G-protein coupled receptor 42 - Homo sapiens (Human)

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O15529 (GPR42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 42

Gene names

Name:	GPR42
Synonyms:	GPR42P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a receptor for short chain fatty acids, such as propionate. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	Sequence differences between GPR42 and FFAR3 are due to polymorphisms.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally (Ref.3) thought to be a pseudogene.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 346

346

G-protein coupled receptor 42

PRO_0000069570

Regions

Topological domain

1 – 19

Extracellular Potential

Transmembrane

20 – 40

Helical; Name=1; Potential

Topological domain

41 – 47

Cytoplasmic

Transmembrane

48 – 68

Helical; Name=2; Potential

Topological domain

69 – 90

Extracellular Potential

Transmembrane

91 – 111

Helical; Name=3; Potential

Topological domain

112 – 132

Cytoplasmic Potential

Transmembrane

133 – 153

Helical; Name=4; Potential

Topological domain

154 – 178

Extracellular Potential

Transmembrane

179 – 199

Helical; Name=5; Potential

Topological domain

200 – 222

Cytoplasmic Potential

Transmembrane

223 – 243

Helical; Name=6; Potential

Topological domain

244 – 258

Extracellular Potential

Transmembrane

259 – 279

Helical; Name=7; Potential

Topological domain

280 – 346

Cytoplasmic Potential

Amino acid modifications

Glycosylation

166

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

R → Q. Ref.4

VAR_062860

Natural variant

C → R. Ref.4

VAR_033468

Natural variant

174

W → R Restores responses to propionate. Ref.3 Ref.4

VAR_062861

Natural variant

227

V → L. Ref.4

VAR_033469

Natural variant

256

V → A. Ref.4

VAR_033470

Natural variant

346

N → S. Ref.4

VAR_062862

Sequences

Sequence

Length

Mass (Da)

Tools

O15529 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 03F6742DA4B798D0
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FASTA

346

38,695

        10         20         30         40         50         60 
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS 

        70         80         90        100        110        120 
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP 

       130        140        150        160        170        180 
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI 

       190        200        210        220        230        240 
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP 

       250        260        270        280        290        300 
YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 

       310        320        330        340 
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1." Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F. Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids." Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J., Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C., Marshall F.H., Szekeres P.G., Wilson S. , Ignar D.M., Foord S.M., Wise A., Dowell S.J. J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT ARG-174.
[4]	"Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42." Liaw C.W., Connolly D.T. DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A FUNCTIONAL GENE, FUNCTION, POLYMORPHISM, VARIANTS GLN-44; ARG-45; ARG-174; LEU-227; ALA-256 AND SER-346.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF024689 Genomic DNA. Translation: AAB86712.1. AC002511 Genomic DNA. Translation: AAB67885.1.
IPI	IPI00007314.
PIR	JC5716.
3D structure databases
ProteinModelPortal	O15529.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	O15529.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000454971; ENSP00000410925; ENSG00000126251. ENST00000597214; ENSP00000473212; ENSG00000126251.
UCSC	uc021usn.1. human.
Organism-specific databases
GeneCards	GC19P035862.
H-InvDB	HIX0040157.
HGNC	HGNC:4500. GPR42.
HPA	HPA044681.
MIM	603822. gene.
neXtProt	NX_O15529.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47521.
HOGENOM	HOG000026778.
HOVERGEN	HBG051811.
InParanoid	O15529.
OMA	ETASAMY.
OrthoDB	EOG4XSKQX.
PhylomeDB	O15529.
Gene expression databases
Bgee	O15529.
Genevestigator	O15529.
GermOnline	ENSG00000126251. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR013312. GPR40-rel_orph. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01904. GPR40FAMILY.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

GPR42_HUMAN

Accession

Primary (citable) accession number: O15529

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.