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Protein

Synaptobrevin homolog YKT6

Gene

YKT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.2 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein-cysteine S-palmitoyltransferase activity Source: HGNC
  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: HGNC
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: HGNC
  • vesicle docking involved in exocytosis Source: HGNC
  • vesicle fusion Source: GO_Central
  • vesicle targeting Source: HGNC

Keywordsi

Molecular functionTransferase
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-1 Publication)
Gene namesi
Name:YKT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000106636.7
HGNCiHGNC:16959 YKT6
MIMi606209 gene
neXtProtiNX_O15498

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42F → E: Increases palmitoylation. Targeted to Golgi membranes. Targeted to Golgi and cytosol; when associated with S-194. Targeted to cytosol; when associated with S-195. 2 Publications1
Mutagenesisi194C → S: Decreases palmitoylation by 55%. Prevents palmitoylation; when associated with S-195. Targeted to Golgi and cytosol; when associated with E-42. 2 Publications1
Mutagenesisi195C → S: Prevents farnesylation. Targeted to cytosol; when associated with E-42. Decreases palmitoylation by 13%. Prevents palmitoylation; when associated with S-194. 2 Publications1

Organism-specific databases

DisGeNETi10652
OpenTargetsiENSG00000106636
PharmGKBiPA145007308

Polymorphism and mutation databases

BioMutaiYKT6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807091 – 195Synaptobrevin homolog YKT6Add BLAST195
PropeptideiPRO_0000396661196 – 198Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineCombined sources1
Lipidationi194S-palmitoyl cysteine1 Publication1
Modified residuei195Cysteine methyl esterCurated1
Lipidationi195S-farnesyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.2 Publications
Farnesylation is required for Golgi targeting.

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiO15498
MaxQBiO15498
PaxDbiO15498
PeptideAtlasiO15498
PRIDEiO15498
TopDownProteomicsiO15498-1 [O15498-1]

PTM databases

iPTMnetiO15498
PhosphoSitePlusiO15498
SwissPalmiO15498

Expressioni

Gene expression databases

BgeeiENSG00000106636
CleanExiHS_YKT6
ExpressionAtlasiO15498 baseline and differential
GenevisibleiO15498 HS

Organism-specific databases

HPAiHPA030817
HPA030818

Interactioni

Subunit structurei

Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.By similarity

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi115895, 53 interactors
IntActiO15498, 13 interactors
MINTiO15498
STRINGi9606.ENSP00000223369

Structurei

3D structure databases

ProteinModelPortaliO15498
SMRiO15498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 126LonginPROSITE-ProRule annotationAdd BLAST119
Domaini138 – 198v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Domaini

The longin domain regulates palmitoylation and membrane targeting.

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00390000015164
HOGENOMiHOG000189970
HOVERGENiHBG088939
InParanoidiO15498
KOiK08516
OMAiYPVRPAF
OrthoDBiEOG091G0MPE
PhylomeDBiO15498
TreeFamiTF105606

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLYSLSVLY KGEAKVVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SSKGTRASVK EQDYLCHVYV RNDSLAGVVI ADNEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PVGSPATIHY PALDGHLSRY QNPREADPMT KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGTQ SKAFYKTARK QNSCCAIM
Length:198
Mass (Da):22,418
Last modified:January 1, 1998 - v1
Checksum:i2AB0C12832D1B943
GO
Isoform 2 (identifier: O15498-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-187: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,580
Checksum:i660854BBA5AC6C27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63D → N in CAG46805 (Ref. 4) Curated1
Sequence conflicti138P → L in BAD97208 (Ref. 5) Curated1
Sequence conflicti198M → I in CAG33270 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056071154 – 187Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95735 mRNA Translation: AAB81131.1
BT007078 mRNA Translation: AAP35741.1
AK299158 mRNA Translation: BAG61206.1
CR456989 mRNA Translation: CAG33270.1
CR542008 mRNA Translation: CAG46805.1
AK223488 mRNA Translation: BAD97208.1
AC006454 Genomic DNA No translation available.
BC007319 mRNA Translation: AAH07319.1
CCDSiCCDS5482.1 [O15498-1]
RefSeqiNP_006546.1, NM_006555.3 [O15498-1]
XP_016867171.1, XM_017011682.1 [O15498-2]
UniGeneiHs.520794

Genome annotation databases

EnsembliENST00000223369; ENSP00000223369; ENSG00000106636 [O15498-1]
ENST00000496112; ENSP00000420805; ENSG00000106636 [O15498-2]
GeneIDi10652
KEGGihsa:10652
UCSCiuc003tkm.4 human [O15498-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiYKT6_HUMAN
AccessioniPrimary (citable) accession number: O15498
Secondary accession number(s): B4DR94
, Q53F01, Q6FGU9, Q6IB15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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