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O15467

- CCL16_HUMAN

UniProt

O15467 - CCL16_HUMAN

Protein

C-C motif chemokine 16

Gene

CCL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. cell communication Source: ProtInc
    4. chemotaxis Source: ProtInc
    5. immune response Source: InterPro
    6. inflammatory response Source: UniProtKB-KW
    7. positive chemotaxis Source: GOC

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 16
    Alternative name(s):
    Chemokine CC-4
    Short name:
    HCC-4
    Chemokine LEC
    IL-10-inducible chemokine
    LCC-1
    Liver-expressed chemokine
    Lymphocyte and monocyte chemoattractant
    Short name:
    LMC
    Monotactin-1
    Short name:
    MTN-1
    NCC-4
    Small-inducible cytokine A16
    Gene namesi
    Name:CCL16
    Synonyms:ILINCK, NCC4, SCYA16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10614. CCL16.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35547.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 12097C-C motif chemokine 16PRO_0000005209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 60By similarity
    Disulfide bondi38 ↔ 76By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO15467.
    PeptideAtlasiO15467.
    PRIDEiO15467.

    Expressioni

    Tissue specificityi

    Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

    Inductioni

    By IL10/interleukin-10.

    Gene expression databases

    ArrayExpressiO15467.
    BgeeiO15467.
    CleanExiHS_CCL16.
    GenevestigatoriO15467.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5831N.
    MINTiMINT-140607.
    STRINGi9606.ENSP00000293275.

    Structurei

    3D structure databases

    ProteinModelPortaliO15467.
    SMRiO15467. Positions 34-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG78179.
    HOGENOMiHOG000036685.
    InParanoidiO15467.
    KOiK05514.
    OMAiSPHERGD.
    PhylomeDBiO15467.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL    50
    VVGYRKALNC HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN 100
    LSTVKIITAK NGQPQLLNSQ 120
    Length:120
    Mass (Da):13,600
    Last modified:January 1, 1998 - v1
    Checksum:i373D73016134D894
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91746 mRNA. Translation: AAC05587.1.
    AB007454 mRNA. Translation: BAA24057.1.
    AF088219 Genomic DNA. Translation: AAC63330.1.
    AF055467 mRNA. Translation: AAC28844.1.
    AB018249 Genomic DNA. Translation: BAA35138.1.
    AF039954 Genomic DNA. Translation: AAC97450.1.
    AF039955 mRNA. Translation: AAC97451.1.
    BC099662 mRNA. Translation: AAH99662.1.
    CCDSiCCDS11303.1.
    PIRiJE0177.
    RefSeqiNP_004581.1. NM_004590.2.
    XP_005258077.1. XM_005258020.2.
    XP_006725397.1. XM_006725334.1.
    UniGeneiHs.10458.

    Genome annotation databases

    GeneIDi6360.
    KEGGihsa:6360.
    UCSCiuc002hkl.3. human.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL16 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U91746 mRNA. Translation: AAC05587.1 .
    AB007454 mRNA. Translation: BAA24057.1 .
    AF088219 Genomic DNA. Translation: AAC63330.1 .
    AF055467 mRNA. Translation: AAC28844.1 .
    AB018249 Genomic DNA. Translation: BAA35138.1 .
    AF039954 Genomic DNA. Translation: AAC97450.1 .
    AF039955 mRNA. Translation: AAC97451.1 .
    BC099662 mRNA. Translation: AAH99662.1 .
    CCDSi CCDS11303.1.
    PIRi JE0177.
    RefSeqi NP_004581.1. NM_004590.2.
    XP_005258077.1. XM_005258020.2.
    XP_006725397.1. XM_006725334.1.
    UniGenei Hs.10458.

    3D structure databases

    ProteinModelPortali O15467.
    SMRi O15467. Positions 34-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5831N.
    MINTi MINT-140607.
    STRINGi 9606.ENSP00000293275.

    Proteomic databases

    PaxDbi O15467.
    PeptideAtlasi O15467.
    PRIDEi O15467.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6360.
    KEGGi hsa:6360.
    UCSCi uc002hkl.3. human.

    Organism-specific databases

    CTDi 6360.
    GeneCardsi GC17M034303.
    HGNCi HGNC:10614. CCL16.
    MIMi 601394. gene.
    neXtProti NX_O15467.
    PharmGKBi PA35547.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78179.
    HOGENOMi HOG000036685.
    InParanoidi O15467.
    KOi K05514.
    OMAi SPHERGD.
    PhylomeDBi O15467.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 6360.
    NextBioi 24712.
    PROi O15467.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15467.
    Bgeei O15467.
    CleanExi HS_CCL16.
    Genevestigatori O15467.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10."
      Hedrick J.A., Helms A., Vicari A., Zlotnik A.
      Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
      Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
      J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity."
      Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr., Hangoc G., Kwon B.S.
      Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Genomic organization of the genes for human and mouse CC chemokine LEC."
      Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H.
      DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    6. "Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver."
      Yang J.-Y., Spanaus K.S., Widmer U.
      Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Liver.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCCL16_HUMAN
    AccessioniPrimary (citable) accession number: O15467
    Secondary accession number(s): Q4KKU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3