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O15453 (NBR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Next to BRCA1 gene 2 protein
Alternative name(s):
Neighbor of BRCA1 gene 2 protein
Gene names
Name:NBR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Ubiquitous.

Miscellaneous

BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 112112Next to BRCA1 gene 2 protein
PRO_0000096750

Natural variations

Natural variant1021Q → E.
Corresponds to variant rs11657835 [ dbSNP | Ensembl ].
VAR_034096

Sequences

Sequence LengthMass (Da)Tools
O15453 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 3A4A174F7EFF834E

FASTA11212,357
        10         20         30         40         50         60 
MWKGGRSHPF LPCSSRRAGS GGQLDSILPH QSPAWGPWGC KDLSSGVPSF LTSSILWKSA 

        70         80         90        100        110 
VFAEDNGLKI HLCSYKRDDL VLFYDCTSFV LTFGPSPWFL TQGFLNPLEF SA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene."
Xu C.-F., Brown M.A., Nicolai H., Chambers J.A., Griffiths B.L., Solomon E.
Hum. Mol. Genet. 6:1057-1062(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary gland and Placenta.
[2]Raymond C.K., Paddock M., Subramanian S., Deodato C., Zhou Y., Haugen E., Kaul R., Olson M.V.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88573 mRNA. Translation: AAB65619.1.
DQ190450 Genomic DNA. Translation: ABA29209.1.
DQ190451 Genomic DNA. Translation: ABA29212.1.
DQ190452 Genomic DNA. Translation: ABA29215.1.
DQ190453 Genomic DNA. Translation: ABA29218.1.
DQ190454 Genomic DNA. Translation: ABA29221.1.
DQ190455 Genomic DNA. Translation: ABA29224.1.
DQ190456 Genomic DNA. Translation: ABA29227.1.
DQ190457 Genomic DNA. Translation: ABA29230.1.
DQ478408 Genomic DNA. Translation: ABF14463.1.
BC107773 mRNA. No translation available.

3D structure databases

ProteinModelPortalO15453.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000349375.

Proteomic databases

PaxDbO15453.
PRIDEO15453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC17P041277.
H-InvDBHIX0202501.
HGNCHGNC:20691. NBR2.
neXtProtNX_O15453.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000293228.
HOVERGENHBG001196.
PhylomeDBO15453.

Gene expression databases

GenevestigatorO15453.

Family and domain databases

ProtoNetSearch...

Other

NextBio35537551.
PROO15453.

Entry information

Entry nameNBR2_HUMAN
AccessionPrimary (citable) accession number: O15453
Secondary accession number(s): Q3LRJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: January 22, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM