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O15520

- FGF10_HUMAN

UniProt

O15520 - FGF10_HUMAN

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Protein

Fibroblast growth factor 10

Gene

FGF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.1 Publication

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. fibroblast growth factor receptor binding Source: UniProtKB
  3. growth factor activity Source: UniProtKB
  4. heparin binding Source: UniProtKB
  5. type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. activation of MAPK activity Source: UniProtKB
  3. angiogenesis Source: Ensembl
  4. blood vessel remodeling Source: Ensembl
  5. branch elongation involved in salivary gland morphogenesis Source: Ensembl
  6. branching morphogenesis of an epithelial tube Source: UniProtKB
  7. bronchiole morphogenesis Source: Ensembl
  8. bud elongation involved in lung branching Source: Ensembl
  9. bud outgrowth involved in lung branching Source: MGI
  10. determination of left/right symmetry Source: Ensembl
  11. embryonic camera-type eye development Source: Ensembl
  12. embryonic digestive tract morphogenesis Source: Ensembl
  13. embryonic genitalia morphogenesis Source: Ensembl
  14. embryonic pattern specification Source: Ensembl
  15. epidermal growth factor receptor signaling pathway Source: Reactome
  16. epithelial cell migration Source: Ensembl
  17. epithelial cell proliferation Source: UniProtKB
  18. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  19. ERK1 and ERK2 cascade Source: UniProtKB
  20. establishment of mitotic spindle orientation Source: Ensembl
  21. Fc-epsilon receptor signaling pathway Source: Reactome
  22. female genitalia morphogenesis Source: Ensembl
  23. fibroblast growth factor receptor signaling pathway Source: Reactome
  24. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  25. hair follicle morphogenesis Source: Ensembl
  26. Harderian gland development Source: Ensembl
  27. induction of positive chemotaxis Source: Ensembl
  28. innate immune response Source: Reactome
  29. insulin receptor signaling pathway Source: Reactome
  30. keratinocyte proliferation Source: Ensembl
  31. lacrimal gland development Source: UniProtKB
  32. limb bud formation Source: Ensembl
  33. lung epithelium development Source: MGI
  34. lung proximal/distal axis specification Source: Ensembl
  35. lung saccule development Source: UniProtKB
  36. male genitalia morphogenesis Source: Ensembl
  37. mammary gland bud formation Source: Ensembl
  38. mesenchymal cell differentiation involved in lung development Source: Ensembl
  39. mesenchymal-epithelial cell signaling involved in lung development Source: Ensembl
  40. mesonephros development Source: UniProtKB
  41. metanephros development Source: UniProtKB
  42. metanephros morphogenesis Source: Ensembl
  43. muscle cell fate commitment Source: Ensembl
  44. negative regulation of cell cycle arrest Source: UniProtKB
  45. negative regulation of cell proliferation Source: Ensembl
  46. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  47. neurotrophin TRK receptor signaling pathway Source: Reactome
  48. odontogenesis of dentin-containing tooth Source: Ensembl
  49. organ induction Source: Ensembl
  50. otic vesicle formation Source: Ensembl
  51. pancreas development Source: Ensembl
  52. phosphatidylinositol-mediated signaling Source: Reactome
  53. pituitary gland development Source: Ensembl
  54. positive chemotaxis Source: UniProtKB
  55. positive regulation of ATPase activity Source: UniProtKB
  56. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  57. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  58. positive regulation of DNA repair Source: UniProtKB
  59. positive regulation of DNA replication Source: UniProtKB
  60. positive regulation of epithelial cell migration Source: UniProtKB
  61. positive regulation of epithelial cell proliferation Source: UniProtKB
  62. positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
  63. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  64. positive regulation of fibroblast proliferation Source: Ensembl
  65. positive regulation of hair follicle cell proliferation Source: UniProtKB
  66. positive regulation of keratinocyte migration Source: UniProtKB
  67. positive regulation of keratinocyte proliferation Source: UniProtKB
  68. positive regulation of lymphocyte proliferation Source: UniProtKB
  69. positive regulation of MAPK cascade Source: UniProtKB
  70. positive regulation of mitotic cell cycle Source: Ensembl
  71. positive regulation of Notch signaling pathway Source: Ensembl
  72. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  73. positive regulation of Ras protein signal transduction Source: UniProtKB
  74. positive regulation of transcription, DNA-templated Source: UniProtKB
  75. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  76. positive regulation of urothelial cell proliferation Source: UniProtKB
  77. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  78. positive regulation of white fat cell proliferation Source: Ensembl
  79. prostatic bud formation Source: Ensembl
  80. protein localization to cell surface Source: UniProtKB
  81. radial glial cell differentiation Source: UniProtKB
  82. regulation of activin receptor signaling pathway Source: Ensembl
  83. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
  84. regulation of saliva secretion Source: UniProtKB
  85. regulation of smoothened signaling pathway Source: Ensembl
  86. response to estradiol Source: Ensembl
  87. response to lipopolysaccharide Source: Ensembl
  88. salivary gland development Source: UniProtKB
  89. secretion by lung epithelial cell involved in lung growth Source: UniProtKB
  90. semicircular canal fusion Source: Ensembl
  91. smooth muscle cell differentiation Source: Ensembl
  92. somatic stem cell maintenance Source: Ensembl
  93. spleen development Source: Ensembl
  94. submandibular salivary gland formation Source: Ensembl
  95. tear secretion Source: UniProtKB
  96. thymus development Source: UniProtKB
  97. thyroid gland development Source: Ensembl
  98. tissue regeneration Source: Ensembl
  99. Type II pneumocyte differentiation Source: Ensembl
  100. urothelial cell proliferation Source: UniProtKB
  101. white fat cell differentiation Source: Ensembl
  102. wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121398. Signaling by FGFR mutants.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiO15520.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:FGF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3666. FGF10.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061C → F in LADDS. 1 Publication
VAR_029888
Natural varianti156 – 1561I → R in LADDS. 1 Publication
VAR_029889

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Lacrimo-auriculo-dento-digital syndrome

Organism-specific databases

MIMi149730. phenotype.
180920. phenotype.
Orphaneti86815. Aplasia of lacrimal and salivary glands.
2363. Lacrimoauriculodentodigital syndrome.
PharmGKBiPA28106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 208171Fibroblast growth factor 10PRO_0000008981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15520.
PRIDEiO15520.

PTM databases

PhosphoSiteiO15520.

Expressioni

Gene expression databases

BgeeiO15520.
CleanExiHS_FGF10.
ExpressionAtlasiO15520. baseline and differential.
GenevestigatoriO15520.

Organism-specific databases

HPAiCAB010315.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR2P218022EBI-1035684,EBI-1028658

Protein-protein interaction databases

BioGridi108546. 6 interactions.
DIPiDIP-6037N.
IntActiO15520. 1 interaction.
MINTiMINT-257957.
STRINGi9606.ENSP00000264664.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi70 – 734Combined sources
Beta strandi76 – 849Combined sources
Beta strandi89 – 924Combined sources
Beta strandi98 – 1014Combined sources
Beta strandi111 – 1177Combined sources
Beta strandi120 – 1256Combined sources
Turni126 – 1294Combined sources
Beta strandi130 – 1345Combined sources
Beta strandi138 – 1458Combined sources
Beta strandi150 – 1567Combined sources
Beta strandi162 – 17110Combined sources
Beta strandi174 – 1774Combined sources
Helixi189 – 1913Combined sources
Helixi197 – 1993Combined sources
Beta strandi201 – 2055Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NUNX-ray2.90A64-208[»]
ProteinModelPortaliO15520.
SMRiO15520. Positions 69-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15520.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 6211Poly-SerAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327524.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO15520.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiO15520.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15520-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT
60 70 80 90 100
NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG
110 120 130 140 150
TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC
160 170 180 190 200
KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH

FLPMVVHS
Length:208
Mass (Da):23,436
Last modified:January 1, 1998 - v1
Checksum:iC0A0705C108680B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431D → V in CAG46489. 1 PublicationCurated
Sequence conflicti120 – 1201V → A in AAL05875. 1 PublicationCurated
Sequence conflicti134 – 1341M → R in AAL05875. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061C → F in LADDS. 1 Publication
VAR_029888
Natural varianti156 – 1561I → R in LADDS. 1 Publication
VAR_029889

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002097 mRNA. Translation: BAA22331.1.
U67918 mRNA. Translation: AAB61991.1.
AF411527 mRNA. Translation: AAL05875.1.
GQ351295 mRNA. Translation: ACU00617.1.
CR541665 mRNA. Translation: CAG46466.1.
CR541688 mRNA. Translation: CAG46489.1.
AY604046 Genomic DNA. Translation: AAS99733.1.
CH471119 Genomic DNA. Translation: EAW56075.1.
BC069561 mRNA. Translation: AAH69561.1.
BC105021 mRNA. Translation: AAI05022.1.
BC105023 mRNA. Translation: AAI05024.1.
CCDSiCCDS3950.1.
RefSeqiNP_004456.1. NM_004465.1.
XP_005248321.1. XM_005248264.1.
UniGeneiHs.664499.

Genome annotation databases

EnsembliENST00000264664; ENSP00000264664; ENSG00000070193.
GeneIDi2255.
KEGGihsa:2255.
UCSCiuc003jog.1. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002097 mRNA. Translation: BAA22331.1 .
U67918 mRNA. Translation: AAB61991.1 .
AF411527 mRNA. Translation: AAL05875.1 .
GQ351295 mRNA. Translation: ACU00617.1 .
CR541665 mRNA. Translation: CAG46466.1 .
CR541688 mRNA. Translation: CAG46489.1 .
AY604046 Genomic DNA. Translation: AAS99733.1 .
CH471119 Genomic DNA. Translation: EAW56075.1 .
BC069561 mRNA. Translation: AAH69561.1 .
BC105021 mRNA. Translation: AAI05022.1 .
BC105023 mRNA. Translation: AAI05024.1 .
CCDSi CCDS3950.1.
RefSeqi NP_004456.1. NM_004465.1.
XP_005248321.1. XM_005248264.1.
UniGenei Hs.664499.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NUN X-ray 2.90 A 64-208 [» ]
ProteinModelPortali O15520.
SMRi O15520. Positions 69-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108546. 6 interactions.
DIPi DIP-6037N.
IntActi O15520. 1 interaction.
MINTi MINT-257957.
STRINGi 9606.ENSP00000264664.

PTM databases

PhosphoSitei O15520.

Proteomic databases

PaxDbi O15520.
PRIDEi O15520.

Protocols and materials databases

DNASUi 2255.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264664 ; ENSP00000264664 ; ENSG00000070193 .
GeneIDi 2255.
KEGGi hsa:2255.
UCSCi uc003jog.1. human.

Organism-specific databases

CTDi 2255.
GeneCardsi GC05M044340.
HGNCi HGNC:3666. FGF10.
HPAi CAB010315.
MIMi 149730. phenotype.
180920. phenotype.
602115. gene.
neXtProti NX_O15520.
Orphaneti 86815. Aplasia of lacrimal and salivary glands.
2363. Lacrimoauriculodentodigital syndrome.
PharmGKBi PA28106.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327524.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi O15520.
KOi K04358.
OMAi SSIPVTC.
OrthoDBi EOG7992S1.
PhylomeDBi O15520.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121398. Signaling by FGFR mutants.
REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinki O15520.

Miscellaneous databases

EvolutionaryTracei O15520.
GeneWikii FGF10.
GenomeRNAii 2255.
NextBioi 9135.
PROi O15520.
SOURCEi Search...

Gene expression databases

Bgeei O15520.
CleanExi HS_FGF10.
ExpressionAtlasi O15520. baseline and differential.
Genevestigatori O15520.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cutaneous wound healing by keratinocyte growth factor 2."
    Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., Dillon P.A., Duan R.D.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Expression of FGF10 in human prostate stromal cells."
    Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. NIEHS SNPs program
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
    Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
    Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFBP1.
  10. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  11. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors."
    Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., Ron D., Aaronson S.A., Mohammadi M.
    Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2.
  13. "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands."
    Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., Arakaki R., Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., Jonsson R., Wahren-Herlenius M., Dahl N.
    Nat. Genet. 37:125-127(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ALSG.
  14. Cited for: VARIANT LADDS ARG-156.
  15. Cited for: VARIANT LADDS PHE-106.

Entry informationi

Entry nameiFGF10_HUMAN
AccessioniPrimary (citable) accession number: O15520
Secondary accession number(s): C7FDY0
, Q6FHR3, Q6FHT6, Q96P59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3