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O15467

- CCL16_HUMAN

UniProt

O15467 - CCL16_HUMAN

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Protein

C-C motif chemokine 16

Gene

CCL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

GO - Molecular functioni

  1. chemoattractant activity Source: UniProtKB
  2. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. cell communication Source: ProtInc
  4. chemotaxis Source: ProtInc
  5. immune response Source: InterPro
  6. inflammatory response Source: UniProtKB-KW
  7. positive chemotaxis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 16
Alternative name(s):
Chemokine CC-4
Short name:
HCC-4
Chemokine LEC
IL-10-inducible chemokine
LCC-1
Liver-expressed chemokine
Lymphocyte and monocyte chemoattractant
Short name:
LMC
Monotactin-1
Short name:
MTN-1
NCC-4
Small-inducible cytokine A16
Gene namesi
Name:CCL16
Synonyms:ILINCK, NCC4, SCYA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10614. CCL16.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 12097C-C motif chemokine 16PRO_0000005209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 60By similarity
Disulfide bondi38 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15467.
PeptideAtlasiO15467.
PRIDEiO15467.

Expressioni

Tissue specificityi

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Inductioni

By IL10/interleukin-10.

Gene expression databases

BgeeiO15467.
CleanExiHS_CCL16.
ExpressionAtlasiO15467. differential.
GenevestigatoriO15467.

Interactioni

Protein-protein interaction databases

DIPiDIP-5831N.
MINTiMINT-140607.
STRINGi9606.ENSP00000293275.

Structurei

3D structure databases

ProteinModelPortaliO15467.
SMRiO15467. Positions 34-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78179.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
InParanoidiO15467.
KOiK05514.
OMAiSPHERGD.
PhylomeDBiO15467.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15467-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL
60 70 80 90 100
VVGYRKALNC HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN
110 120
LSTVKIITAK NGQPQLLNSQ
Length:120
Mass (Da):13,600
Last modified:January 1, 1998 - v1
Checksum:i373D73016134D894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA. Translation: AAC05587.1.
AB007454 mRNA. Translation: BAA24057.1.
AF088219 Genomic DNA. Translation: AAC63330.1.
AF055467 mRNA. Translation: AAC28844.1.
AB018249 Genomic DNA. Translation: BAA35138.1.
AF039954 Genomic DNA. Translation: AAC97450.1.
AF039955 mRNA. Translation: AAC97451.1.
BC099662 mRNA. Translation: AAH99662.1.
CCDSiCCDS11303.1.
PIRiJE0177.
RefSeqiNP_004581.1. NM_004590.2.
XP_005258077.1. XM_005258020.2.
XP_006725397.1. XM_006725334.1.
UniGeneiHs.10458.

Genome annotation databases

EnsembliENST00000611905; ENSP00000478024; ENSG00000275152.
ENST00000621559; ENSP00000482168; ENSG00000275095.
GeneIDi6360.
KEGGihsa:6360.
UCSCiuc002hkl.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91746 mRNA. Translation: AAC05587.1 .
AB007454 mRNA. Translation: BAA24057.1 .
AF088219 Genomic DNA. Translation: AAC63330.1 .
AF055467 mRNA. Translation: AAC28844.1 .
AB018249 Genomic DNA. Translation: BAA35138.1 .
AF039954 Genomic DNA. Translation: AAC97450.1 .
AF039955 mRNA. Translation: AAC97451.1 .
BC099662 mRNA. Translation: AAH99662.1 .
CCDSi CCDS11303.1.
PIRi JE0177.
RefSeqi NP_004581.1. NM_004590.2.
XP_005258077.1. XM_005258020.2.
XP_006725397.1. XM_006725334.1.
UniGenei Hs.10458.

3D structure databases

ProteinModelPortali O15467.
SMRi O15467. Positions 34-90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5831N.
MINTi MINT-140607.
STRINGi 9606.ENSP00000293275.

Proteomic databases

PaxDbi O15467.
PeptideAtlasi O15467.
PRIDEi O15467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000611905 ; ENSP00000478024 ; ENSG00000275152 .
ENST00000621559 ; ENSP00000482168 ; ENSG00000275095 .
GeneIDi 6360.
KEGGi hsa:6360.
UCSCi uc002hkl.3. human.

Organism-specific databases

CTDi 6360.
GeneCardsi GC17M034303.
HGNCi HGNC:10614. CCL16.
MIMi 601394. gene.
neXtProti NX_O15467.
PharmGKBi PA35547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78179.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
InParanoidi O15467.
KOi K05514.
OMAi SPHERGD.
PhylomeDBi O15467.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 6360.
NextBioi 24712.
PROi O15467.
SOURCEi Search...

Gene expression databases

Bgeei O15467.
CleanExi HS_CCL16.
ExpressionAtlasi O15467. differential.
Genevestigatori O15467.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10."
    Hedrick J.A., Helms A., Vicari A., Zlotnik A.
    Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity."
    Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr., Hangoc G., Kwon B.S.
    Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Genomic organization of the genes for human and mouse CC chemokine LEC."
    Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H.
    DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  6. "Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver."
    Yang J.-Y., Spanaus K.S., Widmer U.
    Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Liver.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCCL16_HUMAN
AccessioniPrimary (citable) accession number: O15467
Secondary accession number(s): Q4KKU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3