J., Takesono A., Ma C., Lizano J.S., Xie X., Fuernkranz H., Lanier S.M., Duzic E.
      Nat. Biotechnol. 17:878-883(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    4. "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues."
      Liang Y., Li C., Gozamn V.W., Woodwrad D.F.
      FEBS J. 272:791-799(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
      Tissue: Eye.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Melanoma.
    10. "Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 44-180.

    Entry informationi

    Entry nameiRGS5_HUMAN
    AccessioniPrimary (citable) accession number: O15539
    Secondary accession number(s): E9PMP5, Q53XA9, Q599J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3