##gff-version 3 O15534 UniProtKB Chain 1 1290 . . . ID=PRO_0000162627;Note=Period circadian protein homolog 1 O15534 UniProtKB Domain 208 275 . . . Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 O15534 UniProtKB Domain 348 414 . . . Note=PAS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 O15534 UniProtKB Domain 422 465 . . . Note=PAC O15534 UniProtKB Region 1 151 . . . Note=Interaction with BTRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222 O15534 UniProtKB Region 1 134 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 508 544 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 596 815 . . . Note=Required for phosphorylation by CSNK1E;Ontology_term=ECO:0000250;evidence=ECO:0000250 O15534 UniProtKB Region 646 698 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 749 772 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 805 874 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 938 977 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 996 1037 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 1051 1098 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Region 1149 1290 . . . Note=CRY binding domain;Ontology_term=ECO:0000250;evidence=ECO:0000250 O15534 UniProtKB Region 1207 1290 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Motif 138 147 . . . Note=Nuclear export signal 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54943 O15534 UniProtKB Motif 489 498 . . . Note=Nuclear export signal 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35973 O15534 UniProtKB Motif 827 843 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35973 O15534 UniProtKB Motif 982 989 . . . Note=Nuclear export signal 3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O54943 O15534 UniProtKB Motif 1043 1047 . . . Note=LXXLL O15534 UniProtKB Compositional bias 21 37 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 43 134 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 646 670 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 751 769 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 827 845 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 857 874 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Compositional bias 947 970 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O15534 UniProtKB Modified residue 121 121 . . . Note=Phosphothreonine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255 O15534 UniProtKB Modified residue 122 122 . . . Note=Phosphoserine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255 O15534 UniProtKB Modified residue 126 126 . . . Note=Phosphoserine%3B by CSNK1E;Ontology_term=ECO:0000255;evidence=ECO:0000255 O15534 UniProtKB Modified residue 661 661 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35973 O15534 UniProtKB Modified residue 663 663 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35973 O15534 UniProtKB Modified residue 704 704 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163 O15534 UniProtKB Modified residue 815 815 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163 O15534 UniProtKB Modified residue 979 979 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17081983;Dbxref=PMID:17081983 O15534 UniProtKB Modified residue 980 980 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17081983;Dbxref=PMID:17081983 O15534 UniProtKB Alternative sequence 1 32 . . . ID=VSP_056205;Note=In isoform 2. MSGPLEGADGGGDPRPGESFCPGGVPSPGPPQ->MLEVLEEIWSVRARRA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O15534 UniProtKB Alternative sequence 822 875 . . . ID=VSP_056206;Note=In isoform 2. CHHGPAPPSRRHHCRSKAKRSRHHQNPRAEAPCYVSHPSPVPPSTPWPTPPATT->SHLGPPGACPLPSLGLDCWGVGLKGGVSAPGTQAGVASTTRPCLGTGPSLASPH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O15534 UniProtKB Alternative sequence 876 1290 . . . ID=VSP_056207;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O15534 UniProtKB Natural variant 422 422 . . . ID=VAR_079176;Note=Found in a patient with Moyamoya disease%3B uncertain significance. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27717682;Dbxref=dbSNP:rs1464745710,PMID:27717682 O15534 UniProtKB Natural variant 696 696 . . . ID=VAR_036038;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 O15534 UniProtKB Natural variant 962 962 . . . ID=VAR_047899;Note=A->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10857746,ECO:0000269|PubMed:10940553,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:9323128,ECO:0000269|PubMed:9333243,ECO:0000269|PubMed:9455484,ECO:0000269|Ref.9;Dbxref=dbSNP:rs2585405,PMID:10857746,PMID:10940553,PMID:15489334,PMID:9323128,PMID:9333243,PMID:9455484 O15534 UniProtKB Natural variant 968 968 . . . ID=VAR_047900;Note=R->H;Dbxref=dbSNP:rs3027193 O15534 UniProtKB Natural variant 985 985 . . . ID=VAR_036039;Note=In a breast cancer sample%3B somatic mutation. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1323588262,PMID:16959974 O15534 UniProtKB Natural variant 1060 1060 . . . ID=VAR_036040;Note=In a colorectal cancer sample%3B somatic mutation. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs761958964,PMID:16959974 O15534 UniProtKB Mutagenesis 121 126 . . . Note=Strongly decreases interaction with BTRC and FBXW11 and inhibits degradation promoted by CSNK1E. TSGCSS->AAGCSA O15534 UniProtKB Mutagenesis 210 213 . . . Note=No effect on interaction with BTRC and FBXW11. SEYT->AEYA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222 O15534 UniProtKB Mutagenesis 714 726 . . . Note=No effect on interaction with BTRC and FBXW11. SVVSVTSQCSFSS->AVVAVTAQCAFAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222 O15534 UniProtKB Mutagenesis 794 798 . . . Note=Strongly decreases interaction with BTRC and FBXW11. FLSRF->ALSRA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917222;Dbxref=PMID:15917222