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Protein

Melanoma-associated antigen B4

Gene

MAGEB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B4
Alternative name(s):
MAGE-B4 antigen
Gene namesi
Name:MAGEB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6811. MAGEB4.

Subcellular locationi

  • Cytoplasm By similarity

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30557.

Polymorphism and mutation databases

BioMutaiMAGEB4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Melanoma-associated antigen B4PRO_0000156715Add
BLAST

Proteomic databases

PaxDbiO15481.
PeptideAtlasiO15481.
PRIDEiO15481.

PTM databases

iPTMnetiO15481.
PhosphoSiteiO15481.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiENSG00000120289.
CleanExiHS_MAGEB4.
GenevisibleiO15481. HS.

Organism-specific databases

HPAiCAB032794.
HPA030456.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-751857,EBI-10171416
FERD3LQ96RJ63EBI-751857,EBI-10183007
HGSO149643EBI-751857,EBI-740220
KANK2Q63ZY33EBI-751857,EBI-2556193
KRT38O760153EBI-751857,EBI-1047263
LZTS2Q9BRK43EBI-751857,EBI-741037
MAGEA8P433613EBI-751857,EBI-10182930
MED21Q135033EBI-751857,EBI-394678
ROCK1Q134643EBI-751857,EBI-876651
RUNDC3AQ59EK93EBI-751857,EBI-747225
TNRA1L3063EBI-751857,EBI-10182881
USHBP1Q8N6Y03EBI-751857,EBI-739895
USP25Q9UHP33EBI-751857,EBI-2513462
WDR62O433793EBI-751857,EBI-714790
ZNF341Q9BYN73EBI-751857,EBI-9089622

Protein-protein interaction databases

BioGridi110289. 21 interactions.
IntActiO15481. 16 interactions.
STRINGi9606.ENSP00000368266.

Structurei

3D structure databases

ProteinModelPortaliO15481.
SMRiO15481. Positions 98-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 307199MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiO15481.
OMAiSKKYKEH.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO15481.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRQRTRG QTQDLKVGQP TAAEKEESPS SSSSVLRDTA
60 70 80 90 100
SSSLAFGIPQ EPQREPPTTS AAAAMSCTGS DKGDESQDEE NASSSQASTS
110 120 130 140 150
TERSLKDSLT RKTKMLVQFL LYKYKMKEPT TKAEMLKIIS KKYKEHFPEI
160 170 180 190 200
FRKVSQRTEL VFGLALKEVN PTTHSYILVS MLGPNDGNQS SAWTLPRNGL
210 220 230 240 250
LMPLLSVIFL NGNCAREEEI WEFLNMLGIY DGKRHLIFGE PRKLITQDLV
260 270 280 290 300
QEKYLEYQQV PNSDPPRYQF LWGPRAHAET SKMKVLEFLA KVNDTTPNNF
310 320 330 340
PLLYEEALRD EEERAGARPR VAARRGTTAM TSAYSRATSS SSSQPM
Length:346
Mass (Da):38,923
Last modified:January 1, 1998 - v1
Checksum:i804F260BD50F036A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411S → P in AAH32852 (PubMed:15489334).Curated
Sequence conflicti186 – 1861D → Y in AAH32852 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23619.1.
CR541779 mRNA. Translation: CAG46578.1.
AK313769 mRNA. Translation: BAG36507.1.
AC005185 Genomic DNA. Translation: AAD10637.1.
CH471074 Genomic DNA. Translation: EAW99050.1.
BC032852 mRNA. Translation: AAH32852.1.
CCDSiCCDS14221.1.
RefSeqiNP_002358.1. NM_002367.3.
UniGeneiHs.113291.

Genome annotation databases

EnsembliENST00000378982; ENSP00000368266; ENSG00000120289.
GeneIDi4115.
KEGGihsa:4115.
UCSCiuc004dcb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23619.1.
CR541779 mRNA. Translation: CAG46578.1.
AK313769 mRNA. Translation: BAG36507.1.
AC005185 Genomic DNA. Translation: AAD10637.1.
CH471074 Genomic DNA. Translation: EAW99050.1.
BC032852 mRNA. Translation: AAH32852.1.
CCDSiCCDS14221.1.
RefSeqiNP_002358.1. NM_002367.3.
UniGeneiHs.113291.

3D structure databases

ProteinModelPortaliO15481.
SMRiO15481. Positions 98-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110289. 21 interactions.
IntActiO15481. 16 interactions.
STRINGi9606.ENSP00000368266.

PTM databases

iPTMnetiO15481.
PhosphoSiteiO15481.

Polymorphism and mutation databases

BioMutaiMAGEB4.

Proteomic databases

PaxDbiO15481.
PeptideAtlasiO15481.
PRIDEiO15481.

Protocols and materials databases

DNASUi4115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378982; ENSP00000368266; ENSG00000120289.
GeneIDi4115.
KEGGihsa:4115.
UCSCiuc004dcb.4. human.

Organism-specific databases

CTDi4115.
GeneCardsiMAGEB4.
HGNCiHGNC:6811. MAGEB4.
HPAiCAB032794.
HPA030456.
MIMi300153. gene.
neXtProtiNX_O15481.
PharmGKBiPA30557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiO15481.
OMAiSKKYKEH.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO15481.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii4115.
PROiO15481.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120289.
CleanExiHS_MAGEB4.
GenevisibleiO15481. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGB4_HUMAN
AccessioniPrimary (citable) accession number: O15481
Secondary accession number(s): B2R9G0, Q6FHH4, Q8IZ00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.