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Protein

Melanoma-associated antigen B3

Gene

MAGEB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Enzyme and pathway databases

BioCyciZFISH:G66-31686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B3
Alternative name(s):
MAGE-B3 antigen
Gene namesi
Name:MAGEB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6810. MAGEB3.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198798.
PharmGKBiPA30556.

Polymorphism and mutation databases

BioMutaiMAGEB3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567141 – 346Melanoma-associated antigen B3Add BLAST346

Proteomic databases

EPDiO15480.
MaxQBiO15480.
PaxDbiO15480.
PeptideAtlasiO15480.
PRIDEiO15480.

PTM databases

iPTMnetiO15480.
PhosphoSitePlusiO15480.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiENSG00000198798.
CleanExiHS_MAGEB3.
GenevisibleiO15480. HS.

Interactioni

Protein-protein interaction databases

BioGridi110288. 2 interactors.
STRINGi9606.ENSP00000355198.

Structurei

3D structure databases

ProteinModelPortaliO15480.
SMRiO15480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 310MAGEPROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiO15480.
OMAiMLVQFLM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO15480.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGQKSTLH AREKRQQTRG QTQDHQGAQI TATNKKKVSF SSPLILGATI
60 70 80 90 100
QKKSAGRSRS ALKKPQRALS TTTSVDVSYK KSYKGANSKI EKKQSFSQGL
110 120 130 140 150
SSTVQSRTDP LIMKTNMLVQ FLMEMYKMKK PIMKADMLKI VQKSHKNCFP
160 170 180 190 200
EILKKASFNM EVVFGVDLKK VDSTKDSYVL VSKMDLPNNG TVTRGRGFPK
210 220 230 240 250
TGLLLNLLGV IFMKGNCATE EKIWEFLNKM RIYDGKKHFI FGEPRKLITQ
260 270 280 290 300
DLVKLKYLEY RQVPNSNPAR YEFLWGPRAH AETSKMKVLE FWAKVNKTVP
310 320 330 340
SAFQFWYEEA LRDEEERVQA AAMLNDGSSA MGRKCSKAKA SSSSHA
Length:346
Mass (Da):39,211
Last modified:May 5, 2009 - v2
Checksum:i053407C60CBEFFE5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021360107R → H.3 PublicationsCorresponds to variant rs2071308dbSNPEnsembl.1
Natural variantiVAR_021361112I → T.3 PublicationsCorresponds to variant rs2071309dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23618.1.
AK057441 mRNA. Translation: BAG51914.1.
AC005185 Genomic DNA. Translation: AAD10636.1.
BC069784 mRNA. Translation: AAH69784.1.
BC074756 mRNA. Translation: AAH74756.1.
BC126320 mRNA. Translation: AAI26321.1.
BC126322 mRNA. Translation: AAI26323.1.
CCDSiCCDS14220.1.
RefSeqiNP_002356.2. NM_002365.4.
XP_011543815.1. XM_011545513.2.
XP_011543816.1. XM_011545514.2.
UniGeneiHs.113290.

Genome annotation databases

EnsembliENST00000361644; ENSP00000355198; ENSG00000198798.
ENST00000620842; ENSP00000478513; ENSG00000198798.
GeneIDi4114.
KEGGihsa:4114.
UCSCiuc004dca.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23618.1.
AK057441 mRNA. Translation: BAG51914.1.
AC005185 Genomic DNA. Translation: AAD10636.1.
BC069784 mRNA. Translation: AAH69784.1.
BC074756 mRNA. Translation: AAH74756.1.
BC126320 mRNA. Translation: AAI26321.1.
BC126322 mRNA. Translation: AAI26323.1.
CCDSiCCDS14220.1.
RefSeqiNP_002356.2. NM_002365.4.
XP_011543815.1. XM_011545513.2.
XP_011543816.1. XM_011545514.2.
UniGeneiHs.113290.

3D structure databases

ProteinModelPortaliO15480.
SMRiO15480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110288. 2 interactors.
STRINGi9606.ENSP00000355198.

PTM databases

iPTMnetiO15480.
PhosphoSitePlusiO15480.

Polymorphism and mutation databases

BioMutaiMAGEB3.

Proteomic databases

EPDiO15480.
MaxQBiO15480.
PaxDbiO15480.
PeptideAtlasiO15480.
PRIDEiO15480.

Protocols and materials databases

DNASUi4114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361644; ENSP00000355198; ENSG00000198798.
ENST00000620842; ENSP00000478513; ENSG00000198798.
GeneIDi4114.
KEGGihsa:4114.
UCSCiuc004dca.3. human.

Organism-specific databases

CTDi4114.
GeneCardsiMAGEB3.
H-InvDBHIX0018358.
HGNCiHGNC:6810. MAGEB3.
MIMi300152. gene.
neXtProtiNX_O15480.
OpenTargetsiENSG00000198798.
PharmGKBiPA30556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiO15480.
OMAiMLVQFLM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiO15480.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:G66-31686-MONOMER.

Miscellaneous databases

GenomeRNAii4114.
PROiO15480.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198798.
CleanExiHS_MAGEB3.
GenevisibleiO15480. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGB3_HUMAN
AccessioniPrimary (citable) accession number: O15480
Secondary accession number(s): A0AVE4, B3KQ52, O75861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.