O15535 (ZSC9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 9

Alternative name(s):
Cell proliferation-inducing gene 12 protein
PRD51
Zinc finger protein 193

Gene names

Name:	ZSCAN9
Synonyms:	ZNF193
ORF Names:	PIG12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15535-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15535-2)

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: T → TDLIRSLRRRAVLIPLGAHLFSTDTFLFSKPVVIPQLKGGGETWPNNRGVLR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Zinc finger and SCAN domain-containing protein 9		PRO_0000047446
Regions
	Domain	52 – 134	83	SCAN box
	Zinc finger	254 – 276	23	C2H2-type 1
	Zinc finger	282 – 304	23	C2H2-type 2
	Zinc finger	310 – 332	23	C2H2-type 3
	Zinc finger	338 – 360	23	C2H2-type 4
	Zinc finger	366 – 388	23	C2H2-type 5
Natural variations
	Alternative sequence	189	1	T → TDLIRSLRRRAVLIPLGAHL FSTDTFLFSKPVVIPQLKGG GETWPNNRGVLR in isoform 2.		VSP_044798
Experimental info
	Sequence conflict	7	1	E → G in BAG64928. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4CEC2BBC3E39EA40	FASTA	394	45,954
	10 20 30 40 50 60 MNTNSKEVLS LGVQVPEAWE ELLTMKVEAK SHLQWQESRL KRSNPLAREI FRRHFRQLCY 70 80 90 100 110 120 QETPGPREAL TRLQELCYQW LRPHVSTKEQ ILDLLVLEQF LSILPKELQG WVREHCPESG 130 140 150 160 170 180 EEAVILLEDL ERELDEPQHE MVAHRHRQEV LCKEMVPLAE QTPLTLQSQP KEPQLTCDSA 190 200 210 220 230 240 QKCHSIGETD EVTKTEDREL VLRKDCPKIV EPHGKMFNEQ TWEVSQQDPS HGEVGEHKDR 250 260 270 280 290 300 IERQWGNLLG EGQHKCDECG KSFTQSSGLI RHQRIHTGER PYECNECGKA FSRSSGLFNH 310 320 330 340 350 360 RGIHNIQKRY HCKECGKVFS QSAGLIQHQR IHKGEKPYQC SQCSKSYSRR SFLIEHQRSH 370 380 390 TGERPHQCIE CGKSFNRHCN LIRHQKIHTV AELV
	Isoform 2 [UniParc]. Checksum: 8D955B1226963018	FASTA	445	51,650
	10 20 30 40 50 60 MNTNSKEVLS LGVQVPEAWE ELLTMKVEAK SHLQWQESRL KRSNPLAREI FRRHFRQLCY 70 80 90 100 110 120 QETPGPREAL TRLQELCYQW LRPHVSTKEQ ILDLLVLEQF LSILPKELQG WVREHCPESG 130 140 150 160 170 180 EEAVILLEDL ERELDEPQHE MVAHRHRQEV LCKEMVPLAE QTPLTLQSQP KEPQLTCDSA 190 200 210 220 230 240 QKCHSIGETD LIRSLRRRAV LIPLGAHLFS TDTFLFSKPV VIPQLKGGGE TWPNNRGVLR 250 260 270 280 290 300 DEVTKTEDRE LVLRKDCPKI VEPHGKMFNE QTWEVSQQDP SHGEVGEHKD RIERQWGNLL 310 320 330 340 350 360 GEGQHKCDEC GKSFTQSSGL IRHQRIHTGE RPYECNECGK AFSRSSGLFN HRGIHNIQKR 370 380 390 400 410 420 YHCKECGKVF SQSAGLIQHQ RIHKGEKPYQ CSQCSKSYSR RSFLIEHQRS HTGERPHQCI 430 440 ECGKSFNRHC NLIRHQKIHT VAELV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain." Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Beutler E. Genomics 43:191-201(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Tissue: Duodenum.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[3]	"Identification of a human cell proliferation inducing gene." Kim J.W. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62392 mRNA. Translation: AAC51659.1. U88082, U88081 Genomic DNA. Translation: AAC51661.1. AK304013 mRNA. Translation: BAG64928.1. AY550973 mRNA. Translation: AAT52219.1. AL022393 Genomic DNA. Translation: CAA18533.1. CH471081 Genomic DNA. Translation: EAX03140.1. BC010374 mRNA. Translation: AAH10374.1.
IPI	IPI00007330. IPI00909838.
RefSeq	NP_001186408.1. NM_001199479.1. NP_001186409.1. NM_001199480.1. NP_006290.1. NM_006299.4.
UniGene	Hs.100921. Hs.731936.
3D structure databases
ProteinModelPortal	O15535.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15535. 1 interaction.
MINT	MINT-1483710.
STRING	9606.ENSP00000252207.
PTM databases
PhosphoSite	O15535.
Proteomic databases
PaxDb	O15535.
PRIDE	O15535.
Protocols and materials databases
DNASU	7746.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252207; ENSP00000252207; ENSG00000137185. ENST00000425468; ENSP00000404074; ENSG00000137185. ENST00000531979; ENSP00000433402; ENSG00000137185.
GeneID	7746.
KEGG	hsa:7746.
UCSC	uc003nkq.2. human.
Organism-specific databases
CTD	7746.
GeneCards	GC06P028193.
HGNC	HGNC:12984. ZSCAN9.
MIM	602246. gene.
neXtProt	NX_O15535.
PharmGKB	PA37564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG330991.
HOGENOM	HOG000234619.
HOVERGEN	HBG018163.
InParanoid	O15535.
KO	K09230.
OMA	HEMVAYR.
OrthoDB	EOG4FXR7R.
PhylomeDB	O15535.
Gene expression databases
ArrayExpress	O15535.
Bgee	O15535.
CleanEx	HS_ZNF193.
Genevestigator	O15535.
GermOnline	ENSG00000137185. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7746.
NextBio	29980.
SOURCE	Search...

Entry information

Entry name

ZSC9_HUMAN

Accession

Primary (citable) accession number: O15535
Secondary accession number(s): B4E1W6, E7EVQ2, Q2TTR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 128 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.