Reviewed,
UniProtKB/Swiss-Prot O15479 (MAGB2_HUMAN)
Last modified
June 16, 2009.
Version 76.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Melanoma-associated antigen B2 Alternative name(s): MAGE-B2 antigen DSS-AHC critical interval MAGE superfamily 6 Short name=DAM6 MAGE XP-2 antigen Cancer/testis antigen 3.2 Short name=CT3.2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 319 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Tissue specificity | Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types. |
| Sequence similarities | Contains 1 MAGE domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Molecular function | Tumor antigen |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CSNK2B | P67870 | 1 | EBI-1057615,EBI-348169 | |
| LXN | Q9BS40 | 1 | EBI-1057615,EBI-1044504 | |
| RPL23A | P62750 | 1 | EBI-1057615,EBI-353254 | |
| RPL24 | P83731 | 1 | EBI-1057615,EBI-353146 | |
| RPL26 | P61254 | 1 | EBI-1057615,EBI-352405 | |
| RPL28 | P46779 | 1 | EBI-1057615,EBI-366357 | |
| RPL31 | P62899 | 1 | EBI-1057615,EBI-1053664 | |
| RPL34 | P49207 | 1 | EBI-1057615,EBI-1051893 | |
| RPL36 | Q9Y3U8 | 1 | EBI-1057615,EBI-1057689 | |
| RPL36A | P83881 | 1 | EBI-1057615,EBI-1054835 | |
| RPS11 | P62280 | 1 | EBI-1057615,EBI-1047710 | |
| RPS14 | P62263 | 1 | EBI-1057615,EBI-352783 | |
| RPS16 | P62249 | 1 | EBI-1057615,EBI-352480 | |
| RPS19 | P39019 | 1 | EBI-1057615,EBI-354451 | |
| RPS26 | P62854 | 1 | EBI-1057615,EBI-353438 | |
| RPS3A | P61247 | 1 | EBI-1057615,EBI-352378 | |
| RPS9 | P46781 | 1 | EBI-1057615,EBI-351206 | |
| USP7 | Q93009 | 1 | EBI-1057615,EBI-302474 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 319 | 319 | Melanoma-associated antigen B2 | PRO_0000156713 | |||||
Regions | |||||||||
| Domain | 111 – 310 | 200 | MAGE | ||||||
Amino acid modifications | |||||||||
| Modified residue | 77 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 105 | 1 | Phosphoserine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 61 | 1 | K → E: dbSNP rs2529541. Ref.4 | VAR_027675 | |||||
| Natural variant | 318 | 1 | G → R: dbSNP rs5972090. | VAR_027676 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins." Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V., De Plaen E., Brasseur R., Monaco A.P., Boon T. Genomics 46:397-408(1997) [PubMed: 9441743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "A family of rapidly evolving genes from the sex reversal critical region in Xp21." Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G. Mamm. Genome 6:571-580(1995) [PubMed: 8535061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [3] | "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera." McCurdy D.K., Tai L.-Q., Nguyen J., Wang Z., Yang H.M., Udar N., Naiem F., Concannon P., Gatti R.A. Mol. Genet. Metab. 63:3-13(1998) [PubMed: 9538511] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-61. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [6] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-105, MASS SPECTROMETRY. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U93163 Genomic DNA. Translation: AAC23617.1. AF015766 mRNA. Translation: AAD01565.1. AC005185 Genomic DNA. Translation: AAD10635.1. BC026071 mRNA. Translation: AAH26071.1. | |
| IPI | IPI00006726. |
| UniGene | Hs.113824 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O15479. 40 interactions. |
PTM databases | |
| PhosphoSite | O15479. |
Proteomic databases | |
| PeptideAtlas | O15479. |
| PRIDE | O15479. |
Genome annotation databases | |
| Ensembl | ENSG00000099399. Homo sapiens. [Contig view] |
| KEGG | hsa:4113. |
Organism-specific databases | |
| GeneCards | GC0XP030143. |
| HGNC | HGNC:6809. MAGEB2. |
| MIM | 300098. gene. |
| PharmGKB | PA30555. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O15479. |
| HOVERGEN | O15479. |
Gene expression databases | |
| ArrayExpress | O15479. |
| Bgee | O15479. |
| CleanEx | HS_MAGEB2. |
| GermOnline | ENSG00000099399. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002190. MAGE. [Graphical view] |
| PANTHER | PTHR11736. MAGE. 1 hit. |
| Pfam | PF01454. MAGE. 1 hit. [Graphical view] |
| PROSITE | PS50838. MAGE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 16150. |
| SOURCE | Search... |
Entry information
| Entry name | MAGB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O15479 Secondary accession number(s): O75860 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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