Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15479

- MAGB2_HUMAN

UniProt

O15479 - MAGB2_HUMAN

Protein

Melanoma-associated antigen B2

Gene

MAGEB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

    Keywords - Molecular functioni

    Tumor antigen

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen B2
    Alternative name(s):
    Cancer/testis antigen 3.2
    Short name:
    CT3.2
    DSS-AHC critical interval MAGE superfamily 6
    Short name:
    DAM6
    MAGE XP-2 antigen
    MAGE-B2 antigen
    Gene namesi
    Name:MAGEB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6809. MAGEB2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Melanoma-associated antigen B2PRO_0000156713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771Phosphoserine1 Publication
    Modified residuei105 – 1051Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15479.
    PaxDbiO15479.
    PeptideAtlasiO15479.
    PRIDEiO15479.

    PTM databases

    PhosphoSiteiO15479.

    Expressioni

    Tissue specificityi

    Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.

    Gene expression databases

    BgeeiO15479.
    CleanExiHS_MAGEB2.
    GenevestigatoriO15479.

    Interactioni

    Subunit structurei

    Interacts with TRIM28.1 Publication

    Protein-protein interaction databases

    BioGridi110287. 24 interactions.
    IntActiO15479. 3 interactions.
    MINTiMINT-8417691.
    STRINGi9606.ENSP00000368273.

    Structurei

    3D structure databases

    ProteinModelPortaliO15479.
    SMRiO15479. Positions 100-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini111 – 310200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320712.
    HOGENOMiHOG000231161.
    HOVERGENiHBG006315.
    InParanoidiO15479.
    OMAiRFREHFP.
    OrthoDBiEOG75F4GM.
    PhylomeDBiO15479.
    TreeFamiTF328505.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15479-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA    50
    SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS 100
    TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP 150
    EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR 200
    RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK 250
    DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP 300
    CAFPTHYEEA LKDEEKAGV 319
    Length:319
    Mass (Da):35,277
    Last modified:January 11, 2011 - v3
    Checksum:iCF0BD27A832D5CBB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611E → K.4 Publications
    Corresponds to variant rs2529541 [ dbSNP | Ensembl ].
    VAR_027675
    Natural varianti318 – 3181G → R.
    Corresponds to variant rs5972090 [ dbSNP | Ensembl ].
    VAR_027676

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U93163 Genomic DNA. Translation: AAC23617.1.
    AF015766 mRNA. Translation: AAD01565.1.
    AC005185 Genomic DNA. Translation: AAD10635.1.
    BC026071 mRNA. Translation: AAH26071.1.
    CCDSiCCDS14219.1.
    RefSeqiNP_002355.2. NM_002364.4.
    UniGeneiHs.113824.

    Genome annotation databases

    EnsembliENST00000378988; ENSP00000368273; ENSG00000099399.
    GeneIDi4113.
    KEGGihsa:4113.
    UCSCiuc004dbz.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U93163 Genomic DNA. Translation: AAC23617.1 .
    AF015766 mRNA. Translation: AAD01565.1 .
    AC005185 Genomic DNA. Translation: AAD10635.1 .
    BC026071 mRNA. Translation: AAH26071.1 .
    CCDSi CCDS14219.1.
    RefSeqi NP_002355.2. NM_002364.4.
    UniGenei Hs.113824.

    3D structure databases

    ProteinModelPortali O15479.
    SMRi O15479. Positions 100-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110287. 24 interactions.
    IntActi O15479. 3 interactions.
    MINTi MINT-8417691.
    STRINGi 9606.ENSP00000368273.

    PTM databases

    PhosphoSitei O15479.

    Proteomic databases

    MaxQBi O15479.
    PaxDbi O15479.
    PeptideAtlasi O15479.
    PRIDEi O15479.

    Protocols and materials databases

    DNASUi 4113.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378988 ; ENSP00000368273 ; ENSG00000099399 .
    GeneIDi 4113.
    KEGGi hsa:4113.
    UCSCi uc004dbz.3. human.

    Organism-specific databases

    CTDi 4113.
    GeneCardsi GC0XP030233.
    H-InvDB HIX0016713.
    HGNCi HGNC:6809. MAGEB2.
    MIMi 300098. gene.
    neXtProti NX_O15479.
    PharmGKBi PA30555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320712.
    HOGENOMi HOG000231161.
    HOVERGENi HBG006315.
    InParanoidi O15479.
    OMAi RFREHFP.
    OrthoDBi EOG75F4GM.
    PhylomeDBi O15479.
    TreeFami TF328505.

    Miscellaneous databases

    GeneWikii MAGEB2.
    GenomeRNAii 4113.
    NextBioi 16150.
    PROi O15479.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15479.
    CleanExi HS_MAGEB2.
    Genevestigatori O15479.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of rapidly evolving genes from the sex reversal critical region in Xp21."
      Dabovic B., Zanaria E., Bardoni B., Lisa A., Bordignon C., Russo V., Matessi C., Traversari C., Camerino G.
      Mamm. Genome 6:571-580(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins."
      Lurquin C., De Smet C., Brasseur F., Muscatelli F., Martelange V., De Plaen E., Brasseur R., Monaco A.P., Boon T.
      Genomics 46:397-408(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-61.
    3. "MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera."
      McCurdy D.K., Tai L.-Q., Nguyen J., Wang Z., Yang H.M., Udar N., Naiem F., Concannon P., Gatti R.A.
      Mol. Genet. Metab. 63:3-13(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-61.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-61.
      Tissue: Testis.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-105, VARIANT [LARGE SCALE ANALYSIS] LYS-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
      Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
      Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRIM28.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMAGB2_HUMAN
    AccessioniPrimary (citable) accession number: O15479
    Secondary accession number(s): O75860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3