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Protein

Actin-related protein 2/3 complex subunit 5

Gene

ARPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-6798695 Neutrophil degranulation
R-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO15511

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5
Alternative name(s):
Arp2/3 complex 16 kDa subunit
Short name:
p16-ARC
Gene namesi
Name:ARPC5
Synonyms:ARC16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162704.15
HGNCiHGNC:708 ARPC5
MIMi604227 gene
neXtProtiNX_O15511

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10092
OpenTargetsiENSG00000162704
PharmGKBiPA25003

Chemistry databases

DrugBankiDB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide

Polymorphism and mutation databases

BioMutaiARPC5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001240542 – 151Actin-related protein 2/3 complex subunit 5Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Post-translational modificationi

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiO15511
MaxQBiO15511
PaxDbiO15511
PeptideAtlasiO15511
PRIDEiO15511
TopDownProteomicsiO15511-1 [O15511-1]
O15511-2 [O15511-2]

2D gel databases

OGPiO15511
SWISS-2DPAGEiO15511

PTM databases

iPTMnetiO15511
PhosphoSitePlusiO15511

Expressioni

Gene expression databases

BgeeiENSG00000162704
CleanExiHS_ARPC5
ExpressionAtlasiO15511 baseline and differential
GenevisibleiO15511 HS

Organism-specific databases

HPAiHPA022013
HPA031972

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115399, 60 interactors
CORUMiO15511
DIPiDIP-33144N
IntActiO15511, 27 interactors
STRINGi9606.ENSP00000352918

Structurei

3D structure databases

ProteinModelPortaliO15511
SMRiO15511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380 Eukaryota
ENOG4111FGV LUCA
GeneTreeiENSGT00390000014806
HOGENOMiHOG000197215
HOVERGENiHBG050583
InParanoidiO15511
KOiK05754
OMAiKYIYKGM
OrthoDBiEOG091G0R2J
PhylomeDBiO15511
TreeFamiTF319716

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
PANTHERiPTHR12644 PTHR12644, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN
60 70 80 90 100
MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK
110 120 130 140 150
NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT

V
Length:151
Mass (Da):16,320
Last modified:January 23, 2007 - v3
Checksum:iF050B11774EA6E66
GO
Isoform 2 (identifier: O15511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: Q → HSIT

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):16,631
Checksum:i0FF22E5126BDC54A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02402848Q → HSIT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006088 mRNA Translation: AAB64193.1
AF017807 mRNA Translation: AAB70561.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91163.1
BC057237 mRNA Translation: AAH57237.1
CCDSiCCDS1357.1 [O15511-1]
CCDS58050.1 [O15511-2]
RefSeqiNP_001257368.1, NM_001270439.1 [O15511-2]
NP_005708.1, NM_005717.3 [O15511-1]
UniGeneiHs.518609

Genome annotation databases

EnsembliENST00000294742; ENSP00000294742; ENSG00000162704 [O15511-2]
ENST00000359856; ENSP00000352918; ENSG00000162704 [O15511-1]
GeneIDi10092
KEGGihsa:10092
UCSCiuc021pgb.3 human [O15511-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARPC5_HUMAN
AccessioniPrimary (citable) accession number: O15511
Secondary accession number(s): A6NEC4, Q6PG42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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