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Protein

Homeobox protein Nkx-2.8

Gene

NKX2-8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi84 – 14360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. liver development Source: UniProtKB
  3. lung development Source: Ensembl
  4. negative regulation of epithelial cell proliferation Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  6. transcription, DNA-templated Source: UniProtKB
  7. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.8
Alternative name(s):
Homeobox protein NK-2 homolog H
Gene namesi
Name:NKX2-8
Synonyms:NKX-2.8, NKX2G, NKX2H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:16364. NKX2-8.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Homeobox protein Nkx-2.8PRO_0000048943Add
BLAST

Proteomic databases

PaxDbiO15522.
PRIDEiO15522.

Expressioni

Gene expression databases

BgeeiO15522.
CleanExiHS_NKX2-8.
GenevestigatoriO15522.

Organism-specific databases

HPAiHPA062879.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258829.

Structurei

3D structure databases

ProteinModelPortaliO15522.
SMRiO15522. Positions 83-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi182 – 1876Poly-Gly

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG243784.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiO15522.
KOiK09347.
OMAiYTAFGPG.
OrthoDBiEOG769ZK0.
PhylomeDBiO15522.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15522-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSGRLSFT VRSLLDLPEQ DAQHLPRREP EPRAPQPDPC AAWLDSERGH
60 70 80 90 100
YPSSDESSLE TSPPDSSQRP SARPASPGSD AEKRKKRRVL FSKAQTLELE
110 120 130 140 150
RRFRQQRYLS APEREQLASL LRLTPTQVKI WFQNHRYKLK RARAPGAAES
160 170 180 190 200
PDLAASAELH AAPGLLRRVV VPVLVRDGQP CGGGGGGEVG TAAAQEKCGA
210 220 230
PPAAACPLPG YPAFGPGSAL GLFPAYQHLA SPALVSWNW
Length:239
Mass (Da):25,866
Last modified:September 23, 2008 - v2
Checksum:iE227378CCD6E9D27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161D → G in AAC71081. (PubMed:9446603)Curated
Sequence conflicti16 – 161D → G in AAC71082. (PubMed:9446603)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161D → A.
VAR_003753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000295 mRNA. Translation: AAC71081.1.
AF000297, AF000296 Genomic DNA. Translation: AAC71082.1.
AK313537 mRNA. Translation: BAG36314.1.
BC041090 mRNA. Translation: AAH41090.1.
CCDSiCCDS9660.1.
RefSeqiNP_055175.2. NM_014360.2.
UniGeneiHs.234763.

Genome annotation databases

EnsembliENST00000258829; ENSP00000258829; ENSG00000136327.
GeneIDi26257.
KEGGihsa:26257.
UCSCiuc001wtx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000295 mRNA. Translation: AAC71081.1.
AF000297, AF000296 Genomic DNA. Translation: AAC71082.1.
AK313537 mRNA. Translation: BAG36314.1.
BC041090 mRNA. Translation: AAH41090.1.
CCDSiCCDS9660.1.
RefSeqiNP_055175.2. NM_014360.2.
UniGeneiHs.234763.

3D structure databases

ProteinModelPortaliO15522.
SMRiO15522. Positions 83-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258829.

Proteomic databases

PaxDbiO15522.
PRIDEiO15522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258829; ENSP00000258829; ENSG00000136327.
GeneIDi26257.
KEGGihsa:26257.
UCSCiuc001wtx.3. human.

Organism-specific databases

CTDi26257.
GeneCardsiGC14M037049.
H-InvDBHIX0026629.
HGNCiHGNC:16364. NKX2-8.
HPAiHPA062879.
MIMi603245. gene.
neXtProtiNX_O15522.
PharmGKBiPA38402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG243784.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiO15522.
KOiK09347.
OMAiYTAFGPG.
OrthoDBiEOG769ZK0.
PhylomeDBiO15522.
TreeFamiTF351204.

Miscellaneous databases

GenomeRNAii26257.
NextBioi48495.
PROiO15522.
SOURCEiSearch...

Gene expression databases

BgeeiO15522.
CleanExiHS_NKX2-8.
GenevestigatoriO15522.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma."
    Apergis G.A., Crawford N., Ghosh D., Steppan C.M., Vorachek W.R., Wen P., Locker J.
    J. Biol. Chem. 273:2917-2925(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNKX28_HUMAN
AccessioniPrimary (citable) accession number: O15522
Secondary accession number(s): Q8IUT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.