ID GPR42_HUMAN Reviewed; 346 AA. AC O15529; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2023, sequence version 2. DT 27-MAR-2024, entry version 172. DE RecName: Full=G-protein coupled receptor 42; GN Name=GPR42; Synonyms=GPR42P; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=9344866; DOI=10.1006/bbrc.1997.7513; RA Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., RA O'Dowd B.F.; RT "A cluster of four novel human G protein-coupled receptor genes occurring RT in close proximity to CD22 gene on chromosome 19q13.1."; RL Biochem. Biophys. Res. Commun. 239:543-547(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT TRP-174. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [3] RP CHARACTERIZATION OF VARIANT TPR-174. RX PubMed=12496283; DOI=10.1074/jbc.m211609200; RA Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., RA Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J., RA Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C., RA Marshall F.H., Szekeres P.G., Wilson S., Ignar D.M., Foord S.M., Wise A., RA Dowell S.J.; RT "The orphan G protein-coupled receptors GPR41 and GPR43 are activated by RT propionate and other short chain carboxylic acids."; RL J. Biol. Chem. 278:11312-11319(2003). RN [4] RP VARIANTS GLN-44; ARG-45; TRP-174; LEU-227; ALA-256 AND SER-346. RX PubMed=19630535; DOI=10.1089/dna.2009.0916; RA Liaw C.W., Connolly D.T.; RT "Sequence polymorphisms provide a common consensus sequence for GPR41 and RT GPR42."; RL DNA Cell Biol. 28:555-560(2009). CC -!- FUNCTION: G protein-coupled receptor that is activated by short chain CC fatty acids (SCFAs), such as propionate. Hence may play a role in the CC regulation of whole-body energy homeostasis and/or in intestinal CC immunity. {ECO:0000269|PubMed:19630535}. CC -!- INTERACTION: CC O15529; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-18076404, EBI-10827839; CC O15529; P20292: ALOX5AP; NbExp=3; IntAct=EBI-18076404, EBI-3904621; CC O15529; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18076404, EBI-12109402; CC O15529; P05090: APOD; NbExp=3; IntAct=EBI-18076404, EBI-715495; CC O15529; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-18076404, EBI-12069500; CC O15529; P51164: ATP4B; NbExp=3; IntAct=EBI-18076404, EBI-3904463; CC O15529; Q99437: ATP6V0B; NbExp=3; IntAct=EBI-18076404, EBI-3904417; CC O15529; P27449: ATP6V0C; NbExp=3; IntAct=EBI-18076404, EBI-721179; CC O15529; Q12983: BNIP3; NbExp=3; IntAct=EBI-18076404, EBI-749464; CC O15529; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-18076404, EBI-8648738; CC O15529; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18076404, EBI-9083477; CC O15529; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-18076404, EBI-10271156; CC O15529; Q08708: CD300C; NbExp=3; IntAct=EBI-18076404, EBI-3915344; CC O15529; P11912: CD79A; NbExp=3; IntAct=EBI-18076404, EBI-7797864; CC O15529; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-18076404, EBI-11749983; CC O15529; P21964: COMT; NbExp=3; IntAct=EBI-18076404, EBI-372265; CC O15529; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-18076404, EBI-12019274; CC O15529; Q07325: CXCL9; NbExp=3; IntAct=EBI-18076404, EBI-3911467; CC O15529; Q8N682: DRAM1; NbExp=3; IntAct=EBI-18076404, EBI-10305400; CC O15529; P52803: EFNA5; NbExp=3; IntAct=EBI-18076404, EBI-1753674; CC O15529; P54849: EMP1; NbExp=3; IntAct=EBI-18076404, EBI-4319440; CC O15529; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-18076404, EBI-10976398; CC O15529; Q92520: FAM3C; NbExp=3; IntAct=EBI-18076404, EBI-2876774; CC O15529; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-18076404, EBI-12175685; CC O15529; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-18076404, EBI-713304; CC O15529; P29033: GJB2; NbExp=3; IntAct=EBI-18076404, EBI-3905204; CC O15529; O14653: GOSR2; NbExp=3; IntAct=EBI-18076404, EBI-4401517; CC O15529; O60883: GPR37L1; NbExp=3; IntAct=EBI-18076404, EBI-2927498; CC O15529; P04921: GYPC; NbExp=3; IntAct=EBI-18076404, EBI-7797098; CC O15529; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-18076404, EBI-725665; CC O15529; P24593: IGFBP5; NbExp=3; IntAct=EBI-18076404, EBI-720480; CC O15529; Q01638-2: IL1RL1; NbExp=3; IntAct=EBI-18076404, EBI-12838366; CC O15529; P11215: ITGAM; NbExp=3; IntAct=EBI-18076404, EBI-2568251; CC O15529; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-18076404, EBI-465137; CC O15529; Q09470: KCNA1; NbExp=3; IntAct=EBI-18076404, EBI-8286599; CC O15529; Q96E93: KLRG1; NbExp=3; IntAct=EBI-18076404, EBI-750770; CC O15529; O43561-2: LAT; NbExp=3; IntAct=EBI-18076404, EBI-8070286; CC O15529; O95214: LEPROTL1; NbExp=3; IntAct=EBI-18076404, EBI-750776; CC O15529; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-18076404, EBI-2820517; CC O15529; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-18076404, EBI-12133176; CC O15529; Q16873: LTC4S; NbExp=3; IntAct=EBI-18076404, EBI-12241118; CC O15529; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18076404, EBI-3920969; CC O15529; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18076404, EBI-2858252; CC O15529; O43451: MGAM; NbExp=3; IntAct=EBI-18076404, EBI-2829774; CC O15529; P11836: MS4A1; NbExp=3; IntAct=EBI-18076404, EBI-2808234; CC O15529; Q9NX14: NDUFB11; NbExp=3; IntAct=EBI-18076404, EBI-1246182; CC O15529; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18076404, EBI-10317425; CC O15529; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18076404, EBI-10262547; CC O15529; P42857: NSG1; NbExp=3; IntAct=EBI-18076404, EBI-6380741; CC O15529; P09466: PAEP; NbExp=3; IntAct=EBI-18076404, EBI-465167; CC O15529; P60201-2: PLP1; NbExp=3; IntAct=EBI-18076404, EBI-12188331; CC O15529; O14494: PLPP1; NbExp=3; IntAct=EBI-18076404, EBI-2865290; CC O15529; Q01453: PMP22; NbExp=3; IntAct=EBI-18076404, EBI-2845982; CC O15529; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-18076404, EBI-8652812; CC O15529; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18076404, EBI-1052363; CC O15529; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18076404, EBI-10244780; CC O15529; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-18076404, EBI-8636004; CC O15529; O00767: SCD; NbExp=3; IntAct=EBI-18076404, EBI-2684237; CC O15529; Q9NRX5: SERINC1; NbExp=3; IntAct=EBI-18076404, EBI-2683145; CC O15529; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-18076404, EBI-749270; CC O15529; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-18076404, EBI-17284533; CC O15529; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18076404, EBI-8644112; CC O15529; Q99726: SLC30A3; NbExp=3; IntAct=EBI-18076404, EBI-10294651; CC O15529; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-18076404, EBI-10262251; CC O15529; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-18076404, EBI-12867720; CC O15529; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-18076404, EBI-9978441; CC O15529; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-18076404, EBI-10314552; CC O15529; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-18076404, EBI-12898013; CC O15529; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-18076404, EBI-12266234; CC O15529; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-18076404, EBI-10290130; CC O15529; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-18076404, EBI-8640191; CC O15529; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-18076404, EBI-741850; CC O15529; P02808: STATH; NbExp=3; IntAct=EBI-18076404, EBI-738687; CC O15529; P0DN84: STRIT1; NbExp=3; IntAct=EBI-18076404, EBI-12200293; CC O15529; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18076404, EBI-727240; CC O15529; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-18076404, EBI-726331; CC O15529; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-18076404, EBI-12187159; CC O15529; Q9Y6I9: TEX264; NbExp=3; IntAct=EBI-18076404, EBI-10329860; CC O15529; P02787: TF; NbExp=3; IntAct=EBI-18076404, EBI-714319; CC O15529; P48230: TM4SF4; NbExp=3; IntAct=EBI-18076404, EBI-8650934; CC O15529; P55061: TMBIM6; NbExp=3; IntAct=EBI-18076404, EBI-1045825; CC O15529; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18076404, EBI-2844246; CC O15529; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-18076404, EBI-348587; CC O15529; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-18076404, EBI-10255122; CC O15529; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-18076404, EBI-741829; CC O15529; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-18076404, EBI-10982110; CC O15529; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-18076404, EBI-11528917; CC O15529; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-18076404, EBI-10315004; CC O15529; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-18076404, EBI-17180389; CC O15529; Q3MIR4: TMEM30B; NbExp=3; IntAct=EBI-18076404, EBI-9527107; CC O15529; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18076404, EBI-2852148; CC O15529; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-18076404, EBI-6656213; CC O15529; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18076404, EBI-16746122; CC O15529; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-18076404, EBI-12195249; CC O15529; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18076404, EBI-11988865; CC O15529; O95070: YIF1A; NbExp=3; IntAct=EBI-18076404, EBI-2799703; CC O15529; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-18076404, EBI-7850136; CC O15529; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18076404, EBI-751204; CC O15529; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-18076404, EBI-751253; CC O15529; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-18076404, EBI-751210; CC O15529; O95159: ZFPL1; NbExp=3; IntAct=EBI-18076404, EBI-718439; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane CC protein {ECO:0000250}. CC -!- POLYMORPHISM: The sequence shown in this entry differs from the CC translation of the reference genome assembly (GRCh38/hg38) due to a CC missense variant at position 174, p.Arg174Trp, in the reference genome, CC that results in the loss of response to short chain fatty acids, CC including propionate. The sequence shown in this entry is that of CC variant p.Trp174Arg. This variant is activated by propionate and has a CC frequency of about 15% in the human population according to the Genome CC Aggregation Database (gnomAD v2.1.1). {ECO:0000269|PubMed:19630535}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- CAUTION: The sequence shown in this entry differs from the translation CC of the reference genome assembly (GRCh38/hg38) due to a missense CC variant at position 174 in the reference genome, that results in the CC loss of response to short chain fatty acids, including propionate. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF024689; AAB86712.1; -; Genomic_DNA. DR EMBL; AC002511; AAB67885.1; -; Genomic_DNA. DR CCDS; CCDS12460.1; -. DR PIR; JC5716; JC5716. DR RefSeq; NP_001335124.1; NM_001348195.1. DR AlphaFoldDB; O15529; -. DR SMR; O15529; -. DR IntAct; O15529; 101. DR STRING; 9606.ENSP00000473212; -. DR GlyCosmos; O15529; 1 site, No reported glycans. DR GlyGen; O15529; 1 site. DR BioMuta; GPR42; -. DR PaxDb; 9606-ENSP00000473212; -. DR PeptideAtlas; O15529; -. DR Antibodypedia; 71522; 16 antibodies from 9 providers. DR DNASU; 2866; -. DR Ensembl; ENST00000454971.3; ENSP00000410925.1; ENSG00000126251.7. DR Ensembl; ENST00000597214.1; ENSP00000473212.1; ENSG00000126251.7. DR GeneID; 2866; -. DR KEGG; hsa:2866; -. DR MANE-Select; ENST00000454971.3; ENSP00000410925.1; NM_001348195.2; NP_001335124.1. DR UCSC; uc021usn.2; human. DR AGR; HGNC:4500; -. DR DisGeNET; 2866; -. DR GeneCards; GPR42; -. DR HGNC; HGNC:4500; GPR42. DR HPA; ENSG00000126251; Not detected. DR MIM; 603822; gene. DR neXtProt; NX_O15529; -. DR VEuPathDB; HostDB:ENSG00000126251; -. DR eggNOG; ENOG502QQGM; Eukaryota. DR HOGENOM; CLU_009579_8_4_1; -. DR InParanoid; O15529; -. DR OrthoDB; 2899073at2759; -. DR PhylomeDB; O15529; -. DR TreeFam; TF350010; -. DR PathwayCommons; O15529; -. DR SignaLink; O15529; -. DR BioGRID-ORCS; 2866; 0 hits in 43 CRISPR screens. DR GenomeRNAi; 2866; -. DR Pharos; O15529; Tdark. DR PRO; PR:O15529; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; O15529; Protein. DR Bgee; ENSG00000126251; Expressed in blood and 34 other cell types or tissues. DR ExpressionAtlas; O15529; baseline and differential. DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc. DR GO; GO:0004930; F:G protein-coupled receptor activity; NAS:UniProtKB. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; NAS:UniProtKB. DR CDD; cd15170; 7tmA_FFAR2_FFAR3; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR013312; GPR40-rel_orph. DR PANTHER; PTHR45822; FREE FATTY ACID RECEPTOR 2-RELATED; 1. DR PANTHER; PTHR45822:SF6; FREE FATTY ACID RECEPTOR 3-RELATED; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01904; GPR40FAMILY. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; O15529; HS. PE 1: Evidence at protein level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..346 FT /note="G-protein coupled receptor 42" FT /id="PRO_0000069570" FT TOPO_DOM 1..19 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 20..40 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 41..47 FT /note="Cytoplasmic" FT TRANSMEM 48..68 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 69..90 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 91..111 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 112..132 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 133..153 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 154..178 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 179..199 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 200..222 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 223..243 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 244..258 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 259..279 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 280..346 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 307..346 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 309..329 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 166 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 44 FT /note="R -> Q (in dbSNP:rs878906072)" FT /evidence="ECO:0000269|PubMed:19630535" FT /id="VAR_062860" FT VARIANT 45 FT /note="C -> R (in dbSNP:rs423385)" FT /evidence="ECO:0000269|PubMed:19630535" FT /id="VAR_033468" FT VARIANT 174 FT /note="R -> W (loss of response to propionate; FT dbSNP:rs424241)" FT /evidence="ECO:0000269|PubMed:12496283, FT ECO:0000269|PubMed:15057824, ECO:0000269|PubMed:19630535" FT /id="VAR_088067" FT VARIANT 227 FT /note="V -> L (in dbSNP:rs403989)" FT /evidence="ECO:0000269|PubMed:19630535" FT /id="VAR_033469" FT VARIANT 256 FT /note="V -> A (in dbSNP:rs424715)" FT /evidence="ECO:0000269|PubMed:19630535" FT /id="VAR_033470" FT VARIANT 346 FT /note="N -> S (in dbSNP:rs381478)" FT /evidence="ECO:0000269|PubMed:19630535" FT /id="VAR_062862" SQ SEQUENCE 346 AA; 38665 MW; 802BC2F010A3CB58 CRC64; MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN //