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O15479

- MAGB2_HUMAN

UniProt

O15479 - MAGB2_HUMAN

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Protein

Melanoma-associated antigen B2

Gene

MAGEB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B2
Alternative name(s):
Cancer/testis antigen 3.2
Short name:
CT3.2
DSS-AHC critical interval MAGE superfamily 6
Short name:
DAM6
MAGE XP-2 antigen
MAGE-B2 antigen
Gene namesi
Name:MAGEB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6809. MAGEB2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Melanoma-associated antigen B2PRO_0000156713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Phosphoserine1 Publication
Modified residuei105 – 1051Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15479.
PaxDbiO15479.
PeptideAtlasiO15479.
PRIDEiO15479.

PTM databases

PhosphoSiteiO15479.

Expressioni

Tissue specificityi

Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.

Gene expression databases

BgeeiO15479.
CleanExiHS_MAGEB2.
GenevestigatoriO15479.

Interactioni

Subunit structurei

Interacts with TRIM28.1 Publication

Protein-protein interaction databases

BioGridi110287. 24 interactions.
IntActiO15479. 3 interactions.
MINTiMINT-8417691.
STRINGi9606.ENSP00000368273.

Structurei

3D structure databases

ProteinModelPortaliO15479.
SMRiO15479. Positions 100-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 310200MAGEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320712.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiO15479.
OMAiRFREHFP.
OrthoDBiEOG75F4GM.
PhylomeDBiO15479.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA
60 70 80 90 100
SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS
110 120 130 140 150
TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP
160 170 180 190 200
EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR
210 220 230 240 250
RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK
260 270 280 290 300
DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP
310
CAFPTHYEEA LKDEEKAGV
Length:319
Mass (Da):35,277
Last modified:January 11, 2011 - v3
Checksum:iCF0BD27A832D5CBB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611E → K.4 Publications
Corresponds to variant rs2529541 [ dbSNP | Ensembl ].
VAR_027675
Natural varianti318 – 3181G → R.
Corresponds to variant rs5972090 [ dbSNP | Ensembl ].
VAR_027676

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23617.1.
AF015766 mRNA. Translation: AAD01565.1.
AC005185 Genomic DNA. Translation: AAD10635.1.
BC026071 mRNA. Translation: AAH26071.1.
CCDSiCCDS14219.1.
RefSeqiNP_002355.2. NM_002364.4.
UniGeneiHs.113824.

Genome annotation databases

EnsembliENST00000378988; ENSP00000368273; ENSG00000099399.
GeneIDi4113.
KEGGihsa:4113.
UCSCiuc004dbz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93163 Genomic DNA. Translation: AAC23617.1 .
AF015766 mRNA. Translation: AAD01565.1 .
AC005185 Genomic DNA. Translation: AAD10635.1 .
BC026071 mRNA. Translation: AAH26071.1 .
CCDSi CCDS14219.1.
RefSeqi NP_002355.2. NM_002364.4.
UniGenei Hs.113824.

3D structure databases

ProteinModelPortali O15479.
SMRi O15479. Positions 100-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110287. 24 interactions.
IntActi O15479. 3 interactions.
MINTi MINT-8417691.
STRINGi 9606.ENSP00000368273.

PTM databases

PhosphoSitei O15479.

Proteomic databases

MaxQBi O15479.
PaxDbi O15479.
PeptideAtlasi O15479.
PRIDEi O15479.

Protocols and materials databases

DNASUi 4113.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378988 ; ENSP00000368273 ; ENSG00000099399 .
GeneIDi 4113.
KEGGi hsa:4113.
UCSCi uc004dbz.3. human.

Organism-specific databases

CTDi 4113.
GeneCardsi GC0XP030233.
H-InvDB HIX0016713.
HGNCi HGNC:6809. MAGEB2.
MIMi 300098. gene.
neXtProti NX_O15479.
PharmGKBi PA30555.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320712.
GeneTreei ENSGT00760000118824.
HOGENOMi HOG000231161.
HOVERGENi HBG006315.
InParanoidi O15479.
OMAi RFREHFP.
OrthoDBi EOG75F4GM.
PhylomeDBi O15479.
TreeFami TF328505.

Miscellaneous databases

GeneWikii MAGEB2.
GenomeRNAii 4113.
NextBioi 16150.
PROi O15479.
SOURCEi Search...

Gene expression databases

Bgeei O15479.
CleanExi HS_MAGEB2.
Genevestigatori O15479.

Family and domain databases

InterProi IPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of rapidly evolving genes from the sex reversal critical region in Xp21."
    Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G.
    Mamm. Genome 6:571-580(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins."
    Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V., De Plaen E., Brasseur R., Monaco A.P., Boon T.
    Genomics 46:397-408(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-61.
  3. "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera."
    McCurdy D.K., Tai L.-Q., Nguyen J., Wang Z., Yang H.M., Udar N., Naiem F., Concannon P., Gatti R.A.
    Mol. Genet. Metab. 63:3-13(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-61.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-61.
    Tissue: Testis.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-105, VARIANT [LARGE SCALE ANALYSIS] LYS-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
    Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
    Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRIM28.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMAGB2_HUMAN
AccessioniPrimary (citable) accession number: O15479
Secondary accession number(s): O75860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3