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Protein

C-C motif chemokine 16

Gene

CCL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • chemokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell chemotaxis Source: GOC
  • cell communication Source: ProtInc
  • chemotaxis Source: ProtInc
  • immune response Source: InterPro
  • inflammatory response Source: UniProtKB-KW
  • positive chemotaxis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 16
Alternative name(s):
Chemokine CC-4
Short name:
HCC-4
Chemokine LEC
IL-10-inducible chemokine
LCC-1
Liver-expressed chemokine
Lymphocyte and monocyte chemoattractant
Short name:
LMC
Monotactin-1
Short name:
MTN-1
NCC-4
Small-inducible cytokine A16
Gene namesi
Name:CCL16
Synonyms:ILINCK, NCC4, SCYA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 17, Unplaced

Organism-specific databases

HGNCiHGNC:10614. CCL16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35547.

Polymorphism and mutation databases

BioMutaiCCL16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 12097C-C motif chemokine 16PRO_0000005209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi38 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15467.
PeptideAtlasiO15467.
PRIDEiO15467.

Expressioni

Tissue specificityi

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Inductioni

By IL10/interleukin-10.

Gene expression databases

BgeeiO15467.
CleanExiHS_CCL16.
ExpressionAtlasiO15467. baseline and differential.
GenevestigatoriO15467.

Interactioni

Protein-protein interaction databases

DIPiDIP-5831N.
MINTiMINT-140607.
STRINGi9606.ENSP00000293275.

Structurei

3D structure databases

ProteinModelPortaliO15467.
SMRiO15467. Positions 34-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78179.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
InParanoidiO15467.
KOiK05514.
OMAiCCLKYHE.
PhylomeDBiO15467.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL
60 70 80 90 100
VVGYRKALNC HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN
110 120
LSTVKIITAK NGQPQLLNSQ
Length:120
Mass (Da):13,600
Last modified:January 1, 1998 - v1
Checksum:i373D73016134D894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA. Translation: AAC05587.1.
AB007454 mRNA. Translation: BAA24057.1.
AF088219 Genomic DNA. Translation: AAC63330.1.
AF055467 mRNA. Translation: AAC28844.1.
AB018249 Genomic DNA. Translation: BAA35138.1.
AF039954 Genomic DNA. Translation: AAC97450.1.
AF039955 mRNA. Translation: AAC97451.1.
BC099662 mRNA. Translation: AAH99662.1.
CCDSiCCDS11303.1.
PIRiJE0177.
RefSeqiNP_004581.1. NM_004590.3.
XP_005258077.1. XM_005258020.3.
XP_006725397.1. XM_006725334.2.
UniGeneiHs.10458.

Genome annotation databases

EnsembliENST00000611905; ENSP00000478024; ENSG00000275152.
ENST00000621559; ENSP00000482168; ENSG00000275095.
GeneIDi6360.
KEGGihsa:6360.
UCSCiuc002hkl.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA. Translation: AAC05587.1.
AB007454 mRNA. Translation: BAA24057.1.
AF088219 Genomic DNA. Translation: AAC63330.1.
AF055467 mRNA. Translation: AAC28844.1.
AB018249 Genomic DNA. Translation: BAA35138.1.
AF039954 Genomic DNA. Translation: AAC97450.1.
AF039955 mRNA. Translation: AAC97451.1.
BC099662 mRNA. Translation: AAH99662.1.
CCDSiCCDS11303.1.
PIRiJE0177.
RefSeqiNP_004581.1. NM_004590.3.
XP_005258077.1. XM_005258020.3.
XP_006725397.1. XM_006725334.2.
UniGeneiHs.10458.

3D structure databases

ProteinModelPortaliO15467.
SMRiO15467. Positions 34-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5831N.
MINTiMINT-140607.
STRINGi9606.ENSP00000293275.

Polymorphism and mutation databases

BioMutaiCCL16.

Proteomic databases

PaxDbiO15467.
PeptideAtlasiO15467.
PRIDEiO15467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611905; ENSP00000478024; ENSG00000275152.
ENST00000621559; ENSP00000482168; ENSG00000275095.
GeneIDi6360.
KEGGihsa:6360.
UCSCiuc002hkl.3. human.

Organism-specific databases

CTDi6360.
GeneCardsiGC17M034303.
HGNCiHGNC:10614. CCL16.
MIMi601394. gene.
neXtProtiNX_O15467.
PharmGKBiPA35547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78179.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
InParanoidiO15467.
KOiK05514.
OMAiCCLKYHE.
PhylomeDBiO15467.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii6360.
NextBioi24712.
PROiO15467.
SOURCEiSearch...

Gene expression databases

BgeeiO15467.
CleanExiHS_CCL16.
ExpressionAtlasiO15467. baseline and differential.
GenevestigatoriO15467.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10."
    Hedrick J.A., Helms A., Vicari A., Zlotnik A.
    Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity."
    Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr., Hangoc G., Kwon B.S.
    Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Genomic organization of the genes for human and mouse CC chemokine LEC."
    Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H.
    DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  6. "Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver."
    Yang J.-Y., Spanaus K.S., Widmer U.
    Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Liver.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCCL16_HUMAN
AccessioniPrimary (citable) accession number: O15467
Secondary accession number(s): Q4KKU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.