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O15520

- FGF10_HUMAN

UniProt

O15520 - FGF10_HUMAN

Protein

Fibroblast growth factor 10

Gene

FGF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.1 Publication

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. fibroblast growth factor receptor binding Source: UniProtKB
    3. growth factor activity Source: UniProtKB
    4. heparin binding Source: UniProtKB
    5. type 2 fibroblast growth factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. activation of MAPK activity Source: UniProtKB
    3. angiogenesis Source: Ensembl
    4. blood vessel remodeling Source: Ensembl
    5. branch elongation involved in salivary gland morphogenesis Source: Ensembl
    6. branching morphogenesis of an epithelial tube Source: UniProtKB
    7. bronchiole morphogenesis Source: Ensembl
    8. bud outgrowth involved in lung branching Source: MGI
    9. determination of left/right symmetry Source: Ensembl
    10. embryonic camera-type eye development Source: Ensembl
    11. embryonic digestive tract morphogenesis Source: Ensembl
    12. embryonic genitalia morphogenesis Source: Ensembl
    13. embryonic pattern specification Source: Ensembl
    14. epidermal growth factor receptor signaling pathway Source: Reactome
    15. epithelial cell migration Source: Ensembl
    16. epithelial cell proliferation Source: UniProtKB
    17. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    18. ERK1 and ERK2 cascade Source: UniProtKB
    19. Fc-epsilon receptor signaling pathway Source: Reactome
    20. female genitalia morphogenesis Source: Ensembl
    21. fibroblast growth factor receptor signaling pathway Source: Reactome
    22. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
    23. hair follicle morphogenesis Source: Ensembl
    24. Harderian gland development Source: Ensembl
    25. induction of positive chemotaxis Source: Ensembl
    26. innate immune response Source: Reactome
    27. insulin receptor signaling pathway Source: Reactome
    28. keratinocyte proliferation Source: Ensembl
    29. lacrimal gland development Source: UniProtKB
    30. limb bud formation Source: Ensembl
    31. lung epithelium development Source: MGI
    32. lung proximal/distal axis specification Source: Ensembl
    33. lung saccule development Source: UniProtKB
    34. male genitalia morphogenesis Source: Ensembl
    35. mammary gland bud formation Source: Ensembl
    36. mesenchymal cell differentiation involved in lung development Source: Ensembl
    37. mesenchymal-epithelial cell signaling involved in lung development Source: Ensembl
    38. mesonephros development Source: UniProtKB
    39. metanephros development Source: UniProtKB
    40. metanephros morphogenesis Source: Ensembl
    41. muscle cell fate commitment Source: Ensembl
    42. negative regulation of cell cycle arrest Source: UniProtKB
    43. negative regulation of cell proliferation Source: Ensembl
    44. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    45. neurotrophin TRK receptor signaling pathway Source: Reactome
    46. odontogenesis of dentin-containing tooth Source: Ensembl
    47. organ induction Source: Ensembl
    48. otic vesicle formation Source: Ensembl
    49. pancreas development Source: Ensembl
    50. phosphatidylinositol-mediated signaling Source: Reactome
    51. pituitary gland development Source: Ensembl
    52. positive chemotaxis Source: UniProtKB
    53. positive regulation of ATPase activity Source: UniProtKB
    54. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    55. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: UniProtKB
    56. positive regulation of DNA repair Source: UniProtKB
    57. positive regulation of DNA replication Source: UniProtKB
    58. positive regulation of epithelial cell migration Source: UniProtKB
    59. positive regulation of epithelial cell proliferation Source: UniProtKB
    60. positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
    61. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    62. positive regulation of fibroblast proliferation Source: Ensembl
    63. positive regulation of hair follicle cell proliferation Source: UniProtKB
    64. positive regulation of keratinocyte migration Source: UniProtKB
    65. positive regulation of keratinocyte proliferation Source: UniProtKB
    66. positive regulation of lymphocyte proliferation Source: UniProtKB
    67. positive regulation of MAPK cascade Source: UniProtKB
    68. positive regulation of mitotic cell cycle Source: Ensembl
    69. positive regulation of Notch signaling pathway Source: Ensembl
    70. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    71. positive regulation of Ras protein signal transduction Source: UniProtKB
    72. positive regulation of transcription, DNA-templated Source: UniProtKB
    73. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    74. positive regulation of urothelial cell proliferation Source: UniProtKB
    75. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
    76. positive regulation of white fat cell proliferation Source: Ensembl
    77. protein localization to cell surface Source: UniProtKB
    78. radial glial cell differentiation Source: UniProtKB
    79. regulation of activin receptor signaling pathway Source: Ensembl
    80. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: Ensembl
    81. regulation of prostatic bud formation Source: Ensembl
    82. regulation of saliva secretion Source: UniProtKB
    83. regulation of smoothened signaling pathway Source: Ensembl
    84. response to estradiol Source: Ensembl
    85. response to lipopolysaccharide Source: Ensembl
    86. salivary gland development Source: UniProtKB
    87. secretion by lung epithelial cell involved in lung growth Source: UniProtKB
    88. semicircular canal fusion Source: Ensembl
    89. smooth muscle cell differentiation Source: Ensembl
    90. somatic stem cell maintenance Source: Ensembl
    91. spleen development Source: Ensembl
    92. submandibular salivary gland formation Source: Ensembl
    93. tear secretion Source: UniProtKB
    94. thymus development Source: UniProtKB
    95. thyroid gland development Source: Ensembl
    96. tissue regeneration Source: Ensembl
    97. Type II pneumocyte differentiation Source: Ensembl
    98. urothelial cell proliferation Source: UniProtKB
    99. white fat cell differentiation Source: Ensembl
    100. wound healing Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9400. FGFR1b ligand binding and activation.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiO15520.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 10
    Short name:
    FGF-10
    Alternative name(s):
    Keratinocyte growth factor 2
    Gene namesi
    Name:FGF10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3666. FGF10.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061C → F in LADDS. 1 Publication
    VAR_029888
    Natural varianti156 – 1561I → R in LADDS. 1 Publication
    VAR_029889

    Keywords - Diseasei

    Disease mutation, Ectodermal dysplasia, Lacrimo-auriculo-dento-digital syndrome

    Organism-specific databases

    MIMi149730. phenotype.
    180920. phenotype.
    Orphaneti86815. Aplasia of lacrimal and salivary glands.
    2363. Lacrimo-auriculo-dento-digital syndrome.
    PharmGKBiPA28106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 208171Fibroblast growth factor 10PRO_0000008981Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO15520.
    PRIDEiO15520.

    PTM databases

    PhosphoSiteiO15520.

    Expressioni

    Gene expression databases

    ArrayExpressiO15520.
    BgeeiO15520.
    CleanExiHS_FGF10.
    GenevestigatoriO15520.

    Organism-specific databases

    HPAiCAB010315.

    Interactioni

    Subunit structurei

    Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FGFR2P218022EBI-1035684,EBI-1028658

    Protein-protein interaction databases

    BioGridi108546. 1 interaction.
    DIPiDIP-6037N.
    IntActiO15520. 1 interaction.
    MINTiMINT-257957.
    STRINGi9606.ENSP00000264664.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi70 – 734
    Beta strandi76 – 849
    Beta strandi89 – 924
    Beta strandi98 – 1014
    Beta strandi111 – 1177
    Beta strandi120 – 1256
    Turni126 – 1294
    Beta strandi130 – 1345
    Beta strandi138 – 1458
    Beta strandi150 – 1567
    Beta strandi162 – 17110
    Beta strandi174 – 1774
    Helixi189 – 1913
    Helixi197 – 1993
    Beta strandi201 – 2055

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NUNX-ray2.90A64-208[»]
    ProteinModelPortaliO15520.
    SMRiO15520. Positions 69-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15520.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi52 – 6211Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG327524.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiO15520.
    KOiK04358.
    OMAiSSIPVTC.
    OrthoDBiEOG7992S1.
    PhylomeDBiO15520.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028252. FGF10.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF21. PTHR11486:SF21. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT    50
    NSSSSSFSSP SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG 100
    TKKENCPYSI LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC 150
    KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH 200
    FLPMVVHS 208
    Length:208
    Mass (Da):23,436
    Last modified:January 1, 1998 - v1
    Checksum:iC0A0705C108680B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431D → V in CAG46489. 1 PublicationCurated
    Sequence conflicti120 – 1201V → A in AAL05875. 1 PublicationCurated
    Sequence conflicti134 – 1341M → R in AAL05875. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061C → F in LADDS. 1 Publication
    VAR_029888
    Natural varianti156 – 1561I → R in LADDS. 1 Publication
    VAR_029889

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002097 mRNA. Translation: BAA22331.1.
    U67918 mRNA. Translation: AAB61991.1.
    AF411527 mRNA. Translation: AAL05875.1.
    GQ351295 mRNA. Translation: ACU00617.1.
    CR541665 mRNA. Translation: CAG46466.1.
    CR541688 mRNA. Translation: CAG46489.1.
    AY604046 Genomic DNA. Translation: AAS99733.1.
    CH471119 Genomic DNA. Translation: EAW56075.1.
    BC069561 mRNA. Translation: AAH69561.1.
    BC105021 mRNA. Translation: AAI05022.1.
    BC105023 mRNA. Translation: AAI05024.1.
    CCDSiCCDS3950.1.
    RefSeqiNP_004456.1. NM_004465.1.
    XP_005248321.1. XM_005248264.1.
    UniGeneiHs.664499.

    Genome annotation databases

    EnsembliENST00000264664; ENSP00000264664; ENSG00000070193.
    GeneIDi2255.
    KEGGihsa:2255.
    UCSCiuc003jog.1. human.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002097 mRNA. Translation: BAA22331.1 .
    U67918 mRNA. Translation: AAB61991.1 .
    AF411527 mRNA. Translation: AAL05875.1 .
    GQ351295 mRNA. Translation: ACU00617.1 .
    CR541665 mRNA. Translation: CAG46466.1 .
    CR541688 mRNA. Translation: CAG46489.1 .
    AY604046 Genomic DNA. Translation: AAS99733.1 .
    CH471119 Genomic DNA. Translation: EAW56075.1 .
    BC069561 mRNA. Translation: AAH69561.1 .
    BC105021 mRNA. Translation: AAI05022.1 .
    BC105023 mRNA. Translation: AAI05024.1 .
    CCDSi CCDS3950.1.
    RefSeqi NP_004456.1. NM_004465.1.
    XP_005248321.1. XM_005248264.1.
    UniGenei Hs.664499.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NUN X-ray 2.90 A 64-208 [» ]
    ProteinModelPortali O15520.
    SMRi O15520. Positions 69-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108546. 1 interaction.
    DIPi DIP-6037N.
    IntActi O15520. 1 interaction.
    MINTi MINT-257957.
    STRINGi 9606.ENSP00000264664.

    PTM databases

    PhosphoSitei O15520.

    Proteomic databases

    PaxDbi O15520.
    PRIDEi O15520.

    Protocols and materials databases

    DNASUi 2255.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264664 ; ENSP00000264664 ; ENSG00000070193 .
    GeneIDi 2255.
    KEGGi hsa:2255.
    UCSCi uc003jog.1. human.

    Organism-specific databases

    CTDi 2255.
    GeneCardsi GC05M044340.
    HGNCi HGNC:3666. FGF10.
    HPAi CAB010315.
    MIMi 149730. phenotype.
    180920. phenotype.
    602115. gene.
    neXtProti NX_O15520.
    Orphaneti 86815. Aplasia of lacrimal and salivary glands.
    2363. Lacrimo-auriculo-dento-digital syndrome.
    PharmGKBi PA28106.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327524.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi O15520.
    KOi K04358.
    OMAi SSIPVTC.
    OrthoDBi EOG7992S1.
    PhylomeDBi O15520.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_13778. Regulation of gene expression in early pancreatic precursor cells.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9400. FGFR1b ligand binding and activation.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki O15520.

    Miscellaneous databases

    EvolutionaryTracei O15520.
    GeneWikii FGF10.
    GenomeRNAii 2255.
    NextBioi 9135.
    PROi O15520.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15520.
    Bgeei O15520.
    CleanExi HS_FGF10.
    Genevestigatori O15520.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028252. FGF10.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF21. PTHR11486:SF21. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Cutaneous wound healing by keratinocyte growth factor 2."
      Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., Dillon P.A., Duan R.D.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Expression of FGF10 in human prostate stromal cells."
      Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. NIEHS SNPs program
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    9. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
      Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
      Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFBP1.
    10. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    11. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    12. "Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors."
      Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., Ron D., Aaronson S.A., Mohammadi M.
      Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2.
    13. "Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands."
      Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., Arakaki R., Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., Jonsson R., Wahren-Herlenius M., Dahl N.
      Nat. Genet. 37:125-127(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ALSG.
    14. Cited for: VARIANT LADDS ARG-156.
    15. Cited for: VARIANT LADDS PHE-106.

    Entry informationi

    Entry nameiFGF10_HUMAN
    AccessioniPrimary (citable) accession number: O15520
    Secondary accession number(s): C7FDY0
    , Q6FHR3, Q6FHT6, Q96P59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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