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O15529

- GPR42_HUMAN

UniProt

O15529 - GPR42_HUMAN

Protein

G-protein coupled receptor 42

Gene

GPR42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.1 Publication

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 42
    Gene namesi
    Name:GPR42
    Synonyms:GPR42P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4500. GPR42.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346G-protein coupled receptor 42PRO_0000069570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO15529.
    PRIDEiO15529.

    Expressioni

    Gene expression databases

    BgeeiO15529.
    GenevestigatoriO15529.

    Organism-specific databases

    HPAiHPA044681.

    Structurei

    3D structure databases

    ProteinModelPortaliO15529.
    SMRiO15529. Positions 6-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini41 – 477Cytoplasmic
    Topological domaini69 – 9022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 17825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 22223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 34667CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei48 – 6821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47521.
    HOGENOMiHOG000026778.
    HOVERGENiHBG051811.
    InParanoidiO15529.
    OMAiIMESTVS.
    OrthoDBiEOG7SFHXH.
    PhylomeDBiO15529.
    TreeFamiTF350010.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR013312. GPR40-rel_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01904. GPR40FAMILY.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15529-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV    50
    DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY 100
    LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV 150
    YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT 200
    SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI 250
    CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 300
    WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN 346
    Length:346
    Mass (Da):38,695
    Last modified:January 1, 1998 - v1
    Checksum:i03F6742DA4B798D0
    GO

    Polymorphismi

    Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441R → Q.1 Publication
    VAR_062860
    Natural varianti45 – 451C → R.1 Publication
    VAR_033468
    Natural varianti174 – 1741W → R Restores responses to propionate. 1 Publication
    VAR_062861
    Natural varianti227 – 2271V → L.1 Publication
    VAR_033469
    Natural varianti256 – 2561V → A.1 Publication
    VAR_033470
    Natural varianti346 – 3461N → S.1 Publication
    VAR_062862

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024689 Genomic DNA. Translation: AAB86712.1.
    AC002511 Genomic DNA. Translation: AAB67885.1.
    PIRiJC5716.

    Genome annotation databases

    EnsembliENST00000454971; ENSP00000410925; ENSG00000126251.
    ENST00000597214; ENSP00000473212; ENSG00000126251.
    UCSCiuc021usn.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024689 Genomic DNA. Translation: AAB86712.1 .
    AC002511 Genomic DNA. Translation: AAB67885.1 .
    PIRi JC5716.

    3D structure databases

    ProteinModelPortali O15529.
    SMRi O15529. Positions 6-295.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O15529.
    PRIDEi O15529.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000454971 ; ENSP00000410925 ; ENSG00000126251 .
    ENST00000597214 ; ENSP00000473212 ; ENSG00000126251 .
    UCSCi uc021usn.1. human.

    Organism-specific databases

    GeneCardsi GC19P035862.
    H-InvDB HIX0040157.
    HGNCi HGNC:4500. GPR42.
    HPAi HPA044681.
    MIMi 603822. gene.
    neXtProti NX_O15529.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47521.
    HOGENOMi HOG000026778.
    HOVERGENi HBG051811.
    InParanoidi O15529.
    OMAi IMESTVS.
    OrthoDBi EOG7SFHXH.
    PhylomeDBi O15529.
    TreeFami TF350010.

    Miscellaneous databases

    PROi O15529.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15529.
    Genevestigatori O15529.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR013312. GPR40-rel_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01904. GPR40FAMILY.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
      Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
      Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: CHARACTERIZATION OF VARIANT ARG-174.
    4. "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."
      Liaw C.W., Connolly D.T.
      DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS A FUNCTIONAL GENE, FUNCTION, POLYMORPHISM, VARIANTS GLN-44; ARG-45; ARG-174; LEU-227; ALA-256 AND SER-346.

    Entry informationi

    Entry nameiGPR42_HUMAN
    AccessioniPrimary (citable) accession number: O15529
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3