Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O15520 (FGF10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 10

Short name=FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene names
Name:FGF10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Ref.10

Subunit structure

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.9 Ref.10

Subcellular location

Secreted Potential.

Involvement in disease

Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14 Ref.15

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseDisease mutation
Ectodermal dysplasia
Lacrimo-auriculo-dento-digital syndrome
   DomainSignal
   Molecular functionGrowth factor
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from direct assay PubMed 17959718. Source: UniProtKB

Fc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

Harderian gland development

Inferred from electronic annotation. Source: Ensembl

Type II pneumocyte differentiation

Inferred from electronic annotation. Source: Ensembl

actin cytoskeleton reorganization

Inferred from direct assay PubMed 17449030. Source: UniProtKB

activation of MAPK activity

Inferred from direct assay PubMed 14975937. Source: UniProtKB

angiogenesis

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Inferred from electronic annotation. Source: Ensembl

branch elongation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching morphogenesis of an epithelial tube

Inferred from direct assay PubMed 17959718. Source: UniProtKB

bronchiole morphogenesis

Inferred from electronic annotation. Source: Ensembl

bud outgrowth involved in lung branching

Inferred from direct assay PubMed 9740653. Source: MGI

determination of left/right symmetry

Inferred from electronic annotation. Source: Ensembl

embryonic camera-type eye development

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic pattern specification

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation

Inferred from direct assay PubMed 19224135. Source: UniProtKB

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

female genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

Inferred from direct assay PubMed 11923311. Source: MGI

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

keratinocyte proliferation

Inferred from electronic annotation. Source: Ensembl

lacrimal gland development

Inferred from mutant phenotype PubMed 17213838. Source: UniProtKB

limb bud formation

Inferred from electronic annotation. Source: Ensembl

lung epithelium development

Inferred from direct assay PubMed 9740653. Source: MGI

lung proximal/distal axis specification

Inferred from electronic annotation. Source: Ensembl

lung saccule development

Inferred from mutant phenotype PubMed 17071719. Source: UniProtKB

male genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

mammary gland bud formation

Inferred from electronic annotation. Source: Ensembl

mesenchymal cell differentiation involved in lung development

Inferred from electronic annotation. Source: Ensembl

mesenchymal-epithelial cell signaling involved in lung development

Inferred from electronic annotation. Source: Ensembl

mesonephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

metanephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

muscle cell fate commitment

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell cycle arrest

Inferred from direct assay PubMed 17188682. Source: UniProtKB

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

organ induction

Inferred from electronic annotation. Source: Ensembl

otic vesicle formation

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

pituitary gland development

Inferred from electronic annotation. Source: Ensembl

positive chemotaxis

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of ATPase activity

Inferred from direct assay PubMed 12804770. Source: UniProtKB

positive regulation of DNA repair

Inferred from direct assay PubMed 14975937. Source: UniProtKB

positive regulation of DNA replication

Inferred from mutant phenotype PubMed 17471512. Source: UniProtKB

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 14975937. Source: UniProtKB

positive regulation of MAPK cascade

Inferred from direct assay PubMed 12804770. Source: UniProtKB

positive regulation of Notch signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of Ras protein signal transduction

Inferred from direct assay PubMed 12804770. Source: UniProtKB

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

Inferred from direct assay PubMed 17188682. Source: UniProtKB

positive regulation of epithelial cell migration

Inferred from direct assay PubMed 17500053. Source: UniProtKB

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 15690149. Source: UniProtKB

positive regulation of epithelial cell proliferation involved in wound healing

Non-traceable author statement PubMed 19152659. Source: UniProtKB

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of hair follicle cell proliferation

Inferred from direct assay PubMed 16086254. Source: UniProtKB

positive regulation of keratinocyte migration

Inferred from direct assay PubMed 17449030PubMed 19152659. Source: UniProtKB

positive regulation of keratinocyte proliferation

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of lymphocyte proliferation

Inferred from direct assay PubMed 19152659. Source: UniProtKB

positive regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 17449030. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 17500053. Source: UniProtKB

positive regulation of urothelial cell proliferation

Inferred from direct assay PubMed 11923311. Source: UniProtKB

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of white fat cell proliferation

Inferred from electronic annotation. Source: Ensembl

protein localization to cell surface

Inferred from direct assay PubMed 17449030. Source: UniProtKB

radial glial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of activin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Inferred from electronic annotation. Source: Ensembl

regulation of prostatic bud formation

Inferred from electronic annotation. Source: Ensembl

regulation of saliva secretion

Inferred from mutant phenotype PubMed 19102732. Source: UniProtKB

regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

salivary gland development

Inferred from mutant phenotype PubMed 17213838. Source: UniProtKB

secretion by lung epithelial cell involved in lung growth

Inferred from direct assay PubMed 10541313. Source: UniProtKB

semicircular canal fusion

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from electronic annotation. Source: Ensembl

submandibular salivary gland formation

Inferred from electronic annotation. Source: Ensembl

tear secretion

Inferred from mutant phenotype PubMed 19102732. Source: UniProtKB

thymus development

Inferred from direct assay PubMed 17969154. Source: UniProtKB

thyroid gland development

Inferred from electronic annotation. Source: Ensembl

tissue regeneration

Inferred from electronic annotation. Source: Ensembl

urothelial cell proliferation

Inferred from direct assay PubMed 11923311. Source: UniProtKB

white fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from direct assay PubMed 11896977PubMed 19152659. Source: UniProtKB

   Cellular_componentcell surface

Inferred from direct assay PubMed 16597614. Source: UniProtKB

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 16597614. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 11923311PubMed 16597614PubMed 17471512. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 16597614. Source: UniProtKB

   Molecular_functionchemoattractant activity

Inferred from direct assay PubMed 17449030. Source: UniProtKB

fibroblast growth factor receptor binding

Inferred from direct assay PubMed 11923311. Source: UniProtKB

growth factor activity

Inferred from direct assay PubMed 11923311PubMed 15690149. Source: UniProtKB

heparin binding

Inferred from direct assay PubMed 11923311. Source: UniProtKB

type 2 fibroblast growth factor receptor binding

Inferred from physical interaction PubMed 19224135. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 208171Fibroblast growth factor 10
PRO_0000008981

Regions

Compositional bias52 – 6211Poly-Ser

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential

Natural variations

Natural variant1061C → F in LADDS. Ref.15
VAR_029888
Natural variant1561I → R in LADDS. Ref.14
VAR_029889

Experimental info

Sequence conflict431D → V in CAG46489. Ref.5
Sequence conflict1201V → A in AAL05875. Ref.3
Sequence conflict1341M → R in AAL05875. Ref.3

Secondary structure

............................. 208
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O15520 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C0A0705C108680B3

FASTA20823,436
        10         20         30         40         50         60 
MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP 

        70         80         90        100        110        120 
SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV 

       130        140        150        160        170        180 
VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL 

       190        200 
NGKGAPRRGQ KTRRKNTSAH FLPMVVHS 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of human fibroblast growth factor-10."
Emoto H., Tagashira S., Mattei M.-G., Yamasaki M., Hashimoto G., Katsumata T., Negoro T., Nakatsuka M., Birnbaum D., Coulier F., Itoh N.
J. Biol. Chem. 272:23191-23194(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Cutaneous wound healing by keratinocyte growth factor 2."
Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., Dillon P.A., Duan R.D.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Expression of FGF10 in human prostate stromal cells."
Nakhla A.M., Hryb D.J., Kahn S.M., Romas N.A., Rosner W.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]NIEHS SNPs program
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[9]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFBP1.
[10]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[11]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[12]"Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors."
Yeh B.K., Igarashi M., Eliseenkova A.V., Plotnikov A.N., Sher I., Ron D., Aaronson S.A., Mohammadi M.
Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2.
[13]"Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands."
Entesarian M., Matsson H., Klar J., Bergendal B., Olson L., Arakaki R., Hayashi Y., Ohuchi H., Falahat B., Bolstad A.I., Jonsson R., Wahren-Herlenius M., Dahl N.
Nat. Genet. 37:125-127(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN ALSG.
[14]"LADD syndrome is caused by FGF10 mutations."
Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B.
Clin. Genet. 69:349-354(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LADDS ARG-156.
[15]"Mutations in different components of FGF signaling in LADD syndrome."
Rohmann E., Brunner H.G., Kayserili H., Uyguner O., Nuernberg G., Lew E.D., Dobbie A., Eswarakumar V.P., Uzumcu A., Ulubil-Emeroglu M., Leroy J.G., Li Y., Becker C., Lehnerdt K., Cremers C.W.R.J., Yueksel-Apak M., Nuernberg P., Kubisch C. expand/collapse author list , Schlessinger J., van Bokhoven H., Wollnik B.
Nat. Genet. 38:414-417(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LADDS PHE-106.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002097 mRNA. Translation: BAA22331.1.
U67918 mRNA. Translation: AAB61991.1.
AF411527 mRNA. Translation: AAL05875.1.
GQ351295 mRNA. Translation: ACU00617.1.
CR541665 mRNA. Translation: CAG46466.1.
CR541688 mRNA. Translation: CAG46489.1.
AY604046 Genomic DNA. Translation: AAS99733.1.
CH471119 Genomic DNA. Translation: EAW56075.1.
BC069561 mRNA. Translation: AAH69561.1.
BC105021 mRNA. Translation: AAI05022.1.
BC105023 mRNA. Translation: AAI05024.1.
CCDSCCDS3950.1.
RefSeqNP_004456.1. NM_004465.1.
XP_005248321.1. XM_005248264.1.
UniGeneHs.664499.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NUNX-ray2.90A64-208[»]
ProteinModelPortalO15520.
SMRO15520. Positions 69-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108546. 1 interaction.
DIPDIP-6037N.
IntActO15520. 1 interaction.
MINTMINT-257957.
STRING9606.ENSP00000264664.

PTM databases

PhosphoSiteO15520.

Proteomic databases

PaxDbO15520.
PRIDEO15520.

Protocols and materials databases

DNASU2255.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264664; ENSP00000264664; ENSG00000070193.
GeneID2255.
KEGGhsa:2255.
UCSCuc003jog.1. human.

Organism-specific databases

CTD2255.
GeneCardsGC05M044340.
HGNCHGNC:3666. FGF10.
HPACAB010315.
MIM149730. phenotype.
180920. phenotype.
602115. gene.
neXtProtNX_O15520.
Orphanet86815. Aplasia of lacrimal and salivary glands.
2363. Lacrimo-auriculo-dento-digital syndrome.
PharmGKBPA28106.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327524.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidO15520.
KOK04358.
OMASSIPVTC.
OrthoDBEOG7992S1.
PhylomeDBO15520.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkO15520.

Gene expression databases

ArrayExpressO15520.
BgeeO15520.
CleanExHS_FGF10.
GenevestigatorO15520.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO15520.
GeneWikiFGF10.
GenomeRNAi2255.
NextBio9135.
PROO15520.
SOURCESearch...

Entry information

Entry nameFGF10_HUMAN
AccessionPrimary (citable) accession number: O15520
Secondary accession number(s): C7FDY0 expand/collapse secondary AC list , Q6FHR3, Q6FHT6, Q96P59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM