O15519 (CFLAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CASP8 and FADD-like apoptosis regulator

Alternative name(s):
Caspase homolog
Short name=CASH
Caspase-eight-related protein
Short name=Casper
Caspase-like apoptosis regulatory protein
Short name=CLARP
Cellular FLICE-like inhibitory protein
Short name=c-FLIP
FADD-like antiapoptotic molecule 1
Short name=FLAME-1
Inhibitor of FLICE
Short name=I-FLICE
MACH-related inducer of toxicity
Short name=MRIT
Usurpin

Cleaved into the following 2 chains:

1. CASP8 and FADD-like apoptosis regulator subunit p43
2. CASP8 and FADD-like apoptosis regulator subunit p12

Gene names

Name:	CFLAR
Synonyms:	CASH, CASP8AP1, CLARP, MRIT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Ref.16
Subunit structure	TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X. Ref.18
Tissue specificity	Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Induction	Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle. Ref.17
Domain	The caspase domain lacks the active sites residues involved in catalysis.
Post-translational modification	Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
Sequence similarities	Belongs to the peptidase C14A family. Contains 2 DED (death effector) domains.

Ontologies

Keywords
Biological process	Apoptosis Host-virus interaction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of apoptotic process Inferred from mutant phenotype PubMed 18202225. Source: BHF-UCL negative regulation of extrinsic apoptotic signaling pathway Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of myoblast fusion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from expression pattern PubMed 12761501. Source: UniProtKB positive regulation of NF-kappaB transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL proteolysis Inferred from electronic annotation. Source: InterPro regulation of satellite cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL skeletal muscle atrophy Inferred from sequence or structural similarity. Source: BHF-UCL skeletal muscle tissue development Inferred from sequence or structural similarity. Source: BHF-UCL skeletal muscle tissue regeneration Inferred from sequence or structural similarity. Source: BHF-UCL skeletal myofibril assembly Inferred from sequence or structural similarity. Source: BHF-UCL virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 18073330. Source: UniProtKB death-inducing signaling complex Inferred from direct assay PubMed 21803845. Source: UniProtKB
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro enzyme activator activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15519-1)

Also known as: FLIP-L; CLARP1; MRIT alpha-1; CASH alpha; I-FLICE 1; FLAME-1 gamma; Usurpin alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15519-2)

Also known as: FLIP-S; CLARP2; MRIT beta-1; CASH beta;

The sequence of this isoform differs from the canonical sequence as follows:
     203-221: LHNGRSKEQRLKEQLGAQQ → MITPYAHCPDLKILGNCSM
     222-480: Missing.

Isoform 3 (identifier: O15519-3)

Also known as: MRIT alpha-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     436-480: KRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → GTIPGSGITESKDMHFSSLGCILLDVL

Isoform 4 (identifier: O15519-4)

Also known as: I-FLICE 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Isoform 5 (identifier: O15519-5)

Also known as: I-FLICE 3;

The sequence of this isoform differs from the canonical sequence as follows:
     449-480: YMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → L

Isoform 6 (identifier: O15519-6)

Also known as: I-FLICE 4;

The sequence of this isoform differs from the canonical sequence as follows:
     2-30: SAEVIHQVEEALDTDEKEMLLFLCRDVAI → LERPPVCSKV
     453-480: WNSRVSAKEKYYVWLQHTLRKKLILSYT → SLEHTGGRY

Isoform 7 (identifier: O15519-7)

Also known as: I-FLICE 5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     203-221: LHNGRSKEQRLKEQLGAQQ → E
     436-480: KRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → GTIPGSGITESKDMHFSSLGCILLDVL

Isoform 8 (identifier: O15519-8)

Also known as: FLAME-1 alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     203-237: Missing.

Isoform 9 (identifier: O15519-9)

Also known as: FLAME-1 beta;

The sequence of this isoform differs from the canonical sequence as follows:
     203-237: Missing.
     267-305: LRDTFTSLGY...FACMPEHRDY → CGVRGPAGGQ...ARAVHSSPRS
     306-480: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 10 (identifier: O15519-10)

Also known as: FLAME-1 delta;

The sequence of this isoform differs from the canonical sequence as follows:
     266-300: LLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP → NAHSWIFTLNSMATCMIGTAEFLPRRNIMFGCSTL
     301-480: Missing.

Isoform 11 (identifier: O15519-11)

Also known as: Usurpin beta;

The sequence of this isoform differs from the canonical sequence as follows:
     436-480: KRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT → GTIPGSGITESKDMHFSSLGCILLDVL

Isoform 12 (identifier: O15519-12)

Also known as: Usurpin gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     265-292: ELLRDTFTSLGYEVQKFLHLSMHGISQI → GWSAMAQSQLTAISTSQVQAILLPQPPE
     293-480: Missing.

Isoform 13 (identifier: O15519-13)

The sequence of this isoform differs from the canonical sequence as follows:
     203-480: Missing.

Isoform 14 (identifier: O15519-14)

The sequence of this isoform differs from the canonical sequence as follows:
     436-480: Missing.

Isoform 15 (identifier: O15519-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 376

376

CASP8 and FADD-like apoptosis regulator subunit p43

PRO_0000004678

Chain

377 – 480

104

CASP8 and FADD-like apoptosis regulator subunit p12 Potential

PRO_0000004679

Regions

Domain

1 – 73

73

DED 1

Domain

92 – 170

79

DED 2

Region

1 – 435

435

Not proteolytically processed and involved in apoptosis inhibition

Region

1 – 305

305

Interaction with caspase-8 propeptide

Region

1 – 227

227

Interaction with FADD

Region

1 – 195

195

Interaction with caspase-8

Region

192 – 480

289

Interaction with TRAF1 and TRAF2

Region

192 – 435

244

Interaction with caspase-3

Region

217 – 480

264

Interaction with caspase-8 subunits p18 and p10

Region

263 – 358

96

Caspase

Region

370 – 480

111

Interaction with caspase-8

Natural variations

Alternative sequence

1 – 245

245

Missing in isoform 4.

VSP_000825

Alternative sequence

1 – 96

96

Missing in isoform 3, isoform 7 and isoform 15.

VSP_000824

Alternative sequence

2 – 30

29

SAEVI…RDVAI → LERPPVCSKV in isoform 6.

VSP_000826

Alternative sequence

203 – 480

278

Missing in isoform 13.

VSP_000831

Alternative sequence

203 – 237

35

Missing in isoform 8 and isoform 9.

VSP_000830

Alternative sequence

203 – 221

19

LHNGR…LGAQQ → MITPYAHCPDLKILGNCSM in isoform 2.

VSP_000828

Alternative sequence

203 – 221

19

LHNGR…LGAQQ → E in isoform 7.

VSP_000827

Alternative sequence

222 – 480

259

Missing in isoform 2.

VSP_000829

Alternative sequence

265 – 292

28

ELLRD…GISQI → GWSAMAQSQLTAISTSQVQA ILLPQPPE in isoform 12.

VSP_000832

Alternative sequence

266 – 300

35

LLRDT…FACMP → NAHSWIFTLNSMATCMIGTA EFLPRRNIMFGCSTL in isoform 10.

VSP_000834

Alternative sequence

267 – 305

39

LRDTF…EHRDY → CGVRGPAGGQQPLGGGWASD EECGIQGSEARAVHSSPRS in isoform 9.

VSP_000836

Alternative sequence

293 – 480

188

Missing in isoform 12.

VSP_000833

Alternative sequence

301 – 480

180

Missing in isoform 10.

VSP_000835

Alternative sequence

306 – 480

175

Missing in isoform 9.

VSP_000837

Alternative sequence

436 – 480

45

KRPLL…ILSYT → GTIPGSGITESKDMHFSSLG CILLDVL in isoform 11, isoform 7 and isoform 3.

VSP_000838

Alternative sequence

436 – 480

45

Missing in isoform 14.

VSP_000839

Alternative sequence

449 – 480

32

YMYDW…ILSYT → L in isoform 5.

VSP_000840

Alternative sequence

453 – 480

28

WNSRV…ILSYT → SLEHTGGRY in isoform 6.

VSP_000841

Natural variant

203

1

L → I.
Corresponds to variant rs13424615 [ dbSNP | Ensembl ].

VAR_048619

Experimental info

Mutagenesis

360

1

Y → F: Decreases apoptosis-inducing activity. Reduces interaction with caspase-3 and proteolytic processing. Ref.1

Mutagenesis

376

1

D → N or A: Abolishes proteolytic processing. Ref.4

Sequence conflict

130 – 132

3

SFL → ISW in AAC15825. Ref.8

Sequence conflict

130 – 132

3

SFL → ISW in AAC15826. Ref.8

Sequence conflict

343

1

D → E in AAC15825. Ref.8

Sequence conflict

364

1

E → D in AAB99794. Ref.6

Sequence conflict

366 – 368

3

QLE → PAG in AAC15825. Ref.8

Sequence conflict

369

1

D → N in CAA74366. Ref.7

Sequence conflict

372

1

L → F in AAB99793. Ref.6

Sequence conflict

373 – 374

2

LE → WR in AAC15825. Ref.8

Secondary structure

1

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480

Helix Strand Turn

Details...

Beta strand

239 – 241

3

Beta strand

249 – 260

12

Helix

266 – 274

9

Beta strand

276 – 283

8

Helix

286 – 297

12

Helix

300 – 304

5

Beta strand

306 – 317

12

Helix

333 – 340

8

Turn

342 – 344

3

Helix

346 – 348

3

Beta strand

353 – 361

9

Beta strand

400 – 409

10

Helix

410 – 412

3

Helix

422 – 433

12

Helix

439 – 454

16

Helix

459 – 461

3

Beta strand

463 – 469

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (FLIP-L) (CLARP1) (MRIT alpha-1) (CASH alpha) (I-FLICE 1) (FLAME-1 gamma) (Usurpin alpha) [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 8C6D7E92AE1EB672	FASTA	480	55,344
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 300 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 310 320 330 340 350 360 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 370 380 390 400 410 420 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 430 440 450 460 470 480 SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT
	Isoform 2 (FLIP-S) (CLARP2) (MRIT beta-1) (CASH beta) [UniParc]. Checksum: 12774D7AB3E53263	FASTA	221	25,379
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 SYRNVLQAAI QKSLKDPSNN FRMITPYAHC PDLKILGNCS M
	Isoform 3 (MRIT alpha-2) [UniParc]. Checksum: B5DB6C8A18608582	FASTA	366	41,319
	10 20 30 40 50 60 MAEIGEDLDK SDVSSLIFLM KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP DQLDLLEKCL 70 80 90 100 110 120 KNIHRIDLKT KIQKYKQSVQ GAGTSYRNVL QAAIQKSLKD PSNNFRLHNG RSKEQRLKEQ 130 140 150 160 170 180 LGAQQEPVKK SIQESEAFLP QSIPEERYKM KSKPLGICLI IDCIGNETEL LRDTFTSLGY 190 200 210 220 230 240 EVQKFLHLSM HGISQILGQF ACMPEHRDYD SFVCVLVSRG GSQSVYGVDQ THSGLPLHHI 250 260 270 280 290 300 RRMFMGDSCP YLAGKPKMFF IQNYVVSEGQ LEDSSLLEVD GPAMKNVEFK AQKRGLCTVH 310 320 330 340 350 360 READFFWSLC TADMSLLEQS HSSPSLYLQC LSQKLRQERG TIPGSGITES KDMHFSSLGC ILLDVL
	Isoform 4 (I-FLICE 2) [UniParc]. Checksum: 1B34FA73556DC390	FASTA	235	27,055
	10 20 30 40 50 60 MKSKPLGICL IIDCIGNETE LLRDTFTSLG YEVQKFLHLS MHGISQILGQ FACMPEHRDY 70 80 90 100 110 120 DSFVCVLVSR GGSQSVYGVD QTHSGLPLHH IRRMFMGDSC PYLAGKPKMF FIQNYVVSEG 130 140 150 160 170 180 QLEDSSLLEV DGPAMKNVEF KAQKRGLCTV HREADFFWSL CTADMSLLEQ SHSSPSLYLQ 190 200 210 220 230 CLSQKLRQER KRPLLDLHIE LNGYMYDWNS RVSAKEKYYV WLQHTLRKKL ILSYT
	Isoform 5 (I-FLICE 3) [UniParc]. Checksum: 8AC8D85BA2F72F7E	FASTA	449	51,390
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 300 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 310 320 330 340 350 360 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 370 380 390 400 410 420 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 430 440 SLYLQCLSQK LRQERKRPLL DLHIELNGL
	Isoform 6 (I-FLICE 4) [UniParc]. Checksum: B20A318B728B2543	FASTA	442	50,661
	10 20 30 40 50 60 MLERPPVCSK VDVVPPNVRD LLDILRERGK LSVGDLAELL YRVRRFDLLK RILKMDRKAV 70 80 90 100 110 120 ETHLLRNPHL VSDYRVLMAE IGEDLDKSDV SSLIFLMKDY MGRGKISKEK SFLDLVVELE 130 140 150 160 170 180 KLNLVAPDQL DLLEKCLKNI HRIDLKTKIQ KYKQSVQGAG TSYRNVLQAA IQKSLKDPSN 190 200 210 220 230 240 NFRLHNGRSK EQRLKEQLGA QQEPVKKSIQ ESEAFLPQSI PEERYKMKSK PLGICLIIDC 250 260 270 280 290 300 IGNETELLRD TFTSLGYEVQ KFLHLSMHGI SQILGQFACM PEHRDYDSFV CVLVSRGGSQ 310 320 330 340 350 360 SVYGVDQTHS GLPLHHIRRM FMGDSCPYLA GKPKMFFIQN YVVSEGQLED SSLLEVDGPA 370 380 390 400 410 420 MKNVEFKAQK RGLCTVHREA DFFWSLCTAD MSLLEQSHSS PSLYLQCLSQ KLRQERKRPL 430 440 LDLHIELNGY MYDSLEHTGG RY
	Isoform 7 (I-FLICE 5) [UniParc]. Checksum: E9F524387399F9CA	FASTA	348	39,245
	10 20 30 40 50 60 MAEIGEDLDK SDVSSLIFLM KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP DQLDLLEKCL 70 80 90 100 110 120 KNIHRIDLKT KIQKYKQSVQ GAGTSYRNVL QAAIQKSLKD PSNNFREEPV KKSIQESEAF 130 140 150 160 170 180 LPQSIPEERY KMKSKPLGIC LIIDCIGNET ELLRDTFTSL GYEVQKFLHL SMHGISQILG 190 200 210 220 230 240 QFACMPEHRD YDSFVCVLVS RGGSQSVYGV DQTHSGLPLH HIRRMFMGDS CPYLAGKPKM 250 260 270 280 290 300 FFIQNYVVSE GQLEDSSLLE VDGPAMKNVE FKAQKRGLCT VHREADFFWS LCTADMSLLE 310 320 330 340 QSHSSPSLYL QCLSQKLRQE RGTIPGSGIT ESKDMHFSSL GCILLDVL
	Isoform 8 (FLAME-1 alpha) [UniParc]. Checksum: 91CD549119606DB2	FASTA	445	51,330
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRSIPEERYK MKSKPLGICL IIDCIGNETE LLRDTFTSLG 250 260 270 280 290 300 YEVQKFLHLS MHGISQILGQ FACMPEHRDY DSFVCVLVSR GGSQSVYGVD QTHSGLPLHH 310 320 330 340 350 360 IRRMFMGDSC PYLAGKPKMF FIQNYVVSEG QLEDSSLLEV DGPAMKNVEF KAQKRGLCTV 370 380 390 400 410 420 HREADFFWSL CTADMSLLEQ SHSSPSLYLQ CLSQKLRQER KRPLLDLHIE LNGYMYDWNS 430 440 RVSAKEKYYV WLQHTLRKKL ILSYT
	Isoform 9 (FLAME-1 beta) [UniParc]. Checksum: 230E9C0C0ADD1003	FASTA	270	30,399
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRSIPEERYK MKSKPLGICL IIDCIGNETE LCGVRGPAGG 250 260 270 QQPLGGGWAS DEECGIQGSE ARAVHSSPRS
	Isoform 10 (FLAME-1 delta) [UniParc]. Checksum: F6A777C2BA1469EF	FASTA	300	34,384
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 300 EERYKMKSKP LGICLIIDCI GNETENAHSW IFTLNSMATC MIGTAEFLPR RNIMFGCSTL
	Isoform 11 (Usurpin beta) [UniParc]. Checksum: D4E0109CBA47EAA3	FASTA	462	52,551
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 300 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 310 320 330 340 350 360 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 370 380 390 400 410 420 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 430 440 450 460 SLYLQCLSQK LRQERGTIPG SGITESKDMH FSSLGCILLD VL
	Isoform 12 (Usurpin gamma) [UniParc]. Checksum: 542E30BD5169F336	FASTA	292	33,273
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 EERYKMKSKP LGICLIIDCI GNETGWSAMA QSQLTAISTS QVQAILLPQP PE
	Isoform 13 [UniParc]. Checksum: 67D3C756AFD14F94	FASTA	202	23,289
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 SYRNVLQAAI QKSLKDPSNN FR
	Isoform 14 [UniParc]. Checksum: B37ED523D7738376	FASTA	435	49,778
	10 20 30 40 50 60 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 70 80 90 100 110 120 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 130 140 150 160 170 180 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 190 200 210 220 230 240 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 250 260 270 280 290 300 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 310 320 330 340 350 360 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 370 380 390 400 410 420 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 430 SLYLQCLSQK LRQER
	Isoform 15 [UniParc]. Checksum: 846E6372DB81F0F6	FASTA	384	44,112
	10 20 30 40 50 60 MAEIGEDLDK SDVSSLIFLM KDYMGRGKIS KEKSFLDLVV ELEKLNLVAP DQLDLLEKCL 70 80 90 100 110 120 KNIHRIDLKT KIQKYKQSVQ GAGTSYRNVL QAAIQKSLKD PSNNFRLHNG RSKEQRLKEQ 130 140 150 160 170 180 LGAQQEPVKK SIQESEAFLP QSIPEERYKM KSKPLGICLI IDCIGNETEL LRDTFTSLGY 190 200 210 220 230 240 EVQKFLHLSM HGISQILGQF ACMPEHRDYD SFVCVLVSRG GSQSVYGVDQ THSGLPLHHI 250 260 270 280 290 300 RRMFMGDSCP YLAGKPKMFF IQNYVVSEGQ LEDSSLLEVD GPAMKNVEFK AQKRGLCTVH 310 320 330 340 350 360 READFFWSLC TADMSLLEQS HSSPSLYLQC LSQKLRQERK RPLLDLHIEL NGYMYDWNSR 370 380 VSAKEKYYVW LQHTLRKKLI LSYT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Casper is a FADD- and caspase-related inducer of apoptosis." Shu H.-B., Halpin D.R., Goeddel D.V. Immunity 6:751-763(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 13 AND 14), MUTAGENESIS OF TYR-360. Tissue: Embryonic kidney and Umbilical vein endothelial cell.
[2]	"MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death." Han D.K.M., Chaudhary P.M., Wright M.E., Friedman C., Trask B.J., Riedel R.T., Baskin D.G., Schwartz S.M., Hood L. Proc. Natl. Acad. Sci. U.S.A. 94:11333-11338(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[3]	"Inhibition of death receptor signals by cellular FLIP." Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.-L., Schroeter M., Burns K., Mattmann C., Rimoldi D., French L.E., Tschopp J. Nature 388:190-195(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Peripheral blood lymphocyte.
[4]	"FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis." Srinivasula S.M., Ahmad M., Ottilie S., Bullrich F., Banks S., Wang Y., Fernandes-Alnemri T., Croce C.M., Litwack G., Tomaselli K.J., Armstrong R.C., Alnemri E.S. J. Biol. Chem. 272:18542-18545(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9 AND 10), MUTAGENESIS OF ASP-376. Tissue: T-cell.
[5]	"I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis." Hu S., Vincenz C., Ni J., Gentz R., Dixit V.M. J. Biol. Chem. 272:17255-17257(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Umbilical vein endothelial cell.
[6]	Hu S., Dixit V.M. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7).
[7]	"CASH, a novel caspase homologue with death effector domains." Goltsev Y.V., Kovalenko A.V., Arnold E., Varfolomeev E.E., Brodianskii V.M., Wallach D. J. Biol. Chem. 272:19641-19644(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Skin fibroblast.
[8]	"CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis." Inohara N., Koseki T., Hu Y., Chen S., Nunez G. Proc. Natl. Acad. Sci. U.S.A. 94:10717-10722(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Colon carcinoma.
[9]	"Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex." Rasper D.M., Vaillancourt J.P., Hadano S., Houtzager V.M., Seiden I., Keen S.L.C., Tawa P., Xanthoudakis S., Nasir J., Martindale D., Koop B.F., Peterson E.P., Thornberry N.A., Huang J., MacPherson D.P., Black S.C., Hornung F., Lenardo M.J. , Hayden M.R., Roy S., Nicholson D.W. Cell Death Differ. 5:271-288(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 11 AND 12). Tissue: Kidney.
[10]	"Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2." Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R. Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 15). Tissue: Cerebellum, Corpus callosum and Subthalamic nucleus.
[13]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph.
[16]	"The role of c-FLIP in modulation of CD95-induced apoptosis." Scaffidi C., Schmitz I., Krammer P.H., Peter M.E. J. Biol. Chem. 274:1541-1548(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[17]	"Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis." Algeciras-Schimnich A., Griffith T.S., Lynch D.H., Paya C.V. J. Immunol. 162:5205-5211(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[18]	"Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal." Kim K.H., Seong B.L. EMBO J. 22:2104-2116(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HBV PROTEIN X.
[19]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF010127 mRNA. Translation: AAB64110.1.
U85059 mRNA. Translation: AAB82648.1.
U97074 mRNA. Translation: AAC51622.1.
U97075 mRNA. Translation: AAC51623.1.
AF009616 mRNA. Translation: AAB70909.1.
AF009617 mRNA. Translation: AAB70910.1.
AF009618 mRNA. Translation: AAB70911.1.
AF009619 mRNA. Translation: AAB70912.1.
AF041458 mRNA. Translation: AAB99790.1.
AF041459 mRNA. Translation: AAB99791.1.
AF041462 mRNA. Translation: AAB99794.1.
AF041461 mRNA. Translation: AAB99793.1.
AF041460 mRNA. Translation: AAB99792.1.
Y14039 mRNA. Translation: CAA74366.1.
Y14040 mRNA. Translation: CAA74367.1.
AF005774 mRNA. Translation: AAC15825.1.
AF005775 mRNA. Translation: AAC15826.1.
AF015450 mRNA. Translation: AAC16439.1.
AF015451 mRNA. Translation: AAC16440.1.
AF015452 mRNA. Translation: AAC16441.1.
AB038972 Genomic DNA. Translation: BAB32551.1.
AB038972 Genomic DNA. Translation: BAB32552.1.
BT006751 mRNA. Translation: AAP35397.1.
AK289913 mRNA. Translation: BAF82602.1.
AK296036 mRNA. Translation: BAG58802.1.
AK315208 mRNA. Translation: BAG37645.1.
AK315924 mRNA. Translation: BAH14295.1.
AC007283 Genomic DNA. Translation: AAY24290.1.
CH471063 Genomic DNA. Translation: EAW70237.1.
CH471063 Genomic DNA. Translation: EAW70244.1.
BC001602 mRNA. Translation: AAH01602.1.

IPI

IPI00007287.
IPI00216956.
IPI00216957.
IPI00216959.
IPI00216960.
IPI00216962.
IPI00216963.
IPI00219239.
IPI00219241.
IPI00219242.
IPI00219243.
IPI00394836.
IPI00414806.
IPI00978912.

RefSeq

NP_001120655.1. NM_001127183.2.
NP_001120656.1. NM_001127184.2.
NP_001189444.1. NM_001202515.1.
NP_001189445.1. NM_001202516.1.
NP_001189446.1. NM_001202517.1.
NP_001189447.1. NM_001202518.1.
NP_001189448.1. NM_001202519.1.
NP_003870.4. NM_003879.5.

UniGene

Hs.390736.
Hs.731912.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3H11	X-ray	1.90	A	209-480	[»]
3H13	X-ray	2.20	A	209-480	[»]

ProteinModelPortal

O15519.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27629N.

IntAct

O15519. 13 interactions.

MINT

MINT-1529273.

Protein family/group databases

MEROPS

C14.971.

PTM databases

PhosphoSite

O15519.

Proteomic databases

PaxDb

O15519.

PRIDE

O15519.

Protocols and materials databases

DNASU

8837.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309955; ENSP00000312455; ENSG00000003402.
ENST00000340870; ENSP00000339326; ENSG00000003402.
ENST00000341222; ENSP00000339335; ENSG00000003402.
ENST00000341582; ENSP00000345807; ENSG00000003402.
ENST00000342795; ENSP00000342809; ENSG00000003402.
ENST00000423241; ENSP00000399420; ENSG00000003402.
ENST00000440180; ENSP00000406775; ENSG00000003402.
ENST00000443227; ENSP00000413270; ENSG00000003402.
ENST00000457277; ENSP00000411535; ENSG00000003402.
ENST00000479953; ENSP00000471805; ENSG00000003402.

GeneID

8837.

KEGG

hsa:8837.

UCSC

uc002uwz.3. human.
uc002uxb.4. human.
uc002uxc.4. human.
uc002uxf.3. human.
uc002uxg.3. human.
uc010fsz.3. human.
uc010zhk.2. human.
uc021vuw.1. human.

Organism-specific databases

CTD

8837.

GeneCards

GC02P201980.

HGNC

HGNC:1876. CFLAR.

HPA

CAB022157.
CAB025216.
HPA019044.

MIM

603599. gene.

neXtProt

NX_O15519.

PharmGKB

PA26425.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG331323.

HOVERGEN

HBG050918.

InParanoid

O15519.

KO

K04724.

OMA

YDWNSRV.

OrthoDB

EOG4DJJX0.

PhylomeDB

O15519.

Enzyme and pathway databases

Pathway_Interaction_DB

faspathway. FAS signaling pathway (CD95).
hivnefpathway. HIV-1 Nef: Negative effector of Fas and TNF-alpha.
trail_pathway. TRAIL signaling pathway.

Gene expression databases

ArrayExpress

O15519.

Bgee

O15519.

Genevestigator

O15519.

GermOnline

ENSG00000003402. Homo sapiens.

Family and domain databases

Gene3D

1.10.533.10. 3 hits.

InterPro

IPR011029. DEATH-like_dom.
IPR001875. DED.
IPR011600. Pept_C14_cat.
IPR001309. Pept_C14_ICE_p20.
IPR002398. Pept_C14_p45.
IPR015917. Pept_C14_p45_core.
[Graphical view]

PANTHER

PTHR10454. PTHR10454. 1 hit.

Pfam

PF01335. DED. 2 hits.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]

SMART

SM00115. CASc. 1 hit.
SM00031. DED. 2 hits.
[Graphical view]

SUPFAM

SSF47986. DEATH_like. 2 hits.

PROSITE

PS50208. CASPASE_P20. 1 hit.
PS50168. DED. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1955713.

ChiTaRS

CFLAR. human.

EvolutionaryTrace

O15519.

GenomeRNAi

8837.

NextBio

33168.

SOURCE

Search...

Entry information

Entry name

CFLAR_HUMAN

Accession

Primary (citable) accession number: O15519
Secondary accession number(s): B4DJE0 , B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.