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Protein

Homeobox protein goosecoid-2

Gene

GSC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi126 – 185HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein goosecoid-2
Short name:
GSC-2
Alternative name(s):
Homeobox protein goosecoid-like
Short name:
GSC-L
Gene namesi
Name:GSC2
Synonyms:GSCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000063515.2
HGNCiHGNC:4613 GSC2
MIMi601845 gene
neXtProtiNX_O15499

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2928
OpenTargetsiENSG00000063515
PharmGKBiPA162390265

Polymorphism and mutation databases

BioMutaiGSC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488911 – 205Homeobox protein goosecoid-2Add BLAST205

Proteomic databases

PaxDbiO15499
PRIDEiO15499

PTM databases

iPTMnetiO15499
PhosphoSitePlusiO15499

Expressioni

Tissue specificityi

Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably expressed in other tissues at low levels.

Developmental stagei

Expressed in early human development as well as in a limited number of adult tissues.

Gene expression databases

BgeeiENSG00000063515
CleanExiHS_GSC2
GenevisibleiO15499 HS

Organism-specific databases

HPAiHPA043011

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000086933

Structurei

3D structure databases

ProteinModelPortaliO15499
SMRiO15499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ala4
Compositional biasi64 – 70Poly-Cys7

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140776
HOGENOMiHOG000112823
HOVERGENiHBG005922
InParanoidiO15499
KOiK09325
OMAiCPFSIEH
OrthoDBiEOG091G0OQ6
PhylomeDBiO15499
TreeFamiTF351613

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O15499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGGAAS RRGAGRPCPF SIEHILSSLP ERSLPARAAC PPQPAGRQSP
60 70 80 90 100
AKPEEPGAPE AAPCACCCCC GPRAAPCGPP EAAAGLGARL AWPLRLGPAV
110 120 130 140 150
PLSLGAPAGG SGALPGAVGP GSQRRTRRHR TIFSEEQLQA LEALFVQNQY
160 170 180 190 200
PDVSTRERLA GRIRLREERV EVWFKNRRAK WRHQKRASAS ARLLPGVKKS

PKGSC
Length:205
Mass (Da):21,545
Last modified:January 1, 1998 - v1
Checksum:i665C33D9C454E7A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00854947R → C1 PublicationCorresponds to variant dbSNP:rs34341950Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96402 Genomic DNA Translation: AAC39544.1
CCDSiCCDS13757.1
RefSeqiNP_005306.1, NM_005315.1
UniGeneiHs.534318

Genome annotation databases

EnsembliENST00000086933; ENSP00000086933; ENSG00000063515
GeneIDi2928
KEGGihsa:2928
UCSCiuc011ags.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGSC2_HUMAN
AccessioniPrimary (citable) accession number: O15499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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