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O15522 (NKX28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Nkx-2.8
Alternative name(s):
Homeobox protein NK-2 homolog H
Gene names
Name:NKX2-8
Synonyms:NKX-2.8, NKX2G, NKX2H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the NK-2 homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Homeobox protein Nkx-2.8
PRO_0000048943

Regions

DNA binding84 – 14360Homeobox
Compositional bias182 – 1876Poly-Gly

Natural variations

Natural variant161D → A.
VAR_003753

Experimental info

Sequence conflict161D → G in AAC71081. Ref.1
Sequence conflict161D → G in AAC71082. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O15522 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: E227378CCD6E9D27

FASTA23925,866
        10         20         30         40         50         60 
MATSGRLSFT VRSLLDLPEQ DAQHLPRREP EPRAPQPDPC AAWLDSERGH YPSSDESSLE 

        70         80         90        100        110        120 
TSPPDSSQRP SARPASPGSD AEKRKKRRVL FSKAQTLELE RRFRQQRYLS APEREQLASL 

       130        140        150        160        170        180 
LRLTPTQVKI WFQNHRYKLK RARAPGAAES PDLAASAELH AAPGLLRRVV VPVLVRDGQP 

       190        200        210        220        230 
CGGGGGGEVG TAAAQEKCGA PPAAACPLPG YPAFGPGSAL GLFPAYQHLA SPALVSWNW 

« Hide

References

« Hide 'large scale' references
[1]"A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma."
Apergis G.A., Crawford N., Ghosh D., Steppan C.M., Vorachek W.R., Wen P., Locker J.
J. Biol. Chem. 273:2917-2925(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000295 mRNA. Translation: AAC71081.1.
AF000297, AF000296 Genomic DNA. Translation: AAC71082.1.
AK313537 mRNA. Translation: BAG36314.1.
BC041090 mRNA. Translation: AAH41090.1.
CCDSCCDS9660.1.
RefSeqNP_055175.2. NM_014360.2.
UniGeneHs.234763.

3D structure databases

ProteinModelPortalO15522.
SMRO15522. Positions 83-143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000258829.

Proteomic databases

PaxDbO15522.
PRIDEO15522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258829; ENSP00000258829; ENSG00000136327.
GeneID26257.
KEGGhsa:26257.
UCSCuc001wtx.3. human.

Organism-specific databases

CTD26257.
GeneCardsGC14M037049.
H-InvDBHIX0026629.
HGNCHGNC:16364. NKX2-8.
HPAHPA062879.
MIM603245. gene.
neXtProtNX_O15522.
PharmGKBPA38402.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG243784.
HOGENOMHOG000231923.
HOVERGENHBG006689.
InParanoidO15522.
KOK09347.
OMAERSHYPS.
OrthoDBEOG769ZK0.
PhylomeDBO15522.
TreeFamTF351204.

Gene expression databases

BgeeO15522.
CleanExHS_NKX2-8.
GenevestigatorO15522.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi26257.
NextBio48495.
PROO15522.
SOURCESearch...

Entry information

Entry nameNKX28_HUMAN
AccessionPrimary (citable) accession number: O15522
Secondary accession number(s): Q8IUT7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM