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O15529

- GPR42_HUMAN

UniProt

O15529 - GPR42_HUMAN

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Protein

G-protein coupled receptor 42

Gene

GPR42

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 42
Gene namesi
Name:GPR42
Synonyms:GPR42P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4500. GPR42.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 477Cytoplasmic
Transmembranei48 – 6821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini69 – 9022ExtracellularSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 13221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini154 – 17825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini200 – 22223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini244 – 25815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini280 – 34667CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346G-protein coupled receptor 42PRO_0000069570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15529.
PRIDEiO15529.

Expressioni

Gene expression databases

BgeeiO15529.
GenevestigatoriO15529.

Organism-specific databases

HPAiHPA044681.

Structurei

3D structure databases

ProteinModelPortaliO15529.
SMRiO15529. Positions 16-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47521.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000026778.
HOVERGENiHBG051811.
InParanoidiO15529.
OMAiIMESTVS.
OrthoDBiEOG7SFHXH.
PhylomeDBiO15529.
TreeFamiTF350010.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15529-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV
60 70 80 90 100
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY
110 120 130 140 150
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV
160 170 180 190 200
YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI LLPVRLEMAV VLFVVPLIIT
210 220 230 240 250
SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI
260 270 280 290 300
CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
310 320 330 340
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN
Length:346
Mass (Da):38,695
Last modified:January 1, 1998 - v1
Checksum:i03F6742DA4B798D0
GO

Polymorphismi

Was originally thought to be a pseudogene due to the presence of a Trp at position 174 which prevents activation by short chain fatty acids, such as propionate (PubMed:12496283). However, the inactivating Trp-174 that differentiate GPR42 from the homologous functional G-protein-coupled receptor FFAR3 is most probably polymorphic for both genes in the human population. The frequency of the active allele of GPR42, with Arg at position 174, is estimated to 61%. Moreover, the 5 other amino acid differences at positions 44, 45, 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the human population (PubMed:19630535).2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → Q.1 Publication
VAR_062860
Natural varianti45 – 451C → R.1 Publication
VAR_033468
Natural varianti174 – 1741W → R Restores responses to propionate. 1 Publication
VAR_062861
Natural varianti227 – 2271V → L.1 Publication
VAR_033469
Natural varianti256 – 2561V → A.1 Publication
VAR_033470
Natural varianti346 – 3461N → S.1 Publication
VAR_062862

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024689 Genomic DNA. Translation: AAB86712.1.
AC002511 Genomic DNA. Translation: AAB67885.1.
PIRiJC5716.

Genome annotation databases

EnsembliENST00000454971; ENSP00000410925; ENSG00000126251.
ENST00000597214; ENSP00000473212; ENSG00000126251.
UCSCiuc021usn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024689 Genomic DNA. Translation: AAB86712.1 .
AC002511 Genomic DNA. Translation: AAB67885.1 .
PIRi JC5716.

3D structure databases

ProteinModelPortali O15529.
SMRi O15529. Positions 16-295.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O15529.
PRIDEi O15529.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000454971 ; ENSP00000410925 ; ENSG00000126251 .
ENST00000597214 ; ENSP00000473212 ; ENSG00000126251 .
UCSCi uc021usn.1. human.

Organism-specific databases

GeneCardsi GC19P035966.
H-InvDB HIX0040157.
HGNCi HGNC:4500. GPR42.
HPAi HPA044681.
MIMi 603822. gene.
neXtProti NX_O15529.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47521.
GeneTreei ENSGT00760000119001.
HOGENOMi HOG000026778.
HOVERGENi HBG051811.
InParanoidi O15529.
OMAi IMESTVS.
OrthoDBi EOG7SFHXH.
PhylomeDBi O15529.
TreeFami TF350010.

Miscellaneous databases

PROi O15529.
SOURCEi Search...

Gene expression databases

Bgeei O15529.
Genevestigatori O15529.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
    Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
    Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: CHARACTERIZATION OF VARIANT ARG-174.
  4. "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."
    Liaw C.W., Connolly D.T.
    DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A FUNCTIONAL GENE, FUNCTION, POLYMORPHISM, VARIANTS GLN-44; ARG-45; ARG-174; LEU-227; ALA-256 AND SER-346.

Entry informationi

Entry nameiGPR42_HUMAN
AccessioniPrimary (citable) accession number: O15529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3