ID FGF10_HUMAN Reviewed; 208 AA. AC O15520; C7FDY0; Q6FHR3; Q6FHT6; Q96P59; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1998, sequence version 1. DT 24-JAN-2024, entry version 195. DE RecName: Full=Fibroblast growth factor 10; DE Short=FGF-10; DE AltName: Full=Keratinocyte growth factor 2; DE Flags: Precursor; GN Name=FGF10; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RX PubMed=9287324; DOI=10.1074/jbc.272.37.23191; RA Emoto H., Tagashira S., Mattei M.-G., Yamasaki M., Hashimoto G., RA Katsumata T., Negoro T., Nakatsuka M., Birnbaum D., Coulier F., Itoh N.; RT "Structure and expression of human fibroblast growth factor-10."; RL J. Biol. Chem. 272:23191-23194(1997). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RA Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., RA Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., RA Dillon P.A., Duan R.D.; RT "Cutaneous wound healing by keratinocyte growth factor 2."; RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W.; RT "Expression of FGF10 in human prostate stromal cells."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., RA LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RG NIEHS SNPs program; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP INTERACTION WITH FGFBP1. RX PubMed=15806171; DOI=10.1038/sj.onc.1208560; RA Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., RA Werner S.; RT "The fibroblast growth factor binding protein is a novel interaction RT partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: RT implications for epithelial repair."; RL Oncogene 24:5269-5277(2005). RN [10] RP INTERACTION WITH FGFR1 AND FGFR2, AND FUNCTION IN STIMULATION OF CELL RP PROLIFERATION. RX PubMed=16597617; DOI=10.1074/jbc.m601252200; RA Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.; RT "Receptor specificity of the fibroblast growth factor family. The complete RT mammalian FGF family."; RL J. Biol. Chem. 281:15694-15700(2006). RN [11] RP REVIEW. RX PubMed=20094046; DOI=10.1038/nrc2780; RA Turner N., Grose R.; RT "Fibroblast growth factor signalling: from development to cancer."; RL Nat. Rev. Cancer 10:116-129(2010). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2. RX PubMed=12591959; DOI=10.1073/pnas.0436500100; RA Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., Ron D., RA Aaronson S.A., Mohammadi M.; RT "Structural basis by which alternative splicing confers specificity in RT fibroblast growth factor receptors."; RL Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003). RN [13] RP INVOLVEMENT IN ALSG. RX PubMed=15654336; DOI=10.1038/ng1507; RA Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., Arakaki R., RA Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., Jonsson R., RA Wahren-Herlenius M., Dahl N.; RT "Mutations in the gene encoding fibroblast growth factor 10 are associated RT with aplasia of lacrimal and salivary glands."; RL Nat. Genet. 37:125-127(2005). RN [14] RP VARIANT LADD3 ARG-156, AND INVOLVEMENT IN LADD3. RX PubMed=16630169; DOI=10.1111/j.1399-0004.2006.00597.x; RA Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B.; RT "LADD syndrome is caused by FGF10 mutations."; RL Clin. Genet. 69:349-354(2006). RN [15] RP VARIANT LADD3 PHE-106, AND INVOLVEMENT IN LADD3. RX PubMed=16501574; DOI=10.1038/ng1757; RA Rohmann E., Brunner H.G., Kayserili H., Uyguner O., Nuernberg G., Lew E.D., RA Dobbie A., Eswarakumar V.P., Uzumcu A., Ulubil-Emeroglu M., Leroy J.G., RA Li Y., Becker C., Lehnerdt K., Cremers C.W.R.J., Yueksel-Apak M., RA Nuernberg P., Kubisch C., Schlessinger J., van Bokhoven H., Wollnik B.; RT "Mutations in different components of FGF signaling in LADD syndrome."; RL Nat. Genet. 38:414-417(2006). CC -!- FUNCTION: Plays an important role in the regulation of embryonic CC development, cell proliferation and cell differentiation. Required for CC normal branching morphogenesis. May play a role in wound healing. CC {ECO:0000269|PubMed:16597617}. CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. CC {ECO:0000269|PubMed:12591959, ECO:0000269|PubMed:15806171, CC ECO:0000269|PubMed:16597617}. CC -!- INTERACTION: CC O15520; P21802: FGFR2; NbExp=2; IntAct=EBI-1035684, EBI-1028658; CC O15520; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-1035684, EBI-10268630; CC O15520; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-1035684, EBI-741515; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- DISEASE: Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A CC rare condition characterized by dry conjunctival mucosae, irritable CC eyes, epiphora (constant tearing), and xerostomia (dryness of the CC mouth), which increases risk of dental erosion, dental caries, CC periodontal disease, and oral infections. ALSG has variable CC expressivity, and affected individuals may have aplasia or hypoplasia CC of the lacrimal, parotid, submandibular, and sublingual glands and CC absence of the lacrimal puncta. {ECO:0000269|PubMed:15654336}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC -!- DISEASE: Lacrimo-auriculo-dento-digital syndrome 3 (LADD3) CC [MIM:620193]: A form of lacrimo-auriculo-dento-digital syndrome, an CC autosomal dominant disease characterized by aplastic/hypoplastic CC lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, CC hypodontia and enamel hypoplasia, and distal limb segments anomalies. CC In addition to these cardinal features, facial dysmorphism, CC malformations of the kidney and respiratory system and abnormal CC genitalia have been reported. Craniosynostosis and severe syndactyly CC are not observed. {ECO:0000269|PubMed:16501574, CC ECO:0000269|PubMed:16630169}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC {ECO:0000305}. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/fgf10/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB002097; BAA22331.1; -; mRNA. DR EMBL; U67918; AAB61991.1; -; mRNA. DR EMBL; AF411527; AAL05875.1; -; mRNA. DR EMBL; GQ351295; ACU00617.1; -; mRNA. DR EMBL; CR541665; CAG46466.1; -; mRNA. DR EMBL; CR541688; CAG46489.1; -; mRNA. DR EMBL; AY604046; AAS99733.1; -; Genomic_DNA. DR EMBL; CH471119; EAW56075.1; -; Genomic_DNA. DR EMBL; BC069561; AAH69561.1; -; mRNA. DR EMBL; BC105021; AAI05022.1; -; mRNA. DR EMBL; BC105023; AAI05024.1; -; mRNA. DR CCDS; CCDS3950.1; -. DR RefSeq; NP_004456.1; NM_004465.1. DR RefSeq; XP_005248321.1; XM_005248264.3. DR PDB; 1NUN; X-ray; 2.90 A; A=64-208. DR PDBsum; 1NUN; -. DR AlphaFoldDB; O15520; -. DR SMR; O15520; -. DR BioGRID; 108546; 12. DR DIP; DIP-6037N; -. DR IntAct; O15520; 9. DR STRING; 9606.ENSP00000264664; -. DR GlyCosmos; O15520; 2 sites, No reported glycans. DR GlyGen; O15520; 2 sites. DR iPTMnet; O15520; -. DR PhosphoSitePlus; O15520; -. DR BioMuta; FGF10; -. DR EPD; O15520; -. DR MassIVE; O15520; -. DR PaxDb; 9606-ENSP00000264664; -. DR PeptideAtlas; O15520; -. DR ProteomicsDB; 48721; -. DR Antibodypedia; 4149; 472 antibodies from 37 providers. DR DNASU; 2255; -. DR Ensembl; ENST00000264664.5; ENSP00000264664.4; ENSG00000070193.5. DR GeneID; 2255; -. DR KEGG; hsa:2255; -. DR MANE-Select; ENST00000264664.5; ENSP00000264664.4; NM_004465.2; NP_004456.1. DR UCSC; uc003jog.2; human. DR AGR; HGNC:3666; -. DR CTD; 2255; -. DR DisGeNET; 2255; -. DR GeneCards; FGF10; -. DR HGNC; HGNC:3666; FGF10. DR HPA; ENSG00000070193; Low tissue specificity. DR MalaCards; FGF10; -. DR MIM; 180920; phenotype. DR MIM; 602115; gene. DR MIM; 620193; phenotype. DR neXtProt; NX_O15520; -. DR OpenTargets; ENSG00000070193; -. DR Orphanet; 86815; Aplasia of lacrimal and salivary glands. DR Orphanet; 2363; Lacrimoauriculodentodigital syndrome. DR PharmGKB; PA28106; -. DR VEuPathDB; HostDB:ENSG00000070193; -. DR eggNOG; KOG3885; Eukaryota. DR GeneTree; ENSGT00940000158907; -. DR HOGENOM; CLU_081609_3_1_1; -. DR InParanoid; O15520; -. DR OMA; EFNTDCK; -. DR OrthoDB; 5382743at2759; -. DR PhylomeDB; O15520; -. DR TreeFam; TF317805; -. DR PathwayCommons; O15520; -. DR Reactome; R-HSA-109704; PI3K Cascade. DR Reactome; R-HSA-1257604; PIP3 activates AKT signaling. DR Reactome; R-HSA-190370; FGFR1b ligand binding and activation. DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation. DR Reactome; R-HSA-2033519; Activated point mutants of FGFR2. DR Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells. DR Reactome; R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer. DR Reactome; R-HSA-5654219; Phospholipase C-mediated cascade: FGFR1. DR Reactome; R-HSA-5654221; Phospholipase C-mediated cascade, FGFR2. DR Reactome; R-HSA-5654687; Downstream signaling of activated FGFR1. DR Reactome; R-HSA-5654688; SHC-mediated cascade:FGFR1. DR Reactome; R-HSA-5654689; PI-3K cascade:FGFR1. DR Reactome; R-HSA-5654693; FRS-mediated FGFR1 signaling. DR Reactome; R-HSA-5654695; PI-3K cascade:FGFR2. DR Reactome; R-HSA-5654699; SHC-mediated cascade:FGFR2. DR Reactome; R-HSA-5654700; FRS-mediated FGFR2 signaling. DR Reactome; R-HSA-5654726; Negative regulation of FGFR1 signaling. DR Reactome; R-HSA-5654727; Negative regulation of FGFR2 signaling. DR Reactome; R-HSA-5655253; Signaling by FGFR2 in disease. DR Reactome; R-HSA-5658623; FGFRL1 modulation of FGFR1 signaling. DR Reactome; R-HSA-5673001; RAF/MAP kinase cascade. DR Reactome; R-HSA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. DR SignaLink; O15520; -. DR SIGNOR; O15520; -. DR BioGRID-ORCS; 2255; 241 hits in 1154 CRISPR screens. DR ChiTaRS; FGF10; human. DR EvolutionaryTrace; O15520; -. DR GeneWiki; FGF10; -. DR GenomeRNAi; 2255; -. DR Pharos; O15520; Tbio. DR PRO; PR:O15520; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; O15520; Protein. DR Bgee; ENSG00000070193; Expressed in buccal mucosa cell and 117 other cell types or tissues. DR ExpressionAtlas; O15520; baseline and differential. DR GO; GO:0009986; C:cell surface; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0042056; F:chemoattractant activity; IDA:UniProtKB. DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IDA:UniProtKB. DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB. DR GO; GO:0008201; F:heparin binding; IDA:UniProtKB. DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IPI:UniProtKB. DR GO; GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB. DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl. DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central. DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl. DR GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IDA:UniProtKB. DR GO; GO:0060436; P:bronchiole morphogenesis; IEA:Ensembl. DR GO; GO:0060449; P:bud elongation involved in lung branching; IEA:Ensembl. DR GO; GO:0060447; P:bud outgrowth involved in lung branching; IDA:MGI. DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central. DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl. DR GO; GO:0031076; P:embryonic camera-type eye development; IEA:Ensembl. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl. DR GO; GO:0030538; P:embryonic genitalia morphogenesis; IEA:Ensembl. DR GO; GO:0009880; P:embryonic pattern specification; IEA:Ensembl. DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl. DR GO; GO:0050673; P:epithelial cell proliferation; IDA:UniProtKB. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IDA:UniProtKB. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl. DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:0048807; P:female genitalia morphogenesis; IEA:Ensembl. DR GO; GO:1902178; P:fibroblast growth factor receptor apoptotic signaling pathway; IEA:Ensembl. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:MGI. DR GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IBA:GO_Central. DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl. DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl. DR GO; GO:0070384; P:Harderian gland development; IEA:Ensembl. DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl. DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl. DR GO; GO:0032808; P:lacrimal gland development; IMP:UniProtKB. DR GO; GO:0060174; P:limb bud formation; IEA:Ensembl. DR GO; GO:0060173; P:limb development; IBA:GO_Central. DR GO; GO:0060428; P:lung epithelium development; IDA:MGI. DR GO; GO:0061115; P:lung proximal/distal axis specification; IEA:Ensembl. DR GO; GO:0060430; P:lung saccule development; IMP:UniProtKB. DR GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl. DR GO; GO:0060615; P:mammary gland bud formation; IEA:Ensembl. DR GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; IEA:Ensembl. DR GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; IEA:Ensembl. DR GO; GO:0001823; P:mesonephros development; IEP:UniProtKB. DR GO; GO:0001656; P:metanephros development; IEP:UniProtKB. DR GO; GO:0003338; P:metanephros morphogenesis; IEA:Ensembl. DR GO; GO:0042693; P:muscle cell fate commitment; IEA:Ensembl. DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl. DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl. DR GO; GO:0001759; P:organ induction; IEA:Ensembl. DR GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl. DR GO; GO:0031016; P:pancreas development; IEA:Ensembl. DR GO; GO:0021983; P:pituitary gland development; IEA:Ensembl. DR GO; GO:0050918; P:positive chemotaxis; IDA:UniProtKB. DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; IDA:UniProtKB. DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central. DR GO; GO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl. DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IDA:UniProtKB. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:UniProtKB. DR GO; GO:0060054; P:positive regulation of epithelial cell proliferation involved in wound healing; NAS:UniProtKB. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central. DR GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; IDA:UniProtKB. DR GO; GO:0051549; P:positive regulation of keratinocyte migration; IDA:UniProtKB. DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IDA:UniProtKB. DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IDA:UniProtKB. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB. DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0050677; P:positive regulation of urothelial cell proliferation; IDA:UniProtKB. DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl. DR GO; GO:0070352; P:positive regulation of white fat cell proliferation; IEA:Ensembl. DR GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl. DR GO; GO:0034394; P:protein localization to cell surface; IDA:UniProtKB. DR GO; GO:0060019; P:radial glial cell differentiation; ISS:UniProtKB. DR GO; GO:0032925; P:regulation of activin receptor signaling pathway; IEA:Ensembl. DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl. DR GO; GO:0046877; P:regulation of saliva secretion; IMP:UniProtKB. DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl. DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0007431; P:salivary gland development; IMP:UniProtKB. DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IDA:UniProtKB. DR GO; GO:0060879; P:semicircular canal fusion; IEA:Ensembl. DR GO; GO:0051145; P:smooth muscle cell differentiation; IEA:Ensembl. DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl. DR GO; GO:0048536; P:spleen development; IEA:Ensembl. DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl. DR GO; GO:0060661; P:submandibular salivary gland formation; IEA:Ensembl. DR GO; GO:0070075; P:tear secretion; IMP:UniProtKB. DR GO; GO:0048538; P:thymus development; IDA:UniProtKB. DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl. DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl. DR GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl. DR GO; GO:0050674; P:urothelial cell proliferation; IDA:UniProtKB. DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl. DR GO; GO:0050872; P:white fat cell differentiation; IEA:Ensembl. DR GO; GO:0070343; P:white fat cell proliferation; IEA:Ensembl. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0042060; P:wound healing; IDA:UniProtKB. DR CDD; cd00058; FGF; 1. DR Gene3D; 2.80.10.50; -; 1. DR IDEAL; IID00527; -. DR InterPro; IPR002209; Fibroblast_GF_fam. DR InterPro; IPR008996; IL1/FGF. DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1. DR PANTHER; PTHR11486:SF21; FIBROBLAST GROWTH FACTOR 10; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; Cytokine; 1. DR PROSITE; PS00247; HBGF_FGF; 1. DR Genevisible; O15520; HS. PE 1: Evidence at protein level; KW 3D-structure; Disease variant; Ectodermal dysplasia; Glycoprotein; KW Growth factor; Lacrimo-auriculo-dento-digital syndrome; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..37 FT /evidence="ECO:0000255" FT CHAIN 38..208 FT /note="Fibroblast growth factor 10" FT /id="PRO_0000008981" FT CARBOHYD 51 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 196 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 106 FT /note="C -> F (in LADD3; dbSNP:rs104893885)" FT /evidence="ECO:0000269|PubMed:16501574" FT /id="VAR_029888" FT VARIANT 156 FT /note="I -> R (in LADD3; dbSNP:rs104893886)" FT /evidence="ECO:0000269|PubMed:16630169" FT /id="VAR_029889" FT CONFLICT 43 FT /note="D -> V (in Ref. 5; CAG46489)" FT /evidence="ECO:0000305" FT CONFLICT 120 FT /note="V -> A (in Ref. 3; AAL05875)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="M -> R (in Ref. 3; AAL05875)" FT /evidence="ECO:0000305" FT HELIX 70..73 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 76..84 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 89..92 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 98..101 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 111..117 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 120..125 FT /evidence="ECO:0007829|PDB:1NUN" FT TURN 126..129 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 130..134 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 138..145 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 150..156 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 162..171 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 174..177 FT /evidence="ECO:0007829|PDB:1NUN" FT HELIX 189..191 FT /evidence="ECO:0007829|PDB:1NUN" FT HELIX 197..199 FT /evidence="ECO:0007829|PDB:1NUN" FT STRAND 201..205 FT /evidence="ECO:0007829|PDB:1NUN" SQ SEQUENCE 208 AA; 23436 MW; C0A0705C108680B3 CRC64; MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH FLPMVVHS //