Reviewed, UniProtKB/Swiss-Prot O15479 (MAGB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Melanoma-associated antigen B2
Alternative name(s):
    MAGE-B2 antigen
    DSS-AHC critical interval MAGE superfamily 6
      Short name=DAM6
    MAGE XP-2 antigen
    Cancer/testis antigen 3.2
      Short name=CT3.2

Gene names

Name:

MAGEB2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CSNK2B	P67870	1	EBI-1057615,EBI-348169
LXN	Q9BS40	1	EBI-1057615,EBI-1044504
RPL23A	P62750	1	EBI-1057615,EBI-353254
RPL24	P83731	1	EBI-1057615,EBI-353146
RPL26	P61254	1	EBI-1057615,EBI-352405
RPL28	P46779	1	EBI-1057615,EBI-366357
RPL31	P62899	1	EBI-1057615,EBI-1053664
RPL34	P49207	1	EBI-1057615,EBI-1051893
RPL36	Q9Y3U8	1	EBI-1057615,EBI-1057689
RPL36A	P83881	1	EBI-1057615,EBI-1054835
RPS11	P62280	1	EBI-1057615,EBI-1047710
RPS14	P62263	1	EBI-1057615,EBI-352783
RPS16	P62249	1	EBI-1057615,EBI-352480
RPS19	P39019	1	EBI-1057615,EBI-354451
RPS26	P62854	1	EBI-1057615,EBI-353438
RPS3A	P61247	1	EBI-1057615,EBI-352378
RPS9	P46781	1	EBI-1057615,EBI-351206
USP7	Q93009	1	EBI-1057615,EBI-302474

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Melanoma-associated antigen B2		PRO_0000156713
Regions
	Domain	111 – 310	200	MAGE
Amino acid modifications
	Modified residue	77	1	Phosphoserine Ref.6
	Modified residue	105	1	Phosphoserine Ref.6
Natural variations
	Natural variant	61	1	K → E: dbSNP rs2529541. Ref.4		VAR_027675
	Natural variant	318	1	G → R: dbSNP rs5972090.		VAR_027676

Sequences

	Sequence		Length	Mass (Da)
	O15479-1 [UniParc]. Last modified August 1, 1998. Version 2. Checksum: CF0BD05A232D592D	FASTA	319	35,276
	10 20 30 40 50 60 MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA SSSPAAGIPQ 70 80 90 100 110 120 KPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ 130 140 150 160 170 180 FLLYKYKIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF 190 200 210 220 230 240 IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV 250 260 270 280 290 300 FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP 310 CAFPTHYEEA LKDEEKAGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins." Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V., De Plaen E., Brasseur R., Monaco A.P., Boon T. Genomics 46:397-408(1997) [PubMed: 9441743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A family of rapidly evolving genes from the sex reversal critical region in Xp21." Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G. Mamm. Genome 6:571-580(1995) [PubMed: 8535061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera." McCurdy D.K., Tai L.-Q., Nguyen J., Wang Z., Yang H.M., Udar N., Naiem F., Concannon P., Gatti R.A. Mol. Genet. Metab. 63:3-13(1998) [PubMed: 9538511] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-61.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-105, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U93163 Genomic DNA. Translation: AAC23617.1. AF015766 mRNA. Translation: AAD01565.1. AC005185 Genomic DNA. Translation: AAD10635.1. BC026071 mRNA. Translation: AAH26071.1.
IPI	IPI00006726.
UniGene	Hs.113824
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O15479. 40 interactions.
PTM databases
PhosphoSite	O15479.
Proteomic databases
PeptideAtlas	O15479.
PRIDE	O15479.
Genome annotation databases
Ensembl	ENSG00000099399. Homo sapiens. [Contig view]
KEGG	hsa:4113.
Organism-specific databases
GeneCards	GC0XP030143.
HGNC	HGNC:6809. MAGEB2.
MIM	300098. gene.
PharmGKB	PA30555.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O15479.
HOVERGEN	O15479.
Gene expression databases
ArrayExpress	O15479.
Bgee	O15479.
CleanEx	HS_MAGEB2.
GermOnline	ENSG00000099399. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. MAGE. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16150.
SOURCE	Search...

Entry information

Entry name

MAGB2_HUMAN

Accession

Primary (citable) accession number: O15479
Secondary accession number(s): O75860

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)