O15467 (CCL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 16

Alternative name(s):
Chemokine CC-4
Short name=HCC-4
Chemokine LEC
IL-10-inducible chemokine
LCC-1
Liver-expressed chemokine
Lymphocyte and monocyte chemoattractant
Short name=LMC
Monotactin-1
Short name=MTN-1
NCC-4
Small-inducible cytokine A16

Gene names

Name:	CCL16
Synonyms:	ILINCK, NCC4, SCYA16

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Subcellular location	Secreted.
Tissue specificity	Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Induction	By IL10/interleukin-10.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.4. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemoattractant activity Inferred from direct assay PubMed 15001559. Source: UniProtKB chemokine activity Traceable author statement Ref.4. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.1
	Chain	24 – 120	97	C-C motif chemokine 16		PRO_0000005209
Amino acid modifications
	Disulfide bond	37 ↔ 60		By similarity
	Disulfide bond	38 ↔ 76		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O15467 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 373D73016134D894	FASTA	120	13,600
	10 20 30 40 50 60 MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL VVGYRKALNC 70 80 90 100 110 120 HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN LSTVKIITAK NGQPQLLNSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10." Hedrick J.A., Helms A., Vicari A., Zlotnik A. Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Liver.
[2]	"Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC." Shoudai K., Hieshima K., Fukuda S., Iio M., Miura R., Imai T., Yoshie O., Nomiyama H. Biochim. Biophys. Acta 1396:273-277(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES." Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O. J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity." Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr., Hangoc G., Kwon B.S. Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Genomic organization of the genes for human and mouse CC chemokine LEC." Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H. DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[6]	"Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver." Yang J.-Y., Spanaus K.S., Widmer U. Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Liver.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL16 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U91746 mRNA. Translation: AAC05587.1. AB007454 mRNA. Translation: BAA24057.1. AF088219 Genomic DNA. Translation: AAC63330.1. AF055467 mRNA. Translation: AAC28844.1. AB018249 Genomic DNA. Translation: BAA35138.1. AF039954 Genomic DNA. Translation: AAC97450.1. AF039955 mRNA. Translation: AAC97451.1. BC099662 mRNA. Translation: AAH99662.1.
IPI	IPI00006717.
PIR	JE0177.
RefSeq	NP_004581.1. NM_004590.2.
UniGene	Hs.10458.
3D structure databases
ProteinModelPortal	O15467.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5831N.
MINT	MINT-140607.
STRING	9606.ENSP00000293275.
Proteomic databases
PaxDb	O15467.
PeptideAtlas	O15467.
PRIDE	O15467.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293275; ENSP00000293275; ENSG00000161573.
GeneID	6360.
KEGG	hsa:6360.
UCSC	uc002hkl.3. human.
Organism-specific databases
CTD	6360.
GeneCards	GC17M034303.
HGNC	HGNC:10614. CCL16.
MIM	601394. gene.
neXtProt	NX_O15467.
PharmGKB	PA35547.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78179.
HOGENOM	HOG000036685.
InParanoid	O15467.
KO	K05514.
OMA	CCLKYHE.
OrthoDB	EOG4KWJV9.
PhylomeDB	O15467.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O15467.
CleanEx	HS_CCL16.
Genevestigator	O15467.
GermOnline	ENSG00000161573. Homo sapiens.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6360.
NextBio	24712.
SOURCE	Search...

Entry information

Entry name

CCL16_HUMAN

Accession

Primary (citable) accession number: O15467
Secondary accession number(s): Q4KKU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	May 29, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.