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O15467 (CCL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 16
Alternative name(s):
Chemokine CC-4
Short name=HCC-4
Chemokine LEC
IL-10-inducible chemokine
LCC-1
Liver-expressed chemokine
Lymphocyte and monocyte chemoattractant
Short name=LMC
Monotactin-1
Short name=MTN-1
NCC-4
Small-inducible cytokine A16
Gene names
Name:CCL16
Synonyms:ILINCK, NCC4, SCYA16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Subcellular location

Secreted.

Tissue specificity

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Induction

By IL10/interleukin-10.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 12097C-C motif chemokine 16
PRO_0000005209

Amino acid modifications

Disulfide bond37 ↔ 60 By similarity
Disulfide bond38 ↔ 76 By similarity

Sequences

Sequence LengthMass (Da)Tools
O15467 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 373D73016134D894

FASTA12013,600
        10         20         30         40         50         60 
MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL VVGYRKALNC 

        70         80         90        100        110        120 
HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN LSTVKIITAK NGQPQLLNSQ 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10."
Hedrick J.A., Helms A., Vicari A., Zlotnik A.
Blood 91:4242-4247(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
Tissue: Liver.
[2]"Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC."
Shoudai K., Hieshima K., Fukuda S., Iio M., Miura R., Imai T., Yoshie O., Nomiyama H.
Biochim. Biophys. Acta 1396:273-277(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity."
Youn B.-S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr., Hangoc G., Kwon B.S.
Biochem. Biophys. Res. Commun. 247:217-222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Genomic organization of the genes for human and mouse CC chemokine LEC."
Fukuda S., Hanano Y., Iio M., Miura R., Yoshie O., Nomiyama H.
DNA Cell Biol. 18:275-283(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[6]"Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver."
Yang J.-Y., Spanaus K.S., Widmer U.
Cytokine 12:101-109(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Liver.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Wikipedia

CCL16 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U91746 mRNA. Translation: AAC05587.1.
AB007454 mRNA. Translation: BAA24057.1.
AF088219 Genomic DNA. Translation: AAC63330.1.
AF055467 mRNA. Translation: AAC28844.1.
AB018249 Genomic DNA. Translation: BAA35138.1.
AF039954 Genomic DNA. Translation: AAC97450.1.
AF039955 mRNA. Translation: AAC97451.1.
BC099662 mRNA. Translation: AAH99662.1.
CCDSCCDS11303.1.
PIRJE0177.
RefSeqNP_004581.1. NM_004590.2.
XP_005258077.1. XM_005258020.2.
XP_006725397.1. XM_006725334.1.
UniGeneHs.10458.

3D structure databases

ProteinModelPortalO15467.
SMRO15467. Positions 34-90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5831N.
MINTMINT-140607.
STRING9606.ENSP00000293275.

Proteomic databases

PaxDbO15467.
PeptideAtlasO15467.
PRIDEO15467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293275; ENSP00000293275; ENSG00000161573.
GeneID6360.
KEGGhsa:6360.
UCSCuc002hkl.3. human.

Organism-specific databases

CTD6360.
GeneCardsGC17M034303.
HGNCHGNC:10614. CCL16.
MIM601394. gene.
neXtProtNX_O15467.
PharmGKBPA35547.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78179.
HOGENOMHOG000036685.
InParanoidO15467.
KOK05514.
OMASPHERGD.
PhylomeDBO15467.
TreeFamTF334888.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO15467.
BgeeO15467.
CleanExHS_CCL16.
GenevestigatorO15467.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6360.
NextBio24712.
PROO15467.
SOURCESearch...

Entry information

Entry nameCCL16_HUMAN
AccessionPrimary (citable) accession number: O15467
Secondary accession number(s): Q4KKU0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM