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O15529 (GPR42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 42
Gene names
Name:GPR42
Synonyms:GPR42P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a receptor for short chain fatty acids, such as propionate. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

Sequence differences between GPR42 and FFAR3 are due to polymorphisms.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.3) thought to be a pseudogene.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346G-protein coupled receptor 42
PRO_0000069570

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4021Helical; Name=1; Potential
Topological domain41 – 477Cytoplasmic
Transmembrane48 – 6821Helical; Name=2; Potential
Topological domain69 – 9022Extracellular Potential
Transmembrane91 – 11121Helical; Name=3; Potential
Topological domain112 – 13221Cytoplasmic Potential
Transmembrane133 – 15321Helical; Name=4; Potential
Topological domain154 – 17825Extracellular Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Topological domain200 – 22223Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=6; Potential
Topological domain244 – 25815Extracellular Potential
Transmembrane259 – 27921Helical; Name=7; Potential
Topological domain280 – 34667Cytoplasmic Potential

Amino acid modifications

Glycosylation1661N-linked (GlcNAc...) Potential

Natural variations

Natural variant441R → Q. Ref.4
VAR_062860
Natural variant451C → R. Ref.4
VAR_033468
Natural variant1741W → R Restores responses to propionate. Ref.3 Ref.4
VAR_062861
Natural variant2271V → L. Ref.4
VAR_033469
Natural variant2561V → A. Ref.4
VAR_033470
Natural variant3461N → S. Ref.4
VAR_062862

Sequences

Sequence LengthMass (Da)Tools
O15529 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 03F6742DA4B798D0

FASTA34638,695
        10         20         30         40         50         60 
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS 

        70         80         90        100        110        120 
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP 

       130        140        150        160        170        180 
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI 

       190        200        210        220        230        240 
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP 

       250        260        270        280        290        300 
YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 

       310        320        330        340 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN 

« Hide

References

« Hide 'large scale' references
[1]"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids."
Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J., Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C., Marshall F.H., Szekeres P.G., Wilson S. expand/collapse author list , Ignar D.M., Foord S.M., Wise A., Dowell S.J.
J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT ARG-174.
[4]"Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."
Liaw C.W., Connolly D.T.
DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A FUNCTIONAL GENE, FUNCTION, POLYMORPHISM, VARIANTS GLN-44; ARG-45; ARG-174; LEU-227; ALA-256 AND SER-346.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024689 Genomic DNA. Translation: AAB86712.1.
AC002511 Genomic DNA. Translation: AAB67885.1.
PIRJC5716.

3D structure databases

ProteinModelPortalO15529.
SMRO15529. Positions 6-295.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO15529.
PRIDEO15529.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000454971; ENSP00000410925; ENSG00000126251.
ENST00000597214; ENSP00000473212; ENSG00000126251.
UCSCuc021usn.1. human.

Organism-specific databases

GeneCardsGC19P035862.
H-InvDBHIX0040157.
HGNCHGNC:4500. GPR42.
HPAHPA044681.
MIM603822. gene.
neXtProtNX_O15529.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47521.
HOGENOMHOG000026778.
HOVERGENHBG051811.
InParanoidO15529.
OMAIMESTVS.
OrthoDBEOG7SFHXH.
PhylomeDBO15529.
TreeFamTF350010.

Gene expression databases

BgeeO15529.
GenevestigatorO15529.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO15529.
SOURCESearch...

Entry information

Entry nameGPR42_HUMAN
AccessionPrimary (citable) accession number: O15529
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries