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Protein

Fibroblast growth factor 10

Gene

FGF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.1 Publication

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: Reactome
  • chemoattractant activity Source: UniProtKB
  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070193-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-190370. FGFR1b ligand binding and activation.
R-HSA-190377. FGFR2b ligand binding and activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-210747. Regulation of gene expression in early pancreatic precursor cells.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiO15520.
SIGNORiO15520.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:FGF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3666. FGF10.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Aplasia of lacrimal and salivary glands (ALSG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.
See also OMIM:180920
Lacrimo-auriculo-dento-digital syndrome (LADDS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
See also OMIM:149730
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029888106C → F in LADDS. 1 PublicationCorresponds to variant rs104893885dbSNPEnsembl.1
Natural variantiVAR_029889156I → R in LADDS. 1 PublicationCorresponds to variant rs104893886dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Lacrimo-auriculo-dento-digital syndrome

Organism-specific databases

DisGeNETi2255.
MalaCardsiFGF10.
MIMi149730. phenotype.
180920. phenotype.
OpenTargetsiENSG00000070193.
Orphaneti86815. Aplasia of lacrimal and salivary glands.
2363. Lacrimoauriculodentodigital syndrome.
PharmGKBiPA28106.

Polymorphism and mutation databases

BioMutaiFGF10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000898138 – 208Fibroblast growth factor 10Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15520.
PeptideAtlasiO15520.
PRIDEiO15520.

PTM databases

iPTMnetiO15520.
PhosphoSitePlusiO15520.

Expressioni

Gene expression databases

BgeeiENSG00000070193.
CleanExiHS_FGF10.
ExpressionAtlasiO15520. baseline and differential.
GenevisibleiO15520. HS.

Organism-specific databases

HPAiCAB010315.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P218022EBI-1035684,EBI-1028658

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108546. 6 interactors.
DIPiDIP-6037N.
IntActiO15520. 2 interactors.
MINTiMINT-257957.
STRINGi9606.ENSP00000264664.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi70 – 73Combined sources4
Beta strandi76 – 84Combined sources9
Beta strandi89 – 92Combined sources4
Beta strandi98 – 101Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi120 – 125Combined sources6
Turni126 – 129Combined sources4
Beta strandi130 – 134Combined sources5
Beta strandi138 – 145Combined sources8
Beta strandi150 – 156Combined sources7
Beta strandi162 – 171Combined sources10
Beta strandi174 – 177Combined sources4
Helixi189 – 191Combined sources3
Helixi197 – 199Combined sources3
Beta strandi201 – 205Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NUNX-ray2.90A64-208[»]
ProteinModelPortaliO15520.
SMRiO15520.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15520.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 62Poly-SerAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO15520.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG091G0NAY.
PhylomeDBiO15520.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT
60 70 80 90 100
NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG
110 120 130 140 150
TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC
160 170 180 190 200
KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH

FLPMVVHS
Length:208
Mass (Da):23,436
Last modified:January 1, 1998 - v1
Checksum:iC0A0705C108680B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43D → V in CAG46489 (Ref. 5) Curated1
Sequence conflicti120V → A in AAL05875 (Ref. 3) Curated1
Sequence conflicti134M → R in AAL05875 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029888106C → F in LADDS. 1 PublicationCorresponds to variant rs104893885dbSNPEnsembl.1
Natural variantiVAR_029889156I → R in LADDS. 1 PublicationCorresponds to variant rs104893886dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002097 mRNA. Translation: BAA22331.1.
U67918 mRNA. Translation: AAB61991.1.
AF411527 mRNA. Translation: AAL05875.1.
GQ351295 mRNA. Translation: ACU00617.1.
CR541665 mRNA. Translation: CAG46466.1.
CR541688 mRNA. Translation: CAG46489.1.
AY604046 Genomic DNA. Translation: AAS99733.1.
CH471119 Genomic DNA. Translation: EAW56075.1.
BC069561 mRNA. Translation: AAH69561.1.
BC105021 mRNA. Translation: AAI05022.1.
BC105023 mRNA. Translation: AAI05024.1.
CCDSiCCDS3950.1.
RefSeqiNP_004456.1. NM_004465.1.
XP_005248321.1. XM_005248264.3.
UniGeneiHs.248049.
Hs.664499.

Genome annotation databases

EnsembliENST00000264664; ENSP00000264664; ENSG00000070193.
GeneIDi2255.
KEGGihsa:2255.
UCSCiuc003jog.2. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002097 mRNA. Translation: BAA22331.1.
U67918 mRNA. Translation: AAB61991.1.
AF411527 mRNA. Translation: AAL05875.1.
GQ351295 mRNA. Translation: ACU00617.1.
CR541665 mRNA. Translation: CAG46466.1.
CR541688 mRNA. Translation: CAG46489.1.
AY604046 Genomic DNA. Translation: AAS99733.1.
CH471119 Genomic DNA. Translation: EAW56075.1.
BC069561 mRNA. Translation: AAH69561.1.
BC105021 mRNA. Translation: AAI05022.1.
BC105023 mRNA. Translation: AAI05024.1.
CCDSiCCDS3950.1.
RefSeqiNP_004456.1. NM_004465.1.
XP_005248321.1. XM_005248264.3.
UniGeneiHs.248049.
Hs.664499.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NUNX-ray2.90A64-208[»]
ProteinModelPortaliO15520.
SMRiO15520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108546. 6 interactors.
DIPiDIP-6037N.
IntActiO15520. 2 interactors.
MINTiMINT-257957.
STRINGi9606.ENSP00000264664.

PTM databases

iPTMnetiO15520.
PhosphoSitePlusiO15520.

Polymorphism and mutation databases

BioMutaiFGF10.

Proteomic databases

PaxDbiO15520.
PeptideAtlasiO15520.
PRIDEiO15520.

Protocols and materials databases

DNASUi2255.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264664; ENSP00000264664; ENSG00000070193.
GeneIDi2255.
KEGGihsa:2255.
UCSCiuc003jog.2. human.

Organism-specific databases

CTDi2255.
DisGeNETi2255.
GeneCardsiFGF10.
HGNCiHGNC:3666. FGF10.
HPAiCAB010315.
MalaCardsiFGF10.
MIMi149730. phenotype.
180920. phenotype.
602115. gene.
neXtProtiNX_O15520.
OpenTargetsiENSG00000070193.
Orphaneti86815. Aplasia of lacrimal and salivary glands.
2363. Lacrimoauriculodentodigital syndrome.
PharmGKBiPA28106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO15520.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG091G0NAY.
PhylomeDBiO15520.
TreeFamiTF317805.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070193-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-190370. FGFR1b ligand binding and activation.
R-HSA-190377. FGFR2b ligand binding and activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-210747. Regulation of gene expression in early pancreatic precursor cells.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiO15520.
SIGNORiO15520.

Miscellaneous databases

EvolutionaryTraceiO15520.
GeneWikiiFGF10.
GenomeRNAii2255.
PROiO15520.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070193.
CleanExiHS_FGF10.
ExpressionAtlasiO15520. baseline and differential.
GenevisibleiO15520. HS.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF10_HUMAN
AccessioniPrimary (citable) accession number: O15520
Secondary accession number(s): C7FDY0
, Q6FHR3, Q6FHT6, Q96P59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.