Reviewed, UniProtKB/Swiss-Prot O15481 (MAGB4_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma-associated antigen B4
Alternative name(s):
    MAGE-B4 antigen

Gene names

Name:

MAGEB4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in testis.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Molecular function	Tumor antigen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Melanoma-associated antigen B4		PRO_0000156715
Regions
	Domain	109 – 307	199	MAGE
Experimental info
	Sequence conflict	41	1	S → P in AAH32852. Ref.4
	Sequence conflict	186	1	D → Y in AAH32852. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O15481-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 804F260BD50F036A	FASTA	346	38,923
	10 20 30 40 50 60 MPRGQKSKLR AREKRQRTRG QTQDLKVGQP TAAEKEESPS SSSSVLRDTA SSSLAFGIPQ 70 80 90 100 110 120 EPQREPPTTS AAAAMSCTGS DKGDESQDEE NASSSQASTS TERSLKDSLT RKTKMLVQFL 130 140 150 160 170 180 LYKYKMKEPT TKAEMLKIIS KKYKEHFPEI FRKVSQRTEL VFGLALKEVN PTTHSYILVS 190 200 210 220 230 240 MLGPNDGNQS SAWTLPRNGL LMPLLSVIFL NGNCAREEEI WEFLNMLGIY DGKRHLIFGE 250 260 270 280 290 300 PRKLITQDLV QEKYLEYQQV PNSDPPRYQF LWGPRAHAET SKMKVLEFLA KVNDTTPNNF 310 320 330 340 PLLYEEALRD EEERAGARPR VAARRGTTAM TSAYSRATSS SSSQPM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins." Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V., De Plaen E., Brasseur R., Monaco A.P., Boon T. Genomics 46:397-408(1997) [PubMed: 9441743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U93163 Genomic DNA. Translation: AAC23619.1. CR541779 mRNA. Translation: CAG46578.1. AC005185 Genomic DNA. Translation: AAD10637.1. BC032852 mRNA. Translation: AAH32852.1.
IPI	IPI00006737.
RefSeq	NP_002358.1.
UniGene	Hs.113291
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O15481. 1 interaction.
Proteomic databases
PRIDE	O15481.
Genome annotation databases
Ensembl	ENSG00000120289. Homo sapiens. [Contig view]
GeneID	4115.
KEGG	hsa:4115.
Organism-specific databases
GeneCards	GC0XP030171.
H-InvDB	HIX0016714. HIX0056538.
HGNC	HGNC:6811. MAGEB4.
MIM	300153. gene.
PharmGKB	PA30557.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O15481.
OMA	O15481. QRTELVF.
Gene expression databases
ArrayExpress	O15481.
Bgee	O15481.
CleanEx	HS_MAGEB4.
GermOnline	ENSG00000120289. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16158.
SOURCE	Search...

Entry information

Entry name

MAGB4_HUMAN

Accession

Primary (citable) accession number: O15481
Secondary accession number(s): Q6FHH4, Q8IZ00

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)