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O15522

- NKX28_HUMAN

UniProt

O15522 - NKX28_HUMAN

Protein

Homeobox protein Nkx-2.8

Gene

NKX2-8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi84 – 14360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. double-stranded DNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. liver development Source: UniProtKB
    3. lung development Source: Ensembl
    4. negative regulation of epithelial cell proliferation Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB
    6. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-2.8
    Alternative name(s):
    Homeobox protein NK-2 homolog H
    Gene namesi
    Name:NKX2-8
    Synonyms:NKX-2.8, NKX2G, NKX2H
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:16364. NKX2-8.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38402.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Homeobox protein Nkx-2.8PRO_0000048943Add
    BLAST

    Proteomic databases

    PaxDbiO15522.
    PRIDEiO15522.

    Expressioni

    Gene expression databases

    BgeeiO15522.
    CleanExiHS_NKX2-8.
    GenevestigatoriO15522.

    Organism-specific databases

    HPAiHPA062879.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000258829.

    Structurei

    3D structure databases

    ProteinModelPortaliO15522.
    SMRiO15522. Positions 83-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi182 – 1876Poly-Gly

    Sequence similaritiesi

    Belongs to the NK-2 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG243784.
    HOGENOMiHOG000231923.
    HOVERGENiHBG006689.
    InParanoidiO15522.
    KOiK09347.
    OMAiERSHYPS.
    OrthoDBiEOG769ZK0.
    PhylomeDBiO15522.
    TreeFamiTF351204.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15522-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSGRLSFT VRSLLDLPEQ DAQHLPRREP EPRAPQPDPC AAWLDSERGH    50
    YPSSDESSLE TSPPDSSQRP SARPASPGSD AEKRKKRRVL FSKAQTLELE 100
    RRFRQQRYLS APEREQLASL LRLTPTQVKI WFQNHRYKLK RARAPGAAES 150
    PDLAASAELH AAPGLLRRVV VPVLVRDGQP CGGGGGGEVG TAAAQEKCGA 200
    PPAAACPLPG YPAFGPGSAL GLFPAYQHLA SPALVSWNW 239
    Length:239
    Mass (Da):25,866
    Last modified:September 23, 2008 - v2
    Checksum:iE227378CCD6E9D27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161D → G in AAC71081. (PubMed:9446603)Curated
    Sequence conflicti16 – 161D → G in AAC71082. (PubMed:9446603)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161D → A.
    VAR_003753

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000295 mRNA. Translation: AAC71081.1.
    AF000297, AF000296 Genomic DNA. Translation: AAC71082.1.
    AK313537 mRNA. Translation: BAG36314.1.
    BC041090 mRNA. Translation: AAH41090.1.
    CCDSiCCDS9660.1.
    RefSeqiNP_055175.2. NM_014360.2.
    UniGeneiHs.234763.

    Genome annotation databases

    EnsembliENST00000258829; ENSP00000258829; ENSG00000136327.
    GeneIDi26257.
    KEGGihsa:26257.
    UCSCiuc001wtx.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000295 mRNA. Translation: AAC71081.1 .
    AF000297 , AF000296 Genomic DNA. Translation: AAC71082.1 .
    AK313537 mRNA. Translation: BAG36314.1 .
    BC041090 mRNA. Translation: AAH41090.1 .
    CCDSi CCDS9660.1.
    RefSeqi NP_055175.2. NM_014360.2.
    UniGenei Hs.234763.

    3D structure databases

    ProteinModelPortali O15522.
    SMRi O15522. Positions 83-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000258829.

    Proteomic databases

    PaxDbi O15522.
    PRIDEi O15522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258829 ; ENSP00000258829 ; ENSG00000136327 .
    GeneIDi 26257.
    KEGGi hsa:26257.
    UCSCi uc001wtx.3. human.

    Organism-specific databases

    CTDi 26257.
    GeneCardsi GC14M037049.
    H-InvDB HIX0026629.
    HGNCi HGNC:16364. NKX2-8.
    HPAi HPA062879.
    MIMi 603245. gene.
    neXtProti NX_O15522.
    PharmGKBi PA38402.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243784.
    HOGENOMi HOG000231923.
    HOVERGENi HBG006689.
    InParanoidi O15522.
    KOi K09347.
    OMAi ERSHYPS.
    OrthoDBi EOG769ZK0.
    PhylomeDBi O15522.
    TreeFami TF351204.

    Miscellaneous databases

    GenomeRNAii 26257.
    NextBioi 48495.
    PROi O15522.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15522.
    CleanExi HS_NKX2-8.
    Genevestigatori O15522.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma."
      Apergis G.A., Crawford N., Ghosh D., Steppan C.M., Vorachek W.R., Wen P., Locker J.
      J. Biol. Chem. 273:2917-2925(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNKX28_HUMAN
    AccessioniPrimary (citable) accession number: O15522
    Secondary accession number(s): Q8IUT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3